AT7519_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.09685
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0958007
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0869025
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0860715
SAMD4A sterile alpha motif domain containing 4A 0.0827442
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0778259
ALCAM activated leukocyte cell adhesion molecule 0.072082
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0681738
EFNA5 ephrin-A5 0.0678671
NDRG1 N-myc downstream regulated 1 0.0649071
NAV2 neuron navigator 2 0.0500133
SMAD3 SMAD family member 3 0.0446168
ARRDC3 arrestin domain containing 3 0.0446163
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0430699
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0420742
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0394048
RUNX1 runt-related transcription factor 1 0.0348086
SGMS2 sphingomyelin synthase 2 0.0347577
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0342589
EEF2 eukaryotic translation elongation factor 2 0.034227
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336339
FHIT fragile histidine triad 0.0324595
FAM13A family with sequence similarity 13, member A 0.0312899
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0311034
AREG amphiregulin 0.0308276
LDHA lactate dehydrogenase A 0.0304832
CD109 CD109 molecule 0.0303061
LMO7 LIM domain 7 0.0298049
VEGFA vascular endothelial growth factor A 0.0295251
KIAA1217 KIAA1217 0.0289669
ADAM9 ADAM metallopeptidase domain 9 0.0280567
ELL2 elongation factor, RNA polymerase II, 2 0.0267304
ZNF292 zinc finger protein 292 0.0264988
TRIO trio Rho guanine nucleotide exchange factor 0.0264124
BHLHE40 basic helix-loop-helix family, member e40 0.0257157
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0256148
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0255828
MYOF myoferlin 0.0248436
ANO6 anoctamin 6 0.0248252
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0246489
STEAP4 STEAP family member 4 0.0245359
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0245046
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0236597
NAMPT nicotinamide phosphoribosyltransferase 0.0236164
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0234378
ZFP36L1 ZFP36 ring finger protein-like 1 0.0229724
ATP11A ATPase, class VI, type 11A 0.0228787
SVIL supervillin 0.0227375
DSCAM Down syndrome cell adhesion molecule 0.0224012
DOCK5 dedicator of cytokinesis 5 0.0223274
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0222105
ZBTB38 zinc finger and BTB domain containing 38 0.0221205
DEK DEK proto-oncogene 0.0220107
INTS6 integrator complex subunit 6 0.0216002
ATXN1 ataxin 1 0.021518
HMGB2 high mobility group box 2 0.0214773
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0207976
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0206392
RYBP RING1 and YY1 binding protein 0.0204024
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.020346
MBNL1 muscleblind-like splicing regulator 1 0.02023
RAD21 RAD21 homolog (S. pombe) 0.0199475
OSMR oncostatin M receptor 0.019921
DPYSL2 dihydropyrimidinase-like 2 0.0196984
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0196724
BRD2 bromodomain containing 2 0.0196414
SON SON DNA binding protein 0.019023
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0189563
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0187546
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0187147
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0185797
ARHGAP42 Rho GTPase activating protein 42 0.0185459
FER fer (fps/fes related) tyrosine kinase 0.0185081
FXR1 fragile X mental retardation, autosomal homolog 1 0.0184921
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0183088
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0181717
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0180809
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0180513
SEPTIN9 septin 9 0.0180462
RNF145 ring finger protein 145 0.0180046
EREG epiregulin 0.0179583
PTK2 protein tyrosine kinase 2 0.0179523
SMC4 structural maintenance of chromosomes 4 0.0178915
RPLP0 ribosomal protein, large, P0 0.0178507
CENPF centromere protein F, 350/400kDa 0.0176189
DUSP6 dual specificity phosphatase 6 0.0175492
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0175308
ECT2 epithelial cell transforming 2 0.0172596
MCTP2 multiple C2 domains, transmembrane 2 0.0172412
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0172006
CCNI cyclin I 0.0171717
NCOA7 nuclear receptor coactivator 7 0.0171264
ZSWIM6 zinc finger, SWIM-type containing 6 0.0169706
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0169495
CLINT1 clathrin interactor 1 0.0169307
PEG10 paternally expressed 10 0.0168095
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0167572
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0166474
CAPN2 calpain 2, (m/II) large subunit 0.016601
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0165446

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.151176
FTL ferritin, light polypeptide -0.145985
TMSB10 thymosin beta 10 -0.113854
LAMB3 laminin, beta 3 -0.0908429
TPT1 tumor protein, translationally-controlled 1 -0.0814331
RPL37A ribosomal protein L37a -0.0758601
ACTG1 actin gamma 1 -0.0711201
EIF1 eukaryotic translation initiation factor 1 -0.0702111
RPS29 ribosomal protein S29 -0.0698986
FBXO32 F-box protein 32 -0.0692362
RPLP2 ribosomal protein, large, P2 -0.0638717
WSB1 WD repeat and SOCS box containing 1 -0.0584221
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0574578
RPS3 ribosomal protein S3 -0.0570865
HLA-B major histocompatibility complex, class I, B -0.0565686
RPS12 ribosomal protein S12 -0.0536683
IFI27 interferon, alpha-inducible protein 27 -0.0506853
RPL23 ribosomal protein L23 -0.0480543
HLA-A major histocompatibility complex, class I, A -0.047925
MT2A metallothionein 2A -0.0467625
CSTB cystatin B (stefin B) -0.0466057
MAP1B microtubule-associated protein 1B -0.0452949
RPS13 ribosomal protein S13 -0.045253
RPL9 ribosomal protein L9 -0.0443824
IFI6 interferon, alpha-inducible protein 6 -0.0441672
RPS17 ribosomal protein S17 -0.0438899
RPS25 ribosomal protein S25 -0.0434823
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0429653
RPL31 ribosomal protein L31 -0.0426195
RPS23 ribosomal protein S23 -0.0421796
RPS6 ribosomal protein S6 -0.0419618
RPS27A ribosomal protein S27a -0.041408
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0395668
PLAUR plasminogen activator, urokinase receptor -0.039063
UPP1 uridine phosphorylase 1 -0.0390135
LAMC2 laminin, gamma 2 -0.0386795
LPP LIM domain containing preferred translocation partner in lipoma -0.0386443
G0S2 G0/G1 switch 2 -0.038393
RPS8 ribosomal protein S8 -0.0381972
TPM4 tropomyosin 4 -0.0378366
RPS19 ribosomal protein S19 -0.0374326
MDK midkine (neurite growth-promoting factor 2) -0.0365094
RPL37 ribosomal protein L37 -0.0361412
ISG15 ISG15 ubiquitin-like modifier -0.0357252
VIM vimentin -0.0354732
RPL35A ribosomal protein L35a -0.0351471
ITCH itchy E3 ubiquitin protein ligase -0.0349409
UBE2H ubiquitin-conjugating enzyme E2H -0.0343483
RPS10 ribosomal protein S10 -0.0341972
RPL34 ribosomal protein L34 -0.0340284
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0336979
SLMAP sarcolemma associated protein -0.0332927
RBM25 RNA binding motif protein 25 -0.032788
ERBIN erbb2 interacting protein -0.0318724
RPS27 ribosomal protein S27 -0.0315297
OGA O-GlcNAcase -0.0313809
TMEM165 transmembrane protein 165 -0.0307158
RPS21 ribosomal protein S21 -0.0306979
RPL15 ribosomal protein L15 -0.0306497
RPL36 ribosomal protein L36 -0.0305197
RPL36A ribosomal protein L36a -0.027724
SOX4 SRY (sex determining region Y)-box 4 -0.0277123
CD63 CD63 molecule -0.0269765
RPL11 ribosomal protein L11 -0.0266455
ENO2 enolase 2 (gamma, neuronal) -0.0266304
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0263687
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0263328
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.025905
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0257159
BASP1 brain abundant, membrane attached signal protein 1 -0.0255258
RPL7A ribosomal protein L7a -0.0255032
RPL38 ribosomal protein L38 -0.0254856
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0253783
PDLIM5 PDZ and LIM domain 5 -0.0249575
RPS14 ribosomal protein S14 -0.0246269
IGFBP3 insulin-like growth factor binding protein 3 -0.024601
RPS24 ribosomal protein S24 -0.0244414
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0241631
RPLP1 ribosomal protein, large, P1 -0.0241339
RPL19 ribosomal protein L19 -0.023916
H3-3B H3.3 histone B -0.0237653
CAVIN1 caveolae associated protein 1 -0.0236501
RPL26 ribosomal protein L26 -0.023647
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0235994
RBM39 RNA binding motif protein 39 -0.0233476
C15ORF48 chromosome 15 open reading frame 48 -0.0231884
RPS16 ribosomal protein S16 -0.0230134
MSI2 musashi RNA-binding protein 2 -0.022897
KLHL24 kelch-like family member 24 -0.0222016
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0221993
S100A11 S100 calcium binding protein A11 -0.0220261
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0219965
STRN3 striatin, calmodulin binding protein 3 -0.0216553
FBXL20 F-box and leucine-rich repeat protein 20 -0.0216504
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0216158
RPL30 ribosomal protein L30 -0.0215736
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0215566
RAI14 retinoic acid induced 14 -0.0209709
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0208001
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0207449