| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the APTO-253_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FMN1 | formin 1 | 0.110724 |
| NRG3 | neuregulin 3 | 0.0815389 |
| NLGN1 | neuroligin 1 | 0.0649325 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0644794 |
| RUNX1 | runt-related transcription factor 1 | 0.0604556 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0553866 |
| CCND1 | cyclin D1 | 0.0537236 |
| HDAC9 | histone deacetylase 9 | 0.0491478 |
| DST | dystonin | 0.0464365 |
| MSN | moesin | 0.0441525 |
| NOTCH2 | notch 2 | 0.0421499 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0414897 |
| ANGPTL4 | angiopoietin-like 4 | 0.0413889 |
| RAD51B | RAD51 paralog B | 0.0411402 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0410755 |
| NDRG1 | N-myc downstream regulated 1 | 0.0407217 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0406407 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0402346 |
| NAV2 | neuron navigator 2 | 0.0389348 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0386203 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0384286 |
| POTEF | POTE ankyrin domain family, member F | 0.0373646 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.036914 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0368344 |
| PKM | pyruvate kinase, muscle | 0.0344561 |
| MT2A | metallothionein 2A | 0.0339033 |
| FLNA | filamin A, alpha | 0.0332204 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0331817 |
| TXNRD1 | thioredoxin reductase 1 | 0.0311109 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0296643 |
| RNF213 | ring finger protein 213 | 0.0293086 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0284402 |
| SVIL | supervillin | 0.0283188 |
| ATXN1 | ataxin 1 | 0.0276951 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0275805 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0274252 |
| RASAL2 | RAS protein activator like 2 | 0.0269448 |
| ENO1 | enolase 1, (alpha) | 0.0268637 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0263875 |
| SFTPA2 | surfactant protein A2 | 0.0260783 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0260123 |
| HDAC4 | histone deacetylase 4 | 0.0258378 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0256205 |
| FHIT | fragile histidine triad | 0.0252378 |
| CTSB | cathepsin B | 0.0250274 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0248803 |
| ETV6 | ets variant 6 | 0.0247561 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0247111 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0237547 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0237356 |
| FLNB | filamin B, beta | 0.0237281 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0237087 |
| IFI44L | interferon-induced protein 44-like | 0.0237012 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0236524 |
| ADAR | adenosine deaminase, RNA-specific | 0.0233935 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.02316 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0230621 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.0222656 |
| SEPTIN9 | septin 9 | 0.0221462 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0220603 |
| FGGY | FGGY carbohydrate kinase domain containing | 0.021718 |
| FAM219A | family with sequence similarity 219, member A | 0.0215913 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0214425 |
| MCL1 | myeloid cell leukemia 1 | 0.0210234 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.020937 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0208024 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0207748 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0207624 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0204097 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0203962 |
| PLSCR1 | phospholipid scramblase 1 | 0.0202273 |
| RPL3 | ribosomal protein L3 | 0.0202052 |
| OPHN1 | oligophrenin 1 | 0.0200218 |
| SUMF1 | sulfatase modifying factor 1 | 0.0200045 |
| CD44 | CD44 molecule (Indian blood group) | 0.0196349 |
| FOXP1 | forkhead box P1 | 0.0194454 |
| WWOX | WW domain containing oxidoreductase | 0.0190437 |
| SETBP1 | SET binding protein 1 | 0.0189907 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0188323 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0188304 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0188162 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0188047 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0187828 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0185971 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0184838 |
| ACTN4 | actinin, alpha 4 | 0.0183994 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.018311 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0181119 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0178664 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0178064 |
| MACROD2 | MACRO domain containing 2 | 0.0177443 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.017706 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0175627 |
| ASPH | aspartate beta-hydroxylase | 0.0174133 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0171104 |
| SON | SON DNA binding protein | 0.0170272 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0170149 |
| PCBP2 | poly(rC) binding protein 2 | 0.0169552 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0169413 |
| TAPBP | TAP binding protein (tapasin) | 0.0169292 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.205199 |
| VIM | vimentin | -0.201652 |
| LSAMP | limbic system-associated membrane protein | -0.153917 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.104295 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0967474 |
| RPS3 | ribosomal protein S3 | -0.0956007 |
| FN1 | fibronectin 1 | -0.090456 |
| GOLGA4 | golgin A4 | -0.081384 |
| PTMA | prothymosin, alpha | -0.0702587 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0629498 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0624872 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0586941 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0582334 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0525645 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0524209 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0512958 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0494596 |
| FTL | ferritin, light polypeptide | -0.0471336 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0454478 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0411529 |
| RPS6 | ribosomal protein S6 | -0.0405471 |
| SPAG9 | sperm associated antigen 9 | -0.040156 |
| QKI | QKI, KH domain containing, RNA binding | -0.0395479 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.037667 |
| CLINT1 | clathrin interactor 1 | -0.0375208 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0374268 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.037239 |
| TRIM33 | tripartite motif containing 33 | -0.0364089 |
| SETD5 | SET domain containing 5 | -0.036186 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0355477 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0353909 |
| RPL37A | ribosomal protein L37a | -0.0353642 |
| RPL35A | ribosomal protein L35a | -0.035237 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0344114 |
| RPS24 | ribosomal protein S24 | -0.0340963 |
| USP3 | ubiquitin specific peptidase 3 | -0.0336626 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0335059 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0331917 |
| CANX | calnexin | -0.0326591 |
| RPLP1 | ribosomal protein, large, P1 | -0.0321268 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0320564 |
| OGA | O-GlcNAcase | -0.0320215 |
| SLC39A11 | solute carrier family 39, member 11 | -0.031198 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0310814 |
| PMEL | premelanosome protein | -0.0305321 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0303713 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0303445 |
| RAB7A | RAB7A, member RAS oncogene family | -0.030314 |
| ABI1 | abl-interactor 1 | -0.0299691 |
| MORF4L2 | mortality factor 4 like 2 | -0.0298556 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0298161 |
| RPL11 | ribosomal protein L11 | -0.0296064 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0294511 |
| ACTG1 | actin gamma 1 | -0.0291014 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0290884 |
| RACK1 | receptor for activated C kinase 1 | -0.0285216 |
| MATR3 | matrin 3 | -0.0284247 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0282618 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.028123 |
| CA8 | carbonic anhydrase VIII | -0.0280046 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0279448 |
| RPL12 | ribosomal protein L12 | -0.0279313 |
| LDHA | lactate dehydrogenase A | -0.0278078 |
| RPL23 | ribosomal protein L23 | -0.027735 |
| CTTN | cortactin | -0.0274995 |
| RLF | rearranged L-myc fusion | -0.0274948 |
| MSI2 | musashi RNA-binding protein 2 | -0.0274817 |
| RPS12 | ribosomal protein S12 | -0.0274613 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0272315 |
| SBF2 | SET binding factor 2 | -0.0264286 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0262849 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0262069 |
| NGLY1 | N-glycanase 1 | -0.0260775 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.025578 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0253145 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0252345 |
| RPS8 | ribosomal protein S8 | -0.0251632 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0251158 |
| RPL31 | ribosomal protein L31 | -0.0247832 |
| ANLN | anillin, actin binding protein | -0.0247095 |
| RHEB | Ras homolog enriched in brain | -0.0238268 |
| TUBB | tubulin, beta class I | -0.0237064 |
| RPS16 | ribosomal protein S16 | -0.0235908 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0235718 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0233021 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0232729 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0231879 |
| VDAC1 | voltage-dependent anion channel 1 | -0.023178 |
| HELZ | helicase with zinc finger | -0.0231762 |
| KAZN | kazrin, periplakin interacting protein | -0.0230662 |
| TENM1 | teneurin transmembrane protein 1 | -0.0230061 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0226751 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.022581 |
| OLA1 | Obg-like ATPase 1 | -0.0224462 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0224156 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0222848 |
| TFG | TRK-fused gene | -0.0221353 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0221027 |
| MAP4 | microtubule-associated protein 4 | -0.0220707 |
| TMEM263 | transmembrane protein 263 | -0.021981 |
