ATF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description activating transcription factor 1|This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 466)
Similar Terms
Downloads & Tools

Genes

300 genes differentially expressed following the ATF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.16754
FAM180A family with sequence similarity 180, member A 3.16754
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.16754
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.16754
FABP1 fatty acid binding protein 1, liver 3.16754
TNNI2 troponin I type 2 (skeletal, fast) 3.16754
SSTR1 somatostatin receptor 1 3.16754
SIRPB1 signal-regulatory protein beta 1 3.16754
UMOD uromodulin 3.16754
FAM180B family with sequence similarity 180, member B 3.16754
CARD16 caspase recruitment domain family, member 16 3.16754
HNF4A hepatocyte nuclear factor 4, alpha 3.16754
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 3.16754
TSSK4 testis-specific serine kinase 4 3.16754
GJA3 gap junction protein, alpha 3, 46kDa 3.16754
OR5P3 olfactory receptor, family 5, subfamily P, member 3 3.16754
CD5 CD5 molecule 3.16754
LURAP1L leucine rich adaptor protein 1-like 3.16754
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.16754
TYRP1 tyrosinase-related protein 1 3.16754
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 3.16754
TNIP3 TNFAIP3 interacting protein 3 3.16754
TRIM42 tripartite motif containing 42 3.16754
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.16754
NPIPA8 nuclear pore complex interacting protein family, member A8 3.16754
MISP mitotic spindle positioning 3.16754
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 3.16754
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.16754
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.16754
KIAA1755 KIAA1755 3.16754
OCSTAMP osteoclast stimulatory transmembrane protein 3.16754
CRX cone-rod homeobox 3.16754
KCNRG potassium channel regulator 3.16754
REN renin 3.16754
BIRC3 baculoviral IAP repeat containing 3 3.16754
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.16754
BSX brain-specific homeobox 3.16754
F7 coagulation factor VII (serum prothrombin conversion accelerator) 3.16754
OR51A7 olfactory receptor, family 51, subfamily A, member 7 3.16754
PRODH proline dehydrogenase (oxidase) 1 3.16754
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.16754
LRTM3 leucine rich repeat transmembrane protein 3 3.16754
FYB1 FYN binding protein 1 3.16754
H1-6 H1.6 linker histone, cluster member 3.16754
OR10H1 olfactory receptor, family 10, subfamily H, member 1 3.16754
RAG2 recombination activating gene 2 3.16754
ROPN1B rhophilin associated tail protein 1B 3.16754
SIM1 single-minded family bHLH transcription factor 1 3.16754
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.16754
VSIG8 V-set and immunoglobulin domain containing 8 3.16754
GASK1B golgi associated kinase 1B 3.16754
JAML junction adhesion molecule like 3.16754
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.16754
CIMIP4 ciliary microtubule inner protein 4 3.16754
EPCIP exosomal polycystin 1 interacting protein 3.16754
SPMIP3 sperm microtubule inner protein 3 3.16754
AKAIN1 A-kinase anchor inhibitor 1 3.16754
LY6L lymphocyte antigen 6 family member L 3.16754
DNAAF6 dynein axonemal assembly factor 6 3.16754
H2AC1 H2A clustered histone 1 3.16754
CLEC6A C-type lectin domain family 6, member A 3.16754
HNF1A HNF1 homeobox A 3.16754
ASIC4 acid sensing (proton gated) ion channel family member 4 3.16754
SLAMF6 SLAM family member 6 3.16754
MYH13 myosin, heavy chain 13, skeletal muscle 3.16754
HAPLN2 hyaluronan and proteoglycan link protein 2 3.16754
LOC124901449 uncharacterized LOC124901449 3.16754
DNASE2B deoxyribonuclease II beta 3.16754
ITK IL2-inducible T-cell kinase 3.16754
MTNR1B melatonin receptor 1B 3.16754
USH1G Usher syndrome 1G (autosomal recessive) 3.16754
RUNX3 runt-related transcription factor 3 3.16754
CREB3L3 cAMP responsive element binding protein 3-like 3 3.16754
FRK fyn-related Src family tyrosine kinase 3.16754
OR2D2 olfactory receptor, family 2, subfamily D, member 2 3.16754
FAM131C family with sequence similarity 131, member C 3.16754
PTCHD3 patched domain containing 3 3.16754
CLEC17A C-type lectin domain family 17, member A 3.16754
BARX2 BARX homeobox 2 3.16754
INSRR insulin receptor-related receptor 3.16754
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.16754
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.16754
PRDM9 PR domain containing 9 3.16754
SST somatostatin 3.16754
TBX1 T-box 1 3.16754
SPATA31E1 SPATA31 subfamily E, member 1 3.16754
CXCR2 chemokine (C-X-C motif) receptor 2 3.16754
ARR3 arrestin 3, retinal (X-arrestin) 3.16754
ADORA3 adenosine A3 receptor 3.16754
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.16754
RGS13 regulator of G-protein signaling 13 3.16754
PRSS33 protease, serine, 33 3.16754
SHOX2 short stature homeobox 2 3.16754
APLNR apelin receptor 3.16754
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.16754
BTNL2 butyrophilin-like 2 3.16754
IL17REL interleukin 17 receptor E-like 3.16754
NLGN4X neuroligin 4, X-linked 3.16754
MKRN3 makorin ring finger protein 3 3.16754
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.16754
C20ORF144 chromosome 20 open reading frame 144 3.16754
HRCT1 histidine rich carboxyl terminus 1 3.16754
DHH desert hedgehog 3.16754
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.16754
PCDHGA4 protocadherin gamma subfamily A, 4 3.16754
MAB21L1 mab-21-like 1 (C. elegans) 3.16754
MAB21L2 mab-21-like 2 (C. elegans) 3.16754
CATIP ciliogenesis associated TTC17 interacting protein 3.16754
C16ORF78 chromosome 16 open reading frame 78 3.16754
EPGN epithelial mitogen 3.16754
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.16754
HKDC1 hexokinase domain containing 1 3.16754
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.16754
GOLGA6D golgin A6 family, member D 3.16754
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 3.16754
ERICH6B glutamate-rich 6B 3.16754
LHX5 LIM homeobox 5 3.16754
IGIP IgA-inducing protein 3.16754
ALLC allantoicase 3.16754
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.16754
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.16754
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.16754
C10ORF90 chromosome 10 open reading frame 90 3.16754
DHRS7C dehydrogenase/reductase (SDR family) member 7C 3.16754
RNF148 ring finger protein 148 3.16754
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.16754
POU3F3 POU class 3 homeobox 3 3.16754
GH1 growth hormone 1 3.16754
MT1X metallothionein 1X 3.16754
RHAG Rh-associated glycoprotein 3.16754
CCNO cyclin O 3.16754
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.16754
PCDHGB1 protocadherin gamma subfamily B, 1 3.16754
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.16754
LYPD5 LY6/PLAUR domain containing 5 3.16754
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.16754
CCNI2 cyclin I family, member 2 3.16754
IRX4 iroquois homeobox 4 3.16754
NLRP13 NLR family, pyrin domain containing 13 3.16754
KRT15 keratin 15, type I 3.16754
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.16754
GOLGA8S golgin A8 family, member S 3.16754
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.16754
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.16754
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 3.16754
NCOA2 nuclear receptor coactivator 2 3.16066
NUTM2G NUT family member 2G 3.089
WNT4 wingless-type MMTV integration site family, member 4 3.089
SPOCD1 SPOC domain containing 1 3.089
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.92798
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.82987
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.81361
CD2AP CD2-associated protein 2.7729
LRRC4C leucine rich repeat containing 4C 2.7389
TMEM121B transmembrane protein 121B 2.64924
RBM10 RNA binding motif protein 10 2.63866
RMDN3 regulator of microtubule dynamics 3 2.62877
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.58146
MAP2K6 mitogen-activated protein kinase kinase 6 2.57358
PLAC1 placenta-specific 1 2.52593
KLF12 Kruppel-like factor 12 2.52593
CHD6 chromodomain helicase DNA binding protein 6 2.52489
HCST hematopoietic cell signal transducer 2.51845
YTHDC1 YTH domain containing 1 2.49609
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.49148
GUCY2C guanylate cyclase 2C 2.42632
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.41625
TACSTD2 tumor-associated calcium signal transducer 2 2.35249
CNGB3 cyclic nucleotide gated channel beta 3 2.34018
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 2.27791
LCLAT1 lysocardiolipin acyltransferase 1 2.23968
EPHA2 EPH receptor A2 2.22129
SPIDR scaffolding protein involved in DNA repair 2.20804
SSBP2 single-stranded DNA binding protein 2 2.20804
PDIK1L PDLIM1 interacting kinase 1 like 2.19629
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 2.19629
MOGS mannosyl-oligosaccharide glucosidase 2.17952
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2.17952
ZNF226 zinc finger protein 226 2.14781
AQR aquarius intron-binding spliceosomal factor 2.14781
KIF9 kinesin family member 9 2.13997
CDCA4 cell division cycle associated 4 2.11898
ERN2 endoplasmic reticulum to nucleus signaling 2 2.10788
RAI14 retinoic acid induced 14 2.10591
NLGN2 neuroligin 2 2.09657
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.09477
BAIAP3 BAI1-associated protein 3 2.09477
RPS21-DT RPS21 divergent transcript 2.09477
NOD2 nucleotide-binding oligomerization domain containing 2 2.09477
HLA-DMB major histocompatibility complex, class II, DM beta 2.09477
TRIM15 tripartite motif containing 15 2.09477
ATR ATR serine/threonine kinase 2.07464
SMC3 structural maintenance of chromosomes 3 2.07464
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.03628
MARCHF2 membrane associated ring-CH-type finger 2 2.01652
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 2.01394
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 2.00669

decreased expression

Symbol Name Standardized Value
CIMAP1B ciliary microtubule associated protein 1B -3.16754
LGALS4 lectin, galactoside-binding, soluble, 4 -3.16754
CLCN1 chloride channel, voltage-sensitive 1 -3.16754
CPLX4 complexin 4 -3.16754
SPPL2A signal peptide peptidase like 2A -3.16754
MANSC4 MANSC domain containing 4 -3.16754
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -3.16754
NMUR1 neuromedin U receptor 1 -3.16754
SOST sclerostin -3.16754
EBI3 Epstein-Barr virus induced 3 -3.16754
RDH16 retinol dehydrogenase 16 (all-trans) -3.16754
ASCL3 achaete-scute family bHLH transcription factor 3 -3.16754
GGN gametogenetin -3.16754
AGBL4 ATP/GTP binding protein-like 4 -3.16754
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -3.16754
CX3CL1 chemokine (C-X3-C motif) ligand 1 -3.16754
PARP3 poly (ADP-ribose) polymerase family, member 3 -3.16754
INSYN2B inhibitory synaptic factor family member 2B -3.16754
MARCHF10 membrane associated ring-CH-type finger 10 -3.16754
NSG2 neuronal vesicle trafficking associated 2 -3.16754
STYXL2 serine/threonine/tyrosine interacting like 2 -3.16754
MCRIP1 MAPK regulated corepressor interacting protein 1 -3.16754
PDF peptide deformylase (mitochondrial) -3.16754
LEKR1 leucine, glutamate and lysine rich 1 -3.16754
PCDHA3 protocadherin alpha 3 -3.16754
TEX53 testis expressed 53 -3.16754
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -3.16754
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 -3.16754
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -3.16754
MYBPHL myosin binding protein H-like -3.16754
TXLNB taxilin beta -3.16754
MST1 macrophage stimulating 1 -3.16754
SUN3 Sad1 and UNC84 domain containing 3 -3.16754
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -3.16754
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -3.16754
C22ORF15 chromosome 22 open reading frame 15 -3.16754
SCNN1D sodium channel, non voltage gated 1 delta subunit -3.16754
PRSS54 protease, serine, 54 -3.16754
CTXN2 cortexin 2 -3.16754
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -3.16754
UPK1B uroplakin 1B -3.16754
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -3.16754
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -3.16754
FAM163A family with sequence similarity 163, member A -3.16754
IFT70A intraflagellar transport 70A -3.16129
KLF7 Kruppel-like factor 7 (ubiquitous) -3.0808
ANTXR1 anthrax toxin receptor 1 -3.03665
ZNF432 zinc finger protein 432 -2.94536
DAP3 death associated protein 3 -2.94018
NTN1 netrin 1 -2.8704
SPATA17 spermatogenesis associated 17 -2.7696
SCTR secretin receptor -2.75489
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.7389
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.7129
HAX1 HCLS1 associated protein X-1 -2.69537
BBS12 Bardet-Biedl syndrome 12 -2.69318
SGK1 serum/glucocorticoid regulated kinase 1 -2.68289
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -2.53103
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.4564
PODNL1 podocan-like 1 -2.4564
FOXJ1 forkhead box J1 -2.4564
ARMCX1 armadillo repeat containing, X-linked 1 -2.42632
TNNC1 troponin C type 1 (slow) -2.41131
GRHL3 grainyhead-like 3 (Drosophila) -2.39314
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 -2.37199
ZNF888 zinc finger protein 888 -2.36078
EFNA1 ephrin-A1 -2.32476
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.31806
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.30337
GOLGA3 golgin A3 -2.29596
KRTDAP keratinocyte differentiation-associated protein -2.27506
RAD50 RAD50 homolog (S. cerevisiae) -2.26553
STXBP1 syntaxin binding protein 1 -2.26503
AFF2 AF4/FMR2 family, member 2 -2.24621
ZFR2 zinc finger RNA binding protein 2 -2.23822
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.23822
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 -2.22129
CCDC170 coiled-coil domain containing 170 -2.20804
STRC stereocilin -2.20804
SLITRK3 SLIT and NTRK-like family, member 3 -2.20804
HSF5 heat shock transcription factor family member 5 -2.20804
SPATA32 spermatogenesis associated 32 -2.20804
COL9A2 collagen, type IX, alpha 2 -2.20804
MYLK4 myosin light chain kinase family, member 4 -2.20804
LEPROT leptin receptor overlapping transcript -2.20804
ZFP3 ZFP3 zinc finger protein -2.19267
CC2D2B coiled-coil and C2 domain containing 2B -2.19267
PBX4 pre-B-cell leukemia homeobox 4 -2.18174
PIWIL2 piwi-like RNA-mediated gene silencing 2 -2.17463
GDF11 growth differentiation factor 11 -2.17459
TGFB2 transforming growth factor, beta 2 -2.15416
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.14781
UBL5 ubiquitin-like 5 -2.14781
XKR6 XK, Kell blood group complex subunit-related family, member 6 -2.12945
ADRA2C adrenoceptor alpha 2C -2.12367
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.1192
TOP2B topoisomerase (DNA) II beta 180kDa -2.10788
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase -2.0629
TXNDC17 thioredoxin domain containing 17 -2.05755
ZNF675 zinc finger protein 675 -2.05396
FAM117B family with sequence similarity 117, member B -2.02647
CA10 carbonic anhydrase X -2.02012
ZDHHC16 zinc finger, DHHC-type containing 16 -2.02012