APTO-253_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SP100 SP100 nuclear antigen 0.0536889
EXT1 exostosin glycosyltransferase 1 0.0464454
HDAC9 histone deacetylase 9 0.0456877
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0443173
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0417925
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0410837
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0409124
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0380136
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0357983
VCL vinculin 0.0317422
SMAD3 SMAD family member 3 0.0301455
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0267104
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0263469
ZSWIM6 zinc finger, SWIM-type containing 6 0.0261737
ZBTB38 zinc finger and BTB domain containing 38 0.0259121
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0255149
FNIP1 folliculin interacting protein 1 0.0252761
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0252359
PMP22 peripheral myelin protein 22 0.0234627
CLIC4 chloride intracellular channel 4 0.0229082
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0227793
IFI16 interferon, gamma-inducible protein 16 0.0221898
GLS2 glutaminase 2 (liver, mitochondrial) 0.0221495
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0218483
SLIT2 slit homolog 2 (Drosophila) 0.0210857
FNDC3B fibronectin type III domain containing 3B 0.0208667
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0208124
TLE4 transducin-like enhancer of split 4 0.0203336
GOLGB1 golgin B1 0.0201744
SAMD9 sterile alpha motif domain containing 9 0.0201671
WWTR1 WW domain containing transcription regulator 1 0.0200272
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0198464
NRIP1 nuclear receptor interacting protein 1 0.0197911
KYNU kynureninase 0.0197239
IFI44L interferon-induced protein 44-like 0.0191902
NPAS2 neuronal PAS domain protein 2 0.0190692
SMYD3 SET and MYND domain containing 3 0.018659
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.018652
MBD5 methyl-CpG binding domain protein 5 0.0180433
ANXA2 annexin A2 0.0175758
AHNAK AHNAK nucleoprotein 0.0172612
CD44 CD44 molecule (Indian blood group) 0.017122
FRMD4A FERM domain containing 4A 0.0165252
SFPQ splicing factor proline/glutamine-rich 0.0164042
SUMF1 sulfatase modifying factor 1 0.016284
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0153726
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0153009
H1-0 H1.0 linker histone 0.0152235
WNT9A wingless-type MMTV integration site family, member 9A 0.0151519
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0148381
IFIH1 interferon induced with helicase C domain 1 0.0148148
RUNX1 runt-related transcription factor 1 0.0144475
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0143822
BBS9 Bardet-Biedl syndrome 9 0.0142154
PTPRM protein tyrosine phosphatase, receptor type, M 0.0140354
THADA thyroid adenoma associated 0.013927
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0139066
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0136258
CORO1C coronin, actin binding protein, 1C 0.0135375
PLSCR1 phospholipid scramblase 1 0.0133914
ACER3 alkaline ceramidase 3 0.013351
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0133261
PLAT plasminogen activator, tissue 0.0131754
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0131482
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0130032
DAAM1 dishevelled associated activator of morphogenesis 1 0.0129641
SON SON DNA binding protein 0.0128967
FHIT fragile histidine triad 0.0128701
SERBP1 SERPINE1 mRNA binding protein 1 0.0128604
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0126189
PIBF1 progesterone immunomodulatory binding factor 1 0.012515
PICALM phosphatidylinositol binding clathrin assembly protein 0.0125107
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.0123899
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0123602
CREB5 cAMP responsive element binding protein 5 0.0123415
HPCAL1 hippocalcin-like 1 0.0123133
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0122077
RBBP6 retinoblastoma binding protein 6 0.0121285
TTC17 tetratricopeptide repeat domain 17 0.0121209
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0120769
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0120662
TDRD7 tudor domain containing 7 0.0119808
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0119425
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0119218
PRRC2C proline-rich coiled-coil 2C 0.0119122
KDM5C lysine (K)-specific demethylase 5C 0.0118629
FBXL7 F-box and leucine-rich repeat protein 7 0.0117435
UBN1 ubinuclein 1 0.0117219
TASOR transcription activation suppressor 0.011685
SIK3 SIK family kinase 3 0.0116385
NDEL1 nudE neurodevelopment protein 1-like 1 0.0115878
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0114632
TBC1D4 TBC1 domain family, member 4 0.0114327
HSPH1 heat shock 105kDa/110kDa protein 1 0.0114057
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.011356
PHF14 PHD finger protein 14 0.0113377
CYTH3 cytohesin 3 0.0112503
SMC1A structural maintenance of chromosomes 1A 0.0111797
DST dystonin 0.0111755
ATOSA atos homolog A 0.011123

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.320393
B2M beta-2-microglobulin -0.154307
FN1 fibronectin 1 -0.147831
STC1 stanniocalcin 1 -0.131337
FTL ferritin, light polypeptide -0.127103
HLA-B major histocompatibility complex, class I, B -0.123795
NDRG1 N-myc downstream regulated 1 -0.114973
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112058
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.10939
TMSB10 thymosin beta 10 -0.0846336
MT2A metallothionein 2A -0.0823377
COL6A1 collagen, type VI, alpha 1 -0.0738375
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0686182
PTMA prothymosin, alpha -0.0599796
COL1A2 collagen, type I, alpha 2 -0.0544547
POTEF POTE ankyrin domain family, member F -0.0536308
RPL35A ribosomal protein L35a -0.0505399
RPS6 ribosomal protein S6 -0.0497403
CEMIP cell migration inducing protein, hyaluronan binding -0.0494969
IFI6 interferon, alpha-inducible protein 6 -0.0480729
LOXL2 lysyl oxidase-like 2 -0.0478069
HLA-A major histocompatibility complex, class I, A -0.0465942
TPM4 tropomyosin 4 -0.0458915
PGK1 phosphoglycerate kinase 1 -0.0451276
COL1A1 collagen, type I, alpha 1 -0.0437282
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0430257
GNAS GNAS complex locus -0.0427708
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0427469
TGFBI transforming growth factor, beta-induced, 68kDa -0.042471
MMP12 matrix metallopeptidase 12 -0.0405983
CDH13 cadherin 13 -0.040199
RPS25 ribosomal protein S25 -0.0398065
COL6A2 collagen, type VI, alpha 2 -0.039562
RPL31 ribosomal protein L31 -0.0391653
RPLP1 ribosomal protein, large, P1 -0.0372074
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0369664
ACTG1 actin gamma 1 -0.0345053
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0343852
S100A6 S100 calcium binding protein A6 -0.0338509
RPL37A ribosomal protein L37a -0.0331514
EML5 echinoderm microtubule associated protein like 5 -0.0331255
TPT1 tumor protein, translationally-controlled 1 -0.0331239
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0324739
S100A9 S100 calcium binding protein A9 -0.0323428
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0318214
MTSS1 metastasis suppressor 1 -0.0310376
FBN1 fibrillin 1 -0.0305774
RPS21 ribosomal protein S21 -0.0305402
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0299672
LOC112694756 uncharaterized LOC112694756 -0.0298938
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0295265
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0291562
EIF1 eukaryotic translation initiation factor 1 -0.0291509
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0288956
MEF2A myocyte enhancer factor 2A -0.0285891
ENO2 enolase 2 (gamma, neuronal) -0.0284419
EGR1 early growth response 1 -0.0278883
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0272997
HLA-C major histocompatibility complex, class I, C -0.026421
CLMP CXADR-like membrane protein -0.0263488
RPL19 ribosomal protein L19 -0.0259406
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0258809
IER3 immediate early response 3 -0.0257812
RPS13 ribosomal protein S13 -0.0257299
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0255591
BHLHE40 basic helix-loop-helix family, member e40 -0.0255461
WSB1 WD repeat and SOCS box containing 1 -0.0253739
RPS19 ribosomal protein S19 -0.0249572
RPS3 ribosomal protein S3 -0.0248904
UBC ubiquitin C -0.0248103
MMP2 matrix metallopeptidase 2 -0.0245624
NAP1L1 nucleosome assembly protein 1-like 1 -0.0241332
ARL4C ADP-ribosylation factor-like 4C -0.0239423
CTSB cathepsin B -0.0238396
GRB10 growth factor receptor-bound protein 10 -0.0237782
F3 coagulation factor III (thromboplastin, tissue factor) -0.0237668
RPL12 ribosomal protein L12 -0.0234495
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0233607
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0233047
RPL11 ribosomal protein L11 -0.0232272
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.023193
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0231832
ITGA11 integrin, alpha 11 -0.0226866
IGFBP3 insulin-like growth factor binding protein 3 -0.022627
RPLP2 ribosomal protein, large, P2 -0.022538
FBXO11 F-box protein 11 -0.0222542
LMAN1 lectin, mannose-binding, 1 -0.0221826
IFITM3 interferon induced transmembrane protein 3 -0.0220551
BTG1 B-cell translocation gene 1, anti-proliferative -0.0220539
LDHA lactate dehydrogenase A -0.0220409
DDIT4 DNA-damage-inducible transcript 4 -0.0220067
DLG1 discs, large homolog 1 (Drosophila) -0.0218608
RPL36 ribosomal protein L36 -0.0217117
RPS27 ribosomal protein S27 -0.0216006
RPS12 ribosomal protein S12 -0.0213129
CTSL cathepsin L -0.0212157
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0211624
IFITM1 interferon induced transmembrane protein 1 -0.0209645
LINC02762 long intergenic non-protein coding RNA 2762 -0.0208306
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0206088