AT7519_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the AT7519_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.075294
PDE10A phosphodiesterase 10A 0.0685403
COL8A1 collagen, type VIII, alpha 1 0.0634139
KYNU kynureninase 0.0607984
PSD3 pleckstrin and Sec7 domain containing 3 0.0532376
SMOC1 SPARC related modular calcium binding 1 0.0522672
ESYT2 extended synaptotagmin-like protein 2 0.0512691
DST dystonin 0.0431453
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0409373
RAB3B RAB3B, member RAS oncogene family 0.0386501
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0377896
EEF2 eukaryotic translation elongation factor 2 0.0370157
MAML3 mastermind-like 3 (Drosophila) 0.036571
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0363555
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0337094
GRAMD1B GRAM domain containing 1B 0.0327851
CTIF CBP80/20-dependent translation initiation factor 0.0312228
SMAD2 SMAD family member 2 0.0296276
ELL2 elongation factor, RNA polymerase II, 2 0.0292461
FNDC3A fibronectin type III domain containing 3A 0.0286485
PTPRM protein tyrosine phosphatase, receptor type, M 0.0285056
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0279081
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0270973
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0250913
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0245567
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0236212
PRELID2 PRELI domain containing 2 0.0228713
DGKD diacylglycerol kinase, delta 130kDa 0.0227186
ZSWIM6 zinc finger, SWIM-type containing 6 0.0220809
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0219827
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.021824
PRKN parkin RBR E3 ubiquitin protein ligase 0.0217804
LAMA1 laminin, alpha 1 0.0212018
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0207083
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.020701
FNIP1 folliculin interacting protein 1 0.0202123
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0194423
RPH3AL rabphilin 3A-like (without C2 domains) 0.0193684
NCAM1 neural cell adhesion molecule 1 0.0187703
DENND1A DENN/MADD domain containing 1A 0.018582
DISP1 dispatched homolog 1 (Drosophila) 0.0183167
HSPA8 heat shock 70kDa protein 8 0.0181795
BDNF brain-derived neurotrophic factor 0.0180868
PTEN phosphatase and tensin homolog 0.0178116
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0177308
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0176731
HDAC4 histone deacetylase 4 0.0176136
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0174687
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0173846
WWTR1 WW domain containing transcription regulator 1 0.0173548
FMNL2 formin-like 2 0.0173182
SCARA5 scavenger receptor class A, member 5 0.0172212
ATXN7 ataxin 7 0.0169357
RSAD2 radical S-adenosyl methionine domain containing 2 0.0164098
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0162542
INHBA inhibin, beta A 0.0162146
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0160928
FAM107B family with sequence similarity 107, member B 0.0158721
SLF1 SMC5-SMC6 complex localization factor 1 0.015858
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.015761
PLK2 polo-like kinase 2 0.0157461
AKAP13 A kinase (PRKA) anchor protein 13 0.0155364
MBD5 methyl-CpG binding domain protein 5 0.0153861
KMT2E lysine (K)-specific methyltransferase 2E 0.0153056
P3H2 prolyl 3-hydroxylase 2 0.01516
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0150274
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0149641
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0149403
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.01484
ATG10 autophagy related 10 0.0147609
COL5A2 collagen, type V, alpha 2 0.0146851
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0146271
KDM6A lysine (K)-specific demethylase 6A 0.0146228
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0145538
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0145241
ALPK2 alpha-kinase 2 0.014457
GPBP1 GC-rich promoter binding protein 1 0.0143651
SVIL supervillin 0.0143609
CCDC6 coiled-coil domain containing 6 0.0143546
NBAS neuroblastoma amplified sequence 0.0140355
CHL1 cell adhesion molecule L1-like 0.0139859
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0139143
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.013835
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0138282
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0137002
RCOR1 REST corepressor 1 0.0134993
ZEB2 zinc finger E-box binding homeobox 2 0.0134284
ZNF638 zinc finger protein 638 0.0132888
TENT5A terminal nucleotidyltransferase 5A 0.0132514
DNER delta/notch-like EGF repeat containing 0.0129297
FAM168A family with sequence similarity 168, member A 0.0129119
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0128708
WWOX WW domain containing oxidoreductase 0.0128698
SEPTIN9 septin 9 0.0128684
GIGYF2 GRB10 interacting GYF protein 2 0.012855
NHSL1 NHS-like 1 0.0127128
NT5C2 5'-nucleotidase, cytosolic II 0.0126578
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0125856
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0125626
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0125484

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.175151
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.12249
TPT1 tumor protein, translationally-controlled 1 -0.113017
TMSB10 thymosin beta 10 -0.110959
FN1 fibronectin 1 -0.110238
VIM vimentin -0.110049
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100053
RPL37A ribosomal protein L37a -0.0775719
RPS24 ribosomal protein S24 -0.0721907
TM4SF1 transmembrane 4 L six family member 1 -0.0682073
PTMA prothymosin, alpha -0.0676921
RPL26 ribosomal protein L26 -0.064782
GDA guanine deaminase -0.0637747
PDE4D phosphodiesterase 4D, cAMP-specific -0.0635145
RPS12 ribosomal protein S12 -0.061891
RPLP1 ribosomal protein, large, P1 -0.0608494
RPS6 ribosomal protein S6 -0.0602785
RPS3 ribosomal protein S3 -0.0598438
RPLP2 ribosomal protein, large, P2 -0.0563613
FTL ferritin, light polypeptide -0.0509485
ACTG1 actin gamma 1 -0.0500234
RPL12 ribosomal protein L12 -0.0496396
TFPI2 tissue factor pathway inhibitor 2 -0.049138
RPS8 ribosomal protein S8 -0.0491206
RPL9 ribosomal protein L9 -0.0483411
RPL31 ribosomal protein L31 -0.0479175
RPS29 ribosomal protein S29 -0.0469619
RPL35A ribosomal protein L35a -0.0467706
RPS27A ribosomal protein S27a -0.0462507
RPS23 ribosomal protein S23 -0.044908
RPS21 ribosomal protein S21 -0.041897
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.039959
RPLP0 ribosomal protein, large, P0 -0.0396367
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0392762
RPL19 ribosomal protein L19 -0.0389359
RPL36A ribosomal protein L36a -0.0384243
RPL38 ribosomal protein L38 -0.0376648
RPS19 ribosomal protein S19 -0.036504
RPS17 ribosomal protein S17 -0.0364673
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0363589
AKR1C1 aldo-keto reductase family 1, member C1 -0.0362006
NAMPT nicotinamide phosphoribosyltransferase -0.0355577
RPL34 ribosomal protein L34 -0.0346206
EIF1 eukaryotic translation initiation factor 1 -0.0339744
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0337711
S100A6 S100 calcium binding protein A6 -0.033604
TPM4 tropomyosin 4 -0.0331645
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0330211
ASPH aspartate beta-hydroxylase -0.0326412
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0325632
RPL7A ribosomal protein L7a -0.0315588
RGS2 regulator of G-protein signaling 2 -0.0307141
NALF1 NALCN channel auxiliary factor 1 -0.0306947
RPS14 ribosomal protein S14 -0.0305721
RPL11 ribosomal protein L11 -0.0304792
SRGN serglycin -0.0300415
RPL23 ribosomal protein L23 -0.0299467
RPS13 ribosomal protein S13 -0.0298446
RPL13A ribosomal protein L13a -0.0296658
RPS27 ribosomal protein S27 -0.029661
SMYD3 SET and MYND domain containing 3 -0.0295596
MT2A metallothionein 2A -0.0287296
TXNRD1 thioredoxin reductase 1 -0.0280531
RPL36 ribosomal protein L36 -0.0276056
IER3 immediate early response 3 -0.0262211
RPS16 ribosomal protein S16 -0.0258538
RPS25 ribosomal protein S25 -0.0256433
RPL37 ribosomal protein L37 -0.025228
PRDX1 peroxiredoxin 1 -0.0251375
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0251105
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0250309
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0247066
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0245111
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0244463
NRCAM neuronal cell adhesion molecule -0.0243625
THSD4 thrombospondin, type I, domain containing 4 -0.0242452
WARS1 tryptophanyl-tRNA synthetase 1 -0.0234172
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0233586
RPL30 ribosomal protein L30 -0.0233132
AKR1C2 aldo-keto reductase family 1, member C2 -0.0232743
S100A10 S100 calcium binding protein A10 -0.0227322
ENO1 enolase 1, (alpha) -0.0226774
MAP1B microtubule-associated protein 1B -0.0222638
TRIO trio Rho guanine nucleotide exchange factor -0.0217957
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0212914
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0212489
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.020916
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0208942
CDH13 cadherin 13 -0.0207526
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.020477
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0203846
RPL32 ribosomal protein L32 -0.0197771
MGST1 microsomal glutathione S-transferase 1 -0.0194702
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0193197
RPL27 ribosomal protein L27 -0.0193183
HLA-A major histocompatibility complex, class I, A -0.0193008
RPL35 ribosomal protein L35 -0.0190397
RSL1D1 ribosomal L1 domain containing 1 -0.018699
RAN RAN, member RAS oncogene family -0.0185878
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0185307