| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AT7519 perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AT7519_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | 0.143465 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.134812 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0812429 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0787301 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0745664 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0656637 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0655909 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0653852 |
| CLTC | clathrin, heavy chain (Hc) | 0.0647462 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0622406 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0600129 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0590036 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0588424 |
| RPL36 | ribosomal protein L36 | 0.0587897 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0583541 |
| VIM | vimentin | 0.0579006 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0577477 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0557932 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.053948 |
| RPL12 | ribosomal protein L12 | 0.0536102 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.053277 |
| DST | dystonin | 0.0528476 |
| PTK2 | protein tyrosine kinase 2 | 0.0522292 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0515489 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0505675 |
| TPI1 | triosephosphate isomerase 1 | 0.0501667 |
| LDHA | lactate dehydrogenase A | 0.0500424 |
| CANX | calnexin | 0.0481731 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0468642 |
| VMP1 | vacuole membrane protein 1 | 0.0463523 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0461097 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0455585 |
| CDH13 | cadherin 13 | 0.0449803 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0438788 |
| NDRG1 | N-myc downstream regulated 1 | 0.0437584 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0436533 |
| CALR | calreticulin | 0.0436341 |
| PKM | pyruvate kinase, muscle | 0.0418754 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0417599 |
| POTEF | POTE ankyrin domain family, member F | 0.0413483 |
| RPS8 | ribosomal protein S8 | 0.0413011 |
| RPL19 | ribosomal protein L19 | 0.0410067 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0402362 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.039994 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0397008 |
| VEGFA | vascular endothelial growth factor A | 0.0394711 |
| RORA | RAR-related orphan receptor A | 0.0394111 |
| AHNAK | AHNAK nucleoprotein | 0.0389352 |
| MED13 | mediator complex subunit 13 | 0.038856 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.038399 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.038039 |
| PGK1 | phosphoglycerate kinase 1 | 0.0376683 |
| PARD3 | par-3 family cell polarity regulator | 0.0373632 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0370046 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0366476 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0365426 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0363372 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0363136 |
| MATR3 | matrin 3 | 0.0358963 |
| MAP4 | microtubule-associated protein 4 | 0.0357461 |
| MYOF | myoferlin | 0.0343348 |
| TENM3 | teneurin transmembrane protein 3 | 0.034148 |
| ZNF292 | zinc finger protein 292 | 0.0341212 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0339971 |
| FAM13A | family with sequence similarity 13, member A | 0.0339166 |
| PDE10A | phosphodiesterase 10A | 0.0338291 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0329198 |
| ZNF148 | zinc finger protein 148 | 0.0321136 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0316784 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0316627 |
| RPLP0 | ribosomal protein, large, P0 | 0.0312497 |
| ACTG1 | actin gamma 1 | 0.0312098 |
| FLNB | filamin B, beta | 0.031137 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0306505 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0305647 |
| RPS25 | ribosomal protein S25 | 0.0304604 |
| RPL35A | ribosomal protein L35a | 0.030397 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0301347 |
| FTL | ferritin, light polypeptide | 0.0296549 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0295366 |
| SPAG9 | sperm associated antigen 9 | 0.0289727 |
| RPS12 | ribosomal protein S12 | 0.0288896 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0286852 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0285846 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0282634 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.028229 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.027899 |
| RTN4 | reticulon 4 | 0.0277903 |
| STC1 | stanniocalcin 1 | 0.0276162 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0274205 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0272386 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0268557 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0268548 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.026854 |
| RPS24 | ribosomal protein S24 | 0.0265036 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0262009 |
| RPL11 | ribosomal protein L11 | 0.0261709 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.02612 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0246725 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0242746 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.113851 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0991473 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0979484 |
| ITGA6 | integrin, alpha 6 | -0.091002 |
| SLTM | SAFB-like, transcription modulator | -0.0861112 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0807889 |
| TMSB10 | thymosin beta 10 | -0.0799557 |
| PTMA | prothymosin, alpha | -0.0797767 |
| ATP11A | ATPase, class VI, type 11A | -0.0783334 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0738161 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0728603 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0728439 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0720115 |
| PRKCA | protein kinase C, alpha | -0.0719643 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0704434 |
| UBAC2 | UBA domain containing 2 | -0.0696252 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0686863 |
| EGFR | epidermal growth factor receptor | -0.0681571 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.065321 |
| NHSL1 | NHS-like 1 | -0.0650061 |
| PCBP2 | poly(rC) binding protein 2 | -0.0648443 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0619811 |
| PDE8A | phosphodiesterase 8A | -0.0616827 |
| GSE1 | Gse1 coiled-coil protein | -0.0606538 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0596998 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0595692 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0583466 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | -0.0577523 |
| RPLP1 | ribosomal protein, large, P1 | -0.0555319 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0549911 |
| FN1 | fibronectin 1 | -0.0548709 |
| RPS6 | ribosomal protein S6 | -0.0535144 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0533729 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0532093 |
| LMO7 | LIM domain 7 | -0.0529349 |
| RPL27A | ribosomal protein L27a | -0.0521063 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0516213 |
| CNKSR3 | CNKSR family member 3 | -0.0507303 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0502442 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0499787 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0492462 |
| RFX7 | regulatory factor X, 7 | -0.0485329 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0481041 |
| HMGA2 | high mobility group AT-hook 2 | -0.0475696 |
| TXNIP | thioredoxin interacting protein | -0.046716 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0466632 |
| HLA-E | major histocompatibility complex, class I, E | -0.0459317 |
| MYO10 | myosin X | -0.0459051 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0451244 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0450849 |
| OSMR | oncostatin M receptor | -0.0448379 |
| CCDC91 | coiled-coil domain containing 91 | -0.0443422 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0441628 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.043047 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0429393 |
| JMJD1C | jumonji domain containing 1C | -0.0409052 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0408016 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0402677 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0400785 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0396194 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.039138 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0383175 |
| FOXP1 | forkhead box P1 | -0.0373696 |
| TMEM165 | transmembrane protein 165 | -0.0369558 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.036352 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0360565 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0357225 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.034685 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0344607 |
| SVIL | supervillin | -0.0337565 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0336701 |
| TPR | translocated promoter region, nuclear basket protein | -0.0335673 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0331267 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0331047 |
| RPS29 | ribosomal protein S29 | -0.0327236 |
| H3-3B | H3.3 histone B | -0.0323763 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0322921 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0322566 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0311411 |
| RPL36A | ribosomal protein L36a | -0.0310967 |
| MED13L | mediator complex subunit 13-like | -0.0309989 |
| RAD51B | RAD51 paralog B | -0.0303013 |
| CD44 | CD44 molecule (Indian blood group) | -0.0296619 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0294767 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0291839 |
| GOLGB1 | golgin B1 | -0.0287793 |
| NF1 | neurofibromin 1 | -0.0281378 |
| FMNL2 | formin-like 2 | -0.0276279 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0273635 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0273359 |
| RPLP2 | ribosomal protein, large, P2 | -0.0270307 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0257707 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0254163 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0252655 |
| MT2A | metallothionein 2A | -0.0251209 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0250866 |
| RPS27A | ribosomal protein S27a | -0.0250369 |
| SMAD3 | SMAD family member 3 | -0.0249399 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0246632 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0244655 |
