ATF3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description activating transcription factor 3|This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011] (NCBI Entrez Gene Database, 467)
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Genes

342 genes differentially expressed following the ATF3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ITK IL2-inducible T-cell kinase 3.00725
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.00725
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.00725
IGFL3 IGF-like family member 3 3.00725
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.00725
TMEM176A transmembrane protein 176A 3.00725
RAX retina and anterior neural fold homeobox 3.00725
TNNI2 troponin I type 2 (skeletal, fast) 3.00725
TM4SF20 transmembrane 4 L six family member 20 3.00725
NRAP nebulin-related anchoring protein 3.00725
OSR2 odd-skipped related transciption factor 2 3.00725
ALB albumin 3.00725
LAPTM5 lysosomal protein transmembrane 5 3.00725
KLHL33 kelch-like family member 33 3.00725
PCDHA3 protocadherin alpha 3 3.00725
RAB44 RAB44, member RAS oncogene family 3.00725
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.00725
ZNF98 zinc finger protein 98 3.00725
USH1G Usher syndrome 1G (autosomal recessive) 3.00725
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 3.00725
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.00725
COL19A1 collagen, type XIX, alpha 1 3.00725
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.00725
PTAFR platelet-activating factor receptor 3.00725
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.00725
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.00725
BMP3 bone morphogenetic protein 3 3.00725
JCHAIN joining chain of multimeric IgA and IgM 3.00725
MYO1A myosin IA 3.00725
GALR3 galanin receptor 3 3.00725
TCEAL8 transcription elongation factor A (SII)-like 8 3.00725
THEMIS thymocyte selection associated 3.00725
PRR29 proline rich 29 3.00725
LHX1 LIM homeobox 1 3.00725
CCDC87 coiled-coil domain containing 87 3.00725
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.00725
ATOH8 atonal homolog 8 (Drosophila) 3.00725
TBATA thymus, brain and testes associated 3.00725
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.00725
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.00725
GYPB glycophorin B (MNS blood group) 3.00725
LYNX1 Ly6/neurotoxin 1 3.00725
RFPL2 ret finger protein-like 2 3.00725
ADAMTSL5 ADAMTS-like 5 3.00725
C9ORF152 chromosome 9 open reading frame 152 3.00725
TMEM71 transmembrane protein 71 3.00725
NEUROG3 neurogenin 3 3.00725
S100A3 S100 calcium binding protein A3 3.00725
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.00725
LOC124909439 uncharacterized LOC124909439 3.00725
LBHD2 LBH domain containing 2 3.00725
CCN3 cellular communication network factor 3 3.00725
SELENOT selenoprotein T 3.00725
PTH1R parathyroid hormone 1 receptor 3.00725
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.00725
CD300LF CD300 molecule-like family member f 3.00725
MGAT4D MGAT4 family, member D 3.00725
TMIGD1 transmembrane and immunoglobulin domain containing 1 3.00725
FMO2 flavin containing monooxygenase 2 (non-functional) 3.00725
MLN motilin 3.00725
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.00725
CALHM5 calcium homeostasis modulator family member 5 3.00725
LRTM3 leucine rich repeat transmembrane protein 3 3.00725
FAM90A24 family with sequence similarity 90 member A24 3.00725
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.00725
EXOC1L exocyst complex component 1 like 3.00725
LY6S-AS1 LY6S antisense RNA 1 3.00725
TMDD1 transmembrane and death domain 1 3.00725
CIMIP3 ciliary microtubule inner protein 3 3.00725
PRRT1B proline rich transmembrane protein 1B 3.00725
SMIM45 small integral membrane protein 45 3.00725
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.00725
C20ORF202 chromosome 20 open reading frame 202 3.00725
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.00725
IGSF22 immunoglobulin superfamily, member 22 3.00725
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 3.00725
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 3.00725
MIP major intrinsic protein of lens fiber 3.00725
MYH13 myosin, heavy chain 13, skeletal muscle 3.00725
BHLHA9 basic helix-loop-helix family, member a9 3.00725
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.00725
CD79A CD79a molecule, immunoglobulin-associated alpha 3.00725
SCN10A sodium channel, voltage gated, type X alpha subunit 3.00725
IL31RA interleukin 31 receptor A 3.00725
WNT11 wingless-type MMTV integration site family, member 11 3.00725
C1QL2 complement component 1, q subcomponent-like 2 3.00725
C1QTNF1 C1q and tumor necrosis factor related protein 1 3.00725
PAPOLB poly(A) polymerase beta (testis specific) 3.00725
SELL selectin L 3.00725
KL klotho 3.00725
OSTN osteocrin 3.00725
IL16 interleukin 16 3.00725
SAMD11 sterile alpha motif domain containing 11 3.00725
MTMR11 myotubularin related protein 11 3.00725
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.00725
CCR3 chemokine (C-C motif) receptor 3 3.00725
PRR18 proline rich 18 3.00725
VSX2 visual system homeobox 2 3.00725
CABP7 calcium binding protein 7 3.00725
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.00725
TRIM55 tripartite motif containing 55 3.00725
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 3.00725
CCDC27 coiled-coil domain containing 27 3.00725
PCDHGA4 protocadherin gamma subfamily A, 4 3.00725
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.00725
FOXE3 forkhead box E3 3.00725
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.00725
VN1R2 vomeronasal 1 receptor 2 3.00725
PSKH2 protein serine kinase H2 3.00725
MAMLD1 mastermind-like domain containing 1 3.00725
VAX1 ventral anterior homeobox 1 3.00725
VAX2 ventral anterior homeobox 2 3.00725
TESPA1 thymocyte expressed, positive selection associated 1 3.00725
C9ORF64 chromosome 9 open reading frame 64 3.00725
NOX1 NADPH oxidase 1 3.00725
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.00725
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.00725
CCNI2 cyclin I family, member 2 3.00725
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.00725
FBXO40 F-box protein 40 3.00725
CFAP47 cilia and flagella associated protein 47 3.00725
ERVV-2 endogenous retrovirus group V, member 2 3.00725
GPR150 G protein-coupled receptor 150 3.00725
DAGLB diacylglycerol lipase, beta 3.00725
LAMB3 laminin, beta 3 3.00725
LMX1A LIM homeobox transcription factor 1, alpha 3.00725
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.00725
C10ORF105 chromosome 10 open reading frame 105 3.00725
CXORF49C chromosome X open reading frame 49C 3.00725
DRC7 dynein regulatory complex subunit 7 3.00725
C1ORF105 chromosome 1 open reading frame 105 3.00725
LHX5 LIM homeobox 5 3.00725
SPATA9 spermatogenesis associated 9 3.00725
GOLGA8K golgin A8 family, member K 3.00725
IL9R interleukin 9 receptor 3.00725
AICDA activation-induced cytidine deaminase 3.00725
ITGB7 integrin, beta 7 3.00725
NT5DC4 5'-nucleotidase domain containing 4 3.00725
PENK proenkephalin 3.00725
CTSS cathepsin S 3.00725
CTSE cathepsin E 3.00725
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 3.00725
KRT15 keratin 15, type I 3.00725
PSORS1C2 psoriasis susceptibility 1 candidate 2 3.00725
PRSS50 protease, serine, 50 3.00725
CARNS1 carnosine synthase 1 3.00725
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.00725
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.00725
TEX38 testis expressed 38 3.00725
CALML6 calmodulin-like 6 3.00725
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.00725
ITPKA inositol-trisphosphate 3-kinase A 3.00725
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.00725
BPIFC BPI fold containing family C 3.00725
PATE1 prostate and testis expressed 1 3.00725
POTEI POTE ankyrin domain family, member I 3.00725
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.00725
GH2 growth hormone 2 3.00725
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.00725
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.00725
IL12B interleukin 12B 3.00725
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.00725
ARGFX arginine-fifty homeobox 3.00725
TCEAL5 transcription elongation factor A (SII)-like 5 3.00285
CCDC92 coiled-coil domain containing 92 2.94542
CLIP3 CAP-GLY domain containing linker protein 3 2.94542
C9ORF78 chromosome 9 open reading frame 78 2.94542
MAMDC4 MAM domain containing 4 2.94542
ALPK1 alpha-kinase 1 2.94542
ARL4C ADP-ribosylation factor-like 4C 2.94542
AZIN1 antizyme inhibitor 1 2.94542
ZNF660-ZNF197 ZNF660-ZNF197 readthrough 2.89768
ZNF625 zinc finger protein 625 2.87617
MED27 mediator complex subunit 27 2.87617
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 2.79343
NBR1 neighbor of BRCA1 gene 1 2.70026
CTDNEP1 CTD nuclear envelope phosphatase 1 2.60998
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.58714
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.5864
NCBP3 nuclear cap binding subunit 3 2.55387
PEX12 peroxisomal biogenesis factor 12 2.55132
WAPL WAPL cohesin release factor 2.53657
GDAP1 ganglioside induced differentiation associated protein 1 2.52361
IL23A interleukin 23, alpha subunit p19 2.50134
NECTIN3 nectin cell adhesion molecule 3 2.49078
FN3KRP fructosamine 3 kinase related protein 2.48108
ASB17 ankyrin repeat and SOCS box containing 17 2.47866
DISP3 dispatched RND transporter family member 3 2.47034
ATPSCKMT ATP synthase c subunit lysine N-methyltransferase 2.46088
RAD23B RAD23 homolog B (S. cerevisiae) 2.4378
CYB561 cytochrome b561 2.42877
BMS1 BMS1 ribosome biogenesis factor 2.41845
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 2.41708
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.38834
SPAG6 sperm associated antigen 6 2.38834
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.37471
GBA2 glucosidase, beta (bile acid) 2 2.36146
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 2.35111
LEFTY2 left-right determination factor 2 2.35106
FAM89A family with sequence similarity 89, member A 2.35106
TTC9B tetratricopeptide repeat domain 9B 2.35106
VRK2 vaccinia related kinase 2 2.32787
ZNF713 zinc finger protein 713 2.32713
CCDC102B coiled-coil domain containing 102B 2.31988
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 2.31988
ANKMY1 ankyrin repeat and MYND domain containing 1 2.31321
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.31305
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.31076
TMEM50B transmembrane protein 50B 2.29218
ZNF280D zinc finger protein 280D 2.23387
CCDC8 coiled-coil domain containing 8 2.22369
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 2.21722
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 2.19111
AASS aminoadipate-semialdehyde synthase 2.17791
SMN2 survival of motor neuron 2, centromeric 2.17791
CEMIP2 cell migration inducing hyaluronidase 2 2.16248
RPS27 ribosomal protein S27 2.14423
NIFK nucleolar protein interacting with the FHA domain of MKI67 2.14423
TNPO1 transportin 1 2.10627
EGFL6 EGF-like-domain, multiple 6 2.10222
TNN tenascin N 2.09462
GGN gametogenetin 2.09462
CCDC125 coiled-coil domain containing 125 2.09462
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.09462
TMEM61 transmembrane protein 61 2.09462
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.09462
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.09462
ABI3BP ABI family, member 3 (NESH) binding protein 2.09462
NASP nuclear autoantigenic sperm protein (histone-binding) 2.09462
FABP3 fatty acid binding protein 3, muscle and heart 2.09307
C2CD3 C2 calcium-dependent domain containing 3 2.09307
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.09307
TRIR telomerase RNA component interacting RNase 2.09307
SLC30A7 solute carrier family 30 (zinc transporter), member 7 2.08274
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.08274
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.06571
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 2.06535
FGGY FGGY carbohydrate kinase domain containing 2.06535
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2.06444
BCOR BCL6 corepressor 2.04533
ZNF875 zinc finger protein 875 2.02714
PROSER2 proline and serine rich 2 2.01951
GLDC glycine dehydrogenase (decarboxylating) 2.01951
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 2.01264
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.0112
NTS neurotensin 2.00957
TRPC4 transient receptor potential cation channel, subfamily C, member 4 2.00151

decreased expression

Symbol Name Standardized Value
GJC3 gap junction protein, gamma 3, 30.2kDa -3.00725
ITGB8 integrin, beta 8 -3.00725
TMED7 transmembrane emp24 protein transport domain containing 7 -3.00725
KLHL31 kelch-like family member 31 -3.00725
C1ORF87 chromosome 1 open reading frame 87 -3.00725
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.94542
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.94542
SBK2 SH3 domain binding kinase family, member 2 -2.94542
ZIC4 Zic family member 4 -2.94542
BSND barttin CLCNK-type chloride channel accessory beta subunit -2.94542
CARD9 caspase recruitment domain family, member 9 -2.94542
ROM1 retinal outer segment membrane protein 1 -2.94542
PNOC prepronociceptin -2.94542
GNRHR gonadotropin-releasing hormone receptor -2.94542
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -2.94542
KRTAP13-4 keratin associated protein 13-4 -2.94542
PITX2 paired-like homeodomain 2 -2.94542
ANKRD30A ankyrin repeat domain 30A -2.94542
RGPD5 RANBP2-like and GRIP domain containing 5 -2.94542
FGF16 fibroblast growth factor 16 -2.94542
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -2.94542
AMIGO1 adhesion molecule with Ig-like domain 1 -2.94542
STYXL2 serine/threonine/tyrosine interacting like 2 -2.94542
FSHR follicle stimulating hormone receptor -2.94542
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.94542
GATA3 GATA binding protein 3 -2.94542
CFAP90 cilia and flagella associated protein 90 -2.94542
PLA1A phospholipase A1 member A -2.94542
LMOD2 leiomodin 2 (cardiac) -2.94542
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -2.94542
RANBP3L RAN binding protein 3-like -2.94542
SCRT2 scratch family zinc finger 2 -2.94542
H3C13 H3 clustered histone 13 -2.94542
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.91814
MORN4 MORN repeat containing 4 -2.87568
PAAF1 proteasomal ATPase-associated factor 1 -2.8708
GDA guanine deaminase -2.82828
PRXL2C peroxiredoxin like 2C -2.82828
COG5 component of oligomeric golgi complex 5 -2.82379
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 -2.78558
SMOC2 SPARC related modular calcium binding 2 -2.76502
WBP4 WW domain binding protein 4 -2.73091
PARN poly(A)-specific ribonuclease -2.6574
HAGH hydroxyacylglutathione hydrolase -2.65623
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.64434
SYT14 synaptotagmin XIV -2.6146
ARL11 ADP-ribosylation factor-like 11 -2.59765
CCDC124 coiled-coil domain containing 124 -2.56685
SNU13 small nuclear ribonucleoprotein 13 -2.52135
TMPRSS2 transmembrane protease, serine 2 -2.51142
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -2.50632
MRPL30 mitochondrial ribosomal protein L30 -2.48035
ERP44 endoplasmic reticulum protein 44 -2.46088
NALF2 NALCN channel auxiliary factor 2 -2.44927
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -2.41845
TMEM263 transmembrane protein 263 -2.38007
ERICH6 glutamate-rich 6 -2.35106
SPAG4 sperm associated antigen 4 -2.35106
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -2.35106
HIPK3 homeodomain interacting protein kinase 3 -2.34276
TRPT1 tRNA phosphotransferase 1 -2.34171
EMC1 ER membrane protein complex subunit 1 -2.3399
RFC2 replication factor C (activator 1) 2, 40kDa -2.32346
TELO2 telomere maintenance 2 -2.3144
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.27328
ETAA1 Ewing tumor-associated antigen 1 -2.25656
TMEM150B transmembrane protein 150B -2.20971
PRNP prion protein -2.20647
RUVBL2 RuvB-like AAA ATPase 2 -2.20647
P3H3 prolyl 3-hydroxylase 3 -2.18338
NBPF10 neuroblastoma breakpoint family, member 10 -2.16248
RNF145 ring finger protein 145 -2.16248
COMMD7 COMM domain containing 7 -2.16248
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -2.13611
TOX thymocyte selection-associated high mobility group box -2.11393
MACROD2 MACRO domain containing 2 -2.10222
TOGARAM2 TOG array regulator of axonemal microtubules 2 -2.10222
USP35 ubiquitin specific peptidase 35 -2.10222
ETFDH electron-transferring-flavoprotein dehydrogenase -2.10222
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) -2.09462
FLNA filamin A, alpha -2.09307
GFY golgi-associated, olfactory signaling regulator -2.09307
GRB14 growth factor receptor-bound protein 14 -2.09307
NPM3 nucleophosmin/nucleoplasmin 3 -2.09245
TMEM41B transmembrane protein 41B -2.08605
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.08605
RBMXL1 RNA binding motif protein, X-linked-like 1 -2.08274
NMD3 NMD3 ribosome export adaptor -2.0794
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.06535
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.05704
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -2.03641
TMEM63A transmembrane protein 63A -2.03492
MDFI MyoD family inhibitor -2.03059
GAL3ST3 galactose-3-O-sulfotransferase 3 -2.02423
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -2.00663