ASK1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase kinase 5|Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4217)
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Genes

100 substrates of the kinase ASK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
STK38 serine/threonine kinase 38
RAB10 RAB10, member RAS oncogene family
DCBLD1 discoidin, CUB and LCCL domain containing 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
N4BP1 NEDD4 binding protein 1
ACTG1 actin gamma 1
EGFR epidermal growth factor receptor
RNF219 ring finger protein 219
NFE2L2 nuclear factor, erythroid 2-like 2
BCAR1 breast cancer anti-estrogen resistance 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
TNK2 tyrosine kinase, non-receptor, 2
MAP7D3 MAP7 domain containing 3
REPS1 RALBP1 associated Eps domain containing 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
MKI67 marker of proliferation Ki-67
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
HAUS8 HAUS augmin-like complex, subunit 8
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
TTN titin
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
PHRF1 PHD and ring finger domains 1
BAX BCL2-associated X protein
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
FOXK1 forkhead box K1
ZNF687 zinc finger protein 687
FRMD4B FERM domain containing 4B
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
APLP2 amyloid beta (A4) precursor-like protein 2
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
PARVB parvin, beta
SLAMF6 SLAM family member 6
RANBP2 RAN binding protein 2
CDK3 cyclin-dependent kinase 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FRAS1 Fraser extracellular matrix complex subunit 1
PTPRJ protein tyrosine phosphatase, receptor type, J
TUBA3E tubulin, alpha 3e
TUBA3D tubulin, alpha 3d
UNG uracil-DNA glycosylase
ERBB2IP erbb2 interacting protein
ACTA1 actin, alpha 1, skeletal muscle
CDK2 cyclin-dependent kinase 2
GIPC1 GIPC PDZ domain containing family, member 1
ADAM10 ADAM metallopeptidase domain 10
SLC31A1 solute carrier family 31 (copper transporter), member 1
INF2 inverted formin, FH2 and WH2 domain containing
SFRP4 secreted frizzled-related protein 4
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
SGK223 homolog of rat pragma of Rnd2
DIAPH3 diaphanous-related formin 3
TMEM209 transmembrane protein 209
STK38L serine/threonine kinase 38 like
CNOT12 CCR4-NOT transcription complex subunit 12
ACTC1 actin, alpha, cardiac muscle 1
MOB1B MOB kinase activator 1B
MOB1A MOB kinase activator 1A
JARID2 jumonji, AT rich interactive domain 2
ADCY2 adenylate cyclase 2 (brain)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
ABLIM1 actin binding LIM protein 1
TPD52L2 tumor protein D52-like 2
TUBA1C tubulin, alpha 1c
TUBA1B tubulin, alpha 1b
TUBA1A tubulin, alpha 1a
CYTH2 cytohesin 2
HIST1H1C histone cluster 1, H1c
YBX3 Y box binding protein 3
FLNA filamin A, alpha
APP amyloid beta (A4) precursor protein
CD84 CD84 molecule
C12ORF10 chromosome 12 open reading frame 10
TJAP1 tight junction associated protein 1 (peripheral)
CCNY cyclin Y
BRAF B-Raf proto-oncogene, serine/threonine kinase
PRC1 protein regulator of cytokinesis 1
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
CD36 CD36 molecule (thrombospondin receptor)
CSNK2B casein kinase 2, beta polypeptide
MAP3K9 mitogen-activated protein kinase kinase kinase 9
HIST3H3 histone cluster 3, H3
CTNND1 catenin (cadherin-associated protein), delta 1
ACTB actin, beta
H3F3B H3 histone, family 3B (H3.3B)
AURKB aurora kinase B
AURKC aurora kinase C
HSF4 heat shock transcription factor 4
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
HIST1H3F histone cluster 1, H3f
POTEJ POTE ankyrin domain family, member J
POTEI POTE ankyrin domain family, member I
POTEF POTE ankyrin domain family, member F
POTEE POTE ankyrin domain family, member E
CCNYL1 cyclin Y-like 1