| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AT7519 perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AT7519_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | 0.184473 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.127744 |
| COL6A3 | collagen, type VI, alpha 3 | 0.12295 |
| NDRG1 | N-myc downstream regulated 1 | 0.109181 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0860981 |
| CD44 | CD44 molecule (Indian blood group) | 0.0860919 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0845669 |
| VEGFA | vascular endothelial growth factor A | 0.0712559 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0669988 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0630272 |
| PKM | pyruvate kinase, muscle | 0.0626806 |
| CALR | calreticulin | 0.0601877 |
| RNF145 | ring finger protein 145 | 0.0593598 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0583885 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0562497 |
| KYNU | kynureninase | 0.0546672 |
| POTEF | POTE ankyrin domain family, member F | 0.0480952 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0471748 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0469376 |
| ZNF292 | zinc finger protein 292 | 0.0462794 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.045069 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0442611 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0434051 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0433487 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0420005 |
| RYBP | RING1 and YY1 binding protein | 0.0419892 |
| TXNIP | thioredoxin interacting protein | 0.0415779 |
| ARRDC3 | arrestin domain containing 3 | 0.0415032 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0392481 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0385116 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0381043 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0378499 |
| RNF24 | ring finger protein 24 | 0.0369445 |
| NRXN3 | neurexin 3 | 0.03668 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0355125 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0350746 |
| ZNF395 | zinc finger protein 395 | 0.0347605 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0346829 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0343757 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0336885 |
| ANXA5 | annexin A5 | 0.0327651 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0326059 |
| MSN | moesin | 0.0321915 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.031791 |
| PCBP2 | poly(rC) binding protein 2 | 0.0310728 |
| RTN4 | reticulon 4 | 0.0304232 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0301868 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0300772 |
| MYADM | myeloid-associated differentiation marker | 0.0300651 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0300443 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.0298986 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0295534 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0290547 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0290361 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0289926 |
| MATR3 | matrin 3 | 0.0288839 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0287492 |
| INSIG2 | insulin induced gene 2 | 0.0286171 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0285139 |
| CCNL1 | cyclin L1 | 0.0284487 |
| ZNF638 | zinc finger protein 638 | 0.0283991 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0282739 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0282729 |
| ATP13A3 | ATPase type 13A3 | 0.0282511 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0281737 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0281336 |
| MAP1B | microtubule-associated protein 1B | 0.0276449 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0276285 |
| COL5A1 | collagen, type V, alpha 1 | 0.0275436 |
| MKI67 | marker of proliferation Ki-67 | 0.0274999 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0274894 |
| FAM13A | family with sequence similarity 13, member A | 0.0274665 |
| FAT1 | FAT atypical cadherin 1 | 0.0272549 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.026978 |
| MYLK | myosin light chain kinase | 0.0268829 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0268803 |
| SMAD3 | SMAD family member 3 | 0.0266507 |
| SYNPO | synaptopodin | 0.0265291 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0263067 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0262058 |
| MEF2A | myocyte enhancer factor 2A | 0.0261905 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0261786 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0261677 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0255243 |
| CCNI | cyclin I | 0.0254036 |
| ITM2B | integral membrane protein 2B | 0.0253633 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0252795 |
| FUS | FUS RNA binding protein | 0.0251999 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0251578 |
| ERBIN | erbb2 interacting protein | 0.0249815 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0249289 |
| AOPEP | aminopeptidase O (putative) | 0.0248519 |
| TPI1 | triosephosphate isomerase 1 | 0.0243769 |
| PTGES2 | prostaglandin E synthase 2 | 0.0243058 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0240607 |
| TAGLN2 | transgelin 2 | 0.0240418 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0238716 |
| SNX13 | sorting nexin 13 | 0.0238702 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0238453 |
| IL6ST | interleukin 6 signal transducer | 0.0238372 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.172956 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.162631 |
| TMSB10 | thymosin beta 10 | -0.111348 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0786571 |
| HLA-B | major histocompatibility complex, class I, B | -0.0699565 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0665223 |
| HMGA2 | high mobility group AT-hook 2 | -0.064594 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0598799 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0572883 |
| CDH13 | cadherin 13 | -0.0548244 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0534415 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0523302 |
| PTMA | prothymosin, alpha | -0.0519102 |
| RAD51B | RAD51 paralog B | -0.0518781 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0493653 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0480867 |
| S100A6 | S100 calcium binding protein A6 | -0.045963 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0436478 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0433201 |
| RAI14 | retinoic acid induced 14 | -0.0429838 |
| MT2A | metallothionein 2A | -0.0421484 |
| TUBB | tubulin, beta class I | -0.0415474 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0410513 |
| RPLP1 | ribosomal protein, large, P1 | -0.040972 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0404382 |
| NAV2 | neuron navigator 2 | -0.0403761 |
| RRBP1 | ribosome binding protein 1 | -0.0399547 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0387056 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0380705 |
| RPS5 | ribosomal protein S5 | -0.0380367 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0379579 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0378385 |
| TPM4 | tropomyosin 4 | -0.0375769 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0373765 |
| RPS23 | ribosomal protein S23 | -0.0369946 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0363883 |
| RPS8 | ribosomal protein S8 | -0.0361107 |
| EFNA5 | ephrin-A5 | -0.0361039 |
| AHNAK | AHNAK nucleoprotein | -0.0352683 |
| RPS24 | ribosomal protein S24 | -0.0347478 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0335499 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0334657 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0334564 |
| RPL34 | ribosomal protein L34 | -0.0332268 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0326326 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0323896 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0322923 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0322738 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0314547 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0311493 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0308657 |
| RPS11 | ribosomal protein S11 | -0.0307898 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0306716 |
| RPL37 | ribosomal protein L37 | -0.0306041 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0304931 |
| CDK13 | cyclin-dependent kinase 13 | -0.0303731 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0301736 |
| SDC4 | syndecan 4 | -0.0299334 |
| TMSB4X | thymosin beta 4, X-linked | -0.0298719 |
| MT1X | metallothionein 1X | -0.0295939 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0292891 |
| RASA2 | RAS p21 protein activator 2 | -0.0290477 |
| RPL35A | ribosomal protein L35a | -0.0283185 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0278804 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0273691 |
| MORF4L2 | mortality factor 4 like 2 | -0.0273282 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0270405 |
| RPL26 | ribosomal protein L26 | -0.0267798 |
| RPLP2 | ribosomal protein, large, P2 | -0.0260524 |
| FBXO11 | F-box protein 11 | -0.0260176 |
| VCL | vinculin | -0.0258881 |
| ENO1 | enolase 1, (alpha) | -0.0256774 |
| KAZN | kazrin, periplakin interacting protein | -0.0255749 |
| MAP4 | microtubule-associated protein 4 | -0.0253938 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0253624 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0253154 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0252615 |
| LUC7L | LUC7-like (S. cerevisiae) | -0.0251456 |
| CAVIN1 | caveolae associated protein 1 | -0.0250078 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0248092 |
| RPL12 | ribosomal protein L12 | -0.0247983 |
| LASP1 | LIM and SH3 protein 1 | -0.0247871 |
| SMYD3 | SET and MYND domain containing 3 | -0.0247724 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.024641 |
| CLINT1 | clathrin interactor 1 | -0.0244519 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.024444 |
| PCNX4 | pecanex 4 | -0.0243336 |
| RPS19 | ribosomal protein S19 | -0.024309 |
| PURA | purine-rich element binding protein A | -0.0242704 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0240721 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0240214 |
| FRMD6 | FERM domain containing 6 | -0.0240092 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0236444 |
| AUTS2 | autism susceptibility candidate 2 | -0.0235355 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.023504 |
| H3-3B | H3.3 histone B | -0.0233276 |
| NBAS | neuroblastoma amplified sequence | -0.0231325 |
| OSMR | oncostatin M receptor | -0.0231116 |
| CALU | calumenin | -0.0231042 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0227 |
