AR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description androgen receptor|The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 367)
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Genes

361 genes differentially expressed following the AR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TRIM17 tripartite motif containing 17 2.48524
CLDN23 claudin 23 2.48524
TP63 tumor protein p63 2.48524
POTEF POTE ankyrin domain family, member F 2.48524
MORN5 MORN repeat containing 5 2.48524
CRYGN crystallin, gamma N 2.48524
NOX3 NADPH oxidase 3 2.48524
SHD Src homology 2 domain containing transforming protein D 2.48524
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.48524
ICOSLG inducible T-cell co-stimulator ligand 2.48524
MAMLD1 mastermind-like domain containing 1 2.48524
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.48524
C19ORF67 chromosome 19 open reading frame 67 2.48524
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 2.48524
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.48524
ZPLD1 zona pellucida-like domain containing 1 2.48524
RHOJ ras homolog family member J 2.48524
IL32 interleukin 32 2.48524
GRM1 glutamate receptor, metabotropic 1 2.48524
PSD4 pleckstrin and Sec7 domain containing 4 2.48524
IQCN IQ motif containing N 2.48524
MAGIX MAGI family member, X-linked 2.48524
NIBAN3 niban apoptosis regulator 3 2.48524
APCDD1 adenomatosis polyposis coli down-regulated 1 2.48524
TRIM74 tripartite motif containing 74 2.41344
GPR20 G protein-coupled receptor 20 2.41344
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.41344
FHL5 four and a half LIM domains 5 2.41344
FAM90A1 family with sequence similarity 90, member A1 2.41344
SLC15A5 solute carrier family 15, member 5 2.41344
RIMBP2 RIMS binding protein 2 2.41344
CXORF65 chromosome X open reading frame 65 2.41344
SH2D6 SH2 domain containing 6 2.41344
CABS1 calcium-binding protein, spermatid-specific 1 2.41344
GJB3 gap junction protein, beta 3, 31kDa 2.41344
CORT cortistatin 2.41344
MYO1G myosin IG 2.41344
CD34 CD34 molecule 2.41344
DEFB106B defensin, beta 106B 2.41344
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.41344
STRA8 stimulated by retinoic acid 8 2.41344
EVPL envoplakin 2.41344
RTP1 receptor (chemosensory) transporter protein 1 2.41344
PBDC1 polysaccharide biosynthesis domain containing 1 2.41344
GYS2 glycogen synthase 2 (liver) 2.41344
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.41344
RNASE7 ribonuclease, RNase A family, 7 2.41344
ZNF804A zinc finger protein 804A 2.41344
TBATA thymus, brain and testes associated 2.41344
NPR3 natriuretic peptide receptor 3 2.41344
TREML1 triggering receptor expressed on myeloid cells-like 1 2.41344
METTL17 methyltransferase like 17 2.41344
LCN12 lipocalin 12 2.41344
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.41344
PCDH8 protocadherin 8 2.41344
EYA3 EYA transcriptional coactivator and phosphatase 3 2.41344
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.41344
BHLHE40 basic helix-loop-helix family, member e40 2.41344
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.41344
INSYN1 inhibitory synaptic factor 1 2.41344
DUSP8 dual specificity phosphatase 8 2.41344
FIMP1 fertilization-influencing membrane protein 1 2.41344
C9ORF43 chromosome 9 open reading frame 43 2.41344
LMNTD2 lamin tail domain containing 2 2.41344
PAPOLB poly(A) polymerase beta (testis specific) 2.41344
WNT16 wingless-type MMTV integration site family, member 16 2.41344
RASD1 RAS, dexamethasone-induced 1 2.41344
IMPG1 interphotoreceptor matrix proteoglycan 1 2.41344
CIMIP3 ciliary microtubule inner protein 3 2.41344
ALDOB aldolase B, fructose-bisphosphate 2.41344
TMEM275 transmembrane protein 275 2.41344
CCN6 cellular communication network factor 6 2.41344
SMIM45 small integral membrane protein 45 2.41344
TMEM238L transmembrane protein 238 like 2.41344
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.41344
SERTM2 serine rich and transmembrane domain containing 2 2.41344
RNF227 ring finger protein 227 2.41344
CFAP100 cilia and flagella associated protein 100 2.41344
CCDC163 CCDC163 homolog 2.41344
CLXN calaxin 2.41344
PLAAT2 phospholipase A and acyltransferase 2 2.41344
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.41344
OOSP1 oocyte secreted protein 1, pseudogene 2.41344
S100B S100 calcium binding protein B 2.41344
CES3 carboxylesterase 3 2.41344
SPMIP2 sperm microtubule inner protein 2 2.41344
EQTN equatorin, sperm acrosome associated 2.41344
SCG2 secretogranin II 2.41344
CD1D CD1d molecule 2.41344
IL22RA1 interleukin 22 receptor, alpha 1 2.41344
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.41344
ZNF467 zinc finger protein 467 2.41344
HES7 hes family bHLH transcription factor 7 2.41344
SAC3D1 SAC3 domain containing 1 2.41344
FAM3D family with sequence similarity 3, member D 2.41344
FPR2 formyl peptide receptor 2 2.41344
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.41344
RUNX3 runt-related transcription factor 3 2.41344
FKRP fukutin related protein 2.41344
SLC22A25 solute carrier family 22, member 25 2.41344
ZSWIM2 zinc finger, SWIM-type containing 2 2.41344
ITK IL2-inducible T-cell kinase 2.41344
LTBP2 latent transforming growth factor beta binding protein 2 2.41344
KLHL30 kelch-like family member 30 2.41344
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 2.41344
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.41344
TEX19 testis expressed 19 2.41344
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.41344
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.41344
RAD51AP2 RAD51 associated protein 2 2.41344
AMIGO1 adhesion molecule with Ig-like domain 1 2.41344
HPCA hippocalcin 2.41344
OR56A1 olfactory receptor, family 56, subfamily A, member 1 2.41344
PLAC8 placenta-specific 8 2.41344
ERICH6 glutamate-rich 6 2.41344
CH25H cholesterol 25-hydroxylase 2.41344
ZSCAN4 zinc finger and SCAN domain containing 4 2.41344
KCNK2 potassium channel, two pore domain subfamily K, member 2 2.41344
NT5C1B 5'-nucleotidase, cytosolic IB 2.41344
CCL27 chemokine (C-C motif) ligand 27 2.41344
LRRC46 leucine rich repeat containing 46 2.41344
GPR68 G protein-coupled receptor 68 2.41344
FNDC1 fibronectin type III domain containing 1 2.41344
IL17REL interleukin 17 receptor E-like 2.41344
CTAGE4 CTAGE family, member 4 2.41344
CYSLTR1 cysteinyl leukotriene receptor 1 2.41344
RRH retinal pigment epithelium-derived rhodopsin homolog 2.41344
DHH desert hedgehog 2.41344
MUC16 mucin 16, cell surface associated 2.41344
CHKB choline kinase beta 2.41344
ZCCHC18 zinc finger, CCHC domain containing 18 2.41344
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.41344
PSKH2 protein serine kinase H2 2.41344
CLEC4C C-type lectin domain family 4, member C 2.41344
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.41344
PDZRN4 PDZ domain containing ring finger 4 2.41344
OAZ3 ornithine decarboxylase antizyme 3 2.41344
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.41344
KLK5 kallikrein-related peptidase 5 2.41344
MAP6 microtubule-associated protein 6 2.41344
RIPPLY2 ripply transcriptional repressor 2 2.41344
EDF1 endothelial differentiation-related factor 1 2.41344
AMH anti-Mullerian hormone 2.41344
FBXO32 F-box protein 32 2.41344
DHPS deoxyhypusine synthase 2.41344
PITX2 paired-like homeodomain 2 2.41344
WBP2NL WBP2 N-terminal like 2.41344
USP38 ubiquitin specific peptidase 38 2.41344
IL21R interleukin 21 receptor 2.41344
EVI2A ecotropic viral integration site 2A 2.41344
CD80 CD80 molecule 2.41344
GRAPL GRB2-related adaptor protein-like 2.41344
MAGEA12 melanoma antigen family A12 2.41344
SPNS3 spinster homolog 3 (Drosophila) 2.41344
PADI6 peptidyl arginine deiminase, type VI 2.41344
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.41344
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.41344
FOXS1 forkhead box S1 2.41344
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.41344
SLC38A10 solute carrier family 38, member 10 2.41344
EXTL1 exostosin-like glycosyltransferase 1 2.41344
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.41344
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.41344
TTC29 tetratricopeptide repeat domain 29 2.41344
ADGRD1 adhesion G protein-coupled receptor D1 2.41344
DAW1 dynein assembly factor with WDR repeat domains 1 2.41344
AOAH acyloxyacyl hydrolase (neutrophil) 2.41344
CD28 CD28 molecule 2.41344
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.41344
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 2.41344
GLDC glycine dehydrogenase (decarboxylating) 2.41344
ABHD1 abhydrolase domain containing 1 2.41344
PLA2G2C phospholipase A2, group IIC 2.41344
FADS6 fatty acid desaturase 6 2.41344
GPR149 G protein-coupled receptor 149 2.41344
C11ORF42 chromosome 11 open reading frame 42 2.41344
NUTM2A NUT family member 2A 2.41344
NUTM2F NUT family member 2F 2.41344
C5AR2 complement component 5a receptor 2 2.41344
PEX12 peroxisomal biogenesis factor 12 2.40697
HABP4 hyaluronan binding protein 4 2.35319
CDC40 cell division cycle 40 2.34739
TPCN2 two pore segment channel 2 2.32545
ZNF487 zinc finger protein 487 2.31129
SLC35F2 solute carrier family 35, member F2 2.30735
BICDL2 BICD family like cargo adaptor 2 2.30531
TCERG1 transcription elongation regulator 1 2.29058
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 2.29058
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 2.29058
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 2.29058
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 2.28868
CFL2 cofilin 2 (muscle) 2.28635
JAGN1 jagunal homolog 1 (Drosophila) 2.27516
COMMD4 COMM domain containing 4 2.27361
TIGAR TP53 induced glycolysis regulatory phosphatase 2.26857
UFSP1 UFM1-specific peptidase 1 (non-functional) 2.26857
FKBP6 FK506 binding protein 6, 36kDa 2.26857
IFT54 intraflagellar transport 54 2.26857
SGK3 serum/glucocorticoid regulated kinase family, member 3 2.25566
AKAP1 A kinase (PRKA) anchor protein 1 2.25566
PPP1R12B protein phosphatase 1, regulatory subunit 12B 2.2424
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.2346
UBAP2L ubiquitin associated protein 2-like 2.226
MPC1 mitochondrial pyruvate carrier 1 2.20882
ATN1 atrophin 1 2.19668
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.19668
ARID1B AT rich interactive domain 1B (SWI1-like) 2.19498
ZNF700 zinc finger protein 700 2.17976
SLC35F4 solute carrier family 35, member F4 2.17062
ZNF177 zinc finger protein 177 2.16739
AKAP8 A kinase (PRKA) anchor protein 8 2.16739
TSPAN6 tetraspanin 6 2.16545
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 2.15866
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.15013
NCAPH non-SMC condensin I complex, subunit H 2.14468
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 2.13905
CCSER2 coiled-coil serine-rich protein 2 2.13905
GCC1 GRIP and coiled-coil domain containing 1 2.11825
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 2.10919
OSER1 oxidative stress responsive serine-rich 1 2.09306
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 2.07606
ZFHX3 zinc finger homeobox 3 2.06384
PTPRM protein tyrosine phosphatase, receptor type, M 2.04921
PLK5 polo-like kinase 5 2.04864
TM9SF2 transmembrane 9 superfamily member 2 2.04776
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.04573
ADAM10 ADAM metallopeptidase domain 10 2.03086
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.01017
EIF4E3 eukaryotic translation initiation factor 4E family member 3 2.00985
CDK19 cyclin-dependent kinase 19 2.00759
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 2.00759
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.0012

decreased expression

Symbol Name Standardized Value
ZNF816 zinc finger protein 816 -2.48524
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial -2.48524
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.48524
CACNB1 calcium channel, voltage-dependent, beta 1 subunit -2.48524
NKRF NFKB repressing factor -2.48524
ZNF382 zinc finger protein 382 -2.48524
DNAH11 dynein, axonemal, heavy chain 11 -2.46039
MYOCD myocardin -2.41344
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.41344
RAB37 RAB37, member RAS oncogene family -2.41344
RBM43 RNA binding motif protein 43 -2.41344
MELTF melanotransferrin -2.41344
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B -2.41344
PIGA phosphatidylinositol glycan anchor biosynthesis, class A -2.41344
ZCWPW2 zinc finger, CW type with PWWP domain 2 -2.41344
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -2.41344
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -2.41344
RILP Rab interacting lysosomal protein -2.41344
TTF1 transcription termination factor, RNA polymerase I -2.41344
TOP1 topoisomerase (DNA) I -2.41344
PYGL phosphorylase, glycogen, liver -2.41344
AGA-DT AGA divergent transcript -2.41344
GHITM growth hormone inducible transmembrane protein -2.41344
CCDC85A coiled-coil domain containing 85A -2.41344
CASKIN2 CASK interacting protein 2 -2.41344
ZNF410 zinc finger protein 410 -2.41344
RHEB Ras homolog enriched in brain -2.41344
DNAAF11 dynein axonemal assembly factor 11 -2.41344
JCAD junctional cadherin 5 associated -2.41344
TNK1 tyrosine kinase, non-receptor, 1 -2.41344
ZNF641 zinc finger protein 641 -2.41344
VANGL2 VANGL planar cell polarity protein 2 -2.41344
LCMT2 leucine carboxyl methyltransferase 2 -2.41344
SNAI3 snail family zinc finger 3 -2.40697
ADRA2C adrenoceptor alpha 2C -2.40697
CRABP1 cellular retinoic acid binding protein 1 -2.40265
ZNF214 zinc finger protein 214 -2.37144
TMEM63B transmembrane protein 63B -2.37118
ZNF653 zinc finger protein 653 -2.3564
LATS1 large tumor suppressor kinase 1 -2.34974
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -2.34469
DLD dihydrolipoamide dehydrogenase -2.34446
BRD1 bromodomain containing 1 -2.3315
SPOUT1 SPOUT domain containing methyltransferase 1 -2.30326
GPC5 glypican 5 -2.27136
SLC49A3 solute carrier family 49 member 3 -2.26857
KDM6B lysine (K)-specific demethylase 6B -2.26857
LRRC10B leucine rich repeat containing 10B -2.26857
H3C7 H3 clustered histone 7 -2.26857
DUSP13B dual specificity phosphatase 13B -2.26857
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.26857
C1ORF116 chromosome 1 open reading frame 116 -2.26857
HCRTR1 hypocretin (orexin) receptor 1 -2.26857
CATSPER4 cation channel, sperm associated 4 -2.26857
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.26857
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -2.26857
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.26857
RGS22 regulator of G-protein signaling 22 -2.26857
P3H3 prolyl 3-hydroxylase 3 -2.26857
ECSIT ECSIT signalling integrator -2.26857
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -2.26857
SATB2 SATB homeobox 2 -2.26857
ADPRHL1 ADP-ribosylhydrolase like 1 -2.26857
DRC10 dynein regulatory complex subunit 10 -2.26857
TOR1B torsin family 1, member B (torsin B) -2.26857
OTX1 orthodenticle homeobox 1 -2.26857
PTH2R parathyroid hormone 2 receptor -2.26857
HLTF helicase-like transcription factor -2.26857
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.26857
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.26857
ADRA1A adrenoceptor alpha 1A -2.26857
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.26857
GCOM1 GRINL1A complex locus 1 -2.26857
C3ORF49 chromosome 3 open reading frame 49 -2.26857
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.26857
PHLDA2 pleckstrin homology-like domain, family A, member 2 -2.26857
AURKC aurora kinase C -2.26857
MXRA5 matrix-remodelling associated 5 -2.26857
SMIM17 small integral membrane protein 17 -2.26857
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.26857
OPTC opticin -2.26857
MRO maestro -2.26857
TMEM88 transmembrane protein 88 -2.26857
PLA2G10 phospholipase A2, group X -2.26857
SCUBE3 signal peptide, CUB domain, EGF-like 3 -2.26857
NPY neuropeptide Y -2.26857
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.26857
DOC2B double C2-like domains, beta -2.25566
CA10 carbonic anhydrase X -2.25566
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 -2.25566
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.25566
ZNF23 zinc finger protein 23 -2.25566
BEST1 bestrophin 1 -2.25566
TYMP thymidine phosphorylase -2.25566
SERF1A small EDRK-rich factor 1A (telomeric) -2.25566
THSD7B thrombospondin, type I, domain containing 7B -2.25205
CA11 carbonic anhydrase XI -2.25205
ACOT8 acyl-CoA thioesterase 8 -2.23355
SNW1 SNW domain containing 1 -2.23103
CLEC2D C-type lectin domain family 2, member D -2.226
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -2.226
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.22534
HES6 hes family bHLH transcription factor 6 -2.21482
VASN vasorin -2.20844
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta -2.19498
TIMM29 translocase of inner mitochondrial membrane 29 -2.19245
RAB38 RAB38, member RAS oncogene family -2.1724
RHBDD1 rhomboid domain containing 1 -2.16739
SMS spermine synthase -2.16739
CCDC39 coiled-coil domain containing 39 -2.16024
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.14937
RIOK1 RIO kinase 1 -2.14468
TTC27 tetratricopeptide repeat domain 27 -2.14088
RPAIN RPA interacting protein -2.13126
DBP D site of albumin promoter (albumin D-box) binding protein -2.12587
OCLN occludin -2.12557
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.12419
FXN frataxin -2.11861
EMB embigin -2.09991
ARHGAP23 Rho GTPase activating protein 23 -2.08435
RPP25 ribonuclease P/MRP 25kDa subunit -2.08293
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -2.05547
CERCAM cerebral endothelial cell adhesion molecule -2.04633
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.04633
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -2.04573
PRX periaxin -2.02733
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.02733
DYNLT2 dynein light chain Tctex-type 2 -2.02058
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -2.00965