| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AT7519 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AT7519_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.067995 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0460612 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0416336 |
| SQSTM1 | sequestosome 1 | 0.040717 |
| CPNE1 | copine I | 0.0379914 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0348855 |
| BRD2 | bromodomain containing 2 | 0.0328917 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0311659 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0310504 |
| INTS6 | integrator complex subunit 6 | 0.0307792 |
| CALR | calreticulin | 0.0298874 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0296391 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0289238 |
| ANXA1 | annexin A1 | 0.0275809 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0275252 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0273098 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.027283 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0272143 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0266364 |
| GOLGB1 | golgin B1 | 0.0265064 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0259193 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0258471 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.025485 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0254417 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0250238 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0250098 |
| MSN | moesin | 0.024922 |
| EGR1 | early growth response 1 | 0.0243261 |
| DIAPH1 | diaphanous-related formin 1 | 0.024322 |
| TPM3 | tropomyosin 3 | 0.0240498 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0238884 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0235568 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0234112 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0234041 |
| SMAD3 | SMAD family member 3 | 0.0232156 |
| ASPH | aspartate beta-hydroxylase | 0.0229014 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0228186 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0226471 |
| EGFR | epidermal growth factor receptor | 0.0226125 |
| HDAC9 | histone deacetylase 9 | 0.0217226 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0216553 |
| SON | SON DNA binding protein | 0.0214403 |
| KIF5B | kinesin family member 5B | 0.0213562 |
| TXNIP | thioredoxin interacting protein | 0.0211367 |
| GPC5 | glypican 5 | 0.0206103 |
| CREBBP | CREB binding protein | 0.0205505 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0203673 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0203012 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0202866 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0202375 |
| YAP1 | Yes-associated protein 1 | 0.0199256 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0199136 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | 0.0199112 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0198691 |
| ZXDC | ZXD family zinc finger C | 0.0197883 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0193522 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0190203 |
| PAPOLA | poly(A) polymerase alpha | 0.0186044 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0184327 |
| PNN | pinin, desmosome associated protein | 0.0182649 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0179996 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.017881 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0178807 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0178574 |
| ARL13B | ADP-ribosylation factor-like 13B | 0.0177629 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | 0.0175617 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.017492 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0174741 |
| RPS2 | ribosomal protein S2 | 0.0174292 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0173695 |
| UBN2 | ubinuclein 2 | 0.0172946 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0171961 |
| TOP1 | topoisomerase (DNA) I | 0.0171839 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0171378 |
| GOLGA4 | golgin A4 | 0.0170111 |
| SETX | senataxin | 0.0169259 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0168155 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0167597 |
| RPL37A | ribosomal protein L37a | 0.0167204 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0164901 |
| RPL36 | ribosomal protein L36 | 0.016393 |
| INTS8 | integrator complex subunit 8 | 0.0163386 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0163359 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0163013 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.016241 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.0162196 |
| FNIP1 | folliculin interacting protein 1 | 0.0162021 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0159288 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0158174 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0157998 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.015797 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0157429 |
| TAOK1 | TAO kinase 1 | 0.0157292 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.015668 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0156265 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0155236 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0155026 |
| TLK1 | tousled-like kinase 1 | 0.0154439 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0153172 |
| CDC42SE2 | CDC42 small effector 2 | 0.0153111 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.202818 |
| VIM | vimentin | -0.138418 |
| TMSB10 | thymosin beta 10 | -0.128629 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0935782 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0790481 |
| PTMA | prothymosin, alpha | -0.0679402 |
| SDC4 | syndecan 4 | -0.0652013 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0573747 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0567533 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.052201 |
| IGF2 | insulin-like growth factor 2 | -0.04815 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0478609 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0459217 |
| CD44 | CD44 molecule (Indian blood group) | -0.0447123 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0444549 |
| RAD51B | RAD51 paralog B | -0.0434159 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0411776 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0411748 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0410112 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0395709 |
| LDHA | lactate dehydrogenase A | -0.0394941 |
| NALCN | sodium leak channel, non selective | -0.0379455 |
| RORA | RAR-related orphan receptor A | -0.0376434 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0373757 |
| FMN1 | formin 1 | -0.0368718 |
| GNAS | GNAS complex locus | -0.0365471 |
| OSMR | oncostatin M receptor | -0.0365314 |
| PRKCA | protein kinase C, alpha | -0.0358098 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0354568 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0351455 |
| ATXN1 | ataxin 1 | -0.0334339 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0333402 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0331194 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0326415 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0325956 |
| PRELID2 | PRELI domain containing 2 | -0.0322372 |
| TPM4 | tropomyosin 4 | -0.0319535 |
| FLNB | filamin B, beta | -0.0317785 |
| SMYD3 | SET and MYND domain containing 3 | -0.0316718 |
| ANGPTL4 | angiopoietin-like 4 | -0.0315131 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0307263 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0303649 |
| NCOR1 | nuclear receptor corepressor 1 | -0.030319 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0302184 |
| PRSS23 | protease, serine, 23 | -0.0297944 |
| CCNI | cyclin I | -0.0295588 |
| RPL35A | ribosomal protein L35a | -0.0288308 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.028686 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0286847 |
| PGK1 | phosphoglycerate kinase 1 | -0.0277511 |
| MYO9A | myosin IXA | -0.0272946 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0267913 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | -0.0267325 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0262179 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0260004 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0254541 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0254063 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.025381 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0253166 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0252753 |
| RPS3 | ribosomal protein S3 | -0.0251415 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0250957 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0246515 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0246391 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0245598 |
| OGA | O-GlcNAcase | -0.0243483 |
| DNER | delta/notch-like EGF repeat containing | -0.024291 |
| NDRG1 | N-myc downstream regulated 1 | -0.0237556 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0236447 |
| PTK2 | protein tyrosine kinase 2 | -0.0235722 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0235385 |
| DST | dystonin | -0.0234662 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0231623 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0231403 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0230746 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0230431 |
| MEF2A | myocyte enhancer factor 2A | -0.0226757 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0223315 |
| PFN1 | profilin 1 | -0.0221549 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0221115 |
| SEPTIN7 | septin 7 | -0.0219503 |
| CCDC91 | coiled-coil domain containing 91 | -0.0217725 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0216109 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0215901 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0213803 |
| PYGL | phosphorylase, glycogen, liver | -0.0212495 |
| ETV6 | ets variant 6 | -0.0209219 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0209178 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.020787 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0207735 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0206041 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0205796 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0205687 |
| WWOX | WW domain containing oxidoreductase | -0.020379 |
| YEATS2 | YEATS domain containing 2 | -0.0202469 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.020241 |
| LAMB1 | laminin, beta 1 | -0.0202277 |
| ZNF609 | zinc finger protein 609 | -0.0201702 |
| LMO7 | LIM domain 7 | -0.0201669 |
| PURA | purine-rich element binding protein A | -0.0199775 |
