AT7519_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.274666
VEGFA vascular endothelial growth factor A 0.0974001
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0905064
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0787749
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.063029
MYH9 myosin, heavy chain 9, non-muscle 0.0605869
CD44 CD44 molecule (Indian blood group) 0.0592715
FTH1 ferritin, heavy polypeptide 1 0.0515377
WWTR1 WW domain containing transcription regulator 1 0.0455818
FNDC3B fibronectin type III domain containing 3B 0.0429221
EEF2 eukaryotic translation elongation factor 2 0.040883
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0401899
MBNL1 muscleblind-like splicing regulator 1 0.0398133
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0391828
B2M beta-2-microglobulin 0.0369871
AXL AXL receptor tyrosine kinase 0.0363341
POTEF POTE ankyrin domain family, member F 0.0362649
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0358627
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0345395
PKM pyruvate kinase, muscle 0.0342821
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0342125
PDLIM5 PDZ and LIM domain 5 0.0323758
LDHA lactate dehydrogenase A 0.0317821
ALCAM activated leukocyte cell adhesion molecule 0.0317402
CALR calreticulin 0.0313013
POSTN periostin, osteoblast specific factor 0.0311551
DPYSL3 dihydropyrimidinase-like 3 0.0302856
CLIC4 chloride intracellular channel 4 0.0302522
RIGI RNA sensor RIG-I 0.0288909
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0286863
MSN moesin 0.0267365
JAG1 jagged 1 0.0263406
CSF1 colony stimulating factor 1 (macrophage) 0.0261986
ZBTB38 zinc finger and BTB domain containing 38 0.0259694
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0256264
ICAM1 intercellular adhesion molecule 1 0.0254553
MACF1 microtubule-actin crosslinking factor 1 0.024612
EXT1 exostosin glycosyltransferase 1 0.0242407
VCL vinculin 0.0236506
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0235648
SP100 SP100 nuclear antigen 0.0235563
ADAM9 ADAM metallopeptidase domain 9 0.0234167
ADAM17 ADAM metallopeptidase domain 17 0.0232697
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0232169
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0231476
PFN1 profilin 1 0.023095
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0224183
CYB5R3 cytochrome b5 reductase 3 0.0224029
PALLD palladin, cytoskeletal associated protein 0.0220499
VMP1 vacuole membrane protein 1 0.02144
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0210664
DSTN destrin (actin depolymerizing factor) 0.0209737
IL6ST interleukin 6 signal transducer 0.0206824
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0206548
TLE4 transducin-like enhancer of split 4 0.0206433
FLNA filamin A, alpha 0.0206358
ASPH aspartate beta-hydroxylase 0.0200814
YBX1 Y box binding protein 1 0.0199588
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0197755
KMT2E lysine (K)-specific methyltransferase 2E 0.01973
SMAD3 SMAD family member 3 0.0196195
SCARB2 scavenger receptor class B, member 2 0.0195995
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0195822
MYO10 myosin X 0.0195662
PICALM phosphatidylinositol binding clathrin assembly protein 0.0194135
FBXL7 F-box and leucine-rich repeat protein 7 0.0192821
HYOU1 hypoxia up-regulated 1 0.0191984
TFG TRK-fused gene 0.0189976
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.018749
MAP1B microtubule-associated protein 1B 0.0186867
PDIA6 protein disulfide isomerase family A, member 6 0.0186316
FXR1 fragile X mental retardation, autosomal homolog 1 0.0185184
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0181144
MRTFA myocardin related transcription factor A 0.0178805
TAPBP TAP binding protein (tapasin) 0.0177803
MT1X metallothionein 1X 0.0177663
TNIP1 TNFAIP3 interacting protein 1 0.0176942
INTS6 integrator complex subunit 6 0.017679
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0173466
ZFAND3 zinc finger, AN1-type domain 3 0.0172404
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0167997
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0167126
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0166859
UBC ubiquitin C 0.0165582
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.016392
JAK2 Janus kinase 2 0.0163647
H1-0 H1.0 linker histone 0.0163221
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.016298
ANKRD28 ankyrin repeat domain 28 0.0158594
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0158436
TSC22D2 TSC22 domain family, member 2 0.0157115
ARRDC3 arrestin domain containing 3 0.0157048
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0157028
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0156497
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0154364
ZNF644 zinc finger protein 644 0.0153202
SPAG9 sperm associated antigen 9 0.0151275
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.014773
BRD2 bromodomain containing 2 0.0147119
IFI44L interferon-induced protein 44-like 0.0146946

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.196041
COL1A1 collagen, type I, alpha 1 -0.159645
VIM vimentin -0.15227
IER3 immediate early response 3 -0.1439
TGFBI transforming growth factor, beta-induced, 68kDa -0.125287
TIMP3 TIMP metallopeptidase inhibitor 3 -0.124649
COL1A2 collagen, type I, alpha 2 -0.117584
NDRG1 N-myc downstream regulated 1 -0.11115
TMSB10 thymosin beta 10 -0.0812807
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0711393
TPT1 tumor protein, translationally-controlled 1 -0.0615542
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0608213
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0586122
TPM4 tropomyosin 4 -0.0575248
CDH13 cadherin 13 -0.0573307
CAVIN1 caveolae associated protein 1 -0.0559623
LOXL2 lysyl oxidase-like 2 -0.0544828
F3 coagulation factor III (thromboplastin, tissue factor) -0.052599
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0471207
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0429215
RPL35A ribosomal protein L35a -0.0423813
RPS8 ribosomal protein S8 -0.0418908
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0407158
LOX lysyl oxidase -0.0396382
PDE10A phosphodiesterase 10A -0.0389208
RPL37A ribosomal protein L37a -0.0375249
VCAN versican -0.0372726
STC1 stanniocalcin 1 -0.037239
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.037061
HLA-B major histocompatibility complex, class I, B -0.0368894
PTMA prothymosin, alpha -0.0362289
EIF1 eukaryotic translation initiation factor 1 -0.0358028
TM4SF1 transmembrane 4 L six family member 1 -0.0352047
ABI3BP ABI family, member 3 (NESH) binding protein -0.0350982
GNAS GNAS complex locus -0.0341428
RRBP1 ribosome binding protein 1 -0.0328737
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0327489
TMEM165 transmembrane protein 165 -0.0315483
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.031016
WSB1 WD repeat and SOCS box containing 1 -0.0307131
ZMYND8 zinc finger, MYND-type containing 8 -0.0303543
ADM adrenomedullin -0.0299086
FBN1 fibrillin 1 -0.0296613
CADM1 cell adhesion molecule 1 -0.0294077
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0286214
FTL ferritin, light polypeptide -0.0284068
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0282088
RPS6 ribosomal protein S6 -0.0281946
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0280578
COL5A1 collagen, type V, alpha 1 -0.0278855
BNC2 basonuclin 2 -0.0276783
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0274219
LAMB3 laminin, beta 3 -0.0271318
RPS12 ribosomal protein S12 -0.0266077
TRPS1 trichorhinophalangeal syndrome I -0.0260623
TTC3 tetratricopeptide repeat domain 3 -0.0259791
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0257258
NALF1 NALCN channel auxiliary factor 1 -0.0255105
RTN4 reticulon 4 -0.025221
MTDH metadherin -0.0248422
RPS27A ribosomal protein S27a -0.0245888
COL6A2 collagen, type VI, alpha 2 -0.0244914
DPYD dihydropyrimidine dehydrogenase -0.024152
RPL31 ribosomal protein L31 -0.0240393
CLMP CXADR-like membrane protein -0.0236117
S100A6 S100 calcium binding protein A6 -0.0232518
KPNB1 karyopherin (importin) beta 1 -0.0232355
RPL11 ribosomal protein L11 -0.0230367
RPL37 ribosomal protein L37 -0.0225075
ANO10 anoctamin 10 -0.0222865
GOLGA4 golgin A4 -0.0220367
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0220078
GJA1 gap junction protein, alpha 1, 43kDa -0.0217613
RPL38 ribosomal protein L38 -0.0217585
IARS1 isoleucyl-tRNA synthetase 1 -0.0215629
ARL4C ADP-ribosylation factor-like 4C -0.0215493
RPS24 ribosomal protein S24 -0.0214755
MT2A metallothionein 2A -0.0214432
UGDH UDP-glucose 6-dehydrogenase -0.0213799
CD109 CD109 molecule -0.0213239
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0210361
FGFR1 fibroblast growth factor receptor 1 -0.0208555
S100A10 S100 calcium binding protein A10 -0.0208528
S100A9 S100 calcium binding protein A9 -0.0205523
RPL26 ribosomal protein L26 -0.0200402
RPLP2 ribosomal protein, large, P2 -0.019517
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0195063
OGA O-GlcNAcase -0.0194591
PGK1 phosphoglycerate kinase 1 -0.0194368
BIRC6 baculoviral IAP repeat containing 6 -0.0192937
DOCK5 dedicator of cytokinesis 5 -0.0191921
RPLP1 ribosomal protein, large, P1 -0.01911
FBXO32 F-box protein 32 -0.0190607
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0188337
RPL13A ribosomal protein L13a -0.0188226
RPL34 ribosomal protein L34 -0.0186209
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.01839
RPS3 ribosomal protein S3 -0.0182779
ACTG1 actin gamma 1 -0.0182331
HM13 histocompatibility (minor) 13 -0.0181521