ASXL1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description additional sex combs like transcriptional regulator 1|This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 171023)
External Link http://www.ncbi.nlm.nih.gov/gene/171023
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137 interacting proteins for ASXL1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AHCYL2 adenosylhomocysteinase-like 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMMECR1L AMMECR1-like
ANAPC15 anaphase promoting complex subunit 15
ANAPC7 anaphase promoting complex subunit 7
ANKHD1 ankyrin repeat and KH domain containing 1
ANKRD17 ankyrin repeat domain 17
APP amyloid beta (A4) precursor protein
AR androgen receptor
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
C12ORF45 chromosome 12 open reading frame 45
C17ORF85 chromosome 17 open reading frame 85
C1ORF35 chromosome 1 open reading frame 35
C7ORF49 chromosome 7 open reading frame 49
C8ORF33 chromosome 8 open reading frame 33
C9ORF9 chromosome 9 open reading frame 9
CALU calumenin
CBX1 chromobox homolog 1
CBX3 chromobox homolog 3
CBX5 chromobox homolog 5
CCDC28A coiled-coil domain containing 28A
CCNB3 cyclin B3
CCNG1 cyclin G1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNOT8 CCR4-NOT transcription complex, subunit 8
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTTN cortactin
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
DENND6B DENN/MADD domain containing 6B
DEXI Dexi homolog (mouse)
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUX3 double homeobox 3
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EED embryonic ectoderm development
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOF1 elongation factor 1 homolog (S. cerevisiae)
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM126B family with sequence similarity 126, member B
FAM71C family with sequence similarity 71, member C
FGF12 fibroblast growth factor 12
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA1 forkhead box A1
FOXK1 forkhead box K1
FOXK2 forkhead box K2
GCC1 GRIP and coiled-coil domain containing 1
GLIPR2 GLI pathogenesis-related 2
GRB2 growth factor receptor-bound protein 2
HAT1 histone acetyltransferase 1
HCFC1 host cell factor C1
HIST1H1C histone cluster 1, H1c
HIST2H2AC histone cluster 2, H2ac
HMGB2 high mobility group box 2
HMGN3 high mobility group nucleosomal binding domain 3
HRAS Harvey rat sarcoma viral oncogene homolog
IFRD2 interferon-related developmental regulator 2
INTS3 integrator complex subunit 3
IPO4 importin 4
IPO5 importin 5
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KANSL2 KAT8 regulatory NSL complex subunit 2
KDM1A lysine (K)-specific demethylase 1A
KDM1B lysine (K)-specific demethylase 1B
KDM4D lysine (K)-specific demethylase 4D
KDM6A lysine (K)-specific demethylase 6A
KLF3 Kruppel-like factor 3 (basic)
KMT2A lysine (K)-specific methyltransferase 2A
KMT2D lysine (K)-specific methyltransferase 2D
MAP2 microtubule-associated protein 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MSL3 male-specific lethal 3 homolog (Drosophila)
NCK1 NCK adaptor protein 1
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOL7 nucleolar protein 7, 27kDa
NOP16 NOP16 nucleolar protein
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OTUD6B OTU domain containing 6B
PCLO piccolo presynaptic cytomatrix protein
PDAP1 PDGFA associated protein 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
POLB polymerase (DNA directed), beta
PPARG peroxisome proliferator-activated receptor gamma
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRR15 proline rich 15
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
RABEPK Rab9 effector protein with kelch motifs
RAD51AP1 RAD51 associated protein 1
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RBBP7 retinoblastoma binding protein 7
RPL22 ribosomal protein L22
RPL23A ribosomal protein L23a
RPL29 ribosomal protein L29
RPL30 ribosomal protein L30
RPL39L ribosomal protein L39-like
RPS28 ribosomal protein S28
SART3 squamous cell carcinoma antigen recognized by T cells 3
SERTAD1 SERTA domain containing 1
SLAIN2 SLAIN motif family, member 2
SPANXN4 SPANX family, member N4
SPC24 SPC24, NDC80 kinetochore complex component
SPRR4 small proline-rich protein 4
SRP19 signal recognition particle 19kDa
SRPK1 SRSF protein kinase 1
SRSF5 serine/arginine-rich splicing factor 5
SRSF9 serine/arginine-rich splicing factor 9
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TBC1D22B TBC1 domain family, member 22B
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TMEM252 transmembrane protein 252
TRIM44 tripartite motif containing 44
TTLL7 tubulin tyrosine ligase-like family member 7
UBC ubiquitin C
UBD ubiquitin D
UBE2O ubiquitin-conjugating enzyme E2O
UBE2S ubiquitin-conjugating enzyme E2S
VCY variable charge, Y-linked
VRK1 vaccinia related kinase 1
WDR5 WD repeat domain 5
ZNF239 zinc finger protein 239