| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/15944574 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in AQ-390/43364023 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAH12 | dynein, axonemal, heavy chain 12 | 0.79 |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | 0.6 |
| DOCK3 | dedicator of cytokinesis 3 | 0.59 |
| ZNF624 | zinc finger protein 624 | 0.58 |
| ARHGAP44 | Rho GTPase activating protein 44 | 0.5 |
| TNXB | tenascin XB | 0.49 |
| IER3IP1 | immediate early response 3 interacting protein 1 | 0.46 |
| KIF26A | kinesin family member 26A | 0.46 |
| IDUA | iduronidase, alpha-L- | 0.45 |
| EYS | eyes shut homolog (Drosophila) | 0.44 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.44 |
| CNTLN | centlein, centrosomal protein | 0.42 |
| ZFP90 | ZFP90 zinc finger protein | 0.42 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 0.42 |
| GPATCH2L | G patch domain containing 2-like | 0.41 |
| CNST | consortin, connexin sorting protein | 0.39 |
| FMNL3 | formin-like 3 | 0.38 |
| TBC1D16 | TBC1 domain family, member 16 | 0.37 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | 0.37 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | 0.37 |
| R3HDM4 | R3H domain containing 4 | 0.36 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.36 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | 0.35 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.34 |
| TROAP | trophinin associated protein | 0.34 |
| ZNF808 | zinc finger protein 808 | 0.34 |
| HDDC3 | HD domain containing 3 | 0.34 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | 0.34 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | 0.33 |
| WNT16 | wingless-type MMTV integration site family, member 16 | 0.33 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 0.33 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | 0.33 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.32 |
| KNDC1 | kinase non-catalytic C-lobe domain (KIND) containing 1 | 0.32 |
| MYO15B | myosin XVB | 0.31 |
| FIZ1 | FLT3-interacting zinc finger 1 | 0.31 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | 0.31 |
| E4F1 | E4F transcription factor 1 | 0.31 |
| PLXNB1 | plexin B1 | 0.3 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | 0.3 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.3 |
| H3C1 | H3 clustered histone 1 | 0.3 |
| MT1X | metallothionein 1X | 0.29 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.29 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.29 |
| GPR161 | G protein-coupled receptor 161 | 0.29 |
| HFE | hemochromatosis | 0.29 |
| METAP2 | methionyl aminopeptidase 2 | 0.29 |
| TMC6 | transmembrane channel-like 6 | 0.29 |
| CBX7 | chromobox homolog 7 | 0.28 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.28 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.28 |
| BBS10 | Bardet-Biedl syndrome 10 | 0.28 |
| SHLD2 | shieldin complex subunit 2 | 0.28 |
| PRG4 | proteoglycan 4 | 0.28 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.27 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.27 |
| FAM160A1 | family with sequence similarity 160, member A1 | 0.27 |
| SQSTM1 | sequestosome 1 | 0.27 |
| PLAU | plasminogen activator, urokinase | 0.27 |
| FAM126B | family with sequence similarity 126, member B | 0.27 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.27 |
| ZNF37A | zinc finger protein 37A | 0.26 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.26 |
| ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | 0.26 |
| SMAD3 | SMAD family member 3 | 0.26 |
| TUB | tubby bipartite transcription factor | 0.26 |
| SATB2 | SATB homeobox 2 | 0.26 |
| TMPO | thymopoietin | 0.25 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.25 |
| RAET1G | retinoic acid early transcript 1G | 0.25 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.25 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | 0.25 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.25 |
| C8ORF37 | chromosome 8 open reading frame 37 | 0.25 |
| FN1 | fibronectin 1 | 0.25 |
| PWWP2A | PWWP domain containing 2A | 0.24 |
| DTD1 | D-tyrosyl-tRNA deacylase 1 | 0.24 |
| EPDR1 | ependymin related 1 | 0.24 |
| CDC25B | cell division cycle 25B | 0.24 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.24 |
| FAM171B | family with sequence similarity 171, member B | 0.24 |
| C2CD2L | C2CD2-like | 0.24 |
| SPEG | SPEG complex locus | 0.24 |
| TMEM64 | transmembrane protein 64 | 0.24 |
| CHSY3 | chondroitin sulfate synthase 3 | 0.24 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | 0.24 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.24 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | 0.24 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.23 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.23 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.23 |
| ZYG11B | zyg-11 family member B, cell cycle regulator | 0.23 |
| ARL13B | ADP-ribosylation factor-like 13B | 0.23 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | 0.23 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | 0.23 |
| HGFAC | HGF activator | 0.23 |
| VWA5A | von Willebrand factor A domain containing 5A | 0.23 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | 0.23 |
| ACTN4 | actinin, alpha 4 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ALPK3 | alpha-kinase 3 | -3.65 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -1.49 |
| PIP | prolactin-induced protein | -1.37 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.22 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -0.98 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -0.69 |
| KIAA0753 | KIAA0753 | -0.69 |
| CCDC110 | coiled-coil domain containing 110 | -0.68 |
| TBX3 | T-box 3 | -0.66 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.63 |
| AXIN2 | axin 2 | -0.62 |
| B2M | beta-2-microglobulin | -0.6 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | -0.6 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.6 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.56 |
| LRRCC1 | leucine rich repeat and coiled-coil centrosomal protein 1 | -0.55 |
| PRR36 | proline rich 36 | -0.55 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | -0.53 |
| ZNF275 | zinc finger protein 275 | -0.53 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -0.52 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.52 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | -0.5 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.5 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | -0.49 |
| IL6ST | interleukin 6 signal transducer | -0.48 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.47 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.47 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | -0.46 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | -0.42 |
| CCDC138 | coiled-coil domain containing 138 | -0.4 |
| PARPBP | PARP1 binding protein | -0.4 |
| SH2B3 | SH2B adaptor protein 3 | -0.4 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.38 |
| DOP1A | DOP1 leucine zipper like protein A | -0.38 |
| ZNF580 | zinc finger protein 580 | -0.38 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.37 |
| TYK2 | tyrosine kinase 2 | -0.36 |
| DENND3 | DENN/MADD domain containing 3 | -0.36 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.35 |
| ZCCHC14 | zinc finger, CCHC domain containing 14 | -0.35 |
| ANKRD22 | ankyrin repeat domain 22 | -0.34 |
| RGN | regucalcin | -0.34 |
| ZDHHC21 | zinc finger, DHHC-type containing 21 | -0.34 |
| TSN | translin | -0.34 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.33 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.33 |
| FKBP2 | FK506 binding protein 2, 13kDa | -0.33 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -0.33 |
| GSR | glutathione reductase | -0.32 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.31 |
| LGALSL | lectin, galactoside-binding-like | -0.31 |
| ZBTB39 | zinc finger and BTB domain containing 39 | -0.3 |
| CDC26 | cell division cycle 26 | -0.3 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.3 |
| HPS1 | Hermansky-Pudlak syndrome 1 | -0.3 |
| SRXN1 | sulfiredoxin 1 | -0.29 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.29 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.29 |
| MEST | mesoderm specific transcript | -0.28 |
| SPSB3 | splA/ryanodine receptor domain and SOCS box containing 3 | -0.28 |
| TCEA2 | transcription elongation factor A (SII), 2 | -0.28 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.28 |
| RNF17 | ring finger protein 17 | -0.27 |
| RAD51B | RAD51 paralog B | -0.27 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.27 |
| NHSL1 | NHS-like 1 | -0.27 |
| ARG2 | arginase 2 | -0.27 |
| LIX1L | Lix1 homolog (chicken) like | -0.27 |
| STK17B | serine/threonine kinase 17b | -0.26 |
| NENF | neudesin neurotrophic factor | -0.26 |
| PDRG1 | p53 and DNA-damage regulated 1 | -0.26 |
| KLHL29 | kelch-like family member 29 | -0.26 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.25 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.25 |
| ZNF385B | zinc finger protein 385B | -0.25 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.25 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -0.25 |
| NHLRC3 | NHL repeat containing 3 | -0.25 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | -0.25 |
| S100A5 | S100 calcium binding protein A5 | -0.25 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.25 |
| PRMT8 | protein arginine methyltransferase 8 | -0.24 |
| ZDHHC18 | zinc finger, DHHC-type containing 18 | -0.24 |
| CEP68 | centrosomal protein 68kDa | -0.24 |
| NEK4 | NIMA-related kinase 4 | -0.24 |
| PALM3 | paralemmin 3 | -0.24 |
| SDF2 | stromal cell-derived factor 2 | -0.24 |
| MICB | MHC class I polypeptide-related sequence B | -0.24 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -0.23 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | -0.23 |
| LINGO1 | leucine rich repeat and Ig domain containing 1 | -0.23 |
| ABHD17B | abhydrolase domain containing 17B | -0.23 |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | -0.23 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.23 |
| GMIP | GEM interacting protein | -0.23 |
| CTHRC1 | collagen triple helix repeat containing 1 | -0.23 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.23 |
| ATE1 | arginyltransferase 1 | -0.23 |
| KLHL23 | kelch-like family member 23 | -0.23 |
| PCNX3 | pecanex 3 | -0.23 |
