AT7519_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0746946
HDAC9 histone deacetylase 9 0.0543333
PDGFC platelet derived growth factor C 0.0471432
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0422339
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0382393
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.036591
ZFAND3 zinc finger, AN1-type domain 3 0.0347314
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0346451
ZNF608 zinc finger protein 608 0.0343524
ZEB1 zinc finger E-box binding homeobox 1 0.033285
EML4 echinoderm microtubule associated protein like 4 0.0294473
TJP1 tight junction protein 1 0.0293262
DSCAM Down syndrome cell adhesion molecule 0.0292418
EXT1 exostosin glycosyltransferase 1 0.0280059
ZNF292 zinc finger protein 292 0.0274386
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0271075
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0270272
NCEH1 neutral cholesterol ester hydrolase 1 0.0270207
ANK2 ankyrin 2, neuronal 0.0257434
TGFBR3 transforming growth factor, beta receptor III 0.0237371
SAMD4A sterile alpha motif domain containing 4A 0.0235392
SSBP2 single-stranded DNA binding protein 2 0.0235086
ADAM10 ADAM metallopeptidase domain 10 0.0234663
HELZ helicase with zinc finger 0.0232354
EEF2 eukaryotic translation elongation factor 2 0.0231554
NCKAP1 NCK-associated protein 1 0.023045
PUM2 pumilio RNA-binding family member 2 0.0225076
ECT2 epithelial cell transforming 2 0.0221351
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0219126
JMJD1C jumonji domain containing 1C 0.0217145
TXNIP thioredoxin interacting protein 0.0217051
TMEM65 transmembrane protein 65 0.0208769
KDM4C lysine (K)-specific demethylase 4C 0.0207805
NBAS neuroblastoma amplified sequence 0.0200655
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0198615
KDM6A lysine (K)-specific demethylase 6A 0.019561
PICALM phosphatidylinositol binding clathrin assembly protein 0.0194506
FAM91A1 family with sequence similarity 91, member A1 0.0187195
NUP58 nucleoporin 58 0.0186965
MED13 mediator complex subunit 13 0.0186695
RTN4 reticulon 4 0.0185441
PTBP2 polypyrimidine tract binding protein 2 0.0184416
CCNL1 cyclin L1 0.0182302
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0179417
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0179022
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0178601
EGFR epidermal growth factor receptor 0.0177779
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0176902
PRELID2 PRELI domain containing 2 0.0172731
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0171671
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0170322
BMP2K BMP2 inducible kinase 0.0169281
YAP1 Yes-associated protein 1 0.0166159
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0164799
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0164123
PLPP3 phospholipid phosphatase 3 0.0163303
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0162819
MDN1 MDN1, midasin homolog (yeast) 0.0161538
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0161013
BRWD1 bromodomain and WD repeat domain containing 1 0.016045
TRERF1 transcriptional regulating factor 1 0.0159406
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0157484
ZCCHC7 zinc finger, CCHC domain containing 7 0.0156674
KMT2E lysine (K)-specific methyltransferase 2E 0.0155552
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0153628
ANKRD36 ankyrin repeat domain 36 0.0153214
ADAM9 ADAM metallopeptidase domain 9 0.0152508
COG5 component of oligomeric golgi complex 5 0.0151942
CYTH3 cytohesin 3 0.015159
MEF2A myocyte enhancer factor 2A 0.0151552
SRRM2 serine/arginine repetitive matrix 2 0.0150948
RBM39 RNA binding motif protein 39 0.0150753
ATOSA atos homolog A 0.0150393
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0149809
MED13L mediator complex subunit 13-like 0.0149672
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0147353
ARID1A AT rich interactive domain 1A (SWI-like) 0.0146681
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0144802
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0143871
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0142684
TSC22D1 TSC22 domain family, member 1 0.0142587
DENND4A DENN/MADD domain containing 4A 0.0141891
USP24 ubiquitin specific peptidase 24 0.0141681
EZR ezrin 0.0141068
QKI QKI, KH domain containing, RNA binding 0.0139983
KMT2C lysine (K)-specific methyltransferase 2C 0.0139576
TFG TRK-fused gene 0.0139537
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0138617
RUSC2 RUN and SH3 domain containing 2 0.0138612
TNRC6B trinucleotide repeat containing 6B 0.0138436
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0138138
STRN3 striatin, calmodulin binding protein 3 0.0138091
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0137885
ZNF644 zinc finger protein 644 0.0135708
FOXJ3 forkhead box J3 0.0135358
MSI2 musashi RNA-binding protein 2 0.0134233
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0132433
ETNK1 ethanolamine kinase 1 0.0131814
FAT1 FAT atypical cadherin 1 0.0130649
ZNF217 zinc finger protein 217 0.0129991

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.336568
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188423
TPT1 tumor protein, translationally-controlled 1 -0.177851
RPS6 ribosomal protein S6 -0.12689
RPL35A ribosomal protein L35a -0.114846
RPS8 ribosomal protein S8 -0.0983383
BMP10 bone morphogenetic protein 10 -0.08924
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0777099
RPL37A ribosomal protein L37a -0.0758152
RPLP1 ribosomal protein, large, P1 -0.0757855
RPL34 ribosomal protein L34 -0.0706197
VCL vinculin -0.0698156
RPL31 ribosomal protein L31 -0.067187
RPLP2 ribosomal protein, large, P2 -0.0662876
RPL11 ribosomal protein L11 -0.0647152
RPL12 ribosomal protein L12 -0.0643392
ACTG1 actin gamma 1 -0.06187
RPS19 ribosomal protein S19 -0.0608404
RPS27A ribosomal protein S27a -0.0586202
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0575277
RPL26 ribosomal protein L26 -0.0561868
RPLP0 ribosomal protein, large, P0 -0.0545983
RPL9 ribosomal protein L9 -0.0539783
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0537611
RPS23 ribosomal protein S23 -0.0527074
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0508866
RPS13 ribosomal protein S13 -0.0507353
RPS21 ribosomal protein S21 -0.0504565
MKI67 marker of proliferation Ki-67 -0.0502506
RPL23 ribosomal protein L23 -0.0498245
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0493598
RPS25 ribosomal protein S25 -0.0488064
RPS3 ribosomal protein S3 -0.048411
ENO1 enolase 1, (alpha) -0.0465757
NAP1L1 nucleosome assembly protein 1-like 1 -0.0444064
RPL19 ribosomal protein L19 -0.0440163
S100A4 S100 calcium binding protein A4 -0.0434804
MYL12B myosin, light chain 12B, regulatory -0.043376
RPL36 ribosomal protein L36 -0.0431653
RPS17 ribosomal protein S17 -0.0430236
CENPF centromere protein F, 350/400kDa -0.0426894
TMSB10 thymosin beta 10 -0.0423895
S100A6 S100 calcium binding protein A6 -0.0421775
RPS24 ribosomal protein S24 -0.0411833
RPS12 ribosomal protein S12 -0.0410768
KPNB1 karyopherin (importin) beta 1 -0.0404161
HSPB1 heat shock 27kDa protein 1 -0.0397811
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0392017
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0391265
EBNA1BP2 EBNA1 binding protein 2 -0.0386986
CCND1 cyclin D1 -0.0385326
RPS14 ribosomal protein S14 -0.0384976
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0380845
FTL ferritin, light polypeptide -0.0373669
RPL27A ribosomal protein L27a -0.0371873
RPL37 ribosomal protein L37 -0.0368984
AHNAK AHNAK nucleoprotein -0.0366663
RPS29 ribosomal protein S29 -0.0366511
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0366049
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0354675
RPL5 ribosomal protein L5 -0.0347489
RPL13A ribosomal protein L13a -0.0346803
S100A9 S100 calcium binding protein A9 -0.0346611
SMC4 structural maintenance of chromosomes 4 -0.0346085
DIAPH3 diaphanous-related formin 3 -0.0336783
MT2A metallothionein 2A -0.0336526
PFN1 profilin 1 -0.0333423
GNAS GNAS complex locus -0.0330598
TPM4 tropomyosin 4 -0.0326498
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0325936
RPL30 ribosomal protein L30 -0.0325252
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0321272
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0319797
RPL36A ribosomal protein L36a -0.0310846
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0307684
NAV2 neuron navigator 2 -0.030699
RPL8 ribosomal protein L8 -0.0306964
RPL7A ribosomal protein L7a -0.0306687
RPL32 ribosomal protein L32 -0.0305974
HMGB1 high mobility group box 1 -0.0298129
ARL4C ADP-ribosylation factor-like 4C -0.0296864
TUBB4B tubulin, beta 4B class IVb -0.0295021
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0293099
FUS FUS RNA binding protein -0.0291026
TPX2 TPX2, microtubule-associated -0.0288207
RPS11 ribosomal protein S11 -0.0284779
RPL38 ribosomal protein L38 -0.0282614
RPL35 ribosomal protein L35 -0.0282599
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0282255
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0281868
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0277345
PRDX2 peroxiredoxin 2 -0.0276587
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0275471
LOC102724023 ES1 protein homolog, mitochondrial -0.0274149
S100A10 S100 calcium binding protein A10 -0.0270664
RPS27 ribosomal protein S27 -0.0269163
TM4SF1 transmembrane 4 L six family member 1 -0.0262999
UNC13A unc-13 homolog A (C. elegans) -0.0262908
RPS10 ribosomal protein S10 -0.0262526
NPAS2 neuronal PAS domain protein 2 -0.0260534