ATF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description activating transcription factor 1|This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 466)
External Link http://www.ncbi.nlm.nih.gov/gene/466
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Genes

30 interacting proteins for ATF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BRCA1 breast cancer 1, early onset
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CDK3 cyclin-dependent kinase 3
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CREM cAMP responsive element modulator
CSNK1A1 casein kinase 1, alpha 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
EDF1 endothelial differentiation-related factor 1
ESR1 estrogen receptor 1
FOSL2 FOS-like antigen 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
HNF1B HNF1 homeobox B
JUN jun proto-oncogene
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
NFIL3 nuclear factor, interleukin 3 regulated
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SPI1 Spi-1 proto-oncogene
SRA1 steroid receptor RNA activator 1
UBC ubiquitin C