AT7519_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.445259
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.162225
ERRFI1 ERBB receptor feedback inhibitor 1 0.0966571
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0951348
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0946925
TPM3 tropomyosin 3 0.0925541
EEF2 eukaryotic translation elongation factor 2 0.0885367
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0883828
MCL1 myeloid cell leukemia 1 0.0786914
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0774863
COPA coatomer protein complex, subunit alpha 0.0735362
CSDE1 cold shock domain containing E1, RNA-binding 0.0677045
ZCCHC7 zinc finger, CCHC domain containing 7 0.0665961
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0659187
GRAMD1B GRAM domain containing 1B 0.0628069
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0619961
YBX3 Y box binding protein 3 0.0596818
THSD4 thrombospondin, type I, domain containing 4 0.0571447
CSNK1A1 casein kinase 1, alpha 1 0.0560024
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0557274
PDE4D phosphodiesterase 4D, cAMP-specific 0.0538662
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0537629
ADAR adenosine deaminase, RNA-specific 0.0534866
RBM39 RNA binding motif protein 39 0.0534233
IGF1R insulin-like growth factor 1 receptor 0.0503805
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0500692
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0494768
CANX calnexin 0.0487089
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0471861
VCL vinculin 0.0459134
POTEF POTE ankyrin domain family, member F 0.0458027
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0457096
TLN1 talin 1 0.0447739
ELL2 elongation factor, RNA polymerase II, 2 0.0446839
RAB7A RAB7A, member RAS oncogene family 0.044448
VMP1 vacuole membrane protein 1 0.0441864
PDE10A phosphodiesterase 10A 0.0441603
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0440509
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0434306
AHNAK AHNAK nucleoprotein 0.0433778
KDM2A lysine (K)-specific demethylase 2A 0.0433165
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0426867
KRT18 keratin 18, type I 0.0426248
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0416863
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0413012
DOCK5 dedicator of cytokinesis 5 0.0409587
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0398608
WWTR1 WW domain containing transcription regulator 1 0.039534
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0391047
VIM vimentin 0.0390782
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0390519
BRD2 bromodomain containing 2 0.0390071
TPM4 tropomyosin 4 0.0389654
STK4 serine/threonine kinase 4 0.0386793
ATP11A ATPase, class VI, type 11A 0.0384045
ACTG1 actin gamma 1 0.0382327
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0380145
PDIA6 protein disulfide isomerase family A, member 6 0.0379725
CTTN cortactin 0.0379127
HSPA8 heat shock 70kDa protein 8 0.0377194
SRRM2 serine/arginine repetitive matrix 2 0.0376719
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0371966
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0368783
UBC ubiquitin C 0.0367783
LOC102724023 ES1 protein homolog, mitochondrial 0.0366011
TRIP12 thyroid hormone receptor interactor 12 0.0359523
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0358062
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0354236
FMNL2 formin-like 2 0.0353412
STC1 stanniocalcin 1 0.0353393
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.034928
RICTOR RPTOR independent companion of MTOR, complex 2 0.034743
EML4 echinoderm microtubule associated protein like 4 0.0346352
LDHA lactate dehydrogenase A 0.0345322
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0345091
SETX senataxin 0.0344879
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0344325
USP34 ubiquitin specific peptidase 34 0.0342807
WNK1 WNK lysine deficient protein kinase 1 0.0339455
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0335942
SENP6 SUMO1/sentrin specific peptidase 6 0.0335473
ZNF207 zinc finger protein 207 0.0333913
ANO6 anoctamin 6 0.033304
CLTC clathrin, heavy chain (Hc) 0.0330282
KDM3A lysine (K)-specific demethylase 3A 0.0326768
STAU1 staufen double-stranded RNA binding protein 1 0.0323249
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0323209
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0322202
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0317615
FBXO11 F-box protein 11 0.0317571
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0316852
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0316323
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0314836
MYH9 myosin, heavy chain 9, non-muscle 0.0314374
NIPBL Nipped-B homolog (Drosophila) 0.0314212
TRA2A transformer 2 alpha homolog (Drosophila) 0.0313886
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0313028
LATS2 large tumor suppressor kinase 2 0.0312697
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0309039
MACF1 microtubule-actin crosslinking factor 1 0.0305596

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.149938
TFPI2 tissue factor pathway inhibitor 2 -0.121115
MT2A metallothionein 2A -0.0652746
RPL35A ribosomal protein L35a -0.064874
RPLP1 ribosomal protein, large, P1 -0.0539811
RPS29 ribosomal protein S29 -0.0474415
RPL37A ribosomal protein L37a -0.0428653
RPL31 ribosomal protein L31 -0.0424599
RPS15 ribosomal protein S15 -0.0413708
RPL38 ribosomal protein L38 -0.0413315
RPL5 ribosomal protein L5 -0.0403334
RPL12 ribosomal protein L12 -0.0393965
RPLP2 ribosomal protein, large, P2 -0.0393321
MYL12B myosin, light chain 12B, regulatory -0.038648
RPL9 ribosomal protein L9 -0.0364432
RPL34 ribosomal protein L34 -0.0360862
RPL36 ribosomal protein L36 -0.0358657
RPS19 ribosomal protein S19 -0.0355325
RPL23 ribosomal protein L23 -0.0345189
RPL32 ribosomal protein L32 -0.0342255
RTN4 reticulon 4 -0.0326061
FTL ferritin, light polypeptide -0.0320578
RPS27 ribosomal protein S27 -0.0313264
ATP5F1E ATP synthase F1 subunit epsilon -0.0308981
RPL19 ribosomal protein L19 -0.0300875
NACA nascent polypeptide-associated complex alpha subunit -0.0296434
RPS10 ribosomal protein S10 -0.0295011
RPL27 ribosomal protein L27 -0.028878
SMC4 structural maintenance of chromosomes 4 -0.0272874
RPS21 ribosomal protein S21 -0.0269252
RPS6 ribosomal protein S6 -0.0264921
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0251353
RPL35 ribosomal protein L35 -0.0250686
ZBTB20 zinc finger and BTB domain containing 20 -0.0243791
S100A11 S100 calcium binding protein A11 -0.0240938
RPS3 ribosomal protein S3 -0.023901
RPS17 ribosomal protein S17 -0.023665
RPS23 ribosomal protein S23 -0.0236597
WSB1 WD repeat and SOCS box containing 1 -0.023193
SEC61G Sec61 gamma subunit -0.0231867
RPL26 ribosomal protein L26 -0.022602
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0222624
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0218323
RPS14 ribosomal protein S14 -0.0210349
RPL28 ribosomal protein L28 -0.020797
PNISR PNN-interacting serine/arginine-rich protein -0.0207939
EGR1 early growth response 1 -0.0197397
EIF5B eukaryotic translation initiation factor 5B -0.0197041
RPS16 ribosomal protein S16 -0.0196958
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0195121
RPL30 ribosomal protein L30 -0.0192713
RPS8 ribosomal protein S8 -0.0191642
SEPTIN7 septin 7 -0.0188946
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0185997
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0185384
TPT1 tumor protein, translationally-controlled 1 -0.0173433
RASAL2 RAS protein activator like 2 -0.0171738
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0170371
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0170131
RPS11 ribosomal protein S11 -0.0167734
RPL8 ribosomal protein L8 -0.0167386
EGFR epidermal growth factor receptor -0.0165253
HMGB1 high mobility group box 1 -0.0163409
GSTP1 glutathione S-transferase pi 1 -0.0161204
SRSF11 serine/arginine-rich splicing factor 11 -0.016079
UBL5 ubiquitin-like 5 -0.0157299
TUBB4B tubulin, beta 4B class IVb -0.015655
LDHB lactate dehydrogenase B -0.0154711
PBX3 pre-B-cell leukemia homeobox 3 -0.0153452
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.015302
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0151605
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0146805
TUBA1C tubulin, alpha 1c -0.0146789
MRPL51 mitochondrial ribosomal protein L51 -0.014558
PFN1 profilin 1 -0.0142405
ANKRD12 ankyrin repeat domain 12 -0.0141911
RPL7A ribosomal protein L7a -0.0141026
CBX3 chromobox homolog 3 -0.0140808
RPS13 ribosomal protein S13 -0.0140379
ZNF292 zinc finger protein 292 -0.0140043
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0139798
PLCB4 phospholipase C, beta 4 -0.0138987
PKP4 plakophilin 4 -0.0138568
CDK19 cyclin-dependent kinase 19 -0.0137158
PTBP3 polypyrimidine tract binding protein 3 -0.0136357
SPIRE1 spire-type actin nucleation factor 1 -0.0135151
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0134359
ATP5MF ATP synthase membrane subunit f -0.0133063
RANBP17 RAN binding protein 17 -0.0132945
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0132563
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0131725
WDPCP WD repeat containing planar cell polarity effector -0.0129271
UBE2B ubiquitin-conjugating enzyme E2B -0.0128788
DIAPH3 diaphanous-related formin 3 -0.0128612
SFXN1 sideroflexin 1 -0.0128354
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -0.0128341
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0127423
S100A9 S100 calcium binding protein A9 -0.0126159
RPS4X ribosomal protein S4, X-linked -0.0125518
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.0125448