| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.166475 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.13919 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.104034 |
| B2M | beta-2-microglobulin | 0.0800657 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0775619 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0756735 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0752304 |
| TXNIP | thioredoxin interacting protein | 0.073699 |
| TXNRD1 | thioredoxin reductase 1 | 0.0659365 |
| FTL | ferritin, light polypeptide | 0.0645104 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.063321 |
| MT2A | metallothionein 2A | 0.0612642 |
| S100A6 | S100 calcium binding protein A6 | 0.0592391 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0511584 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0483585 |
| CENPF | centromere protein F, 350/400kDa | 0.0474693 |
| TMSB10 | thymosin beta 10 | 0.0472341 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0447935 |
| PTMA | prothymosin, alpha | 0.0424553 |
| HLA-B | major histocompatibility complex, class I, B | 0.0367006 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0366793 |
| LMNA | lamin A/C | 0.0353026 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0347945 |
| RNF145 | ring finger protein 145 | 0.0331556 |
| NXN | nucleoredoxin | 0.0323062 |
| OSMR | oncostatin M receptor | 0.0313533 |
| VIM | vimentin | 0.0312481 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.0309637 |
| SIK3 | SIK family kinase 3 | 0.0304864 |
| NTN4 | netrin 4 | 0.0304421 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0303508 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0297058 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0295618 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | 0.0282997 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.028053 |
| TPI1 | triosephosphate isomerase 1 | 0.0279973 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0279601 |
| DSTN | destrin (actin depolymerizing factor) | 0.0271557 |
| S100A9 | S100 calcium binding protein A9 | 0.0261137 |
| VEGFA | vascular endothelial growth factor A | 0.0259878 |
| IL6 | interleukin 6 | 0.02582 |
| KSR1 | kinase suppressor of ras 1 | 0.0254693 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0252408 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0248291 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0244516 |
| MKI67 | marker of proliferation Ki-67 | 0.0242846 |
| MAP1B | microtubule-associated protein 1B | 0.0238927 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0236994 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0232417 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0231123 |
| NEK7 | NIMA-related kinase 7 | 0.0227688 |
| RPL23 | ribosomal protein L23 | 0.022624 |
| PFN1 | profilin 1 | 0.0225692 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0221449 |
| YBX3 | Y box binding protein 3 | 0.0220363 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0219074 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0217959 |
| RPS19 | ribosomal protein S19 | 0.0216107 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0213687 |
| SSH1 | slingshot protein phosphatase 1 | 0.0213384 |
| POTEF | POTE ankyrin domain family, member F | 0.0209961 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0209224 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0208062 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0204031 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0203315 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0202665 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0201886 |
| RPL34 | ribosomal protein L34 | 0.0199853 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0198985 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0198303 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0197658 |
| BICC1 | BicC family RNA binding protein 1 | 0.0197192 |
| FOSL1 | FOS-like antigen 1 | 0.0196473 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0195322 |
| SVIL | supervillin | 0.0193967 |
| FBXO32 | F-box protein 32 | 0.0193703 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0192762 |
| RDX | radixin | 0.0192752 |
| RHEB | Ras homolog enriched in brain | 0.0192235 |
| PSMD12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 0.0191846 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.019056 |
| MX2 | MX dynamin-like GTPase 2 | 0.0190389 |
| RUNX2 | runt-related transcription factor 2 | 0.0189857 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0188711 |
| GOLGA4 | golgin A4 | 0.0187798 |
| CUL3 | cullin 3 | 0.0184233 |
| NRP1 | neuropilin 1 | 0.0183604 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0183568 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0183294 |
| RPL32 | ribosomal protein L32 | 0.0182756 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0181146 |
| RNF213 | ring finger protein 213 | 0.0179976 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0179924 |
| FNBP1 | formin binding protein 1 | 0.0179719 |
| MATR3 | matrin 3 | 0.0179206 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0177326 |
| MTMR3 | myotubularin related protein 3 | 0.0176637 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.0176417 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0176292 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 0.0175821 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | -0.210185 |
| FN1 | fibronectin 1 | -0.195951 |
| ASPH | aspartate beta-hydroxylase | -0.141278 |
| NRG1 | neuregulin 1 | -0.138232 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.127848 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.115225 |
| NDRG1 | N-myc downstream regulated 1 | -0.091964 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0820848 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0796441 |
| EFNA5 | ephrin-A5 | -0.0769389 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.073266 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0729393 |
| CANX | calnexin | -0.0715488 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0713772 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.067755 |
| ITGA1 | integrin, alpha 1 | -0.0664201 |
| INTS6 | integrator complex subunit 6 | -0.0631723 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.055607 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0536384 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0529849 |
| SYT1 | synaptotagmin I | -0.052512 |
| RAI14 | retinoic acid induced 14 | -0.0520728 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0520215 |
| SQSTM1 | sequestosome 1 | -0.0508044 |
| LOXL2 | lysyl oxidase-like 2 | -0.0490879 |
| CADM1 | cell adhesion molecule 1 | -0.0489959 |
| AEBP2 | AE binding protein 2 | -0.0485526 |
| LRRC23 | leucine rich repeat containing 23 | -0.047958 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0465319 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0441363 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0426306 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0421419 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0411773 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0411605 |
| NUMB | numb homolog (Drosophila) | -0.0399175 |
| AHNAK | AHNAK nucleoprotein | -0.03841 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0381658 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.037656 |
| DUSP6 | dual specificity phosphatase 6 | -0.037548 |
| FAT1 | FAT atypical cadherin 1 | -0.0351186 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0349737 |
| MCL1 | myeloid cell leukemia 1 | -0.0348511 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0347964 |
| FBXO11 | F-box protein 11 | -0.0346196 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0339752 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.033629 |
| FLNB | filamin B, beta | -0.0335769 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0334668 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0329923 |
| PTK2 | protein tyrosine kinase 2 | -0.0327967 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0325237 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0321605 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0321022 |
| TGFB1 | transforming growth factor, beta 1 | -0.0319806 |
| FAM20C | family with sequence similarity 20, member C | -0.0314082 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0311326 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0309465 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0308337 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0307768 |
| PRELID2 | PRELI domain containing 2 | -0.0303033 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0303001 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0302891 |
| TMEM156 | transmembrane protein 156 | -0.0296384 |
| TGFA | transforming growth factor, alpha | -0.0293696 |
| KLF12 | Kruppel-like factor 12 | -0.0288155 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0284667 |
| ATXN1 | ataxin 1 | -0.028235 |
| CTBP2 | C-terminal binding protein 2 | -0.0281289 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0277394 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.02772 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0273674 |
| HPCAL1 | hippocalcin-like 1 | -0.0271457 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0269072 |
| PLEC | plectin | -0.0269031 |
| GPC6 | glypican 6 | -0.0266812 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0266598 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0265818 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.026558 |
| FLNA | filamin A, alpha | -0.0265094 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0263417 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0261147 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.025934 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0257003 |
| ANKRD11 | ankyrin repeat domain 11 | -0.025546 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0254883 |
| FERMT2 | fermitin family member 2 | -0.0253472 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0252881 |
| FMNL2 | formin-like 2 | -0.0251354 |
| ATG7 | autophagy related 7 | -0.0250549 |
| NABP1 | nucleic acid binding protein 1 | -0.0249097 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0247873 |
| ACTN1 | actinin, alpha 1 | -0.0247648 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0246697 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0245148 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0243985 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0242723 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0239064 |
| RUNX1 | runt-related transcription factor 1 | -0.0238028 |
| CALU | calumenin | -0.0236678 |
| ARF1 | ADP-ribosylation factor 1 | -0.0236534 |
