| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AT7519 perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AT7519_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.275284 |
| IGF2 | insulin-like growth factor 2 | 0.146418 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.135356 |
| FMN1 | formin 1 | 0.130877 |
| MEIS2 | Meis homeobox 2 | 0.0953421 |
| PTMA | prothymosin, alpha | 0.0919972 |
| B2M | beta-2-microglobulin | 0.0783776 |
| VIM | vimentin | 0.0767083 |
| MAP1B | microtubule-associated protein 1B | 0.0730321 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0660728 |
| TLE4 | transducin-like enhancer of split 4 | 0.0651988 |
| SYT1 | synaptotagmin I | 0.0639789 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0601903 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0548726 |
| ACTG1 | actin gamma 1 | 0.0537366 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0521402 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0518489 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0508411 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0507508 |
| RPL23 | ribosomal protein L23 | 0.0498256 |
| RNF213 | ring finger protein 213 | 0.0480408 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0480062 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0475925 |
| RPS6 | ribosomal protein S6 | 0.0467454 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.046357 |
| VCL | vinculin | 0.044499 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0425214 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0419214 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0418217 |
| BPTF | bromodomain PHD finger transcription factor | 0.0408973 |
| NRG1 | neuregulin 1 | 0.0400713 |
| RPL19 | ribosomal protein L19 | 0.0388074 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0384395 |
| KLHL13 | kelch-like family member 13 | 0.0374418 |
| PLAT | plasminogen activator, tissue | 0.0373829 |
| RPLP1 | ribosomal protein, large, P1 | 0.0373754 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0372875 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0370754 |
| DPH6 | diphthamine biosynthesis 6 | 0.0366081 |
| COL1A1 | collagen, type I, alpha 1 | 0.0344668 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.034099 |
| MYO6 | myosin VI | 0.0340327 |
| MSI2 | musashi RNA-binding protein 2 | 0.0336422 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0330878 |
| SIK2 | salt-inducible kinase 2 | 0.0324032 |
| AUTS2 | autism susceptibility candidate 2 | 0.0316868 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0314723 |
| TPR | translocated promoter region, nuclear basket protein | 0.0313358 |
| CENPF | centromere protein F, 350/400kDa | 0.0310154 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0306637 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0306492 |
| RPL34 | ribosomal protein L34 | 0.0302601 |
| RPLP0 | ribosomal protein, large, P0 | 0.0297267 |
| DST | dystonin | 0.0297147 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0296549 |
| RPS24 | ribosomal protein S24 | 0.0296053 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0295055 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0284956 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0274637 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0271098 |
| GOLGA4 | golgin A4 | 0.0267055 |
| ENAH | enabled homolog (Drosophila) | 0.0262851 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.026248 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0260817 |
| H3-3B | H3.3 histone B | 0.0259347 |
| RPL35A | ribosomal protein L35a | 0.0258708 |
| GLCCI1 | glucocorticoid induced 1 | 0.025777 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0257579 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0253944 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0253644 |
| NRP1 | neuropilin 1 | 0.0247553 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0246987 |
| MRTFA | myocardin related transcription factor A | 0.0245485 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0245275 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0244374 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0241799 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0237879 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0237514 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0237342 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0237242 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0235608 |
| PRKCA | protein kinase C, alpha | 0.0234802 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0232753 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0231074 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0229849 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0229468 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0229422 |
| VMP1 | vacuole membrane protein 1 | 0.0229282 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0229278 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.022867 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0228603 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0228545 |
| COL3A1 | collagen, type III, alpha 1 | 0.0226155 |
| CUL3 | cullin 3 | 0.0224028 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0221709 |
| RPS12 | ribosomal protein S12 | 0.0219757 |
| RET | ret proto-oncogene | 0.021897 |
| PCDH9 | protocadherin 9 | 0.0215642 |
| FAM13A | family with sequence similarity 13, member A | 0.0215498 |
| SEPTIN9 | septin 9 | 0.0215405 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.0284488 |
| FN1 | fibronectin 1 | -0.0244084 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0241267 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0233942 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0233332 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0222461 |
| DTNA | dystrobrevin, alpha | -0.0218257 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0201621 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0188925 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0184332 |
| GPC6 | glypican 6 | -0.0181425 |
| HMGA2 | high mobility group AT-hook 2 | -0.0170862 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0167819 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0161754 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0155527 |
| ACER3 | alkaline ceramidase 3 | -0.0136229 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0136226 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0135627 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0134057 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0132808 |
| EFNA5 | ephrin-A5 | -0.012717 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0126724 |
| OGA | O-GlcNAcase | -0.0126039 |
| PRELID2 | PRELI domain containing 2 | -0.0124864 |
| RUNX2 | runt-related transcription factor 2 | -0.0124778 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0124055 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0122996 |
| TMSB10 | thymosin beta 10 | -0.0122221 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0121879 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0121766 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0120699 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0120506 |
| MT2A | metallothionein 2A | -0.0120124 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0120079 |
| MYO1D | myosin ID | -0.011994 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0119215 |
| CDH13 | cadherin 13 | -0.0119098 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0118644 |
| LRRC23 | leucine rich repeat containing 23 | -0.011806 |
| CMIP | c-Maf inducing protein | -0.0118022 |
| CDK14 | cyclin-dependent kinase 14 | -0.011737 |
| ANXA5 | annexin A5 | -0.011697 |
| TMEM263 | transmembrane protein 263 | -0.0116774 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0115625 |
| HLA-B | major histocompatibility complex, class I, B | -0.0115554 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0115036 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0114988 |
| ENSA | endosulfine alpha | -0.011424 |
| PMM2 | phosphomannomutase 2 | -0.0111766 |
| NGLY1 | N-glycanase 1 | -0.011103 |
| CLMP | CXADR-like membrane protein | -0.011093 |
| CORIN | corin, serine peptidase | -0.0110784 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0110475 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0110247 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.0109701 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0108286 |
| LAMA4 | laminin, alpha 4 | -0.0107965 |
| RAI14 | retinoic acid induced 14 | -0.0107073 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | -0.0107073 |
| TMEM165 | transmembrane protein 165 | -0.0105661 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0105427 |
| XPO1 | exportin 1 | -0.0104633 |
| PRDM2 | PR domain containing 2, with ZNF domain | -0.010442 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0103471 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0103161 |
| RASA2 | RAS p21 protein activator 2 | -0.0103017 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0101787 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.010129 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.0100948 |
| SUMF1 | sulfatase modifying factor 1 | -0.0100613 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0100534 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0100468 |
| OPHN1 | oligophrenin 1 | -0.0100148 |
| WDR43 | WD repeat domain 43 | -0.0100031 |
| SBF2 | SET binding factor 2 | -0.00995934 |
| LMO7 | LIM domain 7 | -0.00993351 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.00981825 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.00980897 |
| RPL27A | ribosomal protein L27a | -0.00977043 |
| EIF3L | eukaryotic translation initiation factor 3, subunit L | -0.00975489 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00972248 |
| NAV1 | neuron navigator 1 | -0.00970149 |
| CTBP2 | C-terminal binding protein 2 | -0.00967363 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0096474 |
| MYO10 | myosin X | -0.00962932 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.00962643 |
| NUP153 | nucleoporin 153kDa | -0.00959158 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.00958647 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.00956663 |
| ACOX3 | acyl-CoA oxidase 3, pristanoyl | -0.00956061 |
| BCL2L1 | BCL2-like 1 | -0.00948708 |
| TDRP | testis development related protein | -0.00945959 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.00943118 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.00941746 |
| LCLAT1 | lysocardiolipin acyltransferase 1 | -0.00936696 |
| SRSF2 | serine/arginine-rich splicing factor 2 | -0.00932462 |
| STC1 | stanniocalcin 1 | -0.00931659 |
| NABP1 | nucleic acid binding protein 1 | -0.00930668 |
| WWC2 | WW and C2 domain containing 2 | -0.00927433 |
| TMEM39A | transmembrane protein 39A | -0.00925461 |
