APTO-253_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0951128
SMAD3 SMAD family member 3 0.0441902
MSN moesin 0.0342824
GPC6 glypican 6 0.0317171
FTH1 ferritin, heavy polypeptide 1 0.0290748
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0288972
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.026896
VEGFA vascular endothelial growth factor A 0.0240648
MYH9 myosin, heavy chain 9, non-muscle 0.0222978
THBS1 thrombospondin 1 0.0207511
VCL vinculin 0.0200944
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0200465
ZSWIM6 zinc finger, SWIM-type containing 6 0.0197122
EXT1 exostosin glycosyltransferase 1 0.0193179
MKI67 marker of proliferation Ki-67 0.0186058
RPL3 ribosomal protein L3 0.0173364
ENO1 enolase 1, (alpha) 0.0164843
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0164052
RUNX1 runt-related transcription factor 1 0.0160384
FAM3C family with sequence similarity 3, member C 0.0160355
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0154501
CD44 CD44 molecule (Indian blood group) 0.0149388
TGM2 transglutaminase 2 0.0147436
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0146264
PPARD peroxisome proliferator-activated receptor delta 0.0144787
ZBTB38 zinc finger and BTB domain containing 38 0.013974
DUSP10 dual specificity phosphatase 10 0.0138831
HDAC9 histone deacetylase 9 0.0135693
EEF2 eukaryotic translation elongation factor 2 0.0133543
PCLO piccolo presynaptic cytomatrix protein 0.0131969
HSPA8 heat shock 70kDa protein 8 0.0131674
BICC1 BicC family RNA binding protein 1 0.0125357
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.012253
PLPP4 phospholipid phosphatase 4 0.0118861
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0117117
SAMD9 sterile alpha motif domain containing 9 0.0116844
MCL1 myeloid cell leukemia 1 0.011526
CDCP1 CUB domain containing protein 1 0.0113189
DUSP5 dual specificity phosphatase 5 0.0111807
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0110944
BCAR3 breast cancer anti-estrogen resistance 3 0.0109631
TXNIP thioredoxin interacting protein 0.0108738
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0107347
FHIT fragile histidine triad 0.0106329
SPIDR scaffolding protein involved in DNA repair 0.0104436
SH3RF2 SH3 domain containing ring finger 2 0.0104425
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.010363
ERCC6 excision repair cross-complementation group 6 0.0103541
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0100429
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.00998502
BCL9L B-cell CLL/lymphoma 9-like 0.00980605
SVIL supervillin 0.00977285
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.00963166
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.00962973
CREB5 cAMP responsive element binding protein 5 0.00959643
TNIP1 TNFAIP3 interacting protein 1 0.00956055
FAM219A family with sequence similarity 219, member A 0.00951186
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.00947538
MAGED1 melanoma antigen family D1 0.00935662
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.00929015
PHC2 polyhomeotic homolog 2 (Drosophila) 0.00926729
IL1RAP interleukin 1 receptor accessory protein 0.00916282
SHB Src homology 2 domain containing adaptor protein B 0.00913198
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.00890458
ANTXR1 anthrax toxin receptor 1 0.00867708
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00854961
OSMR oncostatin M receptor 0.00851129
NRP1 neuropilin 1 0.00850755
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.008483
ATG10 autophagy related 10 0.00845942
FLNA filamin A, alpha 0.00843954
TUT7 terminal uridylyl transferase 7 0.0084287
SAMD4A sterile alpha motif domain containing 4A 0.00842703
PARP9 poly (ADP-ribose) polymerase family, member 9 0.00842207
EPAS1 endothelial PAS domain protein 1 0.0083942
MMP2 matrix metallopeptidase 2 0.00837955
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.00832488
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0081704
KIF4A kinesin family member 4A 0.00814321
HBEGF heparin-binding EGF-like growth factor 0.00805958
CEP112 centrosomal protein 112kDa 0.00798429
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.00795363
F2R coagulation factor II (thrombin) receptor 0.0078374
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.00783298
ZNF608 zinc finger protein 608 0.00782789
MX1 MX dynamin-like GTPase 1 0.00782494
RPGR retinitis pigmentosa GTPase regulator 0.00778093
KSR1 kinase suppressor of ras 1 0.00770848
PRICKLE2 prickle homolog 2 (Drosophila) 0.00770137
IDS iduronate 2-sulfatase 0.00758951
ARB2A ARB2 cotranscriptional regulator A 0.00754316
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.00753698
FAT1 FAT atypical cadherin 1 0.00742228
ACTN1 actinin, alpha 1 0.0073674
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.00730982
EIF5 eukaryotic translation initiation factor 5 0.00729787
FAM120B family with sequence similarity 120B 0.0072539
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0072507
ZFP36 ZFP36 ring finger protein 0.00716378
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00712978

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.295986
SOD2 superoxide dismutase 2, mitochondrial -0.152731
HLA-B major histocompatibility complex, class I, B -0.134082
TPT1 tumor protein, translationally-controlled 1 -0.12319
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114699
FTL ferritin, light polypeptide -0.105784
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10267
TMSB10 thymosin beta 10 -0.0964193
IER3 immediate early response 3 -0.0947715
CADM1 cell adhesion molecule 1 -0.0915939
MARCKS myristoylated alanine-rich protein kinase C substrate -0.085747
FRMD4A FERM domain containing 4A -0.0825805
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0780796
PGK1 phosphoglycerate kinase 1 -0.0778301
TRIO trio Rho guanine nucleotide exchange factor -0.0718576
RPS24 ribosomal protein S24 -0.0702109
RPS6 ribosomal protein S6 -0.0698791
PTMA prothymosin, alpha -0.0646934
CDH13 cadherin 13 -0.0619135
UGCG UDP-glucose ceramide glucosyltransferase -0.061744
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0599403
NAP1L1 nucleosome assembly protein 1-like 1 -0.0595167
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0571737
ADM adrenomedullin -0.0570081
HLA-A major histocompatibility complex, class I, A -0.0564673
FN1 fibronectin 1 -0.0552499
WSB1 WD repeat and SOCS box containing 1 -0.0549997
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0542978
RPL35A ribosomal protein L35a -0.0522152
IGFBP3 insulin-like growth factor binding protein 3 -0.0521932
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0519799
MT2A metallothionein 2A -0.0488316
CANX calnexin -0.0479125
ZMYND8 zinc finger, MYND-type containing 8 -0.0468761
HLA-E major histocompatibility complex, class I, E -0.0454814
RPL23 ribosomal protein L23 -0.0452792
B2M beta-2-microglobulin -0.0450573
PLIN2 perilipin 2 -0.0446014
EIF1 eukaryotic translation initiation factor 1 -0.0443499
DIAPH2 diaphanous-related formin 2 -0.0442629
TMSB4X thymosin beta 4, X-linked -0.0439052
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0437504
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0435994
RPL37A ribosomal protein L37a -0.0432476
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.043039
ATP13A3 ATPase type 13A3 -0.0425364
LDHA lactate dehydrogenase A -0.0424865
BTG1 B-cell translocation gene 1, anti-proliferative -0.0421559
RPS23 ribosomal protein S23 -0.041221
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.040711
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0401968
OGA O-GlcNAcase -0.0400287
KDM3A lysine (K)-specific demethylase 3A -0.0397435
RPS12 ribosomal protein S12 -0.0394754
SPAG9 sperm associated antigen 9 -0.0393974
WDFY1 WD repeat and FYVE domain containing 1 -0.0393781
WDR45B WD repeat domain 45B -0.0385771
RPS8 ribosomal protein S8 -0.0382637
AFF3 AF4/FMR2 family, member 3 -0.0382023
GOLGA4 golgin A4 -0.0374052
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.03726
MORF4L2 mortality factor 4 like 2 -0.036943
TPM4 tropomyosin 4 -0.0366147
ELL2 elongation factor, RNA polymerase II, 2 -0.0365138
GNAS GNAS complex locus -0.036395
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.036141
RAB1A RAB1A, member RAS oncogene family -0.0354416
RPLP1 ribosomal protein, large, P1 -0.0350627
QKI QKI, KH domain containing, RNA binding -0.0344948
ACTG1 actin gamma 1 -0.0341968
DLG1 discs, large homolog 1 (Drosophila) -0.0335548
RPS3 ribosomal protein S3 -0.0333771
NPEPPS aminopeptidase puromycin sensitive -0.0332937
FRMPD4 FERM and PDZ domain containing 4 -0.0332363
ZNF292 zinc finger protein 292 -0.0329087
RPLP0 ribosomal protein, large, P0 -0.0328606
PDE10A phosphodiesterase 10A -0.0326401
NT5C2 5'-nucleotidase, cytosolic II -0.0324464
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0321577
SLC38A1 solute carrier family 38, member 1 -0.0318829
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0315915
TUBB tubulin, beta class I -0.0312814
AKAP12 A kinase (PRKA) anchor protein 12 -0.0310054
RPL19 ribosomal protein L19 -0.030568
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0304634
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0304276
RACK1 receptor for activated C kinase 1 -0.0303208
DST dystonin -0.0300857
UBC ubiquitin C -0.0300204
CALR calreticulin -0.0299035
KIF13A kinesin family member 13A -0.029799
LOX lysyl oxidase -0.029602
AFF4 AF4/FMR2 family, member 4 -0.0295492
RAI14 retinoic acid induced 14 -0.029454
RPS13 ribosomal protein S13 -0.0292941
HILPDA hypoxia inducible lipid droplet-associated -0.0291484
RPL12 ribosomal protein L12 -0.0291119
MAP4 microtubule-associated protein 4 -0.0290834
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0289163
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.028725