| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AT7519 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AT7519_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.101569 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0795045 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0728395 |
| PDE10A | phosphodiesterase 10A | 0.0617888 |
| SPAG9 | sperm associated antigen 9 | 0.0577019 |
| LMO7 | LIM domain 7 | 0.0571133 |
| PTMA | prothymosin, alpha | 0.0553135 |
| KYNU | kynureninase | 0.0549912 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0529293 |
| ACTG1 | actin gamma 1 | 0.0503035 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0467698 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0456632 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0440895 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0425835 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0417666 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0402503 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0390786 |
| RIGI | RNA sensor RIG-I | 0.0385548 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0382364 |
| CTBP2 | C-terminal binding protein 2 | 0.0376144 |
| TJP1 | tight junction protein 1 | 0.0372901 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0369475 |
| MYO1E | myosin IE | 0.0367408 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0354366 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0351736 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0345801 |
| INTS6 | integrator complex subunit 6 | 0.0326163 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0322905 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0318832 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0315443 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0310104 |
| HSPA8 | heat shock 70kDa protein 8 | 0.030846 |
| RPS8 | ribosomal protein S8 | 0.030275 |
| ANXA2 | annexin A2 | 0.0302196 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0301636 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0298573 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.02978 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0297472 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0296819 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0296553 |
| HM13 | histocompatibility (minor) 13 | 0.0295166 |
| ABLIM1 | actin binding LIM protein 1 | 0.029151 |
| PTK2 | protein tyrosine kinase 2 | 0.0290011 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0289566 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0284175 |
| RBM39 | RNA binding motif protein 39 | 0.0283561 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0282458 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.028158 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0280596 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0272485 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0268651 |
| TMSB4X | thymosin beta 4, X-linked | 0.0268132 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0266992 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0263004 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.026115 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0259334 |
| RNF149 | ring finger protein 149 | 0.0257652 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0255335 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0253811 |
| ANO6 | anoctamin 6 | 0.0253619 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0251412 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0249781 |
| SMAD3 | SMAD family member 3 | 0.0249579 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0247644 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0245414 |
| ANXA1 | annexin A1 | 0.0244958 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0244946 |
| RPS5 | ribosomal protein S5 | 0.0243314 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0242683 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0235864 |
| FUS | FUS RNA binding protein | 0.0230392 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0230127 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0227974 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0227024 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0224741 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0223118 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0221319 |
| CANX | calnexin | 0.0220913 |
| FN1 | fibronectin 1 | 0.0220661 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0219131 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0217303 |
| POTEF | POTE ankyrin domain family, member F | 0.0216044 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0215277 |
| DST | dystonin | 0.0213761 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0211631 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.021112 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0210325 |
| CD44 | CD44 molecule (Indian blood group) | 0.0206822 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0205216 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0205091 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.020495 |
| FLNB | filamin B, beta | 0.0203812 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0203745 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0203711 |
| MYO6 | myosin VI | 0.020196 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0201262 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0201071 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0200691 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0200494 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0199848 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.152858 |
| ATOSA | atos homolog A | -0.103632 |
| LAMC2 | laminin, gamma 2 | -0.0912783 |
| S100A9 | S100 calcium binding protein A9 | -0.0875236 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0723288 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0676649 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0676012 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0661334 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0618165 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0608493 |
| SBF2 | SET binding factor 2 | -0.0580077 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0573093 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0537854 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0534072 |
| RAI14 | retinoic acid induced 14 | -0.0520998 |
| TXNRD1 | thioredoxin reductase 1 | -0.0484982 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.047545 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.045136 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0447202 |
| STC1 | stanniocalcin 1 | -0.0435852 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0426778 |
| RREB1 | ras responsive element binding protein 1 | -0.0425562 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0421195 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0417202 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0415246 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0403499 |
| PRDM1 | PR domain containing 1, with ZNF domain | -0.0398915 |
| KLF6 | Kruppel-like factor 6 | -0.0388292 |
| MEF2A | myocyte enhancer factor 2A | -0.0353627 |
| CSTB | cystatin B (stefin B) | -0.0352287 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0346039 |
| ABHD17C | abhydrolase domain containing 17C | -0.0344795 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0336212 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0333003 |
| CLMP | CXADR-like membrane protein | -0.0330252 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0329931 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0322976 |
| ITGB4 | integrin, beta 4 | -0.032273 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0322191 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.0316432 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0315707 |
| HLA-A | major histocompatibility complex, class I, A | -0.0312984 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0311476 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0309065 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0308372 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0308168 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.0308151 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0303505 |
| NHSL1 | NHS-like 1 | -0.0302249 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0299847 |
| RAD51B | RAD51 paralog B | -0.0299158 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0298805 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0294152 |
| SFMBT2 | Scm-like with four mbt domains 2 | -0.02939 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0293194 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | -0.0292889 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.029286 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0290209 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.028963 |
| KRT17 | keratin 17, type I | -0.0288646 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0287866 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.028743 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0286564 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0282382 |
| RFX7 | regulatory factor X, 7 | -0.028011 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0276201 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0275989 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0273947 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0272967 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0272255 |
| UBE3A | ubiquitin protein ligase E3A | -0.0271714 |
| RNF213 | ring finger protein 213 | -0.0271535 |
| TBC1D5 | TBC1 domain family, member 5 | -0.026956 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0269354 |
| MUC16 | mucin 16, cell surface associated | -0.0268348 |
| HLA-B | major histocompatibility complex, class I, B | -0.0267964 |
| VGF | VGF nerve growth factor inducible | -0.026774 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0263105 |
| CLDN4 | claudin 4 | -0.0259282 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0257711 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0253415 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0252606 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0251648 |
| MAP7 | microtubule-associated protein 7 | -0.0250648 |
| CSNK1E | casein kinase 1, epsilon | -0.0249715 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | -0.0247365 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0247353 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0244661 |
| ZNF217 | zinc finger protein 217 | -0.0244038 |
| WASF2 | WAS protein family, member 2 | -0.0243819 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0243789 |
| CXXC1 | CXXC finger protein 1 | -0.0241309 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0240294 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0236782 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0236197 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0233467 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.023337 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0232065 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0231167 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0228471 |
