ARNTL Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description aryl hydrocarbon receptor nuclear translocator-like|The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 406)
External Link http://www.ncbi.nlm.nih.gov/gene/406
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Genes

71 interacting proteins for ARNTL from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AHR aryl hydrocarbon receptor
AKAP11 A kinase (PRKA) anchor protein 11
ATAD3B ATPase family, AAA domain containing 3B
BHLHE40 basic helix-loop-helix family, member e40
CCNA2 cyclin A2
CDKN2A cyclin-dependent kinase inhibitor 2A
CLOCK clock circadian regulator
CREBBP CREB binding protein
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CTBP2 C-terminal binding protein 2
DCAF7 DDB1 and CUL4 associated factor 7
DDB1 damage-specific DNA binding protein 1, 127kDa
DEC1 deleted in esophageal cancer 1
DYNLL1 dynein, light chain, LC8-type 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
ENAH enabled homolog (Drosophila)
EP300 E1A binding protein p300
EP400 E1A binding protein p400
EPAS1 endothelial PAS domain protein 1
FAM117A family with sequence similarity 117, member A
FAM117B family with sequence similarity 117, member B
FAM53C family with sequence similarity 53, member C
FBXL3 F-box and leucine-rich repeat protein 3
FOXK1 forkhead box K1
GLCCI1 glucocorticoid induced 1
GSK3B glycogen synthase kinase 3 beta
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLF hepatic leukemia factor
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
KAT2B K(lysine) acetyltransferase 2B
KAT8 K(lysine) acetyltransferase 8
KIAA0232 KIAA0232
LZTS2 leucine zipper, putative tumor suppressor 2
MSL3 male-specific lethal 3 homolog (Drosophila)
NPAS2 neuronal PAS domain protein 2
NPAS4 neuronal PAS domain protein 4
NR1D1 nuclear receptor subfamily 1, group D, member 1
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PPP1R3F protein phosphatase 1, regulatory subunit 3F
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTGES3 prostaglandin E synthase 3 (cytosolic)
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RNF169 ring finger protein 169
RXRA retinoid X receptor, alpha
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SKP1 S-phase kinase-associated protein 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TECR trans-2,3-enoyl-CoA reductase
TIMELESS timeless circadian clock
TROAP trophinin associated protein
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE3A ubiquitin protein ligase E3A
USP11 ubiquitin specific peptidase 11
WDR6 WD repeat domain 6
ZNF516 zinc finger protein 516