AR Gene Set

Dataset MotifMap Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description androgen receptor|The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 367)
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Genes

34 target genes of the AR transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

Symbol Name
ADD3 adducin 3 (gamma)
AFG3L1P AFG3-like AAA ATPase 1, pseudogene
ARGLU1 arginine and glutamate rich 1
BICC1 BicC family RNA binding protein 1
C19ORF45 chromosome 19 open reading frame 45
CCDC85A coiled-coil domain containing 85A
DKFZP686K1684 uncharacterized LOC440034
EHF ets homologous factor
FGGY FGGY carbohydrate kinase domain containing
GRB7 growth factor receptor-bound protein 7
GRIA2 glutamate receptor, ionotropic, AMPA 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
IL1R2 interleukin 1 receptor, type II
LOC100049716 uncharacterized LOC100049716
LOC285847 uncharacterized LOC285847
LRRC16A leucine rich repeat containing 16A
MIR3660 microRNA 3660
MIR4329 microRNA 4329
MXD4 MAX dimerization protein 4
PNISR PNN-interacting serine/arginine-rich protein
PRKCH protein kinase C, eta
RAB11B-AS1 RAB11B antisense RNA 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SDCBP2-AS1 SDCBP2 antisense RNA 1
SFPQ splicing factor proline/glutamine-rich
SLC30A2 solute carrier family 30 (zinc transporter), member 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMC5 structural maintenance of chromosomes 5
SMOX spermine oxidase
SSRP1 structure specific recognition protein 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
THRA thyroid hormone receptor, alpha
TPRG1 tumor protein p63 regulated 1
UNC5A unc-5 homolog A (C. elegans)