ASCL2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description achaete-scute family bHLH transcription factor 2|This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 430)
Similar Terms
Downloads & Tools

Genes

357 genes differentially expressed following the ASCL2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 4.05557
CLEC12B C-type lectin domain family 12, member B 4.05557
TIFAB TRAF-interacting protein with forkhead-associated domain, family member B 4.05557
ENAM enamelin 4.05557
TREM1 triggering receptor expressed on myeloid cells 1 4.05557
CDH5 cadherin 5, type 2 (vascular endothelium) 4.05557
CHRND cholinergic receptor, nicotinic, delta (muscle) 4.05557
ZSCAN5B zinc finger and SCAN domain containing 5B 4.05557
SIGLECL1 SIGLEC family like 1 4.05557
MAGEA2 melanoma antigen family A2 4.05557
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 4.05557
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 4.05557
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 4.05557
CD5 CD5 molecule 4.05557
OLAH oleoyl-ACP hydrolase 4.05557
IL31RA interleukin 31 receptor A 4.05557
ZSWIM2 zinc finger, SWIM-type containing 2 4.05557
C4ORF17 chromosome 4 open reading frame 17 4.05557
TUBA3D tubulin, alpha 3d 4.05557
CFAP99 cilia and flagella associated protein 99 4.05557
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 4.05557
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 4.05557
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 4.05557
NDRG1 N-myc downstream regulated 1 4.05557
PDYN prodynorphin 4.05557
PCDHB7 protocadherin beta 7 4.05557
SLC35G6 solute carrier family 35, member G6 4.05557
SLC23A3 solute carrier family 23, member 3 4.05557
HCRTR2 hypocretin (orexin) receptor 2 4.05557
REN renin 4.05557
POSTN periostin, osteoblast specific factor 4.05557
GLRA3 glycine receptor, alpha 3 4.05557
SYCE3 synaptonemal complex central element protein 3 4.05557
SOWAHB sosondowah ankyrin repeat domain family member B 4.05557
S100A1 S100 calcium binding protein A1 4.05557
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 4.05557
CORO6 coronin 6 4.05557
SSTR2 somatostatin receptor 2 4.05557
OLIG2 oligodendrocyte lineage transcription factor 2 4.05557
GFAP glial fibrillary acidic protein 4.05557
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 4.05557
SSTR1 somatostatin receptor 1 4.05557
OSGIN1 oxidative stress induced growth inhibitor 1 4.05557
UNC13C unc-13 homolog C (C. elegans) 4.05557
AZGP1 alpha-2-glycoprotein 1, zinc-binding 4.05557
GSTM5 glutathione S-transferase mu 5 4.05557
GJB1 gap junction protein, beta 1, 32kDa 4.05557
PAX5 paired box 5 4.05557
FAM90A1 family with sequence similarity 90, member A1 4.05557
VGLL2 vestigial-like family member 2 4.05557
JCHAIN joining chain of multimeric IgA and IgM 4.05557
SPMIP7 sperm microtubule inner protein 7 4.05557
TMOD4 tropomodulin 4 (muscle) 4.05557
PTH1R parathyroid hormone 1 receptor 4.05557
RAG1 recombination activating gene 1 4.05557
UNC93A unc-93 homolog A (C. elegans) 4.05557
TRAPPC3L trafficking protein particle complex 3-like 4.05557
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 4.05557
PNLIPRP1 pancreatic lipase-related protein 1 4.05557
TRPC7 transient receptor potential cation channel, subfamily C, member 7 4.05557
TCERG1L transcription elongation regulator 1-like 4.05557
OR2T8 olfactory receptor, family 2, subfamily T, member 8 4.05557
NECTIN4 nectin cell adhesion molecule 4 4.05557
MISP3 MISP family member 3 4.05557
CCDC9B coiled-coil domain containing 9B 4.05557
OOSP4B oocyte secreted protein family member 4B 4.05557
CTXND1 cortexin domain containing 1 4.05557
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 4.05557
SERTM2 serine rich and transmembrane domain containing 2 4.05557
EZHIP EZH inhibitory protein 4.05557
PEAK3 PEAK family member 3 4.05557
CPHXL cytoplasmic polyadenylated homeobox like 4.05557
H2BC3 H2B clustered histone 3 4.05557
RTL5 retrotransposon Gag like 5 4.05557
TBXT T-box transcription factor T 4.05557
KRT80 keratin 80, type II 4.05557
SPRR2E small proline-rich protein 2E 4.05557
FMO2 flavin containing monooxygenase 2 (non-functional) 4.05557
TARM1 T cell-interacting, activating receptor on myeloid cells 1 4.05557
OOSP1 oocyte secreted protein 1, pseudogene 4.05557
OPN5 opsin 5 4.05557
OR10K2 olfactory receptor, family 10, subfamily K, member 2 4.05557
SPATA31G1 SPATA31 subfamily G member 1 4.05557
CCR4 chemokine (C-C motif) receptor 4 4.05557
CCR3 chemokine (C-C motif) receptor 3 4.05557
FAM186A family with sequence similarity 186, member A 4.05557
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 4.05557
TLR5 toll-like receptor 5 4.05557
HAL histidine ammonia-lyase 4.05557
DLK1 delta-like 1 homolog (Drosophila) 4.05557
DLK2 delta-like 2 homolog (Drosophila) 4.05557
PKD2L1 polycystic kidney disease 2-like 1 4.05557
FOXN4 forkhead box N4 4.05557
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 4.05557
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 4.05557
LMNTD1 lamin tail domain containing 1 4.05557
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 4.05557
TMEM40 transmembrane protein 40 4.05557
GC group-specific component (vitamin D binding protein) 4.05557
GATA4 GATA binding protein 4 4.05557
LTB lymphotoxin beta (TNF superfamily, member 3) 4.05557
SIM2 single-minded family bHLH transcription factor 2 4.05557
TMEM156 transmembrane protein 156 4.05557
FAM25G family with sequence similarity 25, member G 4.05557
CSF3R colony stimulating factor 3 receptor (granulocyte) 4.05557
PGR progesterone receptor 4.05557
PENK proenkephalin 4.05557
ECM1 extracellular matrix protein 1 4.05557
OR13A1 olfactory receptor, family 13, subfamily A, member 1 4.05557
KRT15 keratin 15, type I 4.05557
TP63 tumor protein p63 4.05557
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 4.05557
AMER3 APC membrane recruitment protein 3 4.05557
KRT16 keratin 16, type I 4.05557
THEM5 thioesterase superfamily member 5 4.05557
MYADML2 myeloid-associated differentiation marker-like 2 4.05557
FOXP3 forkhead box P3 4.05557
EPN3 epsin 3 4.05557
TRPM5 transient receptor potential cation channel, subfamily M, member 5 4.05557
TRPM8 transient receptor potential cation channel, subfamily M, member 8 4.05557
RHAG Rh-associated glycoprotein 4.05557
MST1 macrophage stimulating 1 4.05557
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 4.05557
NTN5 netrin 5 4.05557
F2RL3 coagulation factor II (thrombin) receptor-like 3 4.05557
AKNAD1 AKNA domain containing 1 4.05557
MAMLD1 mastermind-like domain containing 1 4.05557
MAB21L3 mab-21-like 3 (C. elegans) 4.05557
KLK12 kallikrein-related peptidase 12 4.05557
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 4.05557
DRD5 dopamine receptor D5 4.05557
C2CD4B C2 calcium-dependent domain containing 4B 4.05557
IL19 interleukin 19 4.05557
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 4.05557
IGF2 insulin-like growth factor 2 4.05557
ALAS2 5'-aminolevulinate synthase 2 4.05557
LCT lactase 4.05557
CST1 cystatin SN 4.05557
C8G complement component 8, gamma polypeptide 4.05557
S100A14 S100 calcium binding protein A14 4.05557
C11ORF97 chromosome 11 open reading frame 97 4.05557
CLRN1 clarin 1 4.05557
KRT222 keratin 222, type II 4.05557
PCDHGA2 protocadherin gamma subfamily A, 2 4.05557
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 4.05557
CLEC18B C-type lectin domain family 18, member B 4.05557
OR14A2 olfactory receptor, family 14, subfamily A, member 2 4.05557
SCN3A sodium channel, voltage gated, type III alpha subunit 4.05557
LAMB4 laminin, beta 4 4.05557
OR1G1 olfactory receptor, family 1, subfamily G, member 1 4.05557
OR6B3 olfactory receptor, family 6, subfamily B, member 3 4.05557
AGXT alanine-glyoxylate aminotransferase 4.05557
GOLGA8O golgin A8 family, member O 4.05557
WNT2 wingless-type MMTV integration site family member 2 4.05557
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 4.05557
NPC1L1 NPC1-like 1 4.05557
NWD2 NACHT and WD repeat domain containing 2 4.05557
IL18R1 interleukin 18 receptor 1 4.05557
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 4.05557
FAM181B family with sequence similarity 181, member B 4.05557
TEX36 testis expressed 36 4.05557
SPDEF SAM pointed domain containing ETS transcription factor 4.05557
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 4.05557
GREM1 gremlin 1, DAN family BMP antagonist 4.05557
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 4.05557
SPAG8 sperm associated antigen 8 4.05557
MEIS1 Meis homeobox 1 4.05557
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 4.05557
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 4.05557
CD3D CD3d molecule, delta (CD3-TCR complex) 4.05557
HMX3 H6 family homeobox 3 4.05557
EGFLAM EGF-like, fibronectin type III and laminin G domains 3.97176
PTGER3 prostaglandin E receptor 3 (subtype EP3) 3.97176
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 3.97176
MXRA8 matrix-remodelling associated 8 3.55362
H2BC13 H2B clustered histone 13 3.46798
MAST2 microtubule associated serine/threonine kinase 2 3.44058
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 3.42586
ZAN zonadhesin (gene/pseudogene) 3.35565
ABHD8 abhydrolase domain containing 8 3.35096
SOD2 superoxide dismutase 2, mitochondrial 3.35061
METTL14 methyltransferase like 14 3.12155
ANKDD1B ankyrin repeat and death domain containing 1B 3.11968
TGM1 transglutaminase 1 3.05772
CEP70 centrosomal protein 70kDa 3.02617
ZNF358 zinc finger protein 358 2.96981
TEDC1 tubulin epsilon and delta complex 1 2.92759
UPK3B uroplakin 3B 2.92759
SPDYE17 speedy/RINGO cell cycle regulator family member E17 2.92759
CSF1 colony stimulating factor 1 (macrophage) 2.92759
ARFRP1 ADP-ribosylation factor related protein 1 2.84886
SKIC8 SKI8 subunit of superkiller complex 2.82799
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.79407
DGCR8 DGCR8 microprocessor complex subunit 2.67631
TFCP2L1 transcription factor CP2-like 1 2.67595
CHMP4B charged multivesicular body protein 4B 2.66584
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.63605
SEC63 SEC63 homolog (S. cerevisiae) 2.58719
RBM10 RNA binding motif protein 10 2.53255
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.51698
SPATA6L spermatogenesis associated 6-like 2.51698
PNMA2 paraneoplastic Ma antigen 2 2.51242
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 2.45595
CBARP CACN subunit beta associated regulatory protein 2.43385
C11ORF24 chromosome 11 open reading frame 24 2.42594
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 2.41838
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 2.41838
EVPLL envoplakin-like 2.41347
CLDN23 claudin 23 2.41347
SCN10A sodium channel, voltage gated, type X alpha subunit 2.41347
AGFG2 ArfGAP with FG repeats 2 2.40822
NEU4 sialidase 4 2.40822
DOP1B DOP1 leucine zipper like protein B 2.39139
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.38455
PHOSPHO1 phosphatase, orphan 1 2.38455
LSG1 large 60S subunit nuclear export GTPase 1 2.37464
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.34222
RAB8A RAB8A, member RAS oncogene family 2.33179
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.31691
SERGEF secretion regulating guanine nucleotide exchange factor 2.31532
GFOD2 glucose-fructose oxidoreductase domain containing 2 2.30514
ZNF106 zinc finger protein 106 2.3027
SNX30 sorting nexin family member 30 2.30186
AOC3 amine oxidase, copper containing 3 2.26777
PARK7 parkinson protein 7 2.26551
C6ORF52 chromosome 6 open reading frame 52 2.24305
RAP2B RAP2B, member of RAS oncogene family 2.23797
ESYT1 extended synaptotagmin-like protein 1 2.19958
PNMA3 paraneoplastic Ma antigen 3 2.19958
PARPBP PARP1 binding protein 2.15481
ABI1 abl-interactor 1 2.14937
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 2.12878
FAM222B family with sequence similarity 222, member B 2.11483
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 2.10038
ZNF146 zinc finger protein 146 2.09966
FAM193A family with sequence similarity 193, member A 2.09726
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.09432
FAM89A family with sequence similarity 89, member A 2.09014
KANK1 KN motif and ankyrin repeat domains 1 2.06841
DNMBP dynamin binding protein 2.05962
S1PR3 sphingosine-1-phosphate receptor 3 2.0453
ROMO1 reactive oxygen species modulator 1 2.02512
PNMA8A PNMA family member 8A 2.02323
ANKEF1 ankyrin repeat and EF-hand domain containing 1 2.01747
BEND6 BEN domain containing 6 2.00374

decreased expression

Symbol Name Standardized Value
DIO1 deiodinase, iodothyronine, type I -4.05557
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -4.05557
TMEM171 transmembrane protein 171 -4.05557
TM4SF1 transmembrane 4 L six family member 1 -4.05557
LOX lysyl oxidase -4.05557
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -4.05557
AKAP3 A kinase (PRKA) anchor protein 3 -4.05557
USH1G Usher syndrome 1G (autosomal recessive) -4.05557
TBX22 T-box 22 -4.05557
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -4.05557
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -4.05557
NFAM1 NFAT activating protein with ITAM motif 1 -4.05557
BTBD19 BTB (POZ) domain containing 19 -4.05557
EBI3 Epstein-Barr virus induced 3 -4.05557
NRSN1 neurensin 1 -4.05557
IDUA iduronidase, alpha-L- -4.05557
ADAT3 adenosine deaminase, tRNA-specific 3 -4.05557
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -4.05557
NFE2 nuclear factor, erythroid 2 -4.05557
LYNX1 Ly6/neurotoxin 1 -4.05557
C2CD2L C2CD2-like -4.05557
IZUMO1 izumo sperm-egg fusion 1 -4.05557
PRB3 proline-rich protein BstNI subfamily 3 -4.05557
KLK4 kallikrein-related peptidase 4 -4.05557
TRIM68 tripartite motif containing 68 -4.05557
CBLN3 cerebellin 3 precursor -4.05557
CATSPER4 cation channel, sperm associated 4 -4.05557
EXOC3L1 exocyst complex component 3-like 1 -4.05557
EXD1 exonuclease 3'-5' domain containing 1 -4.05557
MEIS2 Meis homeobox 2 -4.05557
SAMD15 sterile alpha motif domain containing 15 -4.05557
LMNTD2 lamin tail domain containing 2 -4.05557
VN1R1 vomeronasal 1 receptor 1 -4.05557
MUC19 mucin 19, oligomeric -4.05557
LMOD3 leiomodin 3 (fetal) -4.05557
MR1 major histocompatibility complex, class I-related -4.05557
NLRC3 NLR family, CARD domain containing 3 -4.05557
TNR tenascin R -4.05557
TMIE transmembrane inner ear -4.05557
VIT vitrin -4.05557
NUTM2A NUT family member 2A -4.05557
MAP3K19 mitogen-activated protein kinase kinase kinase 19 -4.05557
CD53 CD53 molecule -4.05557
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -4.05557
SBK2 SH3 domain binding kinase family, member 2 -3.97677
DOC2A double C2-like domains, alpha -3.63369
TEX261 testis expressed 261 -3.49957
USO1 USO1 vesicle transport factor -3.26565
WDFY1 WD repeat and FYVE domain containing 1 -3.0366
CR2 complement component (3d/Epstein Barr virus) receptor 2 -3.02888
ARHGAP39 Rho GTPase activating protein 39 -3.00615
AKAP6 A kinase (PRKA) anchor protein 6 -2.96981
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.92759
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -2.92759
FOXH1 forkhead box H1 -2.92759
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -2.92759
CIMAP2 ciliary microtubule associated protein 2 -2.92759
RET ret proto-oncogene -2.89786
ZFAND6 zinc finger, AN1-type domain 6 -2.78823
SAMD1 sterile alpha motif domain containing 1 -2.7652
U2AF1 U2 small nuclear RNA auxiliary factor 1 -2.69558
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.67595
P4HB prolyl 4-hydroxylase, beta polypeptide -2.66076
CCNQ cyclin Q -2.64645
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 -2.58953
IRF9 interferon regulatory factor 9 -2.51698
GAS2L1 growth arrest-specific 2 like 1 -2.38455
LPIN3 lipin 3 -2.37852
PRDX1 peroxiredoxin 1 -2.3744
KDM5A lysine (K)-specific demethylase 5A -2.37309
CHRM2 cholinergic receptor, muscarinic 2 -2.3704
CORIN corin, serine peptidase -2.35801
MYCBPAP MYCBP associated protein -2.32489
HSPB2 heat shock 27kDa protein 2 -2.31691
S1PR1 sphingosine-1-phosphate receptor 1 -2.31532
ANO3 anoctamin 3 -2.31532
SAMD14 sterile alpha motif domain containing 14 -2.31532
FAM32A family with sequence similarity 32, member A -2.31532
DCLK2 doublecortin-like kinase 2 -2.31532
CX3CL1 chemokine (C-X3-C motif) ligand 1 -2.31532
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.31136
RAB3IP RAB3A interacting protein -2.30898
NALF2 NALCN channel auxiliary factor 2 -2.29398
XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like -2.28046
METTL17 methyltransferase like 17 -2.28046
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 -2.26571
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.25527
H4C9 H4 clustered histone 9 -2.25072
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.25072
TMEM106C transmembrane protein 106C -2.21384
ZNF212 zinc finger protein 212 -2.21127
BIRC2 baculoviral IAP repeat containing 2 -2.20702
CDCA7 cell division cycle associated 7 -2.18943
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -2.17045
GAS6 growth arrest-specific 6 -2.15626
LRIF1 ligand dependent nuclear receptor interacting factor 1 -2.14987
BDNF brain-derived neurotrophic factor -2.14937
UVSSA UV-stimulated scaffold protein A -2.14937
GM2A GM2 ganglioside activator -2.14691
KLF13 Kruppel-like factor 13 -2.12943
WASHC1 WASH complex subunit 1 -2.11703
MDH1B malate dehydrogenase 1B, NAD (soluble) -2.05952
MAGED1 melanoma antigen family D1 -2.04729
CLPTM1L CLPTM1-like -2.04657
RNF185 ring finger protein 185 -2.0349
ZNF362 zinc finger protein 362 -2.02512
ADCY1 adenylate cyclase 1 (brain) -2.02512
EVA1B eva-1 homolog B (C. elegans) -2.01223
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -2.00996
IDNK idnK, gluconokinase homolog (E. coli) -2.00996
PPP1R37 protein phosphatase 1, regulatory subunit 37 -2.00996
LRP12 low density lipoprotein receptor-related protein 12 -2.00845