APTO-253_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.341488
PTMA prothymosin, alpha 0.338344
RPS6 ribosomal protein S6 0.12372
RPS8 ribosomal protein S8 0.102912
PKM pyruvate kinase, muscle 0.0896543
TMSB4X thymosin beta 4, X-linked 0.0780531
PDE4D phosphodiesterase 4D, cAMP-specific 0.0778758
EZR ezrin 0.0769414
GOLGA4 golgin A4 0.0659287
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0654334
CENPF centromere protein F, 350/400kDa 0.0649548
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0647176
ENO1 enolase 1, (alpha) 0.0627604
B2M beta-2-microglobulin 0.0604001
LDHA lactate dehydrogenase A 0.0581733
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0563865
MKI67 marker of proliferation Ki-67 0.055161
POTEF POTE ankyrin domain family, member F 0.0534835
RHOA ras homolog family member A 0.0503828
ACTG1 actin gamma 1 0.0490014
RPS12 ribosomal protein S12 0.0486912
PFN1 profilin 1 0.0482169
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0474038
RPL3 ribosomal protein L3 0.0469458
DSTN destrin (actin depolymerizing factor) 0.0452282
EIF1 eukaryotic translation initiation factor 1 0.0451825
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0450541
TXNIP thioredoxin interacting protein 0.0439919
RPL34 ribosomal protein L34 0.0430319
TXNRD1 thioredoxin reductase 1 0.0426877
RPL35A ribosomal protein L35a 0.0426407
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0424264
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0417399
RPLP0 ribosomal protein, large, P0 0.0403494
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0403474
MT2A metallothionein 2A 0.0398447
UBC ubiquitin C 0.0394919
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.039129
HSPB1 heat shock 27kDa protein 1 0.0382274
PRDX2 peroxiredoxin 2 0.038136
SET SET nuclear proto-oncogene 0.0378282
KPNB1 karyopherin (importin) beta 1 0.0376674
TPM4 tropomyosin 4 0.0370844
ANXA1 annexin A1 0.035844
RPLP2 ribosomal protein, large, P2 0.035374
RPL26 ribosomal protein L26 0.0352807
RPL19 ribosomal protein L19 0.034984
RPL7A ribosomal protein L7a 0.0342988
ARL4C ADP-ribosylation factor-like 4C 0.0342531
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0338543
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.033571
RPL32 ribosomal protein L32 0.0334811
ZNF292 zinc finger protein 292 0.0334106
SRRM2 serine/arginine repetitive matrix 2 0.0333969
PRRC2C proline-rich coiled-coil 2C 0.032976
RPL9 ribosomal protein L9 0.0327501
RTN4 reticulon 4 0.0324729
ENO2 enolase 2 (gamma, neuronal) 0.0323241
KIF5B kinesin family member 5B 0.0317472
DUSP4 dual specificity phosphatase 4 0.0316884
TPT1 tumor protein, translationally-controlled 1 0.0314745
S100A10 S100 calcium binding protein A10 0.0312594
S100A6 S100 calcium binding protein A6 0.0311668
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0307516
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0305719
RPL12 ribosomal protein L12 0.030166
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0300905
RACK1 receptor for activated C kinase 1 0.0298691
RPS2 ribosomal protein S2 0.0297105
KTN1 kinectin 1 (kinesin receptor) 0.0289061
ATF4 activating transcription factor 4 0.0287922
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0287513
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0280395
RPS3 ribosomal protein S3 0.0276826
RPL8 ribosomal protein L8 0.0275976
EEF2 eukaryotic translation elongation factor 2 0.0274512
SMC3 structural maintenance of chromosomes 3 0.0272312
LOC102724023 ES1 protein homolog, mitochondrial 0.0272202
RPS19 ribosomal protein S19 0.0271033
RPL11 ribosomal protein L11 0.0269803
HDGF hepatoma-derived growth factor 0.0267667
BRD4 bromodomain containing 4 0.0267489
RPLP1 ribosomal protein, large, P1 0.026454
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0263199
PCBP2 poly(rC) binding protein 2 0.0257499
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.02561
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0254101
PLK2 polo-like kinase 2 0.0253048
TM4SF1 transmembrane 4 L six family member 1 0.0251546
S100A9 S100 calcium binding protein A9 0.0251172
MTDH metadherin 0.0248256
RPS13 ribosomal protein S13 0.0245077
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0242562
RPL30 ribosomal protein L30 0.0238726
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0238355
TJP1 tight junction protein 1 0.0235413
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0233606
FTL ferritin, light polypeptide 0.0233354
RPL27A ribosomal protein L27a 0.0231608
RB1CC1 RB1-inducible coiled-coil 1 0.0231531

decreased expression

Symbol Name Standardized Value
CPED1 cadherin-like and PC-esterase domain containing 1 -0.120225
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.113605
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.108746
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.101332
PDE4B phosphodiesterase 4B, cAMP-specific -0.0718265
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0644081
AHNAK AHNAK nucleoprotein -0.0642371
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0626806
TTC28 tetratricopeptide repeat domain 28 -0.0596395
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0559366
EGFR epidermal growth factor receptor -0.0507408
FHIT fragile histidine triad -0.0474318
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0458343
BMP10 bone morphogenetic protein 10 -0.0443738
CAMKMT calmodulin-lysine N-methyltransferase -0.042146
PRELID2 PRELI domain containing 2 -0.0396291
NPAS2 neuronal PAS domain protein 2 -0.0362497
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0361197
GSE1 Gse1 coiled-coil protein -0.0343318
VCL vinculin -0.033332
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0332274
SMYD3 SET and MYND domain containing 3 -0.0328304
GLI3 GLI family zinc finger 3 -0.0320065
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0317653
BABAM2 BRISC and BRCA1 A complex member 2 -0.0314462
RFC3 replication factor C (activator 1) 3, 38kDa -0.0294935
LPP LIM domain containing preferred translocation partner in lipoma -0.0293815
INTS6 integrator complex subunit 6 -0.0281285
HEG1 heart development protein with EGF-like domains 1 -0.0277838
MSI2 musashi RNA-binding protein 2 -0.0269149
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0266197
NFIA nuclear factor I/A -0.0265766
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0265754
RAD18 RAD18 E3 ubiquitin protein ligase -0.0261784
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0250647
EXOC4 exocyst complex component 4 -0.0242393
NBEA neurobeachin -0.0241053
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0236589
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0235153
PRUNE2 prune homolog 2 (Drosophila) -0.0234685
RRBP1 ribosome binding protein 1 -0.0234264
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 -0.0227397
CAMTA1 calmodulin binding transcription activator 1 -0.0226168
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0222911
SOX6 SRY (sex determining region Y)-box 6 -0.0222025
AEBP2 AE binding protein 2 -0.0220971
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0220161
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0216281
MYOF myoferlin -0.0215477
TTC3 tetratricopeptide repeat domain 3 -0.0214755
PTPRG protein tyrosine phosphatase, receptor type, G -0.0214422
PDE7B phosphodiesterase 7B -0.0206472
GPHN gephyrin -0.0206179
DIAPH2 diaphanous-related formin 2 -0.0201937
EHBP1 EH domain binding protein 1 -0.0199882
ZNF438 zinc finger protein 438 -0.0198317
NEBL nebulette -0.0198312
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0197759
CFAP44 cilia and flagella associated protein 44 -0.0195609
ZNF217 zinc finger protein 217 -0.019279
FOXP1 forkhead box P1 -0.0192387
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0190429
TMEM65 transmembrane protein 65 -0.0190355
PHF3 PHD finger protein 3 -0.0190113
IRS1 insulin receptor substrate 1 -0.0189585
UNC13A unc-13 homolog A (C. elegans) -0.01871
CRPPA CDP-L-ribitol pyrophosphorylase A -0.018699
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0186449
ASPH aspartate beta-hydroxylase -0.0185158
FLNB filamin B, beta -0.0184536
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0183793
TBC1D22A TBC1 domain family, member 22A -0.0183763
MEIS2 Meis homeobox 2 -0.0182271
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.017972
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.017968
PSPC1 paraspeckle component 1 -0.0179465
COMMD10 COMM domain containing 10 -0.017816
SDK1 sidekick cell adhesion molecule 1 -0.0177899
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0177448
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0169483
TAS2R14 taste receptor, type 2, member 14 -0.016919
RAD51B RAD51 paralog B -0.0169188
ARMH4 armadillo like helical domain containing 4 -0.0166593
KIAA1958 KIAA1958 -0.0165526
EFNA5 ephrin-A5 -0.0164753
PRH1 proline-rich protein HaeIII subfamily 1 -0.0164264
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0164085
MYO5C myosin VC -0.0163804
GPATCH8 G patch domain containing 8 -0.0163325
FNDC3B fibronectin type III domain containing 3B -0.0162227
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0161579
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0160707
ENOSF1 enolase superfamily member 1 -0.0160219
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.015931
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0159205
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0158234
KDM4C lysine (K)-specific demethylase 4C -0.0157649
GPATCH2L G patch domain containing 2-like -0.0155934
XXYLT1 xyloside xylosyltransferase 1 -0.0153999
DOCK1 dedicator of cytokinesis 1 -0.0151901