ARF6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ADP-ribosylation factor 6|This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 382)
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Genes

321 genes differentially expressed following the ARF6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LBHD1 LBH domain containing 1 2.72964
IGFL3 IGF-like family member 3 2.72964
CELF3 CUGBP, Elav-like family member 3 2.72964
TMEM176A transmembrane protein 176A 2.72964
FABP1 fatty acid binding protein 1, liver 2.72964
FGL2 fibrinogen-like 2 2.72964
CELA3B chymotrypsin-like elastase family, member 3B 2.72964
SLC35G6 solute carrier family 35, member G6 2.72964
NCF1 neutrophil cytosolic factor 1 2.72964
KRT20 keratin 20, type I 2.72964
TBX18 T-box 18 2.72964
ALOX15 arachidonate 15-lipoxygenase 2.72964
SCN2B sodium channel, voltage gated, type II beta subunit 2.72964
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.72964
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.72964
ACR acrosin 2.72964
GPR6 G protein-coupled receptor 6 2.72964
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.72964
ZACN zinc activated ligand-gated ion channel 2.72964
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.72964
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.72964
MAP3K7CL MAP3K7 C-terminal like 2.72964
CDH5 cadherin 5, type 2 (vascular endothelium) 2.72964
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.72964
TMEM191B transmembrane protein 191B 2.72964
ZNF808 zinc finger protein 808 2.72964
LCN10 lipocalin 10 2.72964
CLEC5A C-type lectin domain family 5, member A 2.72964
MEIKIN meiotic kinetochore factor 2.72964
LGI3 leucine-rich repeat LGI family, member 3 2.72964
HBZ hemoglobin, zeta 2.72964
OXT oxytocin/neurophysin I prepropeptide 2.72964
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.72964
BHMT2 betaine--homocysteine S-methyltransferase 2 2.72964
ATOH1 atonal homolog 1 (Drosophila) 2.72964
MRC1 mannose receptor, C type 1 2.72964
GTF2IRD2 GTF2I repeat domain containing 2 2.72964
BSX brain-specific homeobox 2.72964
CCL5 chemokine (C-C motif) ligand 5 2.72964
PAX4 paired box 4 2.72964
LRG1 leucine-rich alpha-2-glycoprotein 1 2.72964
SSTR3 somatostatin receptor 3 2.72964
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.72964
MFAP5 microfibrillar associated protein 5 2.72964
ARHGAP11A Rho GTPase activating protein 11A 2.72964
PLXNB1 plexin B1 2.72964
SHCBP1L SHC SH2-domain binding protein 1-like 2.72964
CXCL2 chemokine (C-X-C motif) ligand 2 2.72964
CPLX1 complexin 1 2.72964
OR1R1 olfactory receptor family 1 subfamily R member 1 2.72964
PLAAT4 phospholipase A and acyltransferase 4 2.72964
DEPP1 DEPP autophagy regulator 1 2.72964
TCIM transcriptional and immune response regulator 2.72964
ASDURF ASNSD1 upstream open reading frame 2.72964
FYB1 FYN binding protein 1 2.72964
CCDC9B coiled-coil domain containing 9B 2.72964
PRXL2A peroxiredoxin like 2A 2.72964
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.72964
ZNF726 zinc finger protein 726 2.72964
AVPR1A arginine vasopressin receptor 1A 2.72964
H2BC3 H2B clustered histone 3 2.72964
H1-8 H1.8 linker histone 2.72964
SPMIP11 sperm microtubule inner protein 11 2.72964
TEKTL1 tektin like 1 2.72964
LITAFD LITAF domain containing 2.72964
LINC02268 long intergenic non-protein coding RNA 2268 2.72964
IRF2-DT IRF2 divergent transcript 2.72964
GREP1 glycine rich extracellular protein 1 2.72964
H4C12 H4 clustered histone 12 2.72964
H3C3 H3 clustered histone 3 2.72964
MYMK myomaker, myoblast fusion factor 2.72964
H2AC1 H2A clustered histone 1 2.72964
ELOVL3 ELOVL fatty acid elongase 3 2.72964
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 2.72964
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.72964
CELA2A chymotrypsin-like elastase family, member 2A 2.72964
S100B S100 calcium binding protein B 2.72964
CCR1 chemokine (C-C motif) receptor 1 2.72964
FAM186A family with sequence similarity 186, member A 2.72964
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.72964
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.72964
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.72964
TEX101 testis expressed 101 2.72964
C1ORF87 chromosome 1 open reading frame 87 2.72964
PCDHA3 protocadherin alpha 3 2.72964
BARX2 BARX homeobox 2 2.72964
VCX3A variable charge, X-linked 3A 2.72964
TMEM40 transmembrane protein 40 2.72964
BDKRB1 bradykinin receptor B1 2.72964
LY6K lymphocyte antigen 6 complex, locus K 2.72964
GAPT GRB2-binding adaptor protein, transmembrane 2.72964
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.72964
DLK2 delta-like 2 homolog (Drosophila) 2.72964
NPIPB8 nuclear pore complex interacting protein family, member B8 2.72964
LRRC71 leucine rich repeat containing 71 2.72964
STARD6 StAR-related lipid transfer (START) domain containing 6 2.72964
BLNK B-cell linker 2.72964
RAB41 RAB41, member RAS oncogene family 2.72964
HMX3 H6 family homeobox 3 2.72964
PCDHGB4 protocadherin gamma subfamily B, 4 2.72964
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.72964
C11ORF16 chromosome 11 open reading frame 16 2.72964
FIBIN fin bud initiation factor homolog (zebrafish) 2.72964
ODF1 outer dense fiber of sperm tails 1 2.72964
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.72964
NUPR1 nuclear protein, transcriptional regulator, 1 2.72964
MCCD1 mitochondrial coiled-coil domain 1 2.72964
C17ORF99 chromosome 17 open reading frame 99 2.72964
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.72964
IL19 interleukin 19 2.72964
MKRN3 makorin ring finger protein 3 2.72964
HSPA1L heat shock 70kDa protein 1-like 2.72964
A3GALT2 alpha 1,3-galactosyltransferase 2 2.72964
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.72964
LRRC46 leucine rich repeat containing 46 2.72964
TMEM132D transmembrane protein 132D 2.72964
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.72964
NOG noggin 2.72964
CLEC4C C-type lectin domain family 4, member C 2.72964
CSTA cystatin A (stefin A) 2.72964
CST5 cystatin D 2.72964
TESPA1 thymocyte expressed, positive selection associated 1 2.72964
TEKT5 tektin 5 2.72964
TEKT2 tektin 2 (testicular) 2.72964
NYX nyctalopin 2.72964
NKX6-3 NK6 homeobox 3 2.72964
PCDHAC2 protocadherin alpha subfamily C, 2 2.72964
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 2.72964
ARHGAP40 Rho GTPase activating protein 40 2.72964
LAMB4 laminin, beta 4 2.72964
CNGB1 cyclic nucleotide gated channel beta 1 2.72964
DRC1 dynein regulatory complex subunit 1 2.72964
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 2.72964
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.72964
CDH22 cadherin 22, type 2 2.72964
SH2D1B SH2 domain containing 1B 2.72964
HELT helt bHLH transcription factor 2.72964
DHH desert hedgehog 2.72964
ZNF80 zinc finger protein 80 2.72964
THBD thrombomodulin 2.72964
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.72964
ZFP92 ZFP92 zinc finger protein 2.72964
ZNF596 zinc finger protein 596 2.72964
LSMEM1 leucine-rich single-pass membrane protein 1 2.72964
BCL2L15 BCL2-like 15 2.72964
RGS7 regulator of G-protein signaling 7 2.72964
CFI complement factor I 2.72964
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.72964
PRRX1 paired related homeobox 1 2.72964
RHOJ ras homolog family member J 2.72964
NUTM2B NUT family member 2B 2.72964
GPR179 G protein-coupled receptor 179 2.72964
ANXA2R annexin A2 receptor 2.72964
TGM1 transglutaminase 1 2.72964
NUTM2A NUT family member 2A 2.72964
CD34 CD34 molecule 2.72964
TTC36 tetratricopeptide repeat domain 36 2.72964
TMEM52B transmembrane protein 52B 2.72964
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.72964
NLRP3 NLR family, pyrin domain containing 3 2.72964
PLIN4 perilipin 4 2.72964
LRRC31 leucine rich repeat containing 31 2.72964
LOXL4 lysyl oxidase-like 4 2.72964
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.72964
LYZL4 lysozyme-like 4 2.72964
KRTAP12-1 keratin associated protein 12-1 2.72964
PRR15L proline rich 15-like 2.72964
IL33 interleukin 33 2.72964
PRPF6 pre-mRNA processing factor 6 2.72964
TBC1D28 TBC1 domain family, member 28 2.72964
STEAP4 STEAP family member 4 2.72964
ZMYND10 zinc finger, MYND-type containing 10 2.72964
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.72964
DBX2 developing brain homeobox 2 2.72964
ANXA8 annexin A8 2.72964
XCR1 chemokine (C motif) receptor 1 2.72964
TGM6 transglutaminase 6 2.72964
PLA2G4E phospholipase A2, group IVE 2.72964
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.72964
MMP13 matrix metallopeptidase 13 2.72964
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.70058
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.65083
TNS4 tensin 4 2.62774
TTC27 tetratricopeptide repeat domain 27 2.51139
ARMH1 armadillo like helical domain containing 1 2.46374
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.4507
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2.43945
SYCP1 synaptonemal complex protein 1 2.43945
FOXN4 forkhead box N4 2.43945
MB myoglobin 2.43945
BOD1L1 biorientation of chromosomes in cell division 1-like 1 2.4357
CDK18 cyclin-dependent kinase 18 2.43318
TMEM151A transmembrane protein 151A 2.41486
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.41486
MRS2 MRS2 magnesium transporter 2.39979
BCL7C B-cell CLL/lymphoma 7C 2.2981
RIMS4 regulating synaptic membrane exocytosis 4 2.28969
MIPOL1 mirror-image polydactyly 1 2.28953
ZDHHC14 zinc finger, DHHC-type containing 14 2.27925
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.27699
ADAM7 ADAM metallopeptidase domain 7 2.27699
BIN1 bridging integrator 1 2.26876
MTMR1 myotubularin related protein 1 2.26455
GTSE1 G-2 and S-phase expressed 1 2.24484
CDH4 cadherin 4, type 1, R-cadherin (retinal) 2.24229
ADAM10 ADAM metallopeptidase domain 10 2.22311
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.21485
MAPRE3 microtubule-associated protein, RP/EB family, member 3 2.19841
NOMO3 NODAL modulator 3 2.17275
THAP6 THAP domain containing 6 2.16625
MCRIP2 MAPK regulated corepressor interacting protein 2 2.1581
ENKUR enkurin, TRPC channel interacting protein 2.15043
MACF1 microtubule-actin crosslinking factor 1 2.14908
SLC22A17 solute carrier family 22, member 17 2.13602
SPIN2B spindlin family, member 2B 2.13185
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 2.11296
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 2.11219
INTS5 integrator complex subunit 5 2.10803
TTC7A tetratricopeptide repeat domain 7A 2.08871
GEMIN7 gem (nuclear organelle) associated protein 7 2.08871
TLCD3A TLC domain containing 3A 2.08749
STAT5B signal transducer and activator of transcription 5B 2.06168
CNKSR1 connector enhancer of kinase suppressor of Ras 1 2.04759
FN1 fibronectin 1 2.04668
SNCB synuclein, beta 2.03538
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.02953
GMFG glia maturation factor, gamma 2.00976
PTAFR platelet-activating factor receptor 2.00693

decreased expression

Symbol Name Standardized Value
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.72964
CD6 CD6 molecule -2.72964
SLC22A14 solute carrier family 22, member 14 -2.72964
SCTR secretin receptor -2.72964
CDCP2 CUB domain containing protein 2 -2.72964
PPP1R12B protein phosphatase 1, regulatory subunit 12B -2.72964
GDA guanine deaminase -2.72964
ROM1 retinal outer segment membrane protein 1 -2.72964
CBLN1 cerebellin 1 precursor -2.72964
CARD6 caspase recruitment domain family, member 6 -2.72964
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.72964
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -2.72964
CPB2 carboxypeptidase B2 (plasma) -2.72964
DPPA3 developmental pluripotency associated 3 -2.72964
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) -2.72964
COL15A1 collagen, type XV, alpha 1 -2.72964
MYBPC1 myosin binding protein C, slow type -2.72964
PRDM16 PR domain containing 16 -2.72964
PRELP proline/arginine-rich end leucine-rich repeat protein -2.72964
FAM167A family with sequence similarity 167, member A -2.72964
CHADL chondroadherin-like -2.72964
MIP major intrinsic protein of lens fiber -2.72964
KCNT1 potassium channel, sodium activated subfamily T, member 1 -2.72964
NACA2 nascent polypeptide-associated complex alpha subunit 2 -2.72964
COL9A1 collagen, type IX, alpha 1 -2.72964
PNLIPRP2 pancreatic lipase-related protein 2 -2.72964
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.72964
SPHKAP SPHK1 interactor, AKAP domain containing -2.72964
SPEF1 sperm flagellar 1 -2.72964
ORM2 orosomucoid 2 -2.72964
SMIM45 small integral membrane protein 45 -2.72964
SYT5 synaptotagmin V -2.72964
VCF2 VCP nuclear cofactor family member 2 -2.72964
CALR3 calreticulin 3 -2.72964
ZNF57 zinc finger protein 57 -2.72964
OSTN osteocrin -2.72964
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.72964
CD53 CD53 molecule -2.72964
ALOXE3 arachidonate lipoxygenase 3 -2.72964
FMO1 flavin containing monooxygenase 1 -2.72964
DCDC2B doublecortin domain containing 2B -2.72964
NDC80 NDC80 kinetochore complex component -2.70058
ELMOD1 ELMO/CED-12 domain containing 1 -2.68268
OXSR1 oxidative stress responsive 1 -2.65083
DHODH dihydroorotate dehydrogenase (quinone) -2.59381
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -2.58982
ELOVL5 ELOVL fatty acid elongase 5 -2.51005
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.4961
EXOSC1 exosome component 1 -2.4507
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.43584
ZNF785 zinc finger protein 785 -2.4357
F2R coagulation factor II (thrombin) receptor -2.42485
FLT3LG fms-related tyrosine kinase 3 ligand -2.41775
ESPN espin -2.3953
PNPLA3 patatin-like phospholipase domain containing 3 -2.38544
ARF6 ADP-ribosylation factor 6 -2.38102
QRICH2 glutamine rich 2 -2.34078
CAMK1G calcium/calmodulin-dependent protein kinase IG -2.27581
SP1 Sp1 transcription factor -2.27446
ARMC1 armadillo repeat containing 1 -2.24484
XPOT exportin, tRNA -2.21395
PDCD6IP programmed cell death 6 interacting protein -2.20001
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -2.18479
VPS50 VPS50 subunit of EARP/GARPII complex -2.18032
NGRN neugrin, neurite outgrowth associated -2.16625
CMKLR2 chemerin chemokine-like receptor 2 -2.1548
LRRC19 leucine rich repeat containing 19 -2.1544
MEF2B myocyte enhancer factor 2B -2.14755
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -2.14196
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -2.14154
TMEM14A transmembrane protein 14A -2.13602
GPR135 G protein-coupled receptor 135 -2.12923
CLGN calmegin -2.1215
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.11679
SLC10A4 solute carrier family 10, member 4 -2.11679
ZPBP zona pellucida binding protein -2.11679
PITPNM3 PITPNM family member 3 -2.1096
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.10521
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) -2.10379
GSPT1 G1 to S phase transition 1 -2.09548
SLITRK4 SLIT and NTRK-like family, member 4 -2.09175
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.09175
IRF3 interferon regulatory factor 3 -2.09047
TBC1D19 TBC1 domain family, member 19 -2.07896
CCNQ cyclin Q -2.07896
HDGFL2 HDGF like 2 -2.07743
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 -2.06518
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.03103
FUCA2 fucosidase, alpha-L- 2, plasma -2.01317
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -2.01184
MANBA mannosidase, beta A, lysosomal -2.00976
LIN7C lin-7 homolog C (C. elegans) -2.00546
SYT6 synaptotagmin VI -2.00514