ARNT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description aryl hydrocarbon receptor nuclear translocator|This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] (NCBI Entrez Gene Database, 405)
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Genes

339 genes differentially expressed following the ARNT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 2.6657
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.6657
MGAT4D MGAT4 family, member D 2.6657
HCLS1 hematopoietic cell-specific Lyn substrate 1 2.6657
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.6657
SOX18 SRY (sex determining region Y)-box 18 2.6657
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.6657
NPIPB8 nuclear pore complex interacting protein family, member B8 2.6657
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.6657
ATP13A5 ATPase type 13A5 2.6657
LEF1 lymphoid enhancer-binding factor 1 2.6657
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.6657
CBLN3 cerebellin 3 precursor 2.6657
PCDHB12 protocadherin beta 12 2.6657
PCDHGB2 protocadherin gamma subfamily B, 2 2.6657
REN renin 2.6657
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.6657
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.6657
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.6657
GPR183 G protein-coupled receptor 183 2.6657
C1ORF146 chromosome 1 open reading frame 146 2.6657
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.66439
HLF hepatic leukemia factor 2.66439
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.66439
S100A2 S100 calcium binding protein A2 2.66439
ARRDC5 arrestin domain containing 5 2.66439
ZNF492 zinc finger protein 492 2.66439
PSCA prostate stem cell antigen 2.66439
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.66439
GJA3 gap junction protein, alpha 3, 46kDa 2.66439
HBD hemoglobin, delta 2.66439
IL2RA interleukin 2 receptor, alpha 2.66439
FER1L6 fer-1-like family member 6 2.66439
SBK3 SH3 domain binding kinase family, member 3 2.66439
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.66439
MRC1 mannose receptor, C type 1 2.66439
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.66439
ENTHD1 ENTH domain containing 1 2.66439
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.66439
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.66439
ADAD2 adenosine deaminase domain containing 2 2.66439
CD68 CD68 molecule 2.66439
GYPE glycophorin E (MNS blood group) 2.66439
OLIG3 oligodendrocyte transcription factor 3 2.66439
FETUB fetuin B 2.66439
PAX3 paired box 3 2.66439
LRRC52 leucine rich repeat containing 52 2.66439
LRRC56 leucine rich repeat containing 56 2.66439
TMEM217 transmembrane protein 217 2.66439
TM4SF20 transmembrane 4 L six family member 20 2.66439
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.66439
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.66439
GAN gigaxonin 2.66439
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2.66439
TBX15 T-box 15 2.66439
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.66439
THRSP thyroid hormone responsive 2.66439
GPR4 G protein-coupled receptor 4 2.66439
ANKRD42-DT ANKRD42 divergent transcript 2.66439
UNC93A unc-93 homolog A (C. elegans) 2.66439
HPS1 Hermansky-Pudlak syndrome 1 2.66439
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.66439
PANK4 pantothenate kinase 4 2.66439
RAX2 retina and anterior neural fold homeobox 2 2.66439
SCEL sciellin 2.66439
PNLIPRP1 pancreatic lipase-related protein 1 2.66439
SPATA31C1 SPATA31 subfamily C, member 1 2.66439
MLN motilin 2.66439
SPMIP9 sperm microtubule inner protein 9 2.66439
ZC3H7B zinc finger CCCH-type containing 7B 2.66439
ZNF593OS ZNF593 opposite strand 2.66439
MINDY4B MINDY family member 4B 2.66439
LY6L lymphocyte antigen 6 family member L 2.66439
ACP4 acid phosphatase 4 2.66439
H1-8 H1.8 linker histone 2.66439
P3R3URF PIK3R3 upstream open reading frame 2.66439
PHF24 PHD finger protein 24 2.66439
GOLGA6L7 golgin A6 family like 7 2.66439
SELE selectin E 2.66439
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.66439
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.66439
FOXC1 forkhead box C1 2.66439
LRRC70 leucine rich repeat containing 70 2.66439
PGA5 pepsinogen 5, group I (pepsinogen A) 2.66439
TACR2 tachykinin receptor 2 2.66439
RNF113B ring finger protein 113B 2.66439
LOC122394732 uncharacterized LOC122394732 2.66439
TFEC transcription factor EC 2.66439
ANXA13 annexin A13 2.66439
VSX2 visual system homeobox 2 2.66439
TEX101 testis expressed 101 2.66439
PXDC1 PX domain containing 1 2.66439
PRG4 proteoglycan 4 2.66439
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.66439
FCMR Fc fragment of IgM receptor 2.66439
IMPG2 interphotoreceptor matrix proteoglycan 2 2.66439
F5 coagulation factor V (proaccelerin, labile factor) 2.66439
GATA2 GATA binding protein 2 2.66439
CLEC6A C-type lectin domain family 6, member A 2.66439
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.66439
CCDC42 coiled-coil domain containing 42 2.66439
PRG3 proteoglycan 3 2.66439
ACTL8 actin-like 8 2.66439
PTGDR prostaglandin D2 receptor (DP) 2.66439
AQP8 aquaporin 8 2.66439
CPSF4L cleavage and polyadenylation specific factor 4-like 2.66439
GCOM1 GRINL1A complex locus 1 2.66439
SMIM23 small integral membrane protein 23 2.66439
KLF2 Kruppel-like factor 2 2.66439
PKDREJ polycystin (PKD) family receptor for egg jelly 2.66439
CPA5 carboxypeptidase A5 2.66439
APOC2 apolipoprotein C-II 2.66439
MAMLD1 mastermind-like domain containing 1 2.66439
OTC ornithine carbamoyltransferase 2.66439
CST1 cystatin SN 2.66439
MYF6 myogenic factor 6 (herculin) 2.66439
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.66439
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.66439
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.66439
KRT15 keratin 15, type I 2.66439
TBPL2 TATA box binding protein like 2 2.66439
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.66439
ALAS2 5'-aminolevulinate synthase 2 2.66439
EBF3 early B-cell factor 3 2.66439
BPIFB1 BPI fold containing family B, member 1 2.66439
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.66439
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.66439
CCNI2 cyclin I family, member 2 2.66439
GPR142 G protein-coupled receptor 142 2.66439
GPR146 G protein-coupled receptor 146 2.66439
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.66439
OTP orthopedia homeobox 2.66439
LMX1A LIM homeobox transcription factor 1, alpha 2.66439
CXORF58 chromosome X open reading frame 58 2.66439
MB myoglobin 2.66439
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.66439
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.66439
AMH anti-Mullerian hormone 2.66439
CD200R1 CD200 receptor 1 2.66439
TTC9B tetratricopeptide repeat domain 9B 2.66439
DRD2 dopamine receptor D2 2.66439
MCCD1 mitochondrial coiled-coil domain 1 2.66439
DNTT DNA nucleotidylexotransferase 2.66439
IL1B interleukin 1, beta 2.66439
CNGB3 cyclic nucleotide gated channel beta 3 2.66439
C8B complement component 8, beta polypeptide 2.66439
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.66439
CFAP61 cilia and flagella associated protein 61 2.66439
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.66439
LIMS3 LIM and senescent cell antigen-like domains 3 2.66439
LKAAEAR1 LKAAEAR motif containing 1 2.66439
GREM1 gremlin 1, DAN family BMP antagonist 2.66439
ZPLD1 zona pellucida-like domain containing 1 2.66439
STAP1 signal transducing adaptor family member 1 2.66439
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.66439
KRTAP4-9 keratin associated protein 4-9 2.66439
CPT2 carnitine palmitoyltransferase 2 2.66439
AMPD1 adenosine monophosphate deaminase 1 2.66439
HOXB1 homeobox B1 2.66439
ANGPTL5 angiopoietin-like 5 2.66439
WFDC13 WAP four-disulfide core domain 13 2.66439
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.66439
AREG amphiregulin 2.66439
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.66439
ZC2HC1B zinc finger, C2HC-type containing 1B 2.66439
IQSEC2 IQ motif and Sec7 domain 2 2.66439
FAM9C family with sequence similarity 9, member C 2.66439
ASCL1 achaete-scute family bHLH transcription factor 1 2.66439
LRRC74B leucine rich repeat containing 74B 2.66439
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.66439
RHAG Rh-associated glycoprotein 2.66439
POTEF POTE ankyrin domain family, member F 2.66439
LHB luteinizing hormone beta polypeptide 2.66439
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.66439
PRR29 proline rich 29 2.66439
RTP4 receptor (chemosensory) transporter protein 4 2.66439
SLITRK6 SLIT and NTRK-like family, member 6 2.66439
POTEE POTE ankyrin domain family, member E 2.66439
FBLN5 fibulin 5 2.64455
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 2.59078
AQP3 aquaporin 3 (Gill blood group) 2.50985
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 2.50754
ACLY ATP citrate lyase 2.50525
TMLHE trimethyllysine hydroxylase, epsilon 2.46794
ELMO3 engulfment and cell motility 3 2.43567
MTRF1L mitochondrial translational release factor 1-like 2.42521
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 2.42521
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.42219
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.41526
GPM6A glycoprotein M6A 2.37177
SH2D7 SH2 domain containing 7 2.34879
TREH trehalase (brush-border membrane glycoprotein) 2.34879
CLMB calcimembrin 2.32545
FXYD1 FXYD domain containing ion transport regulator 1 2.29707
TCF3 transcription factor 3 2.29655
PGD phosphogluconate dehydrogenase 2.29138
HIF3A hypoxia inducible factor 3, alpha subunit 2.28532
MYCT1 myc target 1 2.26525
ETNPPL ethanolamine-phosphate phospho-lyase 2.26525
TRIM28 tripartite motif containing 28 2.26344
RAD21 RAD21 homolog (S. pombe) 2.25458
TMEM178B transmembrane protein 178B 2.21638
BMPR1A bone morphogenetic protein receptor, type IA 2.20758
ATP5PF ATP synthase peripheral stalk subunit F6 2.20758
COX20 COX20 cytochrome c oxidase assembly factor 2.19836
DZIP1 DAZ interacting zinc finger protein 1 2.18303
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.17971
ADAM28 ADAM metallopeptidase domain 28 2.17298
RANBP1 RAN binding protein 1 2.17069
H3-3A H3.3 histone A 2.15553
AKAP6 A kinase (PRKA) anchor protein 6 2.14561
MAP3K7 mitogen-activated protein kinase kinase kinase 7 2.13881
PODXL2 podocalyxin-like 2 2.13854
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.1288
FAAP100 FA core complex associated protein 100 2.12498
MRPL54 mitochondrial ribosomal protein L54 2.11892
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.1148
BST2 bone marrow stromal cell antigen 2 2.1066
RNF181 ring finger protein 181 2.1066
MARCHF1 membrane associated ring-CH-type finger 1 2.1019
JKAMP JNK1/MAPK8-associated membrane protein 2.08804
DCAF5 DDB1 and CUL4 associated factor 5 2.07151
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.05843
HMGB1 high mobility group box 1 2.05295
ZDHHC23 zinc finger, DHHC-type containing 23 2.04145
FBXO22 F-box protein 22 2.03932
CIP2A cellular inhibitor of PP2A 2.03749
SFXN2 sideroflexin 2 2.00098

decreased expression

Symbol Name Standardized Value
RBM27 RNA binding motif protein 27 -2.6657
CDH9 cadherin 9, type 2 (T1-cadherin) -2.6657
SMCO2 single-pass membrane protein with coiled-coil domains 2 -2.66439
ACER2 alkaline ceramidase 2 -2.66439
IL20RB interleukin 20 receptor beta -2.66439
ANKRD23 ankyrin repeat domain 23 -2.66439
ELOF1 elongation factor 1 homolog (S. cerevisiae) -2.66439
NLRP1 NLR family, pyrin domain containing 1 -2.66439
KLHL25 kelch-like family member 25 -2.66439
AZU1 azurocidin 1 -2.66439
KIAA1614 KIAA1614 -2.66439
ANKRD44 ankyrin repeat domain 44 -2.66439
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 -2.66439
C2CD4D C2 calcium-dependent domain containing 4D -2.66439
PRSS51 protease, serine, 51 -2.66439
CFAP20DC CFAP20 domain containing -2.66439
GPX2 glutathione peroxidase 2 -2.66439
PHETA1 PH domain containing endocytic trafficking adaptor 1 -2.66439
ZNF516 zinc finger protein 516 -2.66439
TAMALIN trafficking regulator and scaffold protein tamalin -2.66439
RFX2 regulatory factor X, 2 (influences HLA class II expression) -2.66223
TMEM215 transmembrane protein 215 -2.65777
BHLHE40 basic helix-loop-helix family, member e40 -2.65777
GIPR gastric inhibitory polypeptide receptor -2.65777
SPNS2 spinster homolog 2 (Drosophila) -2.65777
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -2.65777
AMDHD1 amidohydrolase domain containing 1 -2.65777
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.65777
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.65777
KLLN killin, p53-regulated DNA replication inhibitor -2.65777
POPDC2 popeye domain containing 2 -2.65777
HIGD1C HIG1 hypoxia inducible domain family, member 1C -2.65777
FAM181B family with sequence similarity 181, member B -2.65777
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.65777
VTN vitronectin -2.65777
PCDHB13 protocadherin beta 13 -2.65777
CRACDL CRACD like -2.65777
DUSP9 dual specificity phosphatase 9 -2.65777
CLEC19A C-type lectin domain family 19, member A -2.65777
MAMDC4 MAM domain containing 4 -2.65777
EFCAB9 EF-hand calcium binding domain 9 -2.65777
ADGRG3 adhesion G protein-coupled receptor G3 -2.65777
FAM107A family with sequence similarity 107, member A -2.65777
SLC38A8 solute carrier family 38, member 8 -2.65777
FOXK2 forkhead box K2 -2.65777
SLC38A3 solute carrier family 38, member 3 -2.65777
SFTA2 surfactant associated 2 -2.65777
TCEA3 transcription elongation factor A (SII), 3 -2.65777
IGSF22 immunoglobulin superfamily, member 22 -2.65777
TMEM225B transmembrane protein 225B -2.65777
EXOC2 exocyst complex component 2 -2.65741
DCLK3 doublecortin-like kinase 3 -2.65741
ZBBX zinc finger, B-box domain containing -2.65741
KIAA2013 KIAA2013 -2.56631
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.56471
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -2.529
SYBU syntabulin (syntaxin-interacting) -2.529
ZNF408 zinc finger protein 408 -2.47985
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.42524
SGSM2 small G protein signaling modulator 2 -2.41526
ADCY2 adenylate cyclase 2 (brain) -2.41521
FAM53B family with sequence similarity 53, member B -2.40573
CERCAM cerebral endothelial cell adhesion molecule -2.30474
AJUBA ajuba LIM protein -2.29021
ZNF547 zinc finger protein 547 -2.28954
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.27541
TMT1B thiol methyltransferase 1B -2.27541
EFCAB8 EF-hand calcium binding domain 8 -2.27541
CREBRF CREB3 regulatory factor -2.26716
PTPRO protein tyrosine phosphatase, receptor type, O -2.26716
CDH20 cadherin 20, type 2 -2.21666
DTX3 deltex 3, E3 ubiquitin ligase -2.20758
DERA deoxyribose-phosphate aldolase (putative) -2.18303
CABLES1 Cdk5 and Abl enzyme substrate 1 -2.17002
PNPLA2 patatin-like phospholipase domain containing 2 -2.15643
SYT6 synaptotagmin VI -2.15618
CALHM2 calcium homeostasis modulator 2 -2.13854
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E -2.1359
ZNF865 zinc finger protein 865 -2.13259
AASDH aminoadipate-semialdehyde dehydrogenase -2.12785
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -2.12785
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -2.12151
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -2.11955
NUP62CL nucleoporin 62kDa C-terminal like -2.11955
RFX3 regulatory factor X, 3 (influences HLA class II expression) -2.11955
C14ORF93 chromosome 14 open reading frame 93 -2.11507
RNF135 ring finger protein 135 -2.11507
BICD1 bicaudal D homolog 1 (Drosophila) -2.11307
DPP8 dipeptidyl-peptidase 8 -2.10976
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.10976
MYO7A myosin VIIA -2.10976
VEPH1 ventricular zone expressed PH domain-containing 1 -2.10976
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.10976
FYN FYN proto-oncogene, Src family tyrosine kinase -2.10835
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -2.09181
WWC2 WW and C2 domain containing 2 -2.08011
ZFYVE27 zinc finger, FYVE domain containing 27 -2.07894
AP5B1 adaptor-related protein complex 5, beta 1 subunit -2.07841
CDYL chromodomain protein, Y-like -2.06402
UBAP1 ubiquitin associated protein 1 -2.06402
PPP6R2 protein phosphatase 6, regulatory subunit 2 -2.06373
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.06109
CAVIN1 caveolae associated protein 1 -2.05156
CGNL1 cingulin-like 1 -2.03932
SYP synaptophysin -2.03932
CDHR3 cadherin-related family member 3 -2.02867
ACKR4 atypical chemokine receptor 4 -2.02534
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -2.02534
SPRED2 sprouty-related, EVH1 domain containing 2 -2.00704
ZNF433 zinc finger protein 433 -2.00704
DSCAML1 Down syndrome cell adhesion molecule like 1 -2.00704