APTO-253_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.109546
NCEH1 neutral cholesterol ester hydrolase 1 0.0787955
NEBL nebulette 0.0558562
VCL vinculin 0.0514885
MACC1 metastasis associated in colon cancer 1 0.0430816
CENPF centromere protein F, 350/400kDa 0.0402657
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0388384
MYOF myoferlin 0.0384003
TXNRD1 thioredoxin reductase 1 0.0378575
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0376088
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336077
MKI67 marker of proliferation Ki-67 0.0312196
MYO1E myosin IE 0.0287321
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0255885
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0255552
MAN1A1 mannosidase, alpha, class 1A, member 1 0.025178
ANKRD12 ankyrin repeat domain 12 0.0234933
EXT1 exostosin glycosyltransferase 1 0.0231216
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0208142
TJP1 tight junction protein 1 0.0203706
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0201887
EPS8 epidermal growth factor receptor pathway substrate 8 0.0193495
PDLIM5 PDZ and LIM domain 5 0.01835
ARHGAP26 Rho GTPase activating protein 26 0.0181692
HM13 histocompatibility (minor) 13 0.0180369
SMAD3 SMAD family member 3 0.0179816
ARHGAP42 Rho GTPase activating protein 42 0.0175822
WWC1 WW and C2 domain containing 1 0.0175685
FNDC3A fibronectin type III domain containing 3A 0.0175288
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0169697
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0167499
NSUN6 NOP2/Sun domain family, member 6 0.0165508
SAMD4A sterile alpha motif domain containing 4A 0.0161681
TOM1L2 target of myb1-like 2 (chicken) 0.0156127
TRAPPC9 trafficking protein particle complex 9 0.0154982
PRELID2 PRELI domain containing 2 0.0153617
INTS6 integrator complex subunit 6 0.0152827
RCOR1 REST corepressor 1 0.0152434
ETNK1 ethanolamine kinase 1 0.0151826
ZFAND3 zinc finger, AN1-type domain 3 0.0151675
CLTC clathrin, heavy chain (Hc) 0.0150881
SRP54 signal recognition particle 54kDa 0.0150873
PTGES2 prostaglandin E synthase 2 0.015079
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0147105
ECT2 epithelial cell transforming 2 0.014521
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0141224
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0137356
JMJD1C jumonji domain containing 1C 0.0136729
MALT1 MALT1 paracaspase 0.0135222
GOLGA4 golgin A4 0.0135103
YAP1 Yes-associated protein 1 0.0133809
SMYD3 SET and MYND domain containing 3 0.0132882
SIK3 SIK family kinase 3 0.0132349
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0132137
TLE4 transducin-like enhancer of split 4 0.0132015
TPX2 TPX2, microtubule-associated 0.0129884
LPP LIM domain containing preferred translocation partner in lipoma 0.0129154
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0128477
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0126994
OSBPL10 oxysterol binding protein-like 10 0.0126671
ATAD2 ATPase family, AAA domain containing 2 0.0124988
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0122735
CADPS2 Ca++-dependent secretion activator 2 0.0122006
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0121884
ZSWIM6 zinc finger, SWIM-type containing 6 0.0120039
HMGN2 high mobility group nucleosomal binding domain 2 0.011962
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0119483
LOC102724023 ES1 protein homolog, mitochondrial 0.0119367
RUNX1 runt-related transcription factor 1 0.0117745
SMAD2 SMAD family member 2 0.0117679
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.0117468
PCLO piccolo presynaptic cytomatrix protein 0.0117265
EVI5 ecotropic viral integration site 5 0.0115976
AURKA aurora kinase A 0.0115492
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0114441
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0113865
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0113802
KIAA0040 KIAA0040 0.0112147
ARL15 ADP-ribosylation factor-like 15 0.011191
TGFA transforming growth factor, alpha 0.0111731
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0111374
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0111082
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0110951
SHROOM3 shroom family member 3 0.0108835
TOP1 topoisomerase (DNA) I 0.0108552
LIMS1 LIM and senescent cell antigen-like domains 1 0.0107888
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.010734
STX5 syntaxin 5 0.010709
NLK nemo-like kinase 0.010702
PCBP3 poly(rC) binding protein 3 0.0106774
ZNF292 zinc finger protein 292 0.0106512
FHL2 four and a half LIM domains 2 0.0105759
IRS2 insulin receptor substrate 2 0.0105454
AHRR aryl-hydrocarbon receptor repressor 0.0105435
LARP4 La ribonucleoprotein domain family, member 4 0.0104574
LIMA1 LIM domain and actin binding 1 0.0104124
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0103623
SELENOK selenoprotein K 0.0103435
CCNYL1 cyclin Y-like 1 0.0103014
ITCH itchy E3 ubiquitin protein ligase 0.0102806

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.206932
PTMA prothymosin, alpha -0.150037
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127871
RPS6 ribosomal protein S6 -0.0856543
TPT1 tumor protein, translationally-controlled 1 -0.0831751
RPS25 ribosomal protein S25 -0.081458
MAML2 mastermind-like 2 (Drosophila) -0.0804939
TMSB10 thymosin beta 10 -0.0775998
RPS13 ribosomal protein S13 -0.0680925
RPL35A ribosomal protein L35a -0.0659825
RPL31 ribosomal protein L31 -0.0635694
RPS27A ribosomal protein S27a -0.0633905
RPL37A ribosomal protein L37a -0.0631444
SQSTM1 sequestosome 1 -0.0620381
EIF1 eukaryotic translation initiation factor 1 -0.0576821
RPS12 ribosomal protein S12 -0.0566013
NDRG1 N-myc downstream regulated 1 -0.056519
ZMYND8 zinc finger, MYND-type containing 8 -0.0560257
RPS21 ribosomal protein S21 -0.0540093
RPLP2 ribosomal protein, large, P2 -0.0528744
EPCAM epithelial cell adhesion molecule -0.0517656
RPS11 ribosomal protein S11 -0.0516917
RPL37 ribosomal protein L37 -0.0495003
SLC38A1 solute carrier family 38, member 1 -0.0493982
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.047986
RPL13A ribosomal protein L13a -0.0470237
KRT18 keratin 18, type I -0.0466542
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0463013
RPL28 ribosomal protein L28 -0.0459161
TPM4 tropomyosin 4 -0.0454765
FAT1 FAT atypical cadherin 1 -0.0450627
B2M beta-2-microglobulin -0.0437821
RPS3 ribosomal protein S3 -0.0437122
PKM pyruvate kinase, muscle -0.0436333
CST3 cystatin C -0.0433468
RPL15 ribosomal protein L15 -0.0432872
RPL19 ribosomal protein L19 -0.0411538
RPL36A ribosomal protein L36a -0.0408017
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0396724
RPS17 ribosomal protein S17 -0.0393706
PERP PERP, TP53 apoptosis effector -0.0388986
RPL12 ribosomal protein L12 -0.0384197
RPS29 ribosomal protein S29 -0.038038
IER3 immediate early response 3 -0.0373902
CCND1 cyclin D1 -0.036451
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0357703
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0352005
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0350294
PGK1 phosphoglycerate kinase 1 -0.0340812
RPL36 ribosomal protein L36 -0.0340658
CADPS Ca++-dependent secretion activator -0.0340612
HLA-A major histocompatibility complex, class I, A -0.0337833
AHNAK AHNAK nucleoprotein -0.0334279
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0331998
RPL23 ribosomal protein L23 -0.0327154
HMGA1 high mobility group AT-hook 1 -0.0326031
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.032431
ARHGAP5 Rho GTPase activating protein 5 -0.0323936
RACK1 receptor for activated C kinase 1 -0.0323259
EGR1 early growth response 1 -0.0321173
RPS24 ribosomal protein S24 -0.0320411
KDM3A lysine (K)-specific demethylase 3A -0.0318515
RPL26 ribosomal protein L26 -0.0317935
RPS8 ribosomal protein S8 -0.0315275
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0314637
RPL7A ribosomal protein L7a -0.0309969
GNAS GNAS complex locus -0.0309318
PLAUR plasminogen activator, urokinase receptor -0.0307132
LDHA lactate dehydrogenase A -0.0304037
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0302977
S100A6 S100 calcium binding protein A6 -0.0302311
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0295953
RPL38 ribosomal protein L38 -0.0294796
ACTG1 actin gamma 1 -0.0293708
RPS5 ribosomal protein S5 -0.0292823
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0287079
ZNRF3 zinc and ring finger 3 -0.0286935
RPL5 ribosomal protein L5 -0.028094
ACTN4 actinin, alpha 4 -0.0280885
RPS15 ribosomal protein S15 -0.0279211
KRT8 keratin 8, type II -0.0279198
WSB1 WD repeat and SOCS box containing 1 -0.0275753
RREB1 ras responsive element binding protein 1 -0.0272913
ARHGAP32 Rho GTPase activating protein 32 -0.0272625
AKAP12 A kinase (PRKA) anchor protein 12 -0.0272194
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0270856
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0269797
NKD1 naked cuticle homolog 1 (Drosophila) -0.0269794
RPL30 ribosomal protein L30 -0.0267588
RPL27A ribosomal protein L27a -0.0267021
FTH1 ferritin, heavy polypeptide 1 -0.026632
MATR3 matrin 3 -0.0266058
ATP9A ATPase, class II, type 9A -0.0265243
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0264812
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0262192
KDM7A lysine (K)-specific demethylase 7A -0.0261795
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0260578
NCOA6 nuclear receptor coactivator 6 -0.0260008
RPS20 ribosomal protein S20 -0.025752
BHLHE40 basic helix-loop-helix family, member e40 -0.0254872