| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.164906 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.043751 |
| TENM1 | teneurin transmembrane protein 1 | 0.0365719 |
| FAT1 | FAT atypical cadherin 1 | 0.0364246 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0297984 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0290853 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0193063 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0189786 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.017512 |
| AOPEP | aminopeptidase O (putative) | 0.0166194 |
| PRKD1 | protein kinase D1 | 0.0162812 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.015666 |
| ZNF292 | zinc finger protein 292 | 0.0148763 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0145327 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | 0.0143509 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0141397 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0131504 |
| PDS5B | PDS5 cohesin associated factor B | 0.0126444 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0126444 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0125578 |
| H1-0 | H1.0 linker histone | 0.0121751 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0119719 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0118844 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0114802 |
| XPO1 | exportin 1 | 0.0113501 |
| NRXN1 | neurexin 1 | 0.0109353 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0107554 |
| NUBPL | nucleotide binding protein-like | 0.0106319 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0105535 |
| TXNRD1 | thioredoxin reductase 1 | 0.0104965 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0103459 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0103376 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0102127 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0101682 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.00993495 |
| CENPF | centromere protein F, 350/400kDa | 0.00987834 |
| TBC1D5 | TBC1 domain family, member 5 | 0.00987677 |
| CNBD1 | cyclic nucleotide binding domain containing 1 | 0.00984988 |
| NYAP2 | neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 | 0.00982938 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.00964618 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.00964301 |
| MTMR7 | myotubularin related protein 7 | 0.00958527 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.00955899 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.00924848 |
| MYEF2 | myelin expression factor 2 | 0.0091611 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | 0.00913449 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.00908461 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.00902185 |
| NIN | ninein (GSK3B interacting protein) | 0.00892856 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | 0.00886778 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.00879038 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.00873292 |
| MAPK10 | mitogen-activated protein kinase 10 | 0.0087121 |
| CDK17 | cyclin-dependent kinase 17 | 0.00867947 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.00864574 |
| PPME1 | protein phosphatase methylesterase 1 | 0.00861043 |
| TUBGCP3 | tubulin, gamma complex associated protein 3 | 0.00856442 |
| RNF145 | ring finger protein 145 | 0.00849825 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.00840852 |
| EXOC2 | exocyst complex component 2 | 0.0083923 |
| GRAMD4 | GRAM domain containing 4 | 0.00838454 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 0.00833386 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.00825539 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.00813003 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.00812861 |
| EPN2 | epsin 2 | 0.00812343 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.00810097 |
| CHST8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | 0.00804796 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0079736 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.00785059 |
| ANLN | anillin, actin binding protein | 0.00778035 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.00776761 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.00775462 |
| TXNIP | thioredoxin interacting protein | 0.00775426 |
| POMK | protein-O-mannose kinase | 0.00775181 |
| PBK | PDZ binding kinase | 0.00773351 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.00772035 |
| MIPOL1 | mirror-image polydactyly 1 | 0.00771114 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.00765572 |
| RTTN | rotatin | 0.00764232 |
| KAT7 | K(lysine) acetyltransferase 7 | 0.00759621 |
| TTK | TTK protein kinase | 0.00758947 |
| SGCE | sarcoglycan, epsilon | 0.00755038 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.00754618 |
| GPRIN3 | GPRIN family member 3 | 0.0075014 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.00747705 |
| KITLG | KIT ligand | 0.00741479 |
| HMGB3 | high mobility group box 3 | 0.0074087 |
| CDK8 | cyclin-dependent kinase 8 | 0.00733374 |
| NFIA | nuclear factor I/A | 0.00729731 |
| SETD3 | SET domain containing 3 | 0.00729404 |
| USP24 | ubiquitin specific peptidase 24 | 0.00724002 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.00722399 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.00721718 |
| KIAA1328 | KIAA1328 | 0.007196 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.00717529 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.00713042 |
| KNTC1 | kinetochore associated 1 | 0.00712326 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.00711157 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.00709845 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.122822 |
| STC1 | stanniocalcin 1 | -0.121247 |
| MCL1 | myeloid cell leukemia 1 | -0.108918 |
| GPC6 | glypican 6 | -0.102426 |
| NRG1 | neuregulin 1 | -0.0894948 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0886432 |
| ACTG1 | actin gamma 1 | -0.0835904 |
| EGR1 | early growth response 1 | -0.0792947 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0773132 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0759858 |
| RORA | RAR-related orphan receptor A | -0.0717986 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0660875 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0645005 |
| CPE | carboxypeptidase E | -0.0644157 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0634046 |
| CALCA | calcitonin-related polypeptide alpha | -0.0614489 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0598547 |
| NDRG1 | N-myc downstream regulated 1 | -0.058306 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0578255 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0576701 |
| SCG2 | secretogranin II | -0.0558509 |
| PTMA | prothymosin, alpha | -0.0542732 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0540748 |
| MAP1B | microtubule-associated protein 1B | -0.051108 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0491776 |
| SMYD3 | SET and MYND domain containing 3 | -0.0482966 |
| DTNA | dystrobrevin, alpha | -0.0480082 |
| KIF26B | kinesin family member 26B | -0.0470767 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0457562 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0456454 |
| PTCHD4 | patched domain containing 4 | -0.0456078 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0452019 |
| ENO1 | enolase 1, (alpha) | -0.0447455 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0426957 |
| CHGB | chromogranin B | -0.0424747 |
| RPS3 | ribosomal protein S3 | -0.0420254 |
| ESRRG | estrogen-related receptor gamma | -0.0395726 |
| RPL37A | ribosomal protein L37a | -0.0392933 |
| RPS6 | ribosomal protein S6 | -0.0387727 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0384994 |
| ASPH | aspartate beta-hydroxylase | -0.0379646 |
| CHGA | chromogranin A | -0.0376892 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0366956 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0366659 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0357895 |
| TMSB4X | thymosin beta 4, X-linked | -0.0353521 |
| GPC5 | glypican 5 | -0.0349445 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0331364 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0329058 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0325555 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0322634 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0307866 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0305508 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0305256 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0303616 |
| NBEA | neurobeachin | -0.0302149 |
| RPS8 | ribosomal protein S8 | -0.0301504 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0298058 |
| INHBA | inhibin, beta A | -0.0294446 |
| SNTG1 | syntrophin, gamma 1 | -0.0290279 |
| RPS25 | ribosomal protein S25 | -0.0287912 |
| KLHL29 | kelch-like family member 29 | -0.0287573 |
| RPL37 | ribosomal protein L37 | -0.0284927 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0280982 |
| GOLGB1 | golgin B1 | -0.0278676 |
| RPL31 | ribosomal protein L31 | -0.0278443 |
| SETX | senataxin | -0.0277733 |
| RPS21 | ribosomal protein S21 | -0.0273779 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0270283 |
| ARFGEF3 | ARFGEF family member 3 | -0.0267703 |
| TOP1 | topoisomerase (DNA) I | -0.0266235 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0262607 |
| RPS16 | ribosomal protein S16 | -0.0261826 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0259373 |
| FN1 | fibronectin 1 | -0.0258884 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0256388 |
| RACK1 | receptor for activated C kinase 1 | -0.025518 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0253149 |
| RPL26 | ribosomal protein L26 | -0.0252839 |
| NCKAP5 | NCK-associated protein 5 | -0.0252291 |
| RPL8 | ribosomal protein L8 | -0.0250121 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0247813 |
| NANOS1 | nanos homolog 1 (Drosophila) | -0.0245042 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0244753 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0244364 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0244229 |
| CANX | calnexin | -0.024402 |
| NAV2 | neuron navigator 2 | -0.0243216 |
| SVIL | supervillin | -0.0243153 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -0.0240806 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0239985 |
| EPHA6 | EPH receptor A6 | -0.0239348 |
| CNKSR3 | CNKSR family member 3 | -0.0239084 |
| RPS27A | ribosomal protein S27a | -0.0238812 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -0.0238711 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0235373 |
| RPS12 | ribosomal protein S12 | -0.0234598 |
| FTL | ferritin, light polypeptide | -0.0233402 |
| ZFHX3 | zinc finger homeobox 3 | -0.023014 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0230007 |
