| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/25022340 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in AT 406 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 2.42 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.85 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.79 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.77 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.74 |
| ANKRD36C | ankyrin repeat domain 36C | 0.68 |
| TTC8 | tetratricopeptide repeat domain 8 | 0.63 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.63 |
| THEMIS2 | thymocyte selection associated family member 2 | 0.59 |
| ADCY9 | adenylate cyclase 9 | 0.57 |
| KIAA1324L | KIAA1324-like | 0.56 |
| ALG11 | ALG11, alpha-1,2-mannosyltransferase | 0.55 |
| SP110 | SP110 nuclear body protein | 0.51 |
| MLPH | melanophilin | 0.5 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.48 |
| HCFC2 | host cell factor C2 | 0.48 |
| LMBR1 | limb development membrane protein 1 | 0.46 |
| RGS19 | regulator of G-protein signaling 19 | 0.45 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | 0.45 |
| DGKE | diacylglycerol kinase, epsilon 64kDa | 0.45 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 0.45 |
| NOVA2 | neuro-oncological ventral antigen 2 | 0.44 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | 0.44 |
| C2CD4C | C2 calcium-dependent domain containing 4C | 0.44 |
| KCTD18 | potassium channel tetramerization domain containing 18 | 0.42 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.42 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | 0.4 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.4 |
| RNF13 | ring finger protein 13 | 0.4 |
| ZNF275 | zinc finger protein 275 | 0.38 |
| C1ORF50 | chromosome 1 open reading frame 50 | 0.38 |
| ENGASE | endo-beta-N-acetylglucosaminidase | 0.37 |
| PLEKHH3 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 | 0.37 |
| DOCK10 | dedicator of cytokinesis 10 | 0.37 |
| BAG4 | BCL2-associated athanogene 4 | 0.36 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.36 |
| ATG2A | autophagy related 2A | 0.36 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.36 |
| PLSCR3 | phospholipid scramblase 3 | 0.36 |
| FCHO1 | FCH domain only 1 | 0.36 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.35 |
| FBXO46 | F-box protein 46 | 0.35 |
| ZNF440 | zinc finger protein 440 | 0.34 |
| BID | BH3 interacting domain death agonist | 0.34 |
| TMC4 | transmembrane channel-like 4 | 0.34 |
| ZNF696 | zinc finger protein 696 | 0.33 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.33 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.33 |
| BMP4 | bone morphogenetic protein 4 | 0.33 |
| CHM | choroideremia (Rab escort protein 1) | 0.32 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.32 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.32 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.32 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 0.32 |
| RFK | riboflavin kinase | 0.32 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | 0.31 |
| CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | 0.31 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.31 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | 0.3 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.3 |
| PHF13 | PHD finger protein 13 | 0.3 |
| TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 | 0.3 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.3 |
| MAN2A2 | mannosidase, alpha, class 2A, member 2 | 0.29 |
| RPP21 | ribonuclease P/MRP 21kDa subunit | 0.29 |
| PCGF3 | polycomb group ring finger 3 | 0.29 |
| HELB | helicase (DNA) B | 0.29 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | 0.29 |
| SVBP | small vasohibin binding protein | 0.28 |
| FANCB | Fanconi anemia, complementation group B | 0.28 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.28 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.28 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.27 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.27 |
| HRH1 | histamine receptor H1 | 0.27 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.27 |
| TMEM135 | transmembrane protein 135 | 0.27 |
| CCSER2 | coiled-coil serine-rich protein 2 | 0.27 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.27 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 0.27 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.27 |
| FBXL19 | F-box and leucine-rich repeat protein 19 | 0.26 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.26 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.26 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.26 |
| IER3IP1 | immediate early response 3 interacting protein 1 | 0.26 |
| DNAJC14 | DnaJ (Hsp40) homolog, subfamily C, member 14 | 0.26 |
| ODC1 | ornithine decarboxylase 1 | 0.26 |
| KSR2 | kinase suppressor of ras 2 | 0.26 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.26 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.26 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | 0.26 |
| XIRP2 | xin actin binding repeat containing 2 | 0.26 |
| KLHDC3 | kelch domain containing 3 | 0.25 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.25 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.25 |
| APOB | apolipoprotein B | 0.25 |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | 0.25 |
| CCNYL1 | cyclin Y-like 1 | 0.25 |
| CNTLN | centlein, centrosomal protein | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMYD5 | SMYD family member 5 | -1.82 |
| BIRC2 | baculoviral IAP repeat containing 2 | -1.7 |
| CHURC1 | churchill domain containing 1 | -1.18 |
| ZNF444 | zinc finger protein 444 | -0.82 |
| ATXN7L1 | ataxin 7-like 1 | -0.73 |
| RNF126 | ring finger protein 126 | -0.65 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.62 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | -0.62 |
| PCDH1 | protocadherin 1 | -0.58 |
| NHSL1 | NHS-like 1 | -0.53 |
| MEGF8 | multiple EGF-like-domains 8 | -0.53 |
| UBE3B | ubiquitin protein ligase E3B | -0.53 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.5 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | -0.49 |
| NDFIP2 | Nedd4 family interacting protein 2 | -0.49 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.49 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.48 |
| MT1X | metallothionein 1X | -0.48 |
| DAPK1 | death-associated protein kinase 1 | -0.47 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.46 |
| ZNF397 | zinc finger protein 397 | -0.45 |
| WTAP | Wilms tumor 1 associated protein | -0.45 |
| PITX2 | paired-like homeodomain 2 | -0.45 |
| MT2A | metallothionein 2A | -0.43 |
| WASHC3 | WASH complex subunit 3 | -0.43 |
| COL11A1 | collagen, type XI, alpha 1 | -0.42 |
| PRDX4 | peroxiredoxin 4 | -0.42 |
| TYSND1 | trypsin domain containing 1 | -0.42 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.41 |
| ZNF799 | zinc finger protein 799 | -0.41 |
| RAB5IF | RAB5 interacting factor | -0.41 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.41 |
| FAAH | fatty acid amide hydrolase | -0.41 |
| MCM9 | minichromosome maintenance complex component 9 | -0.38 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | -0.38 |
| SGCE | sarcoglycan, epsilon | -0.38 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | -0.37 |
| ANAPC11 | anaphase promoting complex subunit 11 | -0.37 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | -0.37 |
| MT1E | metallothionein 1E | -0.37 |
| CRTC3 | CREB regulated transcription coactivator 3 | -0.36 |
| KMT5C | lysine methyltransferase 5C | -0.36 |
| MSLN | mesothelin | -0.36 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | -0.36 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.36 |
| ACTBL2 | actin, beta-like 2 | -0.35 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.35 |
| ROGDI | rogdi homolog (Drosophila) | -0.35 |
| MAX | MYC associated factor X | -0.35 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | -0.35 |
| DUSP14 | dual specificity phosphatase 14 | -0.34 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | -0.34 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.34 |
| HINT3 | histidine triad nucleotide binding protein 3 | -0.34 |
| SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | -0.34 |
| SRSF9 | serine/arginine-rich splicing factor 9 | -0.33 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -0.33 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.33 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.33 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 | -0.33 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | -0.33 |
| MOSPD3 | motile sperm domain containing 3 | -0.33 |
| ZNF814 | zinc finger protein 814 | -0.33 |
| SRPX | sushi-repeat containing protein, X-linked | -0.33 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.32 |
| GEMIN8 | gem (nuclear organelle) associated protein 8 | -0.32 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | -0.32 |
| CRTC1 | CREB regulated transcription coactivator 1 | -0.32 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.31 |
| TRIP11 | thyroid hormone receptor interactor 11 | -0.31 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.31 |
| FER1L5 | fer-1-like family member 5 | -0.31 |
| TBC1D20 | TBC1 domain family, member 20 | -0.31 |
| FLNB | filamin B, beta | -0.31 |
| SHROOM1 | shroom family member 1 | -0.31 |
| SYN2 | synapsin II | -0.31 |
| ZNF490 | zinc finger protein 490 | -0.31 |
| TMEM177 | transmembrane protein 177 | -0.3 |
| TMEM106C | transmembrane protein 106C | -0.3 |
| NEBL | nebulette | -0.3 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.3 |
| LAMA3 | laminin, alpha 3 | -0.3 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.3 |
| FTL | ferritin, light polypeptide | -0.3 |
| MED22 | mediator complex subunit 22 | -0.29 |
| CCDC158 | coiled-coil domain containing 158 | -0.29 |
| JUN | jun proto-oncogene | -0.29 |
| C1ORF112 | chromosome 1 open reading frame 112 | -0.29 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.29 |
| LYST | lysosomal trafficking regulator | -0.29 |
| CCNA1 | cyclin A1 | -0.28 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.28 |
| CYB5D2 | cytochrome b5 domain containing 2 | -0.28 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -0.28 |
| PDLIM1 | PDZ and LIM domain 1 | -0.28 |
| CTHRC1 | collagen triple helix repeat containing 1 | -0.28 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | -0.28 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.28 |
| C11ORF54 | chromosome 11 open reading frame 54 | -0.27 |
| CALB2 | calbindin 2 | -0.27 |
