| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AT7519 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AT7519_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.212786 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.154777 |
| FAT1 | FAT atypical cadherin 1 | 0.120549 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.116192 |
| KRT8 | keratin 8, type II | 0.111793 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0846543 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0797786 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0772028 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0752034 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0733348 |
| LMO7 | LIM domain 7 | 0.0677981 |
| LDHA | lactate dehydrogenase A | 0.0646827 |
| TXNIP | thioredoxin interacting protein | 0.0612191 |
| ITGA6 | integrin, alpha 6 | 0.0599979 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0573146 |
| CALR | calreticulin | 0.0546003 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0534969 |
| B2M | beta-2-microglobulin | 0.0512339 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.049505 |
| TRIM2 | tripartite motif containing 2 | 0.0479939 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.047892 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0468172 |
| MUC13 | mucin 13, cell surface associated | 0.046673 |
| AFF1 | AF4/FMR2 family, member 1 | 0.045226 |
| DSPP | dentin sialophosphoprotein | 0.0431716 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.04284 |
| PDZD8 | PDZ domain containing 8 | 0.041144 |
| RNF145 | ring finger protein 145 | 0.0406318 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0404958 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0404428 |
| GOLGA4 | golgin A4 | 0.0403604 |
| VEGFA | vascular endothelial growth factor A | 0.0400352 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0397067 |
| ENO1 | enolase 1, (alpha) | 0.0394467 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0394378 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0388164 |
| POTEF | POTE ankyrin domain family, member F | 0.0381401 |
| PKM | pyruvate kinase, muscle | 0.0379291 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0373101 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0371789 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0367324 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0354269 |
| USP6NL | USP6 N-terminal like | 0.0345916 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0344517 |
| SHROOM3 | shroom family member 3 | 0.0342021 |
| TPD52 | tumor protein D52 | 0.0341135 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0339909 |
| MED13L | mediator complex subunit 13-like | 0.0332523 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0325191 |
| TPM3 | tropomyosin 3 | 0.0324558 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0319589 |
| BRD2 | bromodomain containing 2 | 0.0307819 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0303696 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0303399 |
| CD44 | CD44 molecule (Indian blood group) | 0.0303304 |
| FAM13A | family with sequence similarity 13, member A | 0.0301963 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0299868 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0299519 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0297483 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0296036 |
| MED13 | mediator complex subunit 13 | 0.0289802 |
| FOXP1 | forkhead box P1 | 0.0288869 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0288066 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0287431 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0286811 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0286199 |
| ZNF292 | zinc finger protein 292 | 0.0283583 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.028149 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0277485 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0275511 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0272934 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0271869 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0266082 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.025898 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0256221 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0255273 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0251609 |
| NEBL | nebulette | 0.0250454 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0246289 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0243935 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.02432 |
| RPL3 | ribosomal protein L3 | 0.0241976 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0240455 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0237747 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0236314 |
| PCBP2 | poly(rC) binding protein 2 | 0.0236117 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0235977 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0235329 |
| CANX | calnexin | 0.0231889 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0230672 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0230165 |
| MYO5B | myosin VB | 0.0228072 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0227961 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0226965 |
| SVIL | supervillin | 0.0226336 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0224274 |
| NCKAP1 | NCK-associated protein 1 | 0.0222711 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0222188 |
| PCM1 | pericentriolar material 1 | 0.0220081 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0219779 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.19826 |
| NPSR1 | neuropeptide S receptor 1 | -0.194054 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.185665 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.124949 |
| PTMA | prothymosin, alpha | -0.100011 |
| VCL | vinculin | -0.0922704 |
| TPM4 | tropomyosin 4 | -0.0729705 |
| RPL35A | ribosomal protein L35a | -0.0675988 |
| IER3 | immediate early response 3 | -0.061896 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0613245 |
| FLNB | filamin B, beta | -0.0554089 |
| ONECUT3 | one cut homeobox 3 | -0.0533442 |
| S100A6 | S100 calcium binding protein A6 | -0.0493694 |
| RPS24 | ribosomal protein S24 | -0.048374 |
| RPL9 | ribosomal protein L9 | -0.0469064 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0446447 |
| TFF1 | trefoil factor 1 | -0.0436232 |
| ACTG1 | actin gamma 1 | -0.0417029 |
| FERMT1 | fermitin family member 1 | -0.0405171 |
| ANXA2 | annexin A2 | -0.0380583 |
| RPLP2 | ribosomal protein, large, P2 | -0.0374388 |
| RPL34 | ribosomal protein L34 | -0.0370056 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0366569 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0365638 |
| S100P | S100 calcium binding protein P | -0.0362542 |
| AHNAK | AHNAK nucleoprotein | -0.0361315 |
| RPS6 | ribosomal protein S6 | -0.0361107 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0360565 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0347825 |
| RPLP1 | ribosomal protein, large, P1 | -0.0343858 |
| RPS27A | ribosomal protein S27a | -0.034232 |
| RPS29 | ribosomal protein S29 | -0.0338114 |
| LAMA4 | laminin, alpha 4 | -0.033535 |
| RPS25 | ribosomal protein S25 | -0.0329918 |
| RPL38 | ribosomal protein L38 | -0.0323077 |
| EHBP1 | EH domain binding protein 1 | -0.0318908 |
| RPL37A | ribosomal protein L37a | -0.0318627 |
| KLK10 | kallikrein-related peptidase 10 | -0.0302049 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0295707 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0287581 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.028476 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0283969 |
| RPL26 | ribosomal protein L26 | -0.0282567 |
| KRT19 | keratin 19, type I | -0.0277539 |
| HMGA1 | high mobility group AT-hook 1 | -0.0277373 |
| RPL31 | ribosomal protein L31 | -0.0270209 |
| DIAPH2 | diaphanous-related formin 2 | -0.0268822 |
| HMGB1 | high mobility group box 1 | -0.0260052 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0259571 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0259226 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0258886 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0255497 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0254568 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0247754 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0239691 |
| CSTB | cystatin B (stefin B) | -0.0237955 |
| RPS8 | ribosomal protein S8 | -0.0233606 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0233358 |
| RPL7A | ribosomal protein L7a | -0.0232401 |
| TNS4 | tensin 4 | -0.0232297 |
| LAMB3 | laminin, beta 3 | -0.0228326 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0226443 |
| MUC17 | mucin 17, cell surface associated | -0.0226229 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0226165 |
| RNF217 | ring finger protein 217 | -0.0216411 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.021331 |
| RPS13 | ribosomal protein S13 | -0.0212122 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.021179 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0209768 |
| LSAMP | limbic system-associated membrane protein | -0.0207535 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0203013 |
| RPS21 | ribosomal protein S21 | -0.0202503 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.020184 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0198937 |
| IGFL2 | IGF-like family member 2 | -0.0198063 |
| RPS3 | ribosomal protein S3 | -0.0193937 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0191028 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0189367 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0188722 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0185443 |
| RPL19 | ribosomal protein L19 | -0.0185035 |
| RPS12 | ribosomal protein S12 | -0.0182711 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0178373 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0176703 |
| EGR1 | early growth response 1 | -0.017611 |
| S100A11 | S100 calcium binding protein A11 | -0.0175675 |
| ANXA3 | annexin A3 | -0.0175631 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0173647 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0172966 |
| FDPS | farnesyl diphosphate synthase | -0.0170602 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0169191 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0167449 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0166817 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0164341 |
| RPL23 | ribosomal protein L23 | -0.0162635 |
| NRN1 | neuritin 1 | -0.016146 |
| RPS11 | ribosomal protein S11 | -0.0158872 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0157062 |
| GPR39 | G protein-coupled receptor 39 | -0.0155549 |
| EGFR | epidermal growth factor receptor | -0.0154972 |
