AT7519_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.124461
PDE4D phosphodiesterase 4D, cAMP-specific 0.0945193
PCDH7 protocadherin 7 0.0684934
NLGN1 neuroligin 1 0.0673462
YAP1 Yes-associated protein 1 0.0666291
MMP12 matrix metallopeptidase 12 0.0634483
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0596926
HMGA2 high mobility group AT-hook 2 0.0560595
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0460298
DST dystonin 0.0418307
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0412691
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.039791
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0369396
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0355478
ZSWIM6 zinc finger, SWIM-type containing 6 0.0329651
SLC38A2 solute carrier family 38, member 2 0.0327789
CELF2 CUGBP, Elav-like family member 2 0.0324729
CALR calreticulin 0.031872
TENM3 teneurin transmembrane protein 3 0.0315668
PDGFC platelet derived growth factor C 0.0308295
ASPH aspartate beta-hydroxylase 0.0294784
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0292197
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0289174
EHBP1 EH domain binding protein 1 0.0285364
AHNAK AHNAK nucleoprotein 0.0283877
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0275468
ZBTB20 zinc finger and BTB domain containing 20 0.0274942
NEBL nebulette 0.0272728
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0268503
ANXA1 annexin A1 0.0265192
ATP11A ATPase, class VI, type 11A 0.026433
DPYD dihydropyrimidine dehydrogenase 0.0261205
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0259672
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0256351
HSPA8 heat shock 70kDa protein 8 0.0255903
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0255387
CMIP c-Maf inducing protein 0.0251733
CCSER1 coiled-coil serine-rich protein 1 0.0247368
MED13L mediator complex subunit 13-like 0.0242971
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0240484
INTS6 integrator complex subunit 6 0.0239259
ZFAND3 zinc finger, AN1-type domain 3 0.0235469
NHSL1 NHS-like 1 0.0231895
SPATS2 spermatogenesis associated, serine-rich 2 0.0230951
GSK3B glycogen synthase kinase 3 beta 0.022122
SPTBN1 spectrin, beta, non-erythrocytic 1 0.021898
VMP1 vacuole membrane protein 1 0.0217736
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0216732
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0216712
LPP LIM domain containing preferred translocation partner in lipoma 0.0215423
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0214527
HDAC9 histone deacetylase 9 0.0214479
ZNF217 zinc finger protein 217 0.0208994
ZNF638 zinc finger protein 638 0.0205957
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0199968
TPM3 tropomyosin 3 0.0199345
TRIO trio Rho guanine nucleotide exchange factor 0.0198598
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0198202
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0197457
PDE4B phosphodiesterase 4B, cAMP-specific 0.0195189
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0187174
BIRC3 baculoviral IAP repeat containing 3 0.0187142
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0186833
ZNF804A zinc finger protein 804A 0.0186452
RABGAP1L RAB GTPase activating protein 1-like 0.0185698
EDARADD EDAR-associated death domain 0.0184952
CEP112 centrosomal protein 112kDa 0.0183397
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0182827
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0180483
ARL15 ADP-ribosylation factor-like 15 0.0179909
ERRFI1 ERBB receptor feedback inhibitor 1 0.0179728
ADGRG6 adhesion G protein-coupled receptor G6 0.0178146
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0176293
JMJD1C jumonji domain containing 1C 0.0175671
MPG N-methylpurine-DNA glycosylase 0.0175648
WNK1 WNK lysine deficient protein kinase 1 0.0174319
RIMS2 regulating synaptic membrane exocytosis 2 0.0174303
MTAP methylthioadenosine phosphorylase 0.0173502
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0172999
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0172211
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0169662
NRXN3 neurexin 3 0.0169491
ADIPOR2 adiponectin receptor 2 0.016821
USP34 ubiquitin specific peptidase 34 0.0166839
DOCK1 dedicator of cytokinesis 1 0.0166277
ANKRD17 ankyrin repeat domain 17 0.0165404
DENND5A DENN/MADD domain containing 5A 0.016527
FXR1 fragile X mental retardation, autosomal homolog 1 0.0164953
EXOC4 exocyst complex component 4 0.0162725
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0162516
ERBIN erbb2 interacting protein 0.0161549
WWOX WW domain containing oxidoreductase 0.0161204
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0160965
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.016039
PRKCE protein kinase C, epsilon 0.0160263
NIPBL Nipped-B homolog (Drosophila) 0.0158291
CLTC clathrin, heavy chain (Hc) 0.0157455
TBC1D5 TBC1 domain family, member 5 0.0157093
CANX calnexin 0.0156753
MACF1 microtubule-actin crosslinking factor 1 0.015647

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.156078
TMSB10 thymosin beta 10 -0.147721
VIM vimentin -0.112134
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108824
FTL ferritin, light polypeptide -0.0597414
RPL35A ribosomal protein L35a -0.0564559
MYL12B myosin, light chain 12B, regulatory -0.0406691
PTMA prothymosin, alpha -0.0393994
HMGA1 high mobility group AT-hook 1 -0.0393448
RPL23 ribosomal protein L23 -0.0372042
RPS6 ribosomal protein S6 -0.0357554
PFN1 profilin 1 -0.0340271
RPLP2 ribosomal protein, large, P2 -0.0330709
ATP5F1B ATP synthase F1 subunit beta -0.0308993
RPS3 ribosomal protein S3 -0.0307277
RPS8 ribosomal protein S8 -0.030635
RPLP1 ribosomal protein, large, P1 -0.0305135
RPS12 ribosomal protein S12 -0.0301273
RPL37A ribosomal protein L37a -0.029934
TPT1 tumor protein, translationally-controlled 1 -0.0297292
RPS19 ribosomal protein S19 -0.0279922
RPS13 ribosomal protein S13 -0.027531
RPS21 ribosomal protein S21 -0.0271838
RPS29 ribosomal protein S29 -0.026797
RPL19 ribosomal protein L19 -0.0267256
RPS27A ribosomal protein S27a -0.0265121
RPS23 ribosomal protein S23 -0.0263352
RPL11 ribosomal protein L11 -0.0260791
RPL9 ribosomal protein L9 -0.0251747
RPL26 ribosomal protein L26 -0.0243228
TUBA1B tubulin, alpha 1b -0.0236261
RPL12 ribosomal protein L12 -0.0235489
RPS14 ribosomal protein S14 -0.0232884
RPL31 ribosomal protein L31 -0.0221594
LDHB lactate dehydrogenase B -0.0220774
HSPB1 heat shock 27kDa protein 1 -0.0207763
EGR1 early growth response 1 -0.0207392
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0202046
RPL8 ribosomal protein L8 -0.0194635
RPS24 ribosomal protein S24 -0.0193213
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.019051
RPL37 ribosomal protein L37 -0.0189853
S100A6 S100 calcium binding protein A6 -0.0189602
RPL34 ribosomal protein L34 -0.0187433
RPS27 ribosomal protein S27 -0.0186305
RPL36 ribosomal protein L36 -0.0185945
RPLP0 ribosomal protein, large, P0 -0.0185933
ACTG1 actin gamma 1 -0.0184155
CNRIP1 cannabinoid receptor interacting protein 1 -0.0181931
RPS16 ribosomal protein S16 -0.0175535
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0171056
RPS17 ribosomal protein S17 -0.0161041
GCG glucagon -0.0159779
RPS5 ribosomal protein S5 -0.0154038
RPL27 ribosomal protein L27 -0.0151945
RPS15 ribosomal protein S15 -0.0150671
PA2G4 proliferation-associated 2G4, 38kDa -0.014765
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0144654
RPS11 ribosomal protein S11 -0.0143807
S100A11 S100 calcium binding protein A11 -0.0142132
RPL5 ribosomal protein L5 -0.0142002
RPS25 ribosomal protein S25 -0.0141185
RPL32 ribosomal protein L32 -0.0140899
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0139589
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.013822
RPL36A ribosomal protein L36a -0.0136567
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0133415
PCBP2 poly(rC) binding protein 2 -0.0133389
RPS10 ribosomal protein S10 -0.0131796
RPL28 ribosomal protein L28 -0.0131736
S100A10 S100 calcium binding protein A10 -0.013038
RPS20 ribosomal protein S20 -0.0130332
RPL38 ribosomal protein L38 -0.0129829
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0129157
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0129094
TM4SF1 transmembrane 4 L six family member 1 -0.012713
HMGB1 high mobility group box 1 -0.0124792
CBX3 chromobox homolog 3 -0.0122456
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0122075
RPL15 ribosomal protein L15 -0.0121871
RPL27A ribosomal protein L27a -0.0120419
EIF1 eukaryotic translation initiation factor 1 -0.0118446
NACA nascent polypeptide-associated complex alpha subunit -0.0117471
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0116788
TUBA1C tubulin, alpha 1c -0.0115727
ATP5F1E ATP synthase F1 subunit epsilon -0.0114964
RAN RAN, member RAS oncogene family -0.0114261
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0113905
RACK1 receptor for activated C kinase 1 -0.0112703
RBM25 RNA binding motif protein 25 -0.0111239
YBX1 Y box binding protein 1 -0.0110164
BTG3 BTG family, member 3 -0.0109908
S100A9 S100 calcium binding protein A9 -0.0108624
SMC4 structural maintenance of chromosomes 4 -0.0108535
VDAC1 voltage-dependent anion channel 1 -0.0108274
HLA-A major histocompatibility complex, class I, A -0.0107529
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0107325
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0106907
NDUFA4 NDUFA4, mitochondrial complex associated -0.0103665
GNAS GNAS complex locus -0.0103117