APTO-253_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYO10 myosin X 0.104568
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.102186
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0914929
AKAP12 A kinase (PRKA) anchor protein 12 0.0864051
STC1 stanniocalcin 1 0.0723748
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0642911
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.061337
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0609924
CXCL8 chemokine (C-X-C motif) ligand 8 0.0508983
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.049656
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.045456
ZSWIM6 zinc finger, SWIM-type containing 6 0.0440539
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0437893
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.04153
LOX lysyl oxidase 0.0366888
NOTCH2 notch 2 0.0355043
MAP1B microtubule-associated protein 1B 0.0352303
RUNX1 runt-related transcription factor 1 0.0339438
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0336214
EXT1 exostosin glycosyltransferase 1 0.0304273
FNDC3B fibronectin type III domain containing 3B 0.0304136
TIMP1 TIMP metallopeptidase inhibitor 1 0.0295407
TRIO trio Rho guanine nucleotide exchange factor 0.0291566
NDRG1 N-myc downstream regulated 1 0.0291343
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0284893
ELL2 elongation factor, RNA polymerase II, 2 0.0278913
ASPH aspartate beta-hydroxylase 0.0266468
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0247074
PDE8A phosphodiesterase 8A 0.0246803
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0243047
COL8A1 collagen, type VIII, alpha 1 0.0238339
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0237038
SON SON DNA binding protein 0.0235456
ARHGAP21 Rho GTPase activating protein 21 0.0231626
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0228348
PALLD palladin, cytoskeletal associated protein 0.0217234
FAM13A family with sequence similarity 13, member A 0.0213736
KMT2E lysine (K)-specific methyltransferase 2E 0.0208587
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0203362
HDAC9 histone deacetylase 9 0.0199766
MSN moesin 0.0195019
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0190794
SPAG9 sperm associated antigen 9 0.0189532
AHNAK AHNAK nucleoprotein 0.0189256
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0188115
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0184836
CALU calumenin 0.0184167
ANKRD12 ankyrin repeat domain 12 0.0178479
MYH9 myosin, heavy chain 9, non-muscle 0.0175271
MYADM myeloid-associated differentiation marker 0.0174712
WNT2B wingless-type MMTV integration site family, member 2B 0.0173538
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 0.0172706
FBN1 fibrillin 1 0.0169811
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0167651
SMYD3 SET and MYND domain containing 3 0.0166564
PRELID2 PRELI domain containing 2 0.016618
SEC24D SEC24 family member D 0.0165555
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0161187
ALCAM activated leukocyte cell adhesion molecule 0.0159664
COPA coatomer protein complex, subunit alpha 0.0158713
WLS wntless Wnt ligand secretion mediator 0.0157816
DLG1 discs, large homolog 1 (Drosophila) 0.015683
COL11A1 collagen, type XI, alpha 1 0.0153791
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.0152548
SEC62 SEC62 homolog (S. cerevisiae) 0.0151819
IQGAP1 IQ motif containing GTPase activating protein 1 0.0151521
DPYSL2 dihydropyrimidinase-like 2 0.0149112
HILPDA hypoxia inducible lipid droplet-associated 0.0149092
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0146011
DUSP10 dual specificity phosphatase 10 0.0145588
ADGRB3 adhesion G protein-coupled receptor B3 0.0144366
LGALS1 lectin, galactoside-binding, soluble, 1 0.0143959
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.014348
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0143008
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0141819
SAMD3 sterile alpha motif domain containing 3 0.0141647
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0141602
TXNIP thioredoxin interacting protein 0.0141221
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0139326
JARID2 jumonji, AT rich interactive domain 2 0.0138686
CCDC80 coiled-coil domain containing 80 0.0138676
PDLIM5 PDZ and LIM domain 5 0.0138141
MEF2A myocyte enhancer factor 2A 0.0137756
CALR calreticulin 0.0136988
TNS1 tensin 1 0.0134584
RABGAP1L RAB GTPase activating protein 1-like 0.0134448
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0134244
NUMB numb homolog (Drosophila) 0.0132923
PNRC1 proline-rich nuclear receptor coactivator 1 0.0132595
PDGFC platelet derived growth factor C 0.0131399
PTK2 protein tyrosine kinase 2 0.0131226
DOCK7 dedicator of cytokinesis 7 0.0130383
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0127752
USO1 USO1 vesicle transport factor 0.012769
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0127686
IL6 interleukin 6 0.0126847
ZNF292 zinc finger protein 292 0.0126762
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0126486
SFRP1 secreted frizzled-related protein 1 0.012638
TM4SF1 transmembrane 4 L six family member 1 0.0125373

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.159264
VIM vimentin -0.124276
HLA-B major histocompatibility complex, class I, B -0.0990856
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0978563
TPT1 tumor protein, translationally-controlled 1 -0.0970773
FTL ferritin, light polypeptide -0.0866732
RPL37A ribosomal protein L37a -0.0697662
RPS6 ribosomal protein S6 -0.069231
GREM1 gremlin 1, DAN family BMP antagonist -0.0672229
MMP1 matrix metallopeptidase 1 -0.0602574
NALF1 NALCN channel auxiliary factor 1 -0.0591578
RPS25 ribosomal protein S25 -0.0573311
LIMS1 LIM and senescent cell antigen-like domains 1 -0.057037
RPL31 ribosomal protein L31 -0.0566315
EGR1 early growth response 1 -0.0553479
CEMIP cell migration inducing protein, hyaluronan binding -0.0516898
RPS13 ribosomal protein S13 -0.0516471
MAML3 mastermind-like 3 (Drosophila) -0.0501939
ACTG1 actin gamma 1 -0.0492188
TGFBI transforming growth factor, beta-induced, 68kDa -0.0490139
RPL26 ribosomal protein L26 -0.0485929
HMGA2 high mobility group AT-hook 2 -0.0480025
PDE4D phosphodiesterase 4D, cAMP-specific -0.0477615
RPS29 ribosomal protein S29 -0.0476863
HLA-A major histocompatibility complex, class I, A -0.0471587
RPS3 ribosomal protein S3 -0.0467465
EIF1 eukaryotic translation initiation factor 1 -0.045979
CD44 CD44 molecule (Indian blood group) -0.0441168
VCL vinculin -0.0429256
COL6A3 collagen, type VI, alpha 3 -0.0419666
RPS12 ribosomal protein S12 -0.0417094
HLA-E major histocompatibility complex, class I, E -0.0408341
RPL11 ribosomal protein L11 -0.0406217
RPL35A ribosomal protein L35a -0.0393521
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0385883
CCND1 cyclin D1 -0.0371586
RPS8 ribosomal protein S8 -0.0368911
RPS27A ribosomal protein S27a -0.0367281
RPS23 ribosomal protein S23 -0.0363461
ERBIN erbb2 interacting protein -0.0348949
RACK1 receptor for activated C kinase 1 -0.0347247
G0S2 G0/G1 switch 2 -0.0346774
B2M beta-2-microglobulin -0.0346434
RPL19 ribosomal protein L19 -0.0343472
SOD2 superoxide dismutase 2, mitochondrial -0.0341492
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.033842
RPL38 ribosomal protein L38 -0.0336428
RAB7A RAB7A, member RAS oncogene family -0.0329707
ATF4 activating transcription factor 4 -0.0328377
PRKG1 protein kinase, cGMP-dependent, type I -0.0327604
RPL28 ribosomal protein L28 -0.0326818
RPL37 ribosomal protein L37 -0.0325674
CTSB cathepsin B -0.032508
COL6A1 collagen, type VI, alpha 1 -0.0324717
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0323794
CDH13 cadherin 13 -0.031926
RPL13A ribosomal protein L13a -0.0318195
RPS11 ribosomal protein S11 -0.0315513
EMP1 epithelial membrane protein 1 -0.0315242
MCL1 myeloid cell leukemia 1 -0.0312127
SFTPA2 surfactant protein A2 -0.0307754
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0302716
RAI14 retinoic acid induced 14 -0.0301071
RPLP1 ribosomal protein, large, P1 -0.028939
RPLP2 ribosomal protein, large, P2 -0.028284
SQSTM1 sequestosome 1 -0.0279933
PTMA prothymosin, alpha -0.0279221
IER3 immediate early response 3 -0.027292
COL4A2 collagen, type IV, alpha 2 -0.0268985
RPS16 ribosomal protein S16 -0.0268543
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0265651
PRSS23 protease, serine, 23 -0.0264925
RPL27A ribosomal protein L27a -0.0256103
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0252486
TMSB10 thymosin beta 10 -0.0252076
WSB1 WD repeat and SOCS box containing 1 -0.0244563
ADM adrenomedullin -0.0243411
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0243267
RPL7A ribosomal protein L7a -0.0241254
RPL9 ribosomal protein L9 -0.0240366
TPM4 tropomyosin 4 -0.0238076
AFF3 AF4/FMR2 family, member 3 -0.0237507
PRRX1 paired related homeobox 1 -0.0236176
RPS24 ribosomal protein S24 -0.0235962
RPL23 ribosomal protein L23 -0.02348
COL6A2 collagen, type VI, alpha 2 -0.0234639
UBC ubiquitin C -0.0234615
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0234454
TMEM165 transmembrane protein 165 -0.0232133
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0230863
GOLGB1 golgin B1 -0.022922
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.022912
NAMPT nicotinamide phosphoribosyltransferase -0.0226927
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0226567
ZBTB20 zinc finger and BTB domain containing 20 -0.0226133
VCAN versican -0.0224625
ZEB1 zinc finger E-box binding homeobox 1 -0.0222617
RPL12 ribosomal protein L12 -0.0219429
RPS27 ribosomal protein S27 -0.0219083
RAD51B RAD51 paralog B -0.0219067