AT7519_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.41435
C3 complement component 3 0.154467
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.12742
DSPP dentin sialophosphoprotein 0.10453
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0988345
IGFBP1 insulin-like growth factor binding protein 1 0.0921725
SVIL supervillin 0.0852829
IGF2 insulin-like growth factor 2 0.083286
VEGFA vascular endothelial growth factor A 0.0822932
FN1 fibronectin 1 0.07247
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.06128
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0596831
SLC38A2 solute carrier family 38, member 2 0.0595801
SAMD4A sterile alpha motif domain containing 4A 0.0499786
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0486067
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0475347
POTEF POTE ankyrin domain family, member F 0.0457702
KRT8 keratin 8, type II 0.0450632
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0447902
TNS1 tensin 1 0.0446034
LCOR ligand dependent nuclear receptor corepressor 0.041913
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0411433
BCL2L1 BCL2-like 1 0.0380506
ERRFI1 ERBB receptor feedback inhibitor 1 0.03602
CCN2 cellular communication network factor 2 0.035934
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0359045
FTH1 ferritin, heavy polypeptide 1 0.0358758
TIMP1 TIMP metallopeptidase inhibitor 1 0.0358037
FAT1 FAT atypical cadherin 1 0.0341542
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0340928
KYNU kynureninase 0.0338844
PEG3 paternally expressed 3 0.0316653
DLC1 DLC1 Rho GTPase activating protein 0.0314078
DOCK4 dedicator of cytokinesis 4 0.031137
PDLIM5 PDZ and LIM domain 5 0.0310317
AKAP12 A kinase (PRKA) anchor protein 12 0.0309013
SETD5 SET domain containing 5 0.0303861
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0291198
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0289574
ITGAV integrin, alpha V 0.0284799
MAML2 mastermind-like 2 (Drosophila) 0.0284051
NRIP1 nuclear receptor interacting protein 1 0.0281889
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0280875
PAWR PRKC, apoptosis, WT1, regulator 0.0279045
FOXP1 forkhead box P1 0.0279004
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0278277
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0277229
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0274153
JMJD1C jumonji domain containing 1C 0.0270817
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0267314
MACF1 microtubule-actin crosslinking factor 1 0.0266822
MAN1A1 mannosidase, alpha, class 1A, member 1 0.026401
MYH9 myosin, heavy chain 9, non-muscle 0.0262636
MBNL3 muscleblind-like splicing regulator 3 0.026256
KLF10 Kruppel-like factor 10 0.0262201
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0258281
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0256729
CRY1 cryptochrome circadian clock 1 0.0253802
AHR aryl hydrocarbon receptor 0.024983
EXT1 exostosin glycosyltransferase 1 0.0243706
EPAS1 endothelial PAS domain protein 1 0.0242364
DSTN destrin (actin depolymerizing factor) 0.0240504
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0240344
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0239198
JAG1 jagged 1 0.0238624
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0236168
MBNL2 muscleblind-like splicing regulator 2 0.0234928
KIF5B kinesin family member 5B 0.0234725
OSBPL10 oxysterol binding protein-like 10 0.0234409
ARHGAP9 Rho GTPase activating protein 9 0.0232913
YAP1 Yes-associated protein 1 0.0226295
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0223809
SYNJ2 synaptojanin 2 0.0223774
KIAA1217 KIAA1217 0.0222348
FOXO1 forkhead box O1 0.0220294
SESTD1 SEC14 and spectrin domains 1 0.0219815
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0217066
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0214327
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0208975
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0208854
CUL3 cullin 3 0.0205178
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0205075
RPL21 ribosomal protein L21 0.0202751
LIMS1 LIM and senescent cell antigen-like domains 1 0.0202177
PPARD peroxisome proliferator-activated receptor delta 0.0198247
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0196709
BRD4 bromodomain containing 4 0.0193768
ZNF644 zinc finger protein 644 0.0193166
USP6NL USP6 N-terminal like 0.0193075
AHSG alpha-2-HS-glycoprotein 0.0192874
TXNIP thioredoxin interacting protein 0.0191212
MBNL1 muscleblind-like splicing regulator 1 0.0187391
ATXN1 ataxin 1 0.0185867
NKD1 naked cuticle homolog 1 (Drosophila) 0.0184925
APLP2 amyloid beta (A4) precursor-like protein 2 0.0181307
ITGB5 integrin, beta 5 0.0181157
RSU1 Ras suppressor protein 1 0.017844
KIF21A kinesin family member 21A 0.0177385
FERMT2 fermitin family member 2 0.0175956
BHLHE40 basic helix-loop-helix family, member e40 0.0175951

decreased expression

Symbol Name Standardized Value
RPS27A ribosomal protein S27a -0.140931
TPT1 tumor protein, translationally-controlled 1 -0.129774
GPC3 glypican 3 -0.126354
ENO1 enolase 1, (alpha) -0.117039
UBC ubiquitin C -0.108412
TMSB10 thymosin beta 10 -0.0990163
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0944307
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0927871
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0872192
RPS24 ribosomal protein S24 -0.0842507
RPL23 ribosomal protein L23 -0.0675756
APOB apolipoprotein B -0.0664136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0658108
KDM3A lysine (K)-specific demethylase 3A -0.0611862
SDC4 syndecan 4 -0.0610743
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0575026
TM4SF1 transmembrane 4 L six family member 1 -0.0564153
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0519823
TRIM26 tripartite motif containing 26 -0.0510347
RPL35A ribosomal protein L35a -0.0499279
RPS12 ribosomal protein S12 -0.04929
RPL37A ribosomal protein L37a -0.0475608
RPL38 ribosomal protein L38 -0.0474039
CANX calnexin -0.0469668
FBF1 Fas (TNFRSF6) binding factor 1 -0.0469656
RPLP1 ribosomal protein, large, P1 -0.0464575
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0461775
PTMA prothymosin, alpha -0.0447316
ASPH aspartate beta-hydroxylase -0.0444631
GNAS GNAS complex locus -0.0427838
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0414773
SOD2 superoxide dismutase 2, mitochondrial -0.0402338
JUN jun proto-oncogene -0.0401994
GMDS GDP-mannose 4,6-dehydratase -0.0384687
AMBP alpha-1-microglobulin/bikunin precursor -0.038315
RPL34 ribosomal protein L34 -0.0381033
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0377589
AHNAK AHNAK nucleoprotein -0.0374153
RPS25 ribosomal protein S25 -0.0362661
CP ceruloplasmin (ferroxidase) -0.0358415
RPS29 ribosomal protein S29 -0.0350307
RPS8 ribosomal protein S8 -0.0348413
APOE apolipoprotein E -0.034678
RPL9 ribosomal protein L9 -0.0338218
DTNA dystrobrevin, alpha -0.0333929
CFB complement factor B -0.0329771
RPL31 ribosomal protein L31 -0.0329373
FMNL2 formin-like 2 -0.0328663
IER3 immediate early response 3 -0.0327542
RPL12 ribosomal protein L12 -0.0326015
RPL26 ribosomal protein L26 -0.0318642
RPS3 ribosomal protein S3 -0.0313114
RPL4 ribosomal protein L4 -0.0309134
TRIO trio Rho guanine nucleotide exchange factor -0.0304134
LDHA lactate dehydrogenase A -0.0304026
RPL5 ribosomal protein L5 -0.0302127
NAP1L1 nucleosome assembly protein 1-like 1 -0.0301738
RPS19 ribosomal protein S19 -0.0298972
HDLBP high density lipoprotein binding protein -0.029856
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0294587
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0294158
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0291467
NPR2 natriuretic peptide receptor 2 -0.0286928
LOC112694756 uncharaterized LOC112694756 -0.0285398
EEF1G eukaryotic translation elongation factor 1 gamma -0.0282449
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0278667
GLG1 golgi glycoprotein 1 -0.0277755
PGK1 phosphoglycerate kinase 1 -0.0276393
RPS21 ribosomal protein S21 -0.0273656
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0273466
MT2A metallothionein 2A -0.0273266
VMP1 vacuole membrane protein 1 -0.0269297
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0269174
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0262833
TF transferrin -0.026223
RIGI RNA sensor RIG-I -0.0260782
SQSTM1 sequestosome 1 -0.0260533
APOA2 apolipoprotein A-II -0.0259406
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0253205
RRBP1 ribosome binding protein 1 -0.0252048
RAB1A RAB1A, member RAS oncogene family -0.0250429
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0250017
RPL19 ribosomal protein L19 -0.0244493
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0243163
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0242993
RPL36A ribosomal protein L36a -0.0242376
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0238372
UGP2 UDP-glucose pyrophosphorylase 2 -0.0238226
MSI2 musashi RNA-binding protein 2 -0.0235723
A2M alpha-2-macroglobulin -0.0230001
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0229427
RAN RAN, member RAS oncogene family -0.0228833
WSB1 WD repeat and SOCS box containing 1 -0.0227124
OGA O-GlcNAcase -0.0225069
SPDYA speedy/RINGO cell cycle regulator family member A -0.0224057
ELL2 elongation factor, RNA polymerase II, 2 -0.0222242
CNOT8 CCR4-NOT transcription complex, subunit 8 -0.0221791
RPLP2 ribosomal protein, large, P2 -0.02174
GPC6 glypican 6 -0.0211958
ENKUR enkurin, TRPC channel interacting protein -0.0211541