ATF2_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/ATF2_UP.V1_UP
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Genes

375 genes differentially expressed following the ATF2_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABLIM3 actin binding LIM protein family, member 3
ADAM28 ADAM metallopeptidase domain 28
ADM2 adrenomedullin 2
AKAP4 A kinase (PRKA) anchor protein 4
ALLC allantoicase
ALOX12 arachidonate 12-lipoxygenase
ALX3 ALX homeobox 3
AMELY amelogenin, Y-linked
ANKRD11 ankyrin repeat domain 11
ANKRD34C ankyrin repeat domain 34C
APAF1 apoptotic peptidase activating factor 1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APOD apolipoprotein D
ARHGAP22 Rho GTPase activating protein 22
ARSJ arylsulfatase family, member J
ASPN asporin
ATP13A2 ATPase type 13A2
BAALC brain and acute leukemia, cytoplasmic
BAIAP3 BAI1-associated protein 3
BRAP BRCA1 associated protein
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2CD2L C2CD2-like
C3AR1 complement component 3a receptor 1
C8ORF4 chromosome 8 open reading frame 4
CA14 carbonic anhydrase XIV
CARD9 caspase recruitment domain family, member 9
CBX5 chromobox homolog 5
CCDC94 coiled-coil domain containing 94
CCR4 chemokine (C-C motif) receptor 4
CD19 CD19 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD8A CD8a molecule
CENPO centromere protein O
CENPU centromere protein U
CEP41 centrosomal protein 41kDa
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLDN1 claudin 1
CLDN15 claudin 15
CNTN5 contactin 5
COL2A1 collagen, type II, alpha 1
CORO2B coronin, actin binding protein, 2B
CST5 cystatin D
DCAF4 DDB1 and CUL4 associated factor 4
DENND2A DENN/MADD domain containing 2A
DGKZ diacylglycerol kinase, zeta
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DNASE2B deoxyribonuclease II beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
EMILIN2 elastin microfibril interfacer 2
ENDOG endonuclease G
FABP4 fatty acid binding protein 4, adipocyte
FAM102A family with sequence similarity 102, member A
FANCF Fanconi anemia, complementation group F
FGF16 fibroblast growth factor 16
FGF20 fibroblast growth factor 20
FGFBP1 fibroblast growth factor binding protein 1
FGR FGR proto-oncogene, Src family tyrosine kinase
FOXG1 forkhead box G1
FOXL2 forkhead box L2
FOXM1 forkhead box M1
FRMD1 FERM domain containing 1
FSD1 fibronectin type III and SPRY domain containing 1
FSHB follicle stimulating hormone, beta polypeptide
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALR2 galanin receptor 2
GDF10 growth differentiation factor 10
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GMPPB GDP-mannose pyrophosphorylase B
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPR63 G protein-coupled receptor 63
GPX5 glutathione peroxidase 5
GRAP GRB2-related adaptor protein
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCA1A guanylate cyclase activator 1A (retina)
GZMK granzyme K (granzyme 3; tryptase II)
HMX1 H6 family homeobox 1
HOXB1 homeobox B1
HOXD1 homeobox D1
HOXD11 homeobox D11
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM2 intercellular adhesion molecule 2
IGF2 insulin-like growth factor 2
IL32 interleukin 32
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGA8 integrin, alpha 8
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KISS1 KiSS-1 metastasis-suppressor
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LAS1L LAS1-like (S. cerevisiae)
LIG1 ligase I, DNA, ATP-dependent
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LIPE lipase, hormone-sensitive
LRTM1 leucine-rich repeats and transmembrane domains 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LYPD1 LY6/PLAUR domain containing 1
MAGEC3 melanoma antigen family C3
MAP2 microtubule-associated protein 2
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MELK maternal embryonic leucine zipper kinase
MMP1 matrix metallopeptidase 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
NCAPG non-SMC condensin I complex, subunit G
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NEO1 neogenin 1
NES nestin
NEUROG1 neurogenin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NNAT neuronatin
NRXN2 neurexin 2
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
PACS1 phosphofurin acidic cluster sorting protein 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAX1 paired box 1
PCDH1 protocadherin 1
PCDHA9 protocadherin alpha 9
PCP4 Purkinje cell protein 4
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PELP1 proline, glutamate and leucine rich protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PITX1 paired-like homeodomain 1
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PLK4 polo-like kinase 4
PLXNB3 plexin B3
PNLIP pancreatic lipase
PODXL podocalyxin-like
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PRKCD protein kinase C, delta
PRMT8 protein arginine methyltransferase 8
PRSS50 protease, serine, 50
PTDSS2 phosphatidylserine synthase 2
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTPRT protein tyrosine phosphatase, receptor type, T
RAD51 RAD51 recombinase
RBP1 retinol binding protein 1, cellular
REEP2 receptor accessory protein 2
RNF2 ring finger protein 2
RNF43 ring finger protein 43
RSPH6A radial spoke head 6 homolog A (Chlamydomonas)
S100A4 S100 calcium binding protein A4
SAG S-antigen; retina and pineal gland (arrestin)
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3BGR SH3 domain binding glutamate-rich protein
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SPRR2C small proline-rich protein 2C (pseudogene)
STAT5A signal transducer and activator of transcription 5A
STEAP1B STEAP family member 1B
STRA6 stimulated by retinoic acid 6
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBC1D29 TBC1 domain family, member 29
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TK1 thymidine kinase 1, soluble
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TRIM14 tripartite motif containing 14
TRIM9 tripartite motif containing 9
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSC22D4 TSC22 domain family, member 4
TSPAN32 tetraspanin 32
TSSK2 testis-specific serine kinase 2
UPP1 uridine phosphorylase 1
VIPR2 vasoactive intestinal peptide receptor 2
VRTN vertebrae development associated
WNT5B wingless-type MMTV integration site family, member 5B
ZFR2 zinc finger RNA binding protein 2
ZNF324B zinc finger protein 324B
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
AADAC arylacetamide deacetylase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACACA acetyl-CoA carboxylase alpha
ACVR2A activin A receptor, type IIA
ADAM15 ADAM metallopeptidase domain 15
ADORA2B adenosine A2b receptor
AFF1 AF4/FMR2 family, member 1
AIRE autoimmune regulator
AK4 adenylate kinase 4
AK4P3 adenylate kinase 4 pseudogene 3
ANXA10 annexin A10
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP8B4 ATPase, class I, type 8B, member 4
BHLHE40 basic helix-loop-helix family, member e40
BHMT betaine--homocysteine S-methyltransferase
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CA9 carbonic anhydrase IX
CCK cholecystokinin
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCP110 centriolar coiled coil protein 110kDa
CD1B CD1b molecule
CD200 CD200 molecule
CD302 CD302 molecule
CD68 CD68 molecule
CDH13 cadherin 13
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CECR1 cat eye syndrome chromosome region, candidate 1
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CRLF1 cytokine receptor-like factor 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CXCL12 chemokine (C-X-C motif) ligand 12
CYBRD1 cytochrome b reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DENND2D DENN/MADD domain containing 2D
DENND4C DENN/MADD domain containing 4C
DGKD diacylglycerol kinase, delta 130kDa
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDNRA endothelin receptor type A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERAP2 endoplasmic reticulum aminopeptidase 2
ERO1L ERO1-like (S. cerevisiae)
EVC Ellis van Creveld protein
FAM198B family with sequence similarity 198, member B
FBLN2 fibulin 2
FGF7 fibroblast growth factor 7
FGF9 fibroblast growth factor 9
FMOD fibromodulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FRY furry homolog (Drosophila)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS1 growth arrest-specific 1
GCH1 GTP cyclohydrolase 1
GLRA2 glycine receptor, alpha 2
GOLGA8A golgin A8 family, member A
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPRC5C G protein-coupled receptor, class C, group 5, member C
GSR glutathione reductase
GSTT1 glutathione S-transferase theta 1
GUCA1B guanylate cyclase activator 1B (retina)
HAPLN1 hyaluronan and proteoglycan link protein 1
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HEXIM1 hexamethylene bis-acetamide inducible 1
HKDC1 hexokinase domain containing 1
HMG20A high mobility group 20A
HOXB2 homeobox B2
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
IL1RAP interleukin 1 receptor accessory protein
IL33 interleukin 33
IQCG IQ motif containing G
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
JUP junction plakoglobin
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KEL Kell blood group, metallo-endopeptidase
KLHL21 kelch-like family member 21
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LIMCH1 LIM and calponin homology domains 1
LOC399491
MFAP4 microfibrillar-associated protein 4
MN1 meningioma (disrupted in balanced translocation) 1
MRPL44 mitochondrial ribosomal protein L44
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYO1D myosin ID
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NPPB natriuretic peptide B
NUPL1 nucleoporin like 1
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM3 PDZ and LIM domain 3
PDPN podoplanin
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER3 period circadian clock 3
PID1 phosphotyrosine interaction domain containing 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP prolactin-induced protein
PISD phosphatidylserine decarboxylase
PKP2 plakophilin 2
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEK2 pleckstrin 2
PLN phospholamban
PLS1 plastin 1
PLSCR4 phospholipid scramblase 4
PNMA2 paraneoplastic Ma antigen 2
POGZ pogo transposable element with ZNF domain
PPL periplakin
PPP4R2 protein phosphatase 4, regulatory subunit 2
PTER phosphotriesterase related
PTGFR prostaglandin F receptor (FP)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBL2 retinoblastoma-like 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNASE4 ribonuclease, RNase A family, 4
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
S100A3 S100 calcium binding protein A3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRG1 stimulator of chondrogenesis 1
SDC3 syndecan 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP4 secreted frizzled-related protein 4
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SHOX2 short stature homeobox 2
SIK1 salt-inducible kinase 1
SLC12A8 solute carrier family 12, member 8
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLIT3 slit homolog 3 (Drosophila)
SMAD6 SMAD family member 6
SNCAIP synuclein, alpha interacting protein
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR2B small proline-rich protein 2B
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
STXBP2 syntaxin binding protein 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCF21 transcription factor 21
TGM5 transglutaminase 5
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP3B topoisomerase (DNA) III beta
TP73-AS1 TP73 antisense RNA 1
TPD52 tumor protein D52
TREM1 triggering receptor expressed on myeloid cells 1
UBXN2B UBX domain protein 2B
VCAM1 vascular cell adhesion molecule 1
VTN vitronectin
WISP1 WNT1 inducible signaling pathway protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF432 zinc finger protein 432
ZNF652 zinc finger protein 652
ZSCAN31 zinc finger and SCAN domain containing 31