AR Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description androgen receptor|The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 367)
External Link http://www.ncbi.nlm.nih.gov/gene/367
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Genes

355 interacting proteins for AR from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTB actin, beta
ADAM10 ADAM metallopeptidase domain 10
AES amino-terminal enhancer of split
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOL2 apolipoprotein L, 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARID5A AT rich interactive domain 5A (MRF1-like)
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ASXL1 additional sex combs like transcriptional regulator 1
ATF2 activating transcription factor 2
AURKA aurora kinase A
BAG1 BCL2-associated athanogene
BLK BLK proto-oncogene, Src family tyrosine kinase
BLNK B-cell linker
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BRD2 bromodomain containing 2
BRD3 bromodomain containing 3
BRD4 bromodomain containing 4
BTG2 BTG family, member 2
BTK Bruton agammaglobulinemia tyrosine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALR calreticulin
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCNE1 cyclin E1
CCNH cyclin H
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC37 cell division cycle 37
CDK1 cyclin-dependent kinase 1
CDK5 cyclin-dependent kinase 5
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD8 chromodomain helicase DNA binding protein 8
COPS2 COP9 signalosome subunit 2
COX5B cytochrome c oxidase subunit Vb
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CUL2 cullin 2
CUL4B cullin 4B
DAP3 death associated protein 3
DAXX death-domain associated protein
DCAF6 DDB1 and CUL4 associated factor 6
DCC DCC netrin 1 receptor
DDB2 damage-specific DNA binding protein 2, 48kDa
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DENND5A DENN/MADD domain containing 5A
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
EED embryonic ectoderm development
EFCAB6 EF-hand calcium binding domain 6
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FER fer (fps/fes related) tyrosine kinase
FES FES proto-oncogene, tyrosine kinase
FGF8 fibroblast growth factor 8 (androgen-induced)
FGR FGR proto-oncogene, Src family tyrosine kinase
FHL2 four and a half LIM domains 2
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FLNA filamin A, alpha
FOXA1 forkhead box A1
FOXO1 forkhead box O1
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GAK cyclin G associated kinase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
GRIP1 glutamate receptor interacting protein 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HCK HCK proto-oncogene, Src family tyrosine kinase
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC7 histone deacetylase 7
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK3 homeodomain interacting protein kinase 3
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
HSH2D hematopoietic SH2 domain containing
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPB2 heat shock 27kDa protein 2
IARS isoleucyl-tRNA synthetase
IDE insulin-degrading enzyme
IFI16 interferon, gamma-inducible protein 16
IL6ST interleukin 6 signal transducer
INPPL1 inositol polyphosphate phosphatase-like 1
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KAT7 K(lysine) acetyltransferase 7
KDM1A lysine (K)-specific demethylase 1A
KDM3A lysine (K)-specific demethylase 3A
KDM4A lysine (K)-specific demethylase 4A
KDM4D lysine (K)-specific demethylase 4D
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KIF1A kinesin family member 1A
KIFAP3 kinesin-associated protein 3
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KMT2A lysine (K)-specific methyltransferase 2A
KMT2D lysine (K)-specific methyltransferase 2D
LATS2 large tumor suppressor kinase 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCOR ligand dependent nuclear receptor corepressor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA11 melanoma antigen family A11
MAK male germ cell-associated kinase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MATK megakaryocyte-associated tyrosine kinase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDN1 MDN1, midasin homolog (yeast)
MED1 mediator complex subunit 1
MED12L mediator complex subunit 12-like
MED14 mediator complex subunit 14
MED24 mediator complex subunit 24
MLH3 mutL homolog 3
MYBBP1A MYB binding protein (P160) 1a
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NCOA4 nuclear receptor coactivator 4
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NDE1 nudE neurodevelopment protein 1
NELFCD negative elongation factor complex member C/D
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NISCH nischarin
NLRP10 NLR family, pyrin domain containing 10
NONO non-POU domain containing, octamer-binding
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRIP1 nuclear receptor interacting protein 1
NSD1 nuclear receptor binding SET domain protein 1
PA2G4 proliferation-associated 2G4, 38kDa
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX6 paired box 6
PELP1 proline, glutamate and leucine rich protein 1
PHB prohibitin
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIAS3 protein inhibitor of activated STAT, 3
PIAS4 protein inhibitor of activated STAT, 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKN1 protein kinase N1
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PMEPA1 prostate transmembrane protein, androgen induced 1
PNRC1 proline-rich nuclear receptor coactivator 1
PNRC2 proline-rich nuclear receptor coactivator 2
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POU2F1 POU class 2 homeobox 1
POU2F2 POU class 2 homeobox 2
POU5F1 POU class 5 homeobox 1
PPID peptidylprolyl isomerase D
PPP5C protein phosphatase 5, catalytic subunit
PRDX1 peroxiredoxin 1
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT1 protein arginine methyltransferase 1
PRPF6 pre-mRNA processing factor 6
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC3IP PSMC3 interacting protein
PSPC1 paraspeckle component 1
PTEN phosphatase and tensin homolog
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTK6 protein tyrosine kinase 6
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PXN paxillin
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAN RAN, member RAS oncogene family
RANBP9 RAN binding protein 9
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RB1 retinoblastoma 1
RBAK RB-associated KRAB zinc finger
RBL1 retinoblastoma-like 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REPS2 RALBP1 associated Eps domain containing 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF14 ring finger protein 14
RNF2 ring finger protein 2
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RNF6 ring finger protein (C3H2C3 type) 6
RREB1 ras responsive element binding protein 1
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RUVBL1 RuvB-like AAA ATPase 1
SART3 squamous cell carcinoma antigen recognized by T cells 3
SELENBP1 selenium binding protein 1
SETD7 SET domain containing (lysine methyltransferase) 7
SFPQ splicing factor proline/glutamine-rich
SH2D1A SH2 domain containing 1A
SH2D1B SH2 domain containing 1B
SH2D2A SH2 domain containing 2A
SH2D3C SH2 domain containing 3C
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SHE Src homology 2 domain containing E
SIAH2 siah E3 ubiquitin protein ligase 2
SIN3A SIN3 transcription regulator family member A
SIN3B SIN3 transcription regulator family member B
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIRT3 sirtuin 3
SIRT4 sirtuin 4
SIRT5 sirtuin 5
SIRT6 sirtuin 6
SIRT7 sirtuin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SOCS3 suppressor of cytokine signaling 3
SOCS6 suppressor of cytokine signaling 6
SP1 Sp1 transcription factor
SPDEF SAM pointed domain containing ETS transcription factor
SPOP speckle-type POZ protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRCAP Snf2-related CREBBP activator protein
SREBF1 sterol regulatory element binding transcription factor 1
SRY sex determining region Y
STAP1 signal transducing adaptor family member 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SVIL supervillin
SYK spleen tyrosine kinase
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TADA3 transcriptional adaptor 3
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBP TATA box binding protein
TCF20 transcription factor 20 (AR1)
TCF4 transcription factor 4
TDG thymine-DNA glycosylase
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGIF1 TGFB-induced factor homeobox 1
TMF1 TATA element modulatory factor 1
TNK2 tyrosine kinase, non-receptor, 2
TNS1 tensin 1
TNS4 tensin 4
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TRIM24 tripartite motif containing 24
TRIM68 tripartite motif containing 68
TRIP4 thyroid hormone receptor interactor 4
TSG101 tumor susceptibility 101
TSPY1 testis specific protein, Y-linked 1
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE3A ubiquitin protein ligase E3A
USP10 ubiquitin specific peptidase 10
USP12 ubiquitin specific peptidase 12
USP26 ubiquitin specific peptidase 26
UXT ubiquitously-expressed, prefoldin-like chaperone
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VCP valosin containing protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR77 WD repeat domain 77
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZBTB1 zinc finger and BTB domain containing 1
ZBTB16 zinc finger and BTB domain containing 16
ZBTB32 zinc finger and BTB domain containing 32
ZBTB7A zinc finger and BTB domain containing 7A
ZMIZ1 zinc finger, MIZ-type containing 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF318 zinc finger protein 318
ZNF451 zinc finger protein 451