ATF Gene Set

Dataset MotifMap Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description plasminogen activator, urokinase|This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 5328)
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Genes

133 target genes of the ATF transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

Symbol Name
ADD2 adducin 2 (beta)
AKR1D1 aldo-keto reductase family 1, member D1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARG2 arginase 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C11ORF87 chromosome 11 open reading frame 87
C15ORF52 chromosome 15 open reading frame 52
C3ORF14 chromosome 3 open reading frame 14
CARTPT CART prepropeptide
CD2AP CD2-associated protein
CDADC1 cytidine and dCMP deaminase domain containing 1
CENPW centromere protein W
CEP57 centrosomal protein 57kDa
CLCN3 chloride channel, voltage-sensitive 3
CLSTN3 calsyntenin 3
CMSS1 cms1 ribosomal small subunit homolog (yeast)
CREM cAMP responsive element modulator
CRH corticotropin releasing hormone
CSTF3-AS1 CSTF3 antisense RNA 1 (head to head)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYLD cylindromatosis (turban tumor syndrome)
DAAM2 dishevelled associated activator of morphogenesis 2
DBN1 drebrin 1
DGUOK deoxyguanosine kinase
DIO2-AS1 DIO2 antisense RNA 1
DKFZP686K1684 uncharacterized LOC440034
DLX6 distal-less homeobox 6
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
DRD4 dopamine receptor D4
EXO1 exonuclease 1
FAM131A family with sequence similarity 131, member A
FAM174A family with sequence similarity 174, member A
FAM50A family with sequence similarity 50, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXD3 forkhead box D3
FOXP2 forkhead box P2
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPR3 G protein-coupled receptor 3
GPR6 G protein-coupled receptor 6
GRP gastrin-releasing peptide
HAUS2 HAUS augmin-like complex, subunit 2
HAUS5 HAUS augmin-like complex, subunit 5
HIST2H3C histone cluster 2, H3c
HLF hepatic leukemia factor
HOXC10 homeobox C10
HRK harakiri, BCL2 interacting protein
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ING3 inhibitor of growth family, member 3
IRF6 interferon regulatory factor 6
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LEKR1 leucine, glutamate and lysine rich 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHX1 LIM homeobox 1
LINC00271 long intergenic non-protein coding RNA 271
LMO4 LIM domain only 4
LRRC8A leucine rich repeat containing 8 family, member A
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MED29 mediator complex subunit 29
MEG3 maternally expressed 3 (non-protein coding)
MIMT1 MER1 repeat containing imprinted transcript 1 (non-protein coding)
MIR124-2 microRNA 124-2
MIR124-3 microRNA 124-3
MIR132 microRNA 132
MIR9-1 microRNA 9-1
MIR9-3 microRNA 9-3
MXD1 MAX dimerization protein 1
MXI1 MAX interactor 1, dimerization protein
NAV2 neuron navigator 2
NDEL1 nudE neurodevelopment protein 1-like 1
NDRG4 NDRG family member 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NR2E1 nuclear receptor subfamily 2, group E, member 1
OXSR1 oxidative stress responsive 1
PACRGL PARK2 co-regulated-like
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4A phosphodiesterase 4A, cAMP-specific
PDE7B phosphodiesterase 7B
PFAS phosphoribosylformylglycinamidine synthase
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNRC1 proline-rich nuclear receptor coactivator 1
PPARD peroxisome proliferator-activated receptor delta
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCH protein kinase C, eta
PRKCZ protein kinase C, zeta
PRMT5 protein arginine methyltransferase 5
PTPRU protein tyrosine phosphatase, receptor type, U
RAB25 RAB25, member RAS oncogene family
RAI1 retinoic acid induced 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIC8B RIC8 guanine nucleotide exchange factor B
RPP14 ribonuclease P/MRP 14kDa subunit
RUNDC3A RUN domain containing 3A
SIDT2 SID1 transmembrane family, member 2
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SOS2 son of sevenless homolog 2 (Drosophila)
SPAG6 sperm associated antigen 6
SST somatostatin
ST7 suppression of tumorigenicity 7
STARD3NL STARD3 N-terminal like
STXBP3 syntaxin binding protein 3
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TMEM147 transmembrane protein 147
TMEM151A transmembrane protein 151A
TMEM187 transmembrane protein 187
TMEM59L transmembrane protein 59-like
TOP1 topoisomerase (DNA) I
TPP1 tripeptidyl peptidase I
TRAF4 TNF receptor-associated factor 4
TRAK1 trafficking protein, kinesin binding 1
TRIM39 tripartite motif containing 39
TRIP6 thyroid hormone receptor interactor 6
TSPAN7 tetraspanin 7
TTC1 tetratricopeptide repeat domain 1
TTC16 tetratricopeptide repeat domain 16
UBN1 ubinuclein 1
UCN urocortin
UNK unkempt family zinc finger
VAMP7 vesicle-associated membrane protein 7
VIP vasoactive intestinal peptide
XPO7 exportin 7
ZFYVE27 zinc finger, FYVE domain containing 27
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF410 zinc finger protein 410
ZNF473 zinc finger protein 473
ZNF576 zinc finger protein 576