AT7519_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AT7519 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AT7519_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0635968
VEGFA vascular endothelial growth factor A 0.0498799
FNDC3B fibronectin type III domain containing 3B 0.0421017
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0406345
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0391235
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0335608
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0320539
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0296968
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0288672
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0271867
POTEF POTE ankyrin domain family, member F 0.0271191
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0250593
NRIP1 nuclear receptor interacting protein 1 0.0250031
FAT1 FAT atypical cadherin 1 0.0248695
APLP2 amyloid beta (A4) precursor-like protein 2 0.023469
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0233439
SVIL supervillin 0.0232903
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0225249
TPM3 tropomyosin 3 0.0215931
SHB Src homology 2 domain containing adaptor protein B 0.0205347
SEPTIN9 septin 9 0.0203422
SMAD3 SMAD family member 3 0.0202881
PRPF8 pre-mRNA processing factor 8 0.0194656
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0194084
ATXN1 ataxin 1 0.0186795
TUFT1 tuftelin 1 0.0184674
RUNX1 runt-related transcription factor 1 0.0178121
MEF2D myocyte enhancer factor 2D 0.01761
TGM2 transglutaminase 2 0.0175865
IL6ST interleukin 6 signal transducer 0.0174787
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0172106
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0170603
FLNA filamin A, alpha 0.0170515
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0167032
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0166748
EGFR epidermal growth factor receptor 0.0166496
DOCK5 dedicator of cytokinesis 5 0.0164742
INTS6 integrator complex subunit 6 0.0164488
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0160294
NFE2L1 nuclear factor, erythroid 2-like 1 0.0159563
PLEC plectin 0.0158848
EIF5 eukaryotic translation initiation factor 5 0.0147774
NBAS neuroblastoma amplified sequence 0.0147457
FTH1 ferritin, heavy polypeptide 1 0.0147119
ZC3H12C zinc finger CCCH-type containing 12C 0.0144016
MYH9 myosin, heavy chain 9, non-muscle 0.0143492
MSN moesin 0.014142
FOSL1 FOS-like antigen 1 0.0141238
FOSL2 FOS-like antigen 2 0.0140679
FAM219A family with sequence similarity 219, member A 0.0140259
LOXL2 lysyl oxidase-like 2 0.0138539
ZFYVE16 zinc finger, FYVE domain containing 16 0.0137923
EEF2 eukaryotic translation elongation factor 2 0.0137329
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0137115
FERMT2 fermitin family member 2 0.0136836
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0133593
HIPK2 homeodomain interacting protein kinase 2 0.0133487
ZSWIM6 zinc finger, SWIM-type containing 6 0.0132444
RIC1 RAB6A GEF complex partner 1 0.0131395
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0130026
RB1CC1 RB1-inducible coiled-coil 1 0.0129916
DSG2 desmoglein 2 0.0129197
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0129051
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0126107
CDCP1 CUB domain containing protein 1 0.0125971
ARRDC3 arrestin domain containing 3 0.0125636
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0125631
CD109 CD109 molecule 0.0125294
ANO6 anoctamin 6 0.0124307
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0124155
PGM3 phosphoglucomutase 3 0.0122244
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.012098
AKAP12 A kinase (PRKA) anchor protein 12 0.0119623
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0119481
PCBP3 poly(rC) binding protein 3 0.0117118
LYST lysosomal trafficking regulator 0.0116103
LENG8 leukocyte receptor cluster (LRC) member 8 0.0115828
WDR26 WD repeat domain 26 0.0113833
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0112397
FAM13A family with sequence similarity 13, member A 0.011217
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0112167
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0112011
JARID2 jumonji, AT rich interactive domain 2 0.0111633
CEMIP2 cell migration inducing hyaluronidase 2 0.0111112
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0109016
WASL Wiskott-Aldrich syndrome-like 0.010875
PDLIM5 PDZ and LIM domain 5 0.0108532
PCM1 pericentriolar material 1 0.0107477
NPAS2 neuronal PAS domain protein 2 0.0107069
ZMIZ1 zinc finger, MIZ-type containing 1 0.0105866
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0105093
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0104722
PRELID2 PRELI domain containing 2 0.0104545
MIDEAS mitotic deacetylase associated SANT domain protein 0.0104267
FBXO28 F-box protein 28 0.0103279
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0101936
GPC6 glypican 6 0.0101706
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0100734
BCL9L B-cell CLL/lymphoma 9-like 0.0100689
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0098715

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.27749
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.240722
FN1 fibronectin 1 -0.213314
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.208843
NRG1 neuregulin 1 -0.171121
PTMA prothymosin, alpha -0.162242
TMSB10 thymosin beta 10 -0.148113
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.146177
MT2A metallothionein 2A -0.109144
FTL ferritin, light polypeptide -0.0998206
HLA-B major histocompatibility complex, class I, B -0.0950598
TPT1 tumor protein, translationally-controlled 1 -0.08831
SQSTM1 sequestosome 1 -0.0823346
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0811707
TMSB4X thymosin beta 4, X-linked -0.0791146
S100A6 S100 calcium binding protein A6 -0.0764448
VIM vimentin -0.0735025
HMGA2 high mobility group AT-hook 2 -0.068714
IFI27 interferon, alpha-inducible protein 27 -0.0684277
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0651126
SYT1 synaptotagmin I -0.0635801
CANX calnexin -0.0614486
RPL35A ribosomal protein L35a -0.0567856
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0528673
NAMPT nicotinamide phosphoribosyltransferase -0.0487736
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0484288
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0478767
RPS24 ribosomal protein S24 -0.0458792
IER3 immediate early response 3 -0.0458613
RPL26 ribosomal protein L26 -0.0454162
SOX4 SRY (sex determining region Y)-box 4 -0.0453387
RPS21 ribosomal protein S21 -0.04445
RPLP1 ribosomal protein, large, P1 -0.0434009
GNAS GNAS complex locus -0.0421291
WSB1 WD repeat and SOCS box containing 1 -0.0419273
RPL38 ribosomal protein L38 -0.0419269
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0413649
LMNA lamin A/C -0.0398543
H1-0 H1.0 linker histone -0.0393048
RAI14 retinoic acid induced 14 -0.0387794
EIF1 eukaryotic translation initiation factor 1 -0.0373029
GLIS3 GLIS family zinc finger 3 -0.0360643
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0360346
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0358761
NAP1L1 nucleosome assembly protein 1-like 1 -0.0355246
RPL34 ribosomal protein L34 -0.0355198
RAB1A RAB1A, member RAS oncogene family -0.0352126
TRIO trio Rho guanine nucleotide exchange factor -0.0351444
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0350696
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0349093
RPS6 ribosomal protein S6 -0.0345004
RPS29 ribosomal protein S29 -0.0344436
RPL11 ribosomal protein L11 -0.0343878
RPL37A ribosomal protein L37a -0.0342645
RAD21 RAD21 homolog (S. pombe) -0.0340007
RPS27A ribosomal protein S27a -0.0331922
RPL31 ribosomal protein L31 -0.0328392
RPL23 ribosomal protein L23 -0.0328184
RPS19 ribosomal protein S19 -0.0328177
RPS8 ribosomal protein S8 -0.0325952
LOC102724023 ES1 protein homolog, mitochondrial -0.0325851
PRRC2C proline-rich coiled-coil 2C -0.0325367
HLA-A major histocompatibility complex, class I, A -0.0322884
SPAG9 sperm associated antigen 9 -0.0320802
SLC38A1 solute carrier family 38, member 1 -0.0319349
RPS27 ribosomal protein S27 -0.0317484
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0314153
RACK1 receptor for activated C kinase 1 -0.0311733
S100A10 S100 calcium binding protein A10 -0.0310607
MARCHF6 membrane associated ring-CH-type finger 6 -0.030953
RPS25 ribosomal protein S25 -0.0305107
KDM3A lysine (K)-specific demethylase 3A -0.0303854
DNAH5 dynein, axonemal, heavy chain 5 -0.0303227
RBM39 RNA binding motif protein 39 -0.0302043
TMEM156 transmembrane protein 156 -0.0298941
LOC112694756 uncharaterized LOC112694756 -0.0293765
TFPI2 tissue factor pathway inhibitor 2 -0.0293277
ARF1 ADP-ribosylation factor 1 -0.0292997
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0290221
RPL19 ribosomal protein L19 -0.028418
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0283576
RPS3 ribosomal protein S3 -0.0280523
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0279321
UGDH UDP-glucose 6-dehydrogenase -0.0278887
RLF rearranged L-myc fusion -0.0278738
RPL9 ribosomal protein L9 -0.0276701
RPS20 ribosomal protein S20 -0.0270105
ETV1 ets variant 1 -0.026836
ARHGAP35 Rho GTPase activating protein 35 -0.0268077
PGK1 phosphoglycerate kinase 1 -0.0267814
NPEPPS aminopeptidase puromycin sensitive -0.0265127
RPL12 ribosomal protein L12 -0.0264164
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0260755
RPS23 ribosomal protein S23 -0.0260681
RPS5 ribosomal protein S5 -0.0257599
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.025666
SFRP1 secreted frizzled-related protein 1 -0.0256427
OSBPL8 oxysterol binding protein-like 8 -0.0255809
TM4SF1 transmembrane 4 L six family member 1 -0.0253827
MT1X metallothionein 1X -0.025293