| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AT7519 perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AT7519_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PEG10 | paternally expressed 10 | 0.113583 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0855427 |
| GPC3 | glypican 3 | 0.0830847 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0815814 |
| HDAC9 | histone deacetylase 9 | 0.08092 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0652723 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0647165 |
| SYT1 | synaptotagmin I | 0.0579391 |
| RASAL2 | RAS protein activator like 2 | 0.0565804 |
| TENM2 | teneurin transmembrane protein 2 | 0.055437 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0527451 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0514084 |
| ZNF292 | zinc finger protein 292 | 0.0508633 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0475849 |
| APP | amyloid beta (A4) precursor protein | 0.0469909 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0461794 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0454075 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0453638 |
| ENAH | enabled homolog (Drosophila) | 0.0445405 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0440305 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0438031 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0437433 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.040791 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0406103 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0388976 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0388346 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0387909 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0385479 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0376065 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0372588 |
| ZNF217 | zinc finger protein 217 | 0.0367215 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0364727 |
| CDC73 | cell division cycle 73 | 0.0352355 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0347215 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0343183 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0338943 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0337663 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0328576 |
| DST | dystonin | 0.0325527 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.032072 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0318785 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0314062 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.031349 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0312289 |
| NRG1 | neuregulin 1 | 0.030911 |
| FOXO1 | forkhead box O1 | 0.0306596 |
| RBM20 | RNA binding motif protein 20 | 0.0304384 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0300791 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0300182 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0297363 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0296659 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0294699 |
| CCN2 | cellular communication network factor 2 | 0.0292684 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0286198 |
| PLPP1 | phospholipid phosphatase 1 | 0.0283529 |
| RFPL4B | ret finger protein-like 4B | 0.0282284 |
| PUM1 | pumilio RNA-binding family member 1 | 0.028114 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0280487 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.027955 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0278595 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0278188 |
| FBXO11 | F-box protein 11 | 0.0277012 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0276454 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0275511 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0274687 |
| CDH19 | cadherin 19, type 2 | 0.0273264 |
| USP25 | ubiquitin specific peptidase 25 | 0.0272631 |
| UTRN | utrophin | 0.027115 |
| TMSB4X | thymosin beta 4, X-linked | 0.0266503 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0263817 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0261154 |
| CPA6 | carboxypeptidase A6 | 0.0259957 |
| MED13L | mediator complex subunit 13-like | 0.0259228 |
| COL5A2 | collagen, type V, alpha 2 | 0.0255358 |
| THBS1 | thrombospondin 1 | 0.0254976 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.025225 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.025105 |
| ZNF146 | zinc finger protein 146 | 0.025081 |
| DOCK5 | dedicator of cytokinesis 5 | 0.024998 |
| NEBL | nebulette | 0.0247687 |
| RBM28 | RNA binding motif protein 28 | 0.0245558 |
| MKI67 | marker of proliferation Ki-67 | 0.0239019 |
| ITSN2 | intersectin 2 | 0.0238233 |
| FOXP2 | forkhead box P2 | 0.0235699 |
| LIN28B | lin-28 homolog B (C. elegans) | 0.0235162 |
| TMEM64 | transmembrane protein 64 | 0.0234246 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0233857 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0233529 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0233098 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0232439 |
| MTF2 | metal response element binding transcription factor 2 | 0.0231429 |
| USP15 | ubiquitin specific peptidase 15 | 0.0231396 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0231277 |
| STAG2 | stromal antigen 2 | 0.023004 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0228491 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0227954 |
| PLK2 | polo-like kinase 2 | 0.0227169 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0226845 |
| MED12L | mediator complex subunit 12-like | 0.0226021 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0225363 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.15852 |
| VIM | vimentin | -0.128396 |
| PTMA | prothymosin, alpha | -0.104117 |
| CADM2 | cell adhesion molecule 2 | -0.0944548 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.089031 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0801335 |
| RPL35A | ribosomal protein L35a | -0.0791948 |
| COL11A1 | collagen, type XI, alpha 1 | -0.076058 |
| RPS8 | ribosomal protein S8 | -0.0735881 |
| RPLP1 | ribosomal protein, large, P1 | -0.0711752 |
| RPS6 | ribosomal protein S6 | -0.0676432 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.066714 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0577618 |
| RPS16 | ribosomal protein S16 | -0.0558255 |
| RPL11 | ribosomal protein L11 | -0.0541801 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0526117 |
| RPL23 | ribosomal protein L23 | -0.0520811 |
| RPL19 | ribosomal protein L19 | -0.0466775 |
| ITGAV | integrin, alpha V | -0.0437516 |
| RPL31 | ribosomal protein L31 | -0.0433212 |
| RPL5 | ribosomal protein L5 | -0.0430641 |
| FTL | ferritin, light polypeptide | -0.042455 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0395864 |
| RPS21 | ribosomal protein S21 | -0.0392944 |
| RPS25 | ribosomal protein S25 | -0.0385873 |
| MEIS2 | Meis homeobox 2 | -0.0367298 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0366128 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0361309 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0348351 |
| CBX3 | chromobox homolog 3 | -0.0337815 |
| RPS13 | ribosomal protein S13 | -0.0335436 |
| NDRG1 | N-myc downstream regulated 1 | -0.0334004 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0332831 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0330422 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0326631 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0325536 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0325402 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0321738 |
| S100A9 | S100 calcium binding protein A9 | -0.0319581 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0319478 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0318705 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0313566 |
| RPL34 | ribosomal protein L34 | -0.0310356 |
| THOC2 | THO complex 2 | -0.0308912 |
| RPL12 | ribosomal protein L12 | -0.0307964 |
| RPS12 | ribosomal protein S12 | -0.030079 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0294083 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0294038 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0294017 |
| S100A10 | S100 calcium binding protein A10 | -0.0290532 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0289227 |
| PFN1 | profilin 1 | -0.0288812 |
| RPS19 | ribosomal protein S19 | -0.0287285 |
| RPL36A | ribosomal protein L36a | -0.0286741 |
| SERF2 | small EDRK-rich factor 2 | -0.0279763 |
| RPLP0 | ribosomal protein, large, P0 | -0.0277362 |
| SNX6 | sorting nexin 6 | -0.0276848 |
| SMYD3 | SET and MYND domain containing 3 | -0.0276213 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0273662 |
| B2M | beta-2-microglobulin | -0.027194 |
| RPLP2 | ribosomal protein, large, P2 | -0.0270457 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0268657 |
| DEK | DEK proto-oncogene | -0.0261746 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0256853 |
| RAD51B | RAD51 paralog B | -0.0255127 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0255022 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0254606 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0254434 |
| RPL28 | ribosomal protein L28 | -0.0252487 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0252398 |
| PRTG | protogenin | -0.0244596 |
| ASTN2 | astrotactin 2 | -0.0244356 |
| RPL8 | ribosomal protein L8 | -0.0243206 |
| TOX | thymocyte selection-associated high mobility group box | -0.0242904 |
| TPM4 | tropomyosin 4 | -0.0241958 |
| PARD3 | par-3 family cell polarity regulator | -0.0241661 |
| MYO9B | myosin IXB | -0.0241562 |
| FN1 | fibronectin 1 | -0.0239017 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0238241 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0237636 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0237112 |
| PKM | pyruvate kinase, muscle | -0.0235945 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0234374 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0234149 |
| SMIM44 | small integral membrane protein 44 | -0.0229513 |
| RPL36 | ribosomal protein L36 | -0.0228703 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0228132 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0227842 |
| RTN4 | reticulon 4 | -0.0223756 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0221848 |
| RPS14 | ribosomal protein S14 | -0.0218542 |
| PCDH9 | protocadherin 9 | -0.0216954 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0216354 |
| BBX | bobby sox homolog (Drosophila) | -0.0215529 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0213003 |
| RPS11 | ribosomal protein S11 | -0.0212321 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0211428 |
| DPPA4 | developmental pluripotency associated 4 | -0.0208397 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0204523 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0204063 |
