ARF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ADP-ribosylation factor 1|ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 375)
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Genes

347 genes differentially expressed following the ARF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 2.82131
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.82131
NOTO notochord homeobox 2.82131
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.82131
PARP3 poly (ADP-ribose) polymerase family, member 3 2.82131
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.82131
USP26 ubiquitin specific peptidase 26 2.82131
PI16 peptidase inhibitor 16 2.82131
CD1D CD1d molecule 2.82131
CELA3B chymotrypsin-like elastase family, member 3B 2.82131
PON1 paraoxonase 1 2.82131
NDRG1 N-myc downstream regulated 1 2.82131
FABP9 fatty acid binding protein 9, testis 2.82131
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.82131
PCDHA7 protocadherin alpha 7 2.82131
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 2.82131
SLC35D3 solute carrier family 35, member D3 2.82131
SLFN14 schlafen family member 14 2.82131
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.82131
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 2.82131
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.82131
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.82131
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.82131
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.82131
SOX18 SRY (sex determining region Y)-box 18 2.82131
CLEC19A C-type lectin domain family 19, member A 2.82131
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.82131
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.82131
USP50 ubiquitin specific peptidase 50 2.82131
NLRP10 NLR family, pyrin domain containing 10 2.82131
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.82131
SHD Src homology 2 domain containing transforming protein D 2.82131
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.82131
TBATA thymus, brain and testes associated 2.82131
ACOT12 acyl-CoA thioesterase 12 2.82131
TRPC5OS TRPC5 opposite strand 2.82131
CXCL2 chemokine (C-X-C motif) ligand 2 2.82131
BIRC3 baculoviral IAP repeat containing 3 2.82131
SLC9C2 solute carrier family 9, member C2 (putative) 2.82131
UMOD uromodulin 2.82131
C8ORF48 chromosome 8 open reading frame 48 2.82131
SLC25A45 solute carrier family 25, member 45 2.82131
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.82131
PAX6 paired box 6 2.82131
NEU4 sialidase 4 2.82131
ASPA aspartoacylase 2.82131
GYPB glycophorin B (MNS blood group) 2.82131
LYNX1 Ly6/neurotoxin 1 2.82131
SP7 Sp7 transcription factor 2.82131
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.82131
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.82131
TMEM275 transmembrane protein 275 2.82131
FYB1 FYN binding protein 1 2.82131
H3-5 H3.5 histone 2.82131
H1-6 H1.6 linker histone, cluster member 2.82131
H2BC1 H2B clustered histone 1 2.82131
DUSP8 dual specificity phosphatase 8 2.82131
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.82131
TBC1D3B TBC1 domain family, member 3B 2.82131
ANO3 anoctamin 3 2.82131
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.82131
TMEM271 transmembrane protein 271 2.82131
PLAAT4 phospholipase A and acyltransferase 4 2.82131
PGAP6 post-GPI attachment to proteins 6 2.82131
EXOC1L exocyst complex component 1 like 2.82131
STRIT1 small transmembrane regulator of ion transport 1 2.82131
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.82131
ANKRD42-DT ANKRD42 divergent transcript 2.82131
C1ORF232 chromosome 1 open reading frame 230 2.82131
C20ORF204 chromosome 20 open reading frame 204 2.82131
H2AC1 H2A clustered histone 1 2.82131
GARIN6 golgi associated RAB2 interactor family member 6 2.82131
CATSPERZ catsper channel auxiliary subunit zeta 2.82131
PLPP4 phospholipid phosphatase 4 2.82131
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.82131
PCP4L1 Purkinje cell protein 4 like 1 2.82131
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.82131
C1QL2 complement component 1, q subcomponent-like 2 2.82131
PRRT4 proline-rich transmembrane protein 4 2.82131
ADGRG1 adhesion G protein-coupled receptor G1 2.82131
CXCL14 chemokine (C-X-C motif) ligand 14 2.82131
MSX2 msh homeobox 2 2.82131
CBLN3 cerebellin 3 precursor 2.82131
CBLN2 cerebellin 2 precursor 2.82131
OLAH oleoyl-ACP hydrolase 2.82131
CHRD chordin 2.82131
NPFF neuropeptide FF-amide peptide precursor 2.82131
TACR2 tachykinin receptor 2 2.82131
CAPN8 calpain 8 2.82131
LY6H lymphocyte antigen 6 complex, locus H 2.82131
ZNF705D zinc finger protein 705D 2.82131
FAM228A family with sequence similarity 228, member A 2.82131
OSTN osteocrin 2.82131
LRRN4CL LRRN4 C-terminal like 2.82131
ACE2 angiotensin I converting enzyme 2 2.82131
ARMC12 armadillo repeat containing 12 2.82131
FMR1NB fragile X mental retardation 1 neighbor 2.82131
BLNK B-cell linker 2.82131
VCX3A variable charge, X-linked 3A 2.82131
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.82131
POU3F2 POU class 3 homeobox 2 2.82131
PLAT plasminogen activator, tissue 2.82131
EFCAB3 EF-hand calcium binding domain 3 2.82131
KLHL6 kelch-like family member 6 2.82131
CTAGE9 CTAGE family, member 9 2.82131
NOX1 NADPH oxidase 1 2.82131
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.82131
KLHL41 kelch-like family member 41 2.82131
WFDC1 WAP four-disulfide core domain 1 2.82131
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.82131
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.82131
ZNF703 zinc finger protein 703 2.82131
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.82131
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.82131
C5AR2 complement component 5a receptor 2 2.82131
PRR15L proline rich 15-like 2.82131
TSPAN32 tetraspanin 32 2.82131
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.82131
COL11A2 collagen, type XI, alpha 2 2.82131
NGB neuroglobin 2.82131
C11ORF91 chromosome 11 open reading frame 91 2.82131
PCDHGB4 protocadherin gamma subfamily B, 4 2.82131
CCL27 chemokine (C-C motif) ligand 27 2.82131
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.82131
C2CD4B C2 calcium-dependent domain containing 4B 2.82131
PCDHGA2 protocadherin gamma subfamily A, 2 2.82131
CTSS cathepsin S 2.82131
CCNI2 cyclin I family, member 2 2.82131
HMGB4 high mobility group box 4 2.82131
SLA Src-like-adaptor 2.82131
ADAP2 ArfGAP with dual PH domains 2 2.82131
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.82131
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.82131
CNR2 cannabinoid receptor 2 (macrophage) 2.82131
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.82131
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.82131
DLX2 distal-less homeobox 2 2.82131
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.82131
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.82131
ALOXE3 arachidonate lipoxygenase 3 2.82131
BDKRB2 bradykinin receptor B2 2.82131
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 2.82131
CER1 cerberus 1, DAN family BMP antagonist 2.82131
FBXL22 F-box and leucine-rich repeat protein 22 2.82131
KLK7 kallikrein-related peptidase 7 2.82131
SVOP SV2 related protein homolog (rat) 2.82131
FGR FGR proto-oncogene, Src family tyrosine kinase 2.82131
MXRA5 matrix-remodelling associated 5 2.82131
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.82131
ITGA8 integrin, alpha 8 2.82131
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.82131
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.82131
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.82131
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 2.82131
NRGN neurogranin (protein kinase C substrate, RC3) 2.82131
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.82131
DNAH1 dynein, axonemal, heavy chain 1 2.82131
ANXA1 annexin A1 2.82131
RBP4 retinol binding protein 4, plasma 2.82131
CD86 CD86 molecule 2.82131
PPY pancreatic polypeptide 2.82131
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.82131
NEUROD1 neuronal differentiation 1 2.82131
ADAM29 ADAM metallopeptidase domain 29 2.82131
FGF16 fibroblast growth factor 16 2.82131
PNMT phenylethanolamine N-methyltransferase 2.82131
GH1 growth hormone 1 2.82131
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.82131
AHSG alpha-2-HS-glycoprotein 2.82131
SGSH N-sulfoglucosamine sulfohydrolase 2.82131
SPACA7 sperm acrosome associated 7 2.82131
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.82131
TP53INP2 tumor protein p53 inducible nuclear protein 2 2.82131
CD22 CD22 molecule 2.82131
DPYSL4 dihydropyrimidinase-like 4 2.81667
TCL1B T-cell leukemia/lymphoma 1B 2.81667
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.72663
FAM178B family with sequence similarity 178, member B 2.71868
NGF nerve growth factor (beta polypeptide) 2.71868
SMAD9 SMAD family member 9 2.71868
CBY3 chibby homolog 3 (Drosophila) 2.71868
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 2.67732
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.66242
ZNF326 zinc finger protein 326 2.65267
BHMT2 betaine--homocysteine S-methyltransferase 2 2.57003
WDR74 WD repeat domain 74 2.56203
OXNAD1 oxidoreductase NAD-binding domain containing 1 2.55121
AIP aryl hydrocarbon receptor interacting protein 2.54735
HGD homogentisate 1,2-dioxygenase 2.52113
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.51909
CNOT6L CCR4-NOT transcription complex, subunit 6-like 2.48269
SUFU suppressor of fused homolog (Drosophila) 2.46942
BSG basigin (Ok blood group) 2.43871
DPP4 dipeptidyl-peptidase 4 2.42718
CLEC2L C-type lectin domain family 2, member L 2.42718
ZNF738 zinc finger protein 738 2.37648
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 2.37647
LMTK3 lemur tyrosine kinase 3 2.3761
TSHZ3 teashirt zinc finger homeobox 3 2.33552
FGD6 FYVE, RhoGEF and PH domain containing 6 2.33552
ZNF713 zinc finger protein 713 2.33552
SEPHS1 selenophosphate synthetase 1 2.32014
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.29481
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 2.28805
XPC xeroderma pigmentosum, complementation group C 2.28805
MYT1 myelin transcription factor 1 2.28147
GRAMD1A GRAM domain containing 1A 2.26566
MORF4L2 mortality factor 4 like 2 2.26566
KRABD4 KRAB domain containing 4 2.26071
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.25267
TMEM91 transmembrane protein 91 2.24268
C17ORF75 chromosome 17 open reading frame 75 2.22256
CDC25B cell division cycle 25B 2.21711
ZNF329 zinc finger protein 329 2.20789
IFT140 intraflagellar transport 140 2.20064
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.19786
PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.19678
ARSJ arylsulfatase family, member J 2.19304
BIRC5 baculoviral IAP repeat containing 5 2.19201
TBC1D23 TBC1 domain family, member 23 2.19197
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.15285
THBS3 thrombospondin 3 2.14983
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.14878
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 2.14078
CLTB clathrin, light chain B 2.13424
SPRED1 sprouty-related, EVH1 domain containing 1 2.13424
SNX11 sorting nexin 11 2.13254
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.12988
LONRF1 LON peptidase N-terminal domain and ring finger 1 2.11844
SOX6 SRY (sex determining region Y)-box 6 2.08674
DCTN4 dynactin 4 (p62) 2.07476
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 2.07007
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.07007
HDAC1 histone deacetylase 1 2.05795
ADGRL3 adhesion G protein-coupled receptor L3 2.05267
SP8 Sp8 transcription factor 2.04502
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.04074
PHF20 PHD finger protein 20 2.02989

decreased expression

Symbol Name Standardized Value
KIF18A kinesin family member 18A -2.82131
GAB3 GRB2-associated binding protein 3 -2.82131
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.82131
GPR183 G protein-coupled receptor 183 -2.82131
ARSI arylsulfatase family, member I -2.82131
CRYBB1 crystallin, beta B1 -2.82131
HSPA1L heat shock 70kDa protein 1-like -2.82131
SUSD2 sushi domain containing 2 -2.82131
FSD1 fibronectin type III and SPRY domain containing 1 -2.82131
XKR9 XK, Kell blood group complex subunit-related family, member 9 -2.82131
TTLL9 tubulin tyrosine ligase-like family member 9 -2.82131
UBE2O ubiquitin-conjugating enzyme E2O -2.82131
MMP21 matrix metallopeptidase 21 -2.82131
APCDD1 adenomatosis polyposis coli down-regulated 1 -2.82131
WAS Wiskott-Aldrich syndrome -2.82131
SVIL supervillin -2.82131
KISS1R KISS1 receptor -2.82131
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.82131
ROM1 retinal outer segment membrane protein 1 -2.82131
FZD6 frizzled class receptor 6 -2.82131
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.82131
TTBK1 tau tubulin kinase 1 -2.82131
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -2.82131
XCL1 chemokine (C motif) ligand 1 -2.82131
BMP8B bone morphogenetic protein 8b -2.82131
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.82131
NCOA7 nuclear receptor coactivator 7 -2.82131
MYH15 myosin, heavy chain 15 -2.82131
EFCC1 EF-hand and coiled-coil domain containing 1 -2.82131
ZNF256 zinc finger protein 256 -2.82131
OOSP1 oocyte secreted protein 1, pseudogene -2.82131
CNTN5 contactin 5 -2.82131
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.82131
NSG2 neuronal vesicle trafficking associated 2 -2.82131
ADGRD1 adhesion G protein-coupled receptor D1 -2.82131
ARF1 ADP-ribosylation factor 1 -2.82131
SCRG1 stimulator of chondrogenesis 1 -2.82131
PCDHGA1 protocadherin gamma subfamily A, 1 -2.82131
PLEKHN1 pleckstrin homology domain containing, family N member 1 -2.82131
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -2.82131
IL18 interleukin 18 -2.82131
DENND1C DENN/MADD domain containing 1C -2.82131
MLIP muscular LMNA-interacting protein -2.82131
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 -2.82131
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.82131
CALHM2 calcium homeostasis modulator 2 -2.82131
CA2 carbonic anhydrase II -2.81579
SCART1 scavenger receptor protein family member -2.81579
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -2.78775
PLXNA3 plexin A3 -2.74472
MROH8 maestro heat-like repeat family member 8 -2.68131
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.68131
NATD1 N-acetyltransferase domain containing 1 -2.64796
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -2.63779
CASP8 caspase 8, apoptosis-related cysteine peptidase -2.63779
DNAL1 dynein, axonemal, light chain 1 -2.63595
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.5926
SHISA6 shisa family member 6 -2.5764
GEMIN5 gem (nuclear organelle) associated protein 5 -2.57003
ADCY1 adenylate cyclase 1 (brain) -2.52033
PRKCQ protein kinase C, theta -2.51518
GEMIN6 gem (nuclear organelle) associated protein 6 -2.51121
ZFYVE16 zinc finger, FYVE domain containing 16 -2.46942
MID1 midline 1 -2.45776
MAT1A methionine adenosyltransferase I, alpha -2.38812
CENPW centromere protein W -2.37263
SLC35G1 solute carrier family 35, member G1 -2.3656
SUSD6 sushi domain containing 6 -2.35977
SH3RF2 SH3 domain containing ring finger 2 -2.35977
AGTPBP1 ATP/GTP binding protein 1 -2.34206
TSGA10 testis specific, 10 -2.33878
NPHP4 nephronophthisis 4 -2.3374
ARFIP1 ADP-ribosylation factor interacting protein 1 -2.31663
AMER1 APC membrane recruitment protein 1 -2.30243
TMEM161A transmembrane protein 161A -2.29003
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like -2.28959
PARD3 par-3 family cell polarity regulator -2.28959
NKAP NFKB activating protein -2.28805
NBPF3 neuroblastoma breakpoint family, member 3 -2.2824
WDPCP WD repeat containing planar cell polarity effector -2.27754
UBA2 ubiquitin-like modifier activating enzyme 2 -2.27754
CYB561D2 cytochrome b561 family, member D2 -2.26155
SNX30 sorting nexin family member 30 -2.25074
VSTM5 V-set and transmembrane domain containing 5 -2.24562
PNISR PNN-interacting serine/arginine-rich protein -2.24231
NCAPG non-SMC condensin I complex, subunit G -2.24231
POGLUT3 protein O-glucosyltransferase 3 -2.23267
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -2.20789
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.20064
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.19551
ZNF248 zinc finger protein 248 -2.16869
RNF214 ring finger protein 214 -2.14935
USH2A Usher syndrome 2A (autosomal recessive, mild) -2.14935
RBFA ribosome binding factor A (putative) -2.14802
ETV5 ets variant 5 -2.13263
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.13153
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.11243
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.10575
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -2.08674
H4C3 H4 clustered histone 3 -2.07476
STIP1 stress-induced phosphoprotein 1 -2.06043
TMEM107 transmembrane protein 107 -2.05952
ADCY2 adenylate cyclase 2 (brain) -2.04895
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.02351
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.02184
FNBP4 formin binding protein 4 -2.01956
BCDIN3D BCDIN3 domain containing -2.01387
FBXL19 F-box and leucine-rich repeat protein 19 -2.01272
CCDC200 coiled-coil domain containing 200 -2.0009