AT7519_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.170705
FTL ferritin, light polypeptide 0.153346
PM20D1 peptidase M20 domain containing 1 0.146514
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.115409
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.110227
FTH1 ferritin, heavy polypeptide 1 0.0984482
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0847367
SMOC1 SPARC related modular calcium binding 1 0.0714712
UBASH3B ubiquitin associated and SH3 domain containing B 0.0689539
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0601343
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0598098
DOCK5 dedicator of cytokinesis 5 0.0591481
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0591435
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0564986
B2M beta-2-microglobulin 0.0547431
MACF1 microtubule-actin crosslinking factor 1 0.0543565
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0538428
FMNL2 formin-like 2 0.0532317
SAMD4A sterile alpha motif domain containing 4A 0.0526098
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0525417
ASPH aspartate beta-hydroxylase 0.0464624
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.04435
WAC WW domain containing adaptor with coiled-coil 0.0431179
RPL19 ribosomal protein L19 0.0420534
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0419412
KTN1 kinectin 1 (kinesin receptor) 0.0418526
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0418375
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0417389
CALR calreticulin 0.041711
RICTOR RPTOR independent companion of MTOR, complex 2 0.0415029
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0409245
TPM3 tropomyosin 3 0.0401217
ARHGAP26 Rho GTPase activating protein 26 0.0398971
LMNA lamin A/C 0.0394366
FNDC3B fibronectin type III domain containing 3B 0.0391726
LPP LIM domain containing preferred translocation partner in lipoma 0.0388042
IGFBP3 insulin-like growth factor binding protein 3 0.0385744
TRA2A transformer 2 alpha homolog (Drosophila) 0.0385456
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0382584
UTRN utrophin 0.0375429
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0373961
MYOF myoferlin 0.0367466
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0364203
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0362182
AKAP13 A kinase (PRKA) anchor protein 13 0.0361086
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0360456
EEF2 eukaryotic translation elongation factor 2 0.0357194
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0356817
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0356654
ZNF292 zinc finger protein 292 0.0356365
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0353112
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0349504
RPL23 ribosomal protein L23 0.0346121
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0341039
ATXN1 ataxin 1 0.0325501
HELZ helicase with zinc finger 0.0321828
DOCK4 dedicator of cytokinesis 4 0.0313898
PDE10A phosphodiesterase 10A 0.0313052
BASP1 brain abundant, membrane attached signal protein 1 0.0313014
S100A6 S100 calcium binding protein A6 0.0312396
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0310039
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0308489
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0308024
KYNU kynureninase 0.0307212
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0300501
SMAD2 SMAD family member 2 0.0299727
BMP6 bone morphogenetic protein 6 0.0298438
PDE8A phosphodiesterase 8A 0.0297149
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0295921
S100A10 S100 calcium binding protein A10 0.0294558
MYH9 myosin, heavy chain 9, non-muscle 0.0288992
BZW2 basic leucine zipper and W2 domains 2 0.0287818
FAM107B family with sequence similarity 107, member B 0.02874
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0287348
HLA-B major histocompatibility complex, class I, B 0.0279493
EIF1 eukaryotic translation initiation factor 1 0.0279018
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0278743
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0272401
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0271461
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0269594
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0266073
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0265242
PFN1 profilin 1 0.0262799
FGB fibrinogen beta chain 0.0259996
TFG TRK-fused gene 0.0258022
ELL2 elongation factor, RNA polymerase II, 2 0.0257879
FBXL20 F-box and leucine-rich repeat protein 20 0.0257443
SIK3 SIK family kinase 3 0.0254838
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0253433
RPLP0 ribosomal protein, large, P0 0.0251013
ZSWIM6 zinc finger, SWIM-type containing 6 0.0250399
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.024822
ITCH itchy E3 ubiquitin protein ligase 0.0247094
COPA coatomer protein complex, subunit alpha 0.0246639
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0245813
LAMA5 laminin, alpha 5 0.024534
EPAS1 endothelial PAS domain protein 1 0.0242294
SRRM2 serine/arginine repetitive matrix 2 0.0239914
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0239606
GPBP1 GC-rich promoter binding protein 1 0.0239188

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.169497
TXNRD1 thioredoxin reductase 1 -0.118064
TM4SF1 transmembrane 4 L six family member 1 -0.0856334
EGR1 early growth response 1 -0.0652092
GRAMD1B GRAM domain containing 1B -0.0605458
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0571499
IER3 immediate early response 3 -0.0548458
NAV3 neuron navigator 3 -0.0448408
ACTG1 actin gamma 1 -0.0438189
AKAP12 A kinase (PRKA) anchor protein 12 -0.0435093
THSD4 thrombospondin, type I, domain containing 4 -0.0433135
HDAC9 histone deacetylase 9 -0.0419655
MCL1 myeloid cell leukemia 1 -0.0403483
BICC1 BicC family RNA binding protein 1 -0.0401546
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0392346
MAP1B microtubule-associated protein 1B -0.0361566
AK1 adenylate kinase 1 -0.0361071
TMSB10 thymosin beta 10 -0.033498
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0324057
TPM4 tropomyosin 4 -0.0322591
TFPI2 tissue factor pathway inhibitor 2 -0.0295299
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0287069
OSMR oncostatin M receptor -0.0285349
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0273227
KLF6 Kruppel-like factor 6 -0.0260677
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0253327
ZNF804A zinc finger protein 804A -0.0251693
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0246193
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0234238
HMOX1 heme oxygenase 1 -0.0230453
DGKD diacylglycerol kinase, delta 130kDa -0.0229471
NRG1 neuregulin 1 -0.0223084
VMP1 vacuole membrane protein 1 -0.0222871
NPC1 Niemann-Pick disease, type C1 -0.022129
MKI67 marker of proliferation Ki-67 -0.0215125
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0211603
DST dystonin -0.0207901
RPS29 ribosomal protein S29 -0.0198992
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0193482
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0192381
NABP1 nucleic acid binding protein 1 -0.0183601
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0177914
RTN4 reticulon 4 -0.0177137
INHBA inhibin, beta A -0.0162111
VIM vimentin -0.0156428
TBC1D19 TBC1 domain family, member 19 -0.015636
PYGL phosphorylase, glycogen, liver -0.0155658
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0154419
THBS1 thrombospondin 1 -0.0153831
IER2 immediate early response 2 -0.0151145
BICD1 bicaudal D homolog 1 (Drosophila) -0.0149342
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0146603
CD44 CD44 molecule (Indian blood group) -0.0146506
UPP1 uridine phosphorylase 1 -0.0146479
JUN jun proto-oncogene -0.0146254
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0145257
FRMD6 FERM domain containing 6 -0.0144305
RPL37A ribosomal protein L37a -0.0143385
RASAL2 RAS protein activator like 2 -0.0141359
FLNB filamin B, beta -0.013861
RPL4 ribosomal protein L4 -0.0136693
BABAM2 BRISC and BRCA1 A complex member 2 -0.0134674
MARCHF4 membrane associated ring-CH-type finger 4 -0.0133958
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0133613
TUBB4B tubulin, beta 4B class IVb -0.0132273
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0130413
IGF2 insulin-like growth factor 2 -0.0128737
KLHL5 kelch-like family member 5 -0.0127736
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0126765
CDCP1 CUB domain containing protein 1 -0.012623
SLC39A11 solute carrier family 39, member 11 -0.0125714
ARL5B ADP-ribosylation factor-like 5B -0.0123215
RPLP2 ribosomal protein, large, P2 -0.0122555
WDR43 WD repeat domain 43 -0.0122086
S100A11 S100 calcium binding protein A11 -0.0122004
SQSTM1 sequestosome 1 -0.0121059
ATF4 activating transcription factor 4 -0.0120696
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0119682
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0118444
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0118249
EXT1 exostosin glycosyltransferase 1 -0.0117193
MAP4 microtubule-associated protein 4 -0.011623
FRMD4A FERM domain containing 4A -0.011616
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0109386
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.0109037
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0108028
IARS1 isoleucyl-tRNA synthetase 1 -0.0107987
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0106428
OGFRL1 opioid growth factor receptor-like 1 -0.0105811
TUBB tubulin, beta class I -0.0104739
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0104204
RIN2 Ras and Rab interactor 2 -0.0103439
SLC38A1 solute carrier family 38, member 1 -0.0101024
KPNB1 karyopherin (importin) beta 1 -0.00998598
RAB7A RAB7A, member RAS oncogene family -0.00998317
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.00998021
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.00991034
LIMA1 LIM domain and actin binding 1 -0.00990682
GPATCH2L G patch domain containing 2-like -0.0098722
CENPF centromere protein F, 350/400kDa -0.00986939