ASXL1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description additional sex combs like transcriptional regulator 1|This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 171023)
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Genes

302 genes differentially expressed following the ASXL1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRDM7 PR domain containing 7 3.17847
ZACN zinc activated ligand-gated ion channel 3.17847
LRRD1 leucine-rich repeats and death domain containing 1 3.17847
PRAM1 PML-RARA regulated adaptor molecule 1 3.17847
PCDHGB2 protocadherin gamma subfamily B, 2 3.17847
TEX13C TEX13 family member C 3.17847
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.17847
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.17847
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.17847
ARHGAP15 Rho GTPase activating protein 15 3.17847
PAX5 paired box 5 3.17847
TMPRSS11F transmembrane protease, serine 11F 3.17847
WNT9B wingless-type MMTV integration site family, member 9B 3.17847
GOLGA6B golgin A6 family, member B 3.17847
SHISA3 shisa family member 3 3.17847
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.17847
NRGN neurogranin (protein kinase C substrate, RC3) 3.17847
FGFBP1 fibroblast growth factor binding protein 1 3.17847
CPB1 carboxypeptidase B1 (tissue) 3.17847
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 3.17847
FOXD1 forkhead box D1 3.17847
BIRC7 baculoviral IAP repeat containing 7 3.17847
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 3.13293
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.13293
TMC2 transmembrane channel-like 2 3.13293
SHISA7 shisa family member 7 3.13293
PGA5 pepsinogen 5, group I (pepsinogen A) 3.13293
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 3.13293
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.13293
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.13293
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.13293
IRX5 iroquois homeobox 5 3.13293
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.13293
TMEM52B transmembrane protein 52B 3.13293
R3HDML R3H domain containing-like 3.13293
TDO2 tryptophan 2,3-dioxygenase 3.13293
NPIPB8 nuclear pore complex interacting protein family, member B8 3.13293
NPR3 natriuretic peptide receptor 3 3.13293
GPR85 G protein-coupled receptor 85 3.13293
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.13293
PADI4 peptidyl arginine deiminase, type IV 3.13293
RTP3 receptor (chemosensory) transporter protein 3 3.13293
SPON2 spondin 2, extracellular matrix protein 3.13293
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.13293
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.13293
TDRD6 tudor domain containing 6 3.13293
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.13293
GPR52 G protein-coupled receptor 52 3.13293
FGD2 FYVE, RhoGEF and PH domain containing 2 3.13293
FGF21 fibroblast growth factor 21 3.13293
CCDC116 coiled-coil domain containing 116 3.13293
CFHR2 complement factor H-related 2 3.13293
WEE2 WEE1 homolog 2 (S. pombe) 3.13293
ACR acrosin 3.13293
NPIPB9 nuclear pore complex interacting protein family, member B9 3.13293
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.13293
CHRD chordin 3.13293
CLEC3A C-type lectin domain family 3, member A 3.13293
AKR1D1 aldo-keto reductase family 1, member D1 3.13293
FMO2 flavin containing monooxygenase 2 (non-functional) 3.13293
CBLN2 cerebellin 2 precursor 3.13293
ZIC4 Zic family member 4 3.13293
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.13293
TCF23 transcription factor 23 3.13293
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.13293
APOA2 apolipoprotein A-II 3.13293
OTUD6A OTU deubiquitinase 6A 3.13293
TNIP3 TNFAIP3 interacting protein 3 3.13293
GPR21 G protein-coupled receptor 21 3.13293
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.13293
TLX2 T-cell leukemia homeobox 2 3.13293
CD300A CD300a molecule 3.13293
C6ORF58 chromosome 6 open reading frame 58 3.13293
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.13293
DSG3 desmoglein 3 3.13293
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.13293
FGL2 fibrinogen-like 2 3.13293
DNASE2B deoxyribonuclease II beta 3.13293
SLC22A25 solute carrier family 22, member 25 3.13293
GOLGA6C golgin A6 family, member C 3.13293
LHFPL7 LHFPL tetraspan subfamily member 7 3.13293
GSTT4 glutathione S-transferase theta 4 3.13293
KLK3 kallikrein-related peptidase 3 3.13293
FLACC1 flagellum associated containing coiled-coil domains 1 3.13293
OR2B11 olfactory receptor, family 2, subfamily B, member 11 3.13293
SPATA46 spermatogenesis associated 46 3.13293
EVPLL envoplakin-like 3.13293
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.13293
WNT7B wingless-type MMTV integration site family, member 7B 3.13293
PCDHGA4 protocadherin gamma subfamily A, 4 3.13293
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.13293
ALPG alkaline phosphatase, germ cell 3.13293
C16ORF78 chromosome 16 open reading frame 78 3.13293
NIPAL4 NIPA-like domain containing 4 3.13293
SERINC4 serine incorporator 4 3.13293
WFDC9 WAP four-disulfide core domain 9 3.13293
PRSS33 protease, serine, 33 3.13293
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.13293
BCL2A1 BCL2-related protein A1 3.13293
GSDMC gasdermin C 3.13293
FOXS1 forkhead box S1 3.13293
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.13293
CIMIP2B ciliary microtubule inner protein 2B 3.13293
CLEC18A C-type lectin domain family 18, member A 3.13293
WNT2 wingless-type MMTV integration site family member 2 3.13293
CIMIP4 ciliary microtubule inner protein 4 3.13293
FAIM2 Fas apoptotic inhibitory molecule 2 3.13293
EXOC1L exocyst complex component 1 like 3.13293
NKX6-2 NK6 homeobox 2 3.13293
LRRC8C-DT LRRC8C divergent transcript 3.13293
NOTCH2NLB notch 2 N-terminal like B 3.13293
DEFB109B defensin beta 109B 3.13293
RFPL4B ret finger protein-like 4B 3.13293
RGS8 regulator of G-protein signaling 8 3.13293
WFDC6 WAP four-disulfide core domain 6 3.13293
KLF2 Kruppel-like factor 2 3.13293
SDSL serine dehydratase-like 3.13293
MAGEB17 melanoma antigen family B17 3.13293
KRT80 keratin 80, type II 3.13293
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.13293
OR4D11 olfactory receptor, family 4, subfamily D, member 11 3.13293
FMOD fibromodulin 3.13293
SPATA22 spermatogenesis associated 22 3.13293
TBC1D26 TBC1 domain family, member 26 3.13293
IMPG2 interphotoreceptor matrix proteoglycan 2 3.13293
CARD6 caspase recruitment domain family, member 6 3.13293
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.13293
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.13293
PPY pancreatic polypeptide 3.13293
GRAP2 GRB2-related adaptor protein 2 3.13293
FOXP3 forkhead box P3 3.13293
C4BPA complement component 4 binding protein, alpha 3.13293
TTC36 tetratricopeptide repeat domain 36 3.13293
SMYD1 SET and MYND domain containing 1 3.13293
GP2 glycoprotein 2 (zymogen granule membrane) 3.13293
CRYBB3 crystallin, beta B3 3.13293
CES4A carboxylesterase 4A 3.13293
THTPA thiamine triphosphatase 3.13293
CLIC5 chloride intracellular channel 5 3.13293
MT4 metallothionein 4 3.13293
LRRC46 leucine rich repeat containing 46 3.13293
ARR3 arrestin 3, retinal (X-arrestin) 3.13293
PCDHGB7 protocadherin gamma subfamily B, 7 3.13293
PNLIPRP1 pancreatic lipase-related protein 1 3.13293
SPRY3 sprouty homolog 3 (Drosophila) 3.13293
HAO2 hydroxyacid oxidase 2 (long chain) 3.13293
ARGFX arginine-fifty homeobox 3.08217
GMNC geminin coiled-coil domain containing 3.08217
LOC112694756 uncharaterized LOC112694756 3.08217
ARLN allregulin 3.03324
CYBRD1 cytochrome b reductase 1 3.00595
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.95277
ZNF708 zinc finger protein 708 2.94392
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.76514
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.59174
SYCE2 synaptonemal complex central element protein 2 2.58255
SLC9D1 solute carrier family 9 member D1 2.57365
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.55994
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 2.50172
CYTH1 cytohesin 1 2.4565
TMEM168 transmembrane protein 168 2.44736
DOCK10 dedicator of cytokinesis 10 2.43317
ZNF488 zinc finger protein 488 2.39037
BBS9 Bardet-Biedl syndrome 9 2.36807
OPA1 optic atrophy 1 (autosomal dominant) 2.36132
MAPT microtubule-associated protein tau 2.35682
SMIM38 small integral membrane protein 38 2.32739
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.32739
CXCL14 chemokine (C-X-C motif) ligand 14 2.32739
FXYD3 FXYD domain containing ion transport regulator 3 2.31432
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.31432
TRAF4 TNF receptor-associated factor 4 2.31066
FAM193B family with sequence similarity 193, member B 2.30995
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 2.28541
AK4 adenylate kinase 4 2.28382
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.28203
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 2.23995
TTC28 tetratricopeptide repeat domain 28 2.235
ATXN10 ataxin 10 2.2329
ZFAND3 zinc finger, AN1-type domain 3 2.21144
MPV17 MpV17 mitochondrial inner membrane protein 2.21144
AGPS alkylglycerone phosphate synthase 2.12185
FIGNL2 fidgetin-like 2 2.12185
CFAP52 cilia and flagella associated protein 52 2.11779
MSMP microseminoprotein, prostate associated 2.11779
TBX22 T-box 22 2.11779
CALY calcyon neuron-specific vesicular protein 2.11779
PARP15 poly (ADP-ribose) polymerase family, member 15 2.11779
ZNF750 zinc finger protein 750 2.11779
ITPRID1 ITPR interacting domain containing 1 2.11779
IQGAP3 IQ motif containing GTPase activating protein 3 2.04551
PTX3 pentraxin 3, long 2.04309
ZNF367 zinc finger protein 367 2.03034
THAP4 THAP domain containing 4 2.02582
ZNF846 zinc finger protein 846 2.02527
GRM7 glutamate receptor, metabotropic 7 2.02418
MAST2 microtubule associated serine/threonine kinase 2 2.02326
ADAM17 ADAM metallopeptidase domain 17 2.01506
C4ORF46 chromosome 4 open reading frame 46 2.01104
GRB14 growth factor receptor-bound protein 14 2.0102
AMIGO2 adhesion molecule with Ig-like domain 2 2.00558
TMPO thymopoietin 2.00137
USP53 ubiquitin specific peptidase 53 2.00002

decreased expression

Symbol Name Standardized Value
KCNK13 potassium channel, two pore domain subfamily K, member 13 -3.17847
NR4A2 nuclear receptor subfamily 4, group A, member 2 -3.15608
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -3.15608
TMEM132D transmembrane protein 132D -3.13293
LRTM3 leucine rich repeat transmembrane protein 3 -3.13293
MSH3 mutS homolog 3 -3.13293
LRRC43 leucine rich repeat containing 43 -3.13293
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -3.13293
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -3.13293
PPP1R3A protein phosphatase 1, regulatory subunit 3A -3.13293
LONRF2 LON peptidase N-terminal domain and ring finger 2 -3.13293
RNF17 ring finger protein 17 -3.13293
IRX1 iroquois homeobox 1 -3.13293
NANOS3 nanos homolog 3 (Drosophila) -3.13293
RHOJ ras homolog family member J -3.13293
CIITA class II, major histocompatibility complex, transactivator -3.13293
ADGB androglobin -3.13293
DRP2 dystrophin related protein 2 -3.13293
TTLL2 tubulin tyrosine ligase-like family member 2 -3.13293
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -3.13293
RAD21L1 RAD21-like 1 (S. pombe) -3.13293
EDN3 endothelin 3 -3.13293
UPK1B uroplakin 1B -3.13293
GTF2A1L general transcription factor IIA, 1-like -3.13293
TF transferrin -3.13293
CA5A carbonic anhydrase VA, mitochondrial -3.13293
TMPPE transmembrane protein with metallophosphoesterase domain -3.13293
KASH5 KASH domain containing 5 -3.13293
IQCN IQ motif containing N -3.13293
ANKRD42-DT ANKRD42 divergent transcript -3.13293
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -3.13293
ADAM12 ADAM metallopeptidase domain 12 -3.13293
VWA7 von Willebrand factor A domain containing 7 -3.13293
CPHXL2 cytoplasmic polyadenylated homeobox like 2 -3.13293
HHEX hematopoietically expressed homeobox -3.13293
F2RL2 coagulation factor II (thrombin) receptor-like 2 -3.13293
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -3.06556
FAM133A family with sequence similarity 133, member A -3.03252
MCTS1 malignant T cell amplified sequence 1 -2.88144
SERP2 stress-associated endoplasmic reticulum protein family member 2 -2.80654
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.77808
NUCLEOLIN nucleolin multifunctional protein -2.77597
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) -2.76809
FOXM1 forkhead box M1 -2.70529
PF4 platelet factor 4 -2.70023
TTC21A tetratricopeptide repeat domain 21A -2.68484
GABPB1 GA binding protein transcription factor, beta subunit 1 -2.66549
DSTN destrin (actin depolymerizing factor) -2.65653
IQSEC2 IQ motif and Sec7 domain 2 -2.63153
INAVA innate immunity activator -2.62347
NEU3 sialidase 3 (membrane sialidase) -2.55314
LRRC41 leucine rich repeat containing 41 -2.54381
MTNR1A melatonin receptor 1A -2.54172
TRIM26 tripartite motif containing 26 -2.51632
ZNF57 zinc finger protein 57 -2.49598
PABIR2 PABIR family member 2 -2.47318
GMPPB GDP-mannose pyrophosphorylase B -2.47318
LYST lysosomal trafficking regulator -2.44003
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.44003
TSPAN16 tetraspanin 16 -2.44003
ZNF343 zinc finger protein 343 -2.36909
SGMS2 sphingomyelin synthase 2 -2.32739
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.32739
HECA headcase homolog (Drosophila) -2.32739
LHX6 LIM homeobox 6 -2.25297
TDRD1 tudor domain containing 1 -2.25297
SEC16A SEC16 homolog A (S. cerevisiae) -2.2511
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -2.24644
WDR41 WD repeat domain 41 -2.2419
EDC4 enhancer of mRNA decapping 4 -2.235
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein -2.235
H2BC11 H2B clustered histone 11 -2.235
RHOD ras homolog family member D -2.21144
SALL4 spalt-like transcription factor 4 -2.16856
TMEM126A transmembrane protein 126A -2.14805
NTAQ1 N-terminal glutamine amidase 1 -2.1269
FHIP1A FHF complex subunit HOOK interacting protein 1A -2.11779
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.11779
MINDY4 MINDY lysine 48 deubiquitinase 4 -2.11779
C1QTNF4 C1q and tumor necrosis factor related protein 4 -2.11779
RCC1 regulator of chromosome condensation 1 -2.11779
LRRC45 leucine rich repeat containing 45 -2.10084
IDUA iduronidase, alpha-L- -2.08554
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.08554
LOC124902436 talanin -2.08554
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.08554
ARSI arylsulfatase family, member I -2.08554
H4C16 H4 histone 16 -2.08326
GPR108 G protein-coupled receptor 108 -2.08326
SPRYD7 SPRY domain containing 7 -2.08326
RPL35 ribosomal protein L35 -2.05742
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit -2.04934
DYM dymeclin -2.04591
ZNF311 zinc finger protein 311 -2.0298
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.02805
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.02527
RSPO4 R-spondin 4 -2.01506
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast) -2.01212
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase -2.01053