ASAP2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ArfGAP with SH3 domain, ankyrin repeat and PH domain 2|This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 8853)
External Link http://www.ncbi.nlm.nih.gov/gene/8853
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122 interacting proteins for ASAP2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AGER advanced glycosylation end product-specific receptor
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARF1 ADP-ribosylation factor 1
ARF5 ADP-ribosylation factor 5
ARF6 ADP-ribosylation factor 6
ARHGAP12 Rho GTPase activating protein 12
ARHGAP20 Rho GTPase activating protein 20
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BCR breakpoint cluster region
BIN1 bridging integrator 1
C11ORF84 chromosome 11 open reading frame 84
C1ORF27 chromosome 1 open reading frame 27
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD2AP CD2-associated protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CSRP1 cysteine and glycine-rich protein 1
CTTN cortactin
DIAPH1 diaphanous-related formin 1
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DOCK4 dedicator of cytokinesis 4
DOCK5 dedicator of cytokinesis 5
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
ELMO2 engulfment and cell motility 2
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERRFI1 ERBB receptor feedback inhibitor 1
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FGD6 FYVE, RhoGEF and PH domain containing 6
FRS2 fibroblast growth factor receptor substrate 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GAREML GRB2 associated, regulator of MAPK1-like
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRB2 growth factor receptor-bound protein 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HUNK hormonally up-regulated Neu-associated kinase
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
INPPL1 inositol polyphosphate phosphatase-like 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITSN1 intersectin 1 (SH3 domain protein)
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIRREL kin of IRRE like (Drosophila)
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MYCBP MYC binding protein
NCK1 NCK adaptor protein 1
NCKAP1 NCK-associated protein 1
NISCH nischarin
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP5C protein phosphatase 5, catalytic subunit
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPRJ protein tyrosine phosphatase, receptor type, J
PXN paxillin
RADIL Ras association and DIL domains
RAN RAN, member RAS oncogene family
RBBP6 retinoblastoma binding protein 6
REPS2 RALBP1 associated Eps domain containing 2
SH2D5 SH2 domain containing 5
SH3KBP1 SH3-domain kinase binding protein 1
SH3PXD2A SH3 and PX domains 2A
SH3PXD2B SH3 and PX domains 2B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRPA signal-regulatory protein alpha
SLAIN2 SLAIN motif family, member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SNX18 sorting nexin 18
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAMBP STAM binding protein
SUMO1 small ubiquitin-like modifier 1
SYNJ1 synaptojanin 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBRG4 transforming growth factor beta regulator 4
TEC tec protein tyrosine kinase
THSD7A thrombospondin, type I, domain containing 7A
TSG101 tumor susceptibility 101
TTYH2 tweety family member 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
VAV3 vav 3 guanine nucleotide exchange factor
WASL Wiskott-Aldrich syndrome-like
WDR44 WD repeat domain 44
WDR6 WD repeat domain 6
WDR77 WD repeat domain 77
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPF3 WAS/WASL interacting protein family, member 3
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta