| Dataset | Guide to Pharmacology Protein Ligands of Receptors |
| Category | physical interactions |
| Type | ligand (protein) |
| Description | agouti signaling protein|In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 434) |
| External Link | http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=434 |
| Similar Terms | |
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4 receptors of the ASIP ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.
