AT7519_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.189562
SLTM SAFB-like, transcription modulator 0.0621903
CEMIP cell migration inducing protein, hyaluronan binding 0.058873
TBC1D22A TBC1 domain family, member 22A 0.0552026
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0550817
DOCK5 dedicator of cytokinesis 5 0.0508276
INTS6 integrator complex subunit 6 0.0420174
PDE4D phosphodiesterase 4D, cAMP-specific 0.0414806
SMAD3 SMAD family member 3 0.0398105
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0390654
ELL2 elongation factor, RNA polymerase II, 2 0.0381802
AGO2 argonaute RISC catalytic component 2 0.0374846
DSCAM Down syndrome cell adhesion molecule 0.0358901
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0335609
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0329065
RNF213 ring finger protein 213 0.0318201
GRAMD1B GRAM domain containing 1B 0.0315747
SMYD3 SET and MYND domain containing 3 0.0308676
TRAPPC9 trafficking protein particle complex 9 0.0307727
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0300336
HOMER1 homer scaffolding protein 1 0.0272738
AHNAK AHNAK nucleoprotein 0.0266361
STAT1 signal transducer and activator of transcription 1, 91kDa 0.026561
PM20D1 peptidase M20 domain containing 1 0.0263111
EFNA5 ephrin-A5 0.0260689
BCAR3 breast cancer anti-estrogen resistance 3 0.0259823
SP100 SP100 nuclear antigen 0.025627
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0247159
HSPA8 heat shock 70kDa protein 8 0.0246347
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0245834
EPAS1 endothelial PAS domain protein 1 0.0240146
RAD51B RAD51 paralog B 0.0238199
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0232536
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0226247
MYH9 myosin, heavy chain 9, non-muscle 0.0217945
LGALS12 lectin, galactoside-binding, soluble, 12 0.0217042
DOCK1 dedicator of cytokinesis 1 0.0216878
SMOC1 SPARC related modular calcium binding 1 0.0216301
PLEC plectin 0.0209975
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0209294
MYOF myoferlin 0.0203673
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0200789
CES1 carboxylesterase 1 0.0199623
NTSR1 neurotensin receptor 1 (high affinity) 0.0199386
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0199043
NPAS2 neuronal PAS domain protein 2 0.0197817
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.019273
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0186903
PAPOLA poly(A) polymerase alpha 0.0186521
BMP6 bone morphogenetic protein 6 0.0184286
SAMD4A sterile alpha motif domain containing 4A 0.0181596
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0176379
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0171718
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0169427
RUNX1 runt-related transcription factor 1 0.0165583
IGF1R insulin-like growth factor 1 receptor 0.0164462
LMO7 LIM domain 7 0.0161512
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0154655
SHB Src homology 2 domain containing adaptor protein B 0.0153228
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0153159
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0153122
MKI67 marker of proliferation Ki-67 0.0151318
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0149853
ANO6 anoctamin 6 0.0149331
EXT1 exostosin glycosyltransferase 1 0.014827
PRKCE protein kinase C, epsilon 0.0148146
ARB2A ARB2 cotranscriptional regulator A 0.0147723
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0146438
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0145573
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0145344
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0144729
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0142714
NCOA3 nuclear receptor coactivator 3 0.0142022
HDAC4 histone deacetylase 4 0.0141694
NSUN6 NOP2/Sun domain family, member 6 0.0141633
ZSWIM6 zinc finger, SWIM-type containing 6 0.013969
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0139449
SEPTIN9 septin 9 0.0138926
MYO1E myosin IE 0.013799
USP9X ubiquitin specific peptidase 9, X-linked 0.0137666
MIPOL1 mirror-image polydactyly 1 0.0136402
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0134546
TLE4 transducin-like enhancer of split 4 0.0134134
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0133989
KIAA1217 KIAA1217 0.0133739
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0132074
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0129847
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0128768
AEBP2 AE binding protein 2 0.0128601
MACF1 microtubule-actin crosslinking factor 1 0.0127626
LPP LIM domain containing preferred translocation partner in lipoma 0.0127084
SRRM2 serine/arginine repetitive matrix 2 0.0126802
THSD4 thrombospondin, type I, domain containing 4 0.0126151
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0125394
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0124192
MAP7 microtubule-associated protein 7 0.0123085
CTTN cortactin 0.0122668
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0122313
TOP1 topoisomerase (DNA) I 0.0122134
FBXL17 F-box and leucine-rich repeat protein 17 0.0121114

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.248994
TMSB10 thymosin beta 10 -0.195518
MT2A metallothionein 2A -0.0786654
FTL ferritin, light polypeptide -0.0644645
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0619338
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0557917
PTMA prothymosin, alpha -0.0548106
ACTG1 actin gamma 1 -0.0537199
EGR1 early growth response 1 -0.053576
TPT1 tumor protein, translationally-controlled 1 -0.0522089
S100A10 S100 calcium binding protein A10 -0.0521004
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0482648
SEC61G Sec61 gamma subunit -0.0459034
LAMC2 laminin, gamma 2 -0.0457826
CST3 cystatin C -0.0455976
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.043343
NDRG1 N-myc downstream regulated 1 -0.0403294
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0398403
RPL35A ribosomal protein L35a -0.0393026
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0390795
RPS3 ribosomal protein S3 -0.0370762
TXNRD1 thioredoxin reductase 1 -0.0369951
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0365228
KRT7 keratin 7, type II -0.0364794
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0362412
SLC38A1 solute carrier family 38, member 1 -0.0353185
PKM pyruvate kinase, muscle -0.0352372
RPL37A ribosomal protein L37a -0.0347311
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0346337
LDHA lactate dehydrogenase A -0.0325994
S100A11 S100 calcium binding protein A11 -0.0325577
LOC112694756 uncharaterized LOC112694756 -0.0325575
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0318457
RPS6 ribosomal protein S6 -0.030749
RPLP1 ribosomal protein, large, P1 -0.0298733
RPS25 ribosomal protein S25 -0.0288287
S100A9 S100 calcium binding protein A9 -0.0283623
ENO1 enolase 1, (alpha) -0.0282453
S100A6 S100 calcium binding protein A6 -0.027829
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0278248
RPL11 ribosomal protein L11 -0.0275011
TPM4 tropomyosin 4 -0.0266274
RPS12 ribosomal protein S12 -0.0261652
IFI6 interferon, alpha-inducible protein 6 -0.0259793
RAB27B RAB27B, member RAS oncogene family -0.0256274
RPL31 ribosomal protein L31 -0.0249353
HMGA1 high mobility group AT-hook 1 -0.0246844
AKAP12 A kinase (PRKA) anchor protein 12 -0.0242748
RPS8 ribosomal protein S8 -0.024227
RPL12 ribosomal protein L12 -0.0237113
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0235285
EIF1 eukaryotic translation initiation factor 1 -0.0232945
CAV1 caveolin 1, caveolae protein, 22kDa -0.0229878
RPS24 ribosomal protein S24 -0.0228683
TMEM165 transmembrane protein 165 -0.022545
ZMYND8 zinc finger, MYND-type containing 8 -0.022183
RAB7A RAB7A, member RAS oncogene family -0.0220582
RPLP2 ribosomal protein, large, P2 -0.021797
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0217857
S100P S100 calcium binding protein P -0.0216475
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0214495
RPS23 ribosomal protein S23 -0.0213013
KRT19 keratin 19, type I -0.0211618
RPS17 ribosomal protein S17 -0.0211434
IER3 immediate early response 3 -0.0209012
RPS27A ribosomal protein S27a -0.0206581
RPS21 ribosomal protein S21 -0.0206514
CSTB cystatin B (stefin B) -0.0204846
RPL34 ribosomal protein L34 -0.0198762
PDIA3 protein disulfide isomerase family A, member 3 -0.0197978
RPS29 ribosomal protein S29 -0.0197209
GNAS GNAS complex locus -0.0196486
ATF4 activating transcription factor 4 -0.0193973
PFN1 profilin 1 -0.0193276
ANXA2 annexin A2 -0.0193116
LAMA4 laminin, alpha 4 -0.0192961
RAB1A RAB1A, member RAS oncogene family -0.0192265
CAV2 caveolin 2 -0.018775
PERP PERP, TP53 apoptosis effector -0.0186176
RPL23 ribosomal protein L23 -0.0185276
RPL37 ribosomal protein L37 -0.0184918
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0184822
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0184258
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0183167
SERF2 small EDRK-rich factor 2 -0.018249
MYL12B myosin, light chain 12B, regulatory -0.0182401
AKR1C1 aldo-keto reductase family 1, member C1 -0.0181715
RPS19 ribosomal protein S19 -0.017866
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0176546
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.017638
POTEF POTE ankyrin domain family, member F -0.0174022
CIB1 calcium and integrin binding 1 (calmyrin) -0.0172607
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0172358
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0171653
BTG1 B-cell translocation gene 1, anti-proliferative -0.0171344
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0171249
RPL36A ribosomal protein L36a -0.0170141
RPS27 ribosomal protein S27 -0.0169192
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0167058
RPL36 ribosomal protein L36 -0.0166262