| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.133391 |
| TXNRD1 | thioredoxin reductase 1 | 0.109102 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.106211 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.103802 |
| ENO1 | enolase 1, (alpha) | 0.0993231 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0981973 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0923992 |
| ACTG1 | actin gamma 1 | 0.0909164 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0884594 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0872854 |
| POTEF | POTE ankyrin domain family, member F | 0.0822613 |
| JMJD1C | jumonji domain containing 1C | 0.0745191 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0727786 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0667628 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0632431 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0629945 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0611898 |
| PTMA | prothymosin, alpha | 0.0578966 |
| MCL1 | myeloid cell leukemia 1 | 0.0550675 |
| SGMS2 | sphingomyelin synthase 2 | 0.0546271 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0519623 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0501225 |
| MT2A | metallothionein 2A | 0.0491471 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0491433 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0480293 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0478952 |
| RPL3 | ribosomal protein L3 | 0.0455411 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.044435 |
| UBC | ubiquitin C | 0.0438608 |
| EXT1 | exostosin glycosyltransferase 1 | 0.043694 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0435301 |
| PKM | pyruvate kinase, muscle | 0.042205 |
| CORO1C | coronin, actin binding protein, 1C | 0.040318 |
| B2M | beta-2-microglobulin | 0.0393948 |
| JUN | jun proto-oncogene | 0.0391699 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0390895 |
| RPL35 | ribosomal protein L35 | 0.0383716 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.037806 |
| RPLP1 | ribosomal protein, large, P1 | 0.0376269 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0375705 |
| RPS4X | ribosomal protein S4, X-linked | 0.0374238 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 0.0372642 |
| CREB5 | cAMP responsive element binding protein 5 | 0.037081 |
| LDHA | lactate dehydrogenase A | 0.0369866 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0356008 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0354405 |
| RASA2 | RAS p21 protein activator 2 | 0.0350316 |
| TOP1 | topoisomerase (DNA) I | 0.0347989 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0347171 |
| RPL8 | ribosomal protein L8 | 0.033771 |
| TRAM1 | translocation associated membrane protein 1 | 0.033588 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0334272 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0327066 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.032644 |
| IL6ST | interleukin 6 signal transducer | 0.032597 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0321965 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0321702 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0311009 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0310399 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0306712 |
| CENPF | centromere protein F, 350/400kDa | 0.0306475 |
| CLTC | clathrin, heavy chain (Hc) | 0.0306139 |
| CDK17 | cyclin-dependent kinase 17 | 0.030243 |
| UPP1 | uridine phosphorylase 1 | 0.030024 |
| RPLP0 | ribosomal protein, large, P0 | 0.0297187 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.029676 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.029442 |
| PFN1 | profilin 1 | 0.0292966 |
| YBX1 | Y box binding protein 1 | 0.028365 |
| GPHN | gephyrin | 0.0282975 |
| VMP1 | vacuole membrane protein 1 | 0.0282186 |
| FAM120A | family with sequence similarity 120A | 0.0281872 |
| MKI67 | marker of proliferation Ki-67 | 0.0277167 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0274192 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0273045 |
| ATP13A3 | ATPase type 13A3 | 0.0272756 |
| SHANK1 | SH3 and multiple ankyrin repeat domains 1 | 0.0272585 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0271206 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.026473 |
| TMEM41B | transmembrane protein 41B | 0.0264202 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0261982 |
| TPM4 | tropomyosin 4 | 0.0258212 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.025433 |
| RPS19 | ribosomal protein S19 | 0.0253753 |
| AHNAK | AHNAK nucleoprotein | 0.0252453 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0251821 |
| KLF10 | Kruppel-like factor 10 | 0.0249615 |
| FOSL1 | FOS-like antigen 1 | 0.0244908 |
| KIF5B | kinesin family member 5B | 0.0244533 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0243309 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0243012 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.024155 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0240195 |
| CDC27 | cell division cycle 27 | 0.0238942 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0238822 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0235493 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0234867 |
| TMSB10 | thymosin beta 10 | 0.0234825 |
| RTN4 | reticulon 4 | 0.0233148 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0229521 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD6 | FERM domain containing 6 | -0.159313 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.145646 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.109047 |
| NAV3 | neuron navigator 3 | -0.102599 |
| NABP1 | nucleic acid binding protein 1 | -0.0861967 |
| TTR | transthyretin | -0.0774133 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0675015 |
| RPL37A | ribosomal protein L37a | -0.0645922 |
| BNC2 | basonuclin 2 | -0.0596292 |
| RPS3 | ribosomal protein S3 | -0.0592142 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0588115 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0574185 |
| NAV2 | neuron navigator 2 | -0.0556274 |
| HMGA2 | high mobility group AT-hook 2 | -0.0513229 |
| ZNF438 | zinc finger protein 438 | -0.0466444 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0464225 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0459484 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0459132 |
| DGKI | diacylglycerol kinase, iota | -0.0449024 |
| DENND1A | DENN/MADD domain containing 1A | -0.0442355 |
| INTS6 | integrator complex subunit 6 | -0.0441472 |
| RAD51B | RAD51 paralog B | -0.0439243 |
| RPL13A | ribosomal protein L13a | -0.0429179 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0421173 |
| AEBP2 | AE binding protein 2 | -0.0420107 |
| FHIT | fragile histidine triad | -0.0398629 |
| FRMD4A | FERM domain containing 4A | -0.0394452 |
| RPS12 | ribosomal protein S12 | -0.0387192 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0381269 |
| RPS29 | ribosomal protein S29 | -0.0370603 |
| MTAP | methylthioadenosine phosphorylase | -0.0366714 |
| MSH4 | mutS homolog 4 | -0.0364535 |
| MYRFL | myelin regulatory factor-like | -0.0363548 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0346188 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0344783 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0327767 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0322984 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0322237 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0317806 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0317759 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0316418 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0314625 |
| RPS27A | ribosomal protein S27a | -0.0294904 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0289828 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0288943 |
| FMNL2 | formin-like 2 | -0.0284232 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0279768 |
| RPL7A | ribosomal protein L7a | -0.0277871 |
| CALD1 | caldesmon 1 | -0.0264801 |
| EXOC4 | exocyst complex component 4 | -0.0264074 |
| SMYD3 | SET and MYND domain containing 3 | -0.0261376 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0257487 |
| CFAP54 | cilia and flagella associated 54 | -0.0254581 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0247898 |
| MROH1 | maestro heat-like repeat family member 1 | -0.0247869 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.024742 |
| PTK2 | protein tyrosine kinase 2 | -0.0245846 |
| RPL38 | ribosomal protein L38 | -0.0243068 |
| RPL37 | ribosomal protein L37 | -0.0241854 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0240136 |
| SBF2 | SET binding factor 2 | -0.0240084 |
| CDKL1 | cyclin-dependent kinase-like 1 (CDC2-related kinase) | -0.0239507 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0238857 |
| ASPH | aspartate beta-hydroxylase | -0.023701 |
| DIAPH2 | diaphanous-related formin 2 | -0.0234551 |
| RPL11 | ribosomal protein L11 | -0.023335 |
| RPL31 | ribosomal protein L31 | -0.0231896 |
| TSNARE1 | t-SNARE domain containing 1 | -0.0230632 |
| ANK2 | ankyrin 2, neuronal | -0.0229471 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0229451 |
| GPR75-ASB3 | GPR75-ASB3 readthrough | -0.0224425 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0223838 |
| ZNF638 | zinc finger protein 638 | -0.0221365 |
| CCDC91 | coiled-coil domain containing 91 | -0.0217368 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0214535 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0214402 |
| LAMB3 | laminin, beta 3 | -0.0213537 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.021315 |
| ADAMTSL1 | ADAMTS-like 1 | -0.0212293 |
| KCNMB4 | potassium channel subfamily M regulatory beta subunit 4 | -0.0210729 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0209464 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0208163 |
| NRF1 | nuclear respiratory factor 1 | -0.020754 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0204388 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.019949 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0196857 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0195424 |
| COMMD10 | COMM domain containing 10 | -0.0192763 |
| PRKCE | protein kinase C, epsilon | -0.0192736 |
| RNF220 | ring finger protein 220 | -0.0187837 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.018737 |
| LRRC69 | leucine rich repeat containing 69 | -0.018728 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0185482 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0184358 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0183475 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0182426 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0181177 |
| RCC1 | regulator of chromosome condensation 1 | -0.0180728 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0178642 |
| AOPEP | aminopeptidase O (putative) | -0.0178347 |
