| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | activating transcription factor 4|This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 468) |
| External Link | https://ncbi.nlm.nih.gov/gene/468 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the ATF4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAGEA3 | melanoma antigen family A3 | 0.0144117 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0121759 |
| E2F2 | E2F transcription factor 2 | 0.0117997 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.0114316 |
| MAGEA12 | melanoma antigen family A12 | 0.0114096 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0108226 |
| ETNK1 | ethanolamine kinase 1 | 0.0101261 |
| PEG3 | paternally expressed 3 | 0.0099462 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00961153 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00947932 |
| CP | ceruloplasmin (ferroxidase) | 0.00936293 |
| CTSC | cathepsin C | 0.00916889 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00911484 |
| CLU | clusterin | 0.00910193 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00899861 |
| ALB | albumin | 0.00884507 |
| MAGEA1 | melanoma antigen family A1 | 0.00874583 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00857941 |
| HHEX | hematopoietically expressed homeobox | 0.00847028 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | 0.00839252 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.00833977 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | 0.00820364 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00817494 |
| SHTN1 | shootin 1 | 0.0080064 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.00776947 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00767973 |
| VNN1 | vanin 1 | 0.0075955 |
| MAMLD1 | mastermind-like domain containing 1 | 0.00738189 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | 0.00736926 |
| CD59 | CD59 molecule, complement regulatory protein | 0.00735396 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.00730698 |
| PLAT | plasminogen activator, tissue | 0.00730575 |
| CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | 0.00728538 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00716233 |
| PERP | PERP, TP53 apoptosis effector | 0.00712833 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00709641 |
| ADH1C | alcohol dehydrogenase 1C (class I), gamma polypeptide | 0.00687785 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00681374 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.00679644 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | 0.00675496 |
| EMP3 | epithelial membrane protein 3 | 0.00674461 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00672864 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00655787 |
| CFH | complement factor H | 0.00642222 |
| ATF3 | activating transcription factor 3 | 0.0064186 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00628439 |
| EPAS1 | endothelial PAS domain protein 1 | 0.00627095 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00620837 |
| SSX1 | synovial sarcoma, X breakpoint 1 | 0.00620089 |
| CD163 | CD163 molecule | 0.00619352 |
| MAOB | monoamine oxidase B | 0.00618839 |
| HMGN5 | high mobility group nucleosome binding domain 5 | 0.00618374 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.00614028 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00611385 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | 0.00610297 |
| EDN3 | endothelin 3 | 0.00608571 |
| ARMT1 | acidic residue methyltransferase 1 | 0.00608164 |
| WFDC2 | WAP four-disulfide core domain 2 | 0.00603487 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00602372 |
| CD14 | CD14 molecule | 0.00596501 |
| CRP | C-reactive protein, pentraxin-related | 0.00595599 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | 0.00594892 |
| ABHD3 | abhydrolase domain containing 3 | 0.00592625 |
| MAGEB2 | melanoma antigen family B2 | 0.00588411 |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | 0.00582782 |
| TMEM255A | transmembrane protein 255A | 0.00580503 |
| NPTX2 | neuronal pentraxin II | 0.00580383 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00577848 |
| IL1R2 | interleukin 1 receptor, type II | 0.00574858 |
| ORM1 | orosomucoid 1 | 0.00572574 |
| ESR1 | estrogen receptor 1 | 0.00571443 |
| TMEM165 | transmembrane protein 165 | 0.00568459 |
| S100A2 | S100 calcium binding protein A2 | 0.00566634 |
| STK10 | serine/threonine kinase 10 | 0.00560583 |
| MAGEA4 | melanoma antigen family A4 | 0.00559983 |
| XIC | X chromosome inactivation center | 0.00559588 |
| APOC2 | apolipoprotein C-II | 0.00558807 |
| KRT8 | keratin 8, type II | 0.0055802 |
| RAB5IF | RAB5 interacting factor | 0.00554441 |
| HAMP | hepcidin antimicrobial peptide | 0.00554098 |
| MUC16 | mucin 16, cell surface associated | 0.00553121 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.00550327 |
| SNX10 | sorting nexin 10 | 0.00547862 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 0.00546196 |
| C9 | complement component 9 | 0.00544819 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00542991 |
| GCH1 | GTP cyclohydrolase 1 | 0.00540303 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0053957 |
| GLCE | glucuronic acid epimerase | 0.0053916 |
| CD48 | CD48 molecule | 0.00535942 |
| CLDN1 | claudin 1 | 0.00530339 |
| SFN | stratifin | 0.00529078 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.00526494 |
| GOLT1B | golgi transport 1B | 0.00526063 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 0.00523617 |
| MYO5C | myosin VC | 0.00521455 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.00520903 |
| PROM1 | prominin 1 | 0.00520783 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00517682 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 | 0.00517538 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | 0.00514648 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.0051356 |
| HP | haptoglobin | 0.00513557 |
| MGST3 | microsomal glutathione S-transferase 3 | 0.005131 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00512383 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.00511327 |
| SAR1B | secretion associated, Ras related GTPase 1B | 0.0051105 |
| MAT2B | methionine adenosyltransferase II, beta | 0.00509843 |
| AMBP | alpha-1-microglobulin/bikunin precursor | 0.00509738 |
| CPB2 | carboxypeptidase B2 (plasma) | 0.00509565 |
| DEFB1 | defensin, beta 1 | 0.00507941 |
| COMT | catechol-O-methyltransferase | 0.00507759 |
| UGT2B4 | UDP glucuronosyltransferase 2 family, polypeptide B4 | 0.0050703 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.00506272 |
| COG2 | component of oligomeric golgi complex 2 | 0.00505956 |
| SPA17 | sperm autoantigenic protein 17 | 0.00505313 |
| SERPINA6 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | 0.00504776 |
| EMC3 | ER membrane protein complex subunit 3 | 0.00500341 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 0.0049959 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.00499391 |
| PTER | phosphotriesterase related | 0.00499365 |
| IQCG | IQ motif containing G | 0.00497937 |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.0049783 |
| OXSM | 3-oxoacyl-ACP synthase, mitochondrial | 0.00497672 |
| MAPRE1 | microtubule-associated protein, RP/EB family, member 1 | 0.00491389 |
| CLDN10 | claudin 10 | 0.00490824 |
| KYNU | kynureninase | 0.00489921 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00489869 |
| SALL1 | spalt-like transcription factor 1 | 0.00489371 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.00488472 |
| COBL | cordon-bleu WH2 repeat protein | 0.00487772 |
| SOHLH2 | spermatogenesis and oogenesis specific basic helix-loop-helix 2 | 0.00487703 |
| PAQR3 | progestin and adipoQ receptor family member III | 0.00486891 |
| GTPBP8 | GTP-binding protein 8 (putative) | 0.00485999 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.00485623 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00485139 |
| SPP1 | secreted phosphoprotein 1 | 0.00482505 |
| NXT1 | nuclear transport factor 2-like export factor 1 | 0.00481687 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.00481413 |
| MICB | MHC class I polypeptide-related sequence B | 0.00480497 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | 0.00479542 |
| GPX3 | glutathione peroxidase 3 | 0.00478528 |
| ERGIC2 | ERGIC and golgi 2 | 0.00478402 |
| DPY19L2P2 | DPY19L2 pseudogene 2 | 0.0047701 |
| STXBP2 | syntaxin binding protein 2 | 0.00475498 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | 0.00475462 |
| EFHC2 | EF-hand domain (C-terminal) containing 2 | 0.00473525 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00473421 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.00473132 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.00471467 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00471428 |
| AHSG | alpha-2-HS-glycoprotein | 0.00470227 |
| ARL14 | ADP-ribosylation factor-like 14 | 0.00468893 |
| HSBP1 | heat shock factor binding protein 1 | 0.00467792 |
| MAGEC2 | melanoma antigen family C2 | 0.00467743 |
| FCGBP | Fc fragment of IgG binding protein | 0.0046706 |
| C3 | complement component 3 | 0.00463221 |
| KLHL23 | kelch-like family member 23 | 0.00463087 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00462999 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.00462905 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.00461637 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 0.00461387 |
| TLR5 | toll-like receptor 5 | 0.00460255 |
| UGT2A3 | UDP glucuronosyltransferase 2 family, polypeptide A3 | 0.00460223 |
| MAGEA10 | melanoma antigen family A10 | 0.00460008 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.00459461 |
| ANXA2 | annexin A2 | 0.00458919 |
| NDP | Norrie disease (pseudoglioma) | 0.00458543 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 0.0045753 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | 0.00457508 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | 0.00457115 |
| CD44 | CD44 molecule (Indian blood group) | 0.00457029 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | 0.0045695 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.00456849 |
| SLC38A4 | solute carrier family 38, member 4 | 0.00456482 |
| C2CD5 | C2 calcium-dependent domain containing 5 | 0.00456444 |
| CAPG | capping protein (actin filament), gelsolin-like | 0.00454021 |
| H1-2 | H1.2 linker histone, cluster member | 0.00452717 |
| BCAP29 | B-cell receptor-associated protein 29 | 0.00451646 |
| EHF | ets homologous factor | 0.0045015 |
| CD86 | CD86 molecule | 0.00450018 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00448346 |
| SMC5 | structural maintenance of chromosomes 5 | 0.00448203 |
| KRT15 | keratin 15, type I | 0.0044781 |
| HIST1H2BK | histone cluster 1, H2bk | 0.00447532 |
| SAA4 | serum amyloid A4, constitutive | 0.00446899 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00446586 |
| TPTE | transmembrane phosphatase with tensin homology | 0.00446012 |
| ELOVL2 | ELOVL fatty acid elongase 2 | 0.0044596 |
| DHRS7B | dehydrogenase/reductase (SDR family) member 7B | 0.00445873 |
| APOB | apolipoprotein B | 0.00443951 |
| APOA2 | apolipoprotein A-II | 0.00443431 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00442282 |
| SETMAR | SET domain and mariner transposase fusion gene | 0.00441802 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00441766 |
| SQOR | sulfide quinone oxidoreductase | 0.00440577 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00438367 |
| BEX4 | brain expressed, X-linked 4 | 0.00438077 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.00437359 |
| PBK | PDZ binding kinase | 0.00437227 |
| ANGPTL3 | angiopoietin-like 3 | 0.00437205 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00436657 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00436093 |
| PHF11 | PHD finger protein 11 | 0.00435678 |
| AKR1C4 | aldo-keto reductase family 1, member C4 | 0.00435062 |
| S100A7 | S100 calcium binding protein A7 | 0.00434601 |
| FOXL2 | forkhead box L2 | 0.00434221 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00432665 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | 0.00432608 |
| CALML5 | calmodulin-like 5 | 0.0043225 |
| BCL2L1 | BCL2-like 1 | 0.00431589 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.00431004 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.0042812 |
| EFCAB11 | EF-hand calcium binding domain 11 | 0.00428063 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.00427708 |
| CRIPT | cysteine-rich PDZ-binding protein | 0.00427091 |
| ANKRD36 | ankyrin repeat domain 36 | 0.00426155 |
| SCG5 | secretogranin V | 0.00425769 |
| MTMR1 | myotubularin related protein 1 | 0.00425277 |
| PDLIM4 | PDZ and LIM domain 4 | 0.0042464 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.00424611 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | 0.00424433 |
| FAM169A | family with sequence similarity 169, member A | 0.00424227 |
| CRNKL1 | crooked neck pre-mRNA splicing factor 1 | 0.00423912 |
| SLC30A10 | solute carrier family 30, member 10 | 0.00423574 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 0.00423403 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00422928 |
| FABP1 | fatty acid binding protein 1, liver | 0.00422431 |
| IMPA1 | inositol(myo)-1(or 4)-monophosphatase 1 | 0.00422316 |
| NAXD | NAD(P)HX dehydratase | 0.00422289 |
| RGS1 | regulator of G-protein signaling 1 | 0.00421659 |
| KLF3-AS1 | KLF3 antisense RNA 1 | 0.0042115 |
| USP6NL | USP6 N-terminal like | 0.00420931 |
| HRASLS | HRAS-like suppressor | 0.00420469 |
| DIRAS2 | DIRAS family, GTP-binding RAS-like 2 | 0.00419832 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.00419392 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00419303 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | 0.00418921 |
| SERPINA7 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | 0.00418746 |
| STRAP | serine/threonine kinase receptor associated protein | 0.00418428 |
| TRAF4 | TNF receptor-associated factor 4 | 0.00418211 |
| PKP2 | plakophilin 2 | 0.00417614 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0041749 |
| IL15 | interleukin 15 | 0.00416867 |
| TMSB15A | thymosin beta 15a | 0.0041661 |
| TFEC | transcription factor EC | 0.0041649 |
| ATP5F1C | ATP synthase F1 subunit gamma | 0.00415846 |
| CYP2C8 | cytochrome P450, family 2, subfamily C, polypeptide 8 | 0.0041574 |
| EMP1 | epithelial membrane protein 1 | 0.00415252 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.0141926 |
| NOTCH3 | notch 3 | -0.00898602 |
| STC2 | stanniocalcin 2 | -0.00876618 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00849487 |
| MYLK | myosin light chain kinase | -0.00837327 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.0082828 |
| AUTS2 | autism susceptibility candidate 2 | -0.00827552 |
| CLC | Charcot-Leyden crystal galectin | -0.00820424 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.00785445 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00764481 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.00764161 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00763535 |
| NDRG1 | N-myc downstream regulated 1 | -0.00760952 |
| FBLN1 | fibulin 1 | -0.00760204 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.00756281 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00755701 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -0.00754803 |
| CTSZ | cathepsin Z | -0.00749885 |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | -0.00748246 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00735468 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00732174 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.0071237 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00709663 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00707093 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00704964 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00703119 |
| SULF1 | sulfatase 1 | -0.00691265 |
| BGN | biglycan | -0.00688513 |
| H1-0 | H1.0 linker histone | -0.0068588 |
| AARS1 | alanyl-tRNA synthetase 1 | -0.00685274 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.00680341 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.0067938 |
| NDNF | neuron-derived neurotrophic factor | -0.00677341 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00673494 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.00669874 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00665509 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.00663781 |
| CPE | carboxypeptidase E | -0.00660365 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.00658919 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | -0.00656998 |
| NTS | neurotensin | -0.00656581 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00656443 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00654081 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00642447 |
| RNASE3 | ribonuclease, RNase A family, 3 | -0.00641747 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0063959 |
| ELN | elastin | -0.00638632 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00634659 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00625531 |
| THBS4 | thrombospondin 4 | -0.0062478 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00623157 |
| COMP | cartilage oligomeric matrix protein | -0.00615667 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.00614937 |
| PFKL | phosphofructokinase, liver | -0.00614759 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0061269 |
| CFD | complement factor D (adipsin) | -0.0061016 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -0.00609553 |
| RNF144A | ring finger protein 144A | -0.00608917 |
| CCNB2 | cyclin B2 | -0.00608118 |
| TPM2 | tropomyosin 2 (beta) | -0.00602476 |
| IPO13 | importin 13 | -0.0060214 |
| CADM1 | cell adhesion molecule 1 | -0.00601888 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00599537 |
| VWF | von Willebrand factor | -0.00596534 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.00592944 |
| PWP1 | PWP1 homolog (S. cerevisiae) | -0.00592685 |
| COLEC12 | collectin sub-family member 12 | -0.00591005 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.00590632 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.00584645 |
| PCOLCE | procollagen C-endopeptidase enhancer | -0.00576758 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | -0.00575369 |
| SMYD3 | SET and MYND domain containing 3 | -0.00575319 |
| ZNF586 | zinc finger protein 586 | -0.00573643 |
| RAPSN | receptor-associated protein of the synapse | -0.0057252 |
| LHFP | lipoma HMGIC fusion partner | -0.00572276 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.00564565 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -0.00564512 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00563872 |
| MGP | matrix Gla protein | -0.0056012 |
| TARP | TCR gamma alternate reading frame protein | -0.00557748 |
| PCDH9 | protocadherin 9 | -0.00556558 |
| CRYAB | crystallin, alpha B | -0.00555664 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.00555242 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.00554366 |
| SIRPA | signal-regulatory protein alpha | -0.00550939 |
| TBX3 | T-box 3 | -0.00550341 |
| PLN | phospholamban | -0.00548474 |
| ATF4 | activating transcription factor 4 | -0.00547414 |
| SIRT3 | sirtuin 3 | -0.00547241 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.00547039 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.00546555 |
| C3ORF14 | chromosome 3 open reading frame 14 | -0.00543222 |
| ACP3 | acid phosphatase 3 | -0.00542573 |
| GSE1 | Gse1 coiled-coil protein | -0.00541909 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.00541561 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.00538929 |
| PTK2 | protein tyrosine kinase 2 | -0.0053887 |
| TNS1 | tensin 1 | -0.00538457 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | -0.00535777 |
| G0S2 | G0/G1 switch 2 | -0.00533257 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00533114 |
| NEO1 | neogenin 1 | -0.00532979 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00527639 |
| CALCA | calcitonin-related polypeptide alpha | -0.0052706 |
| ADM | adrenomedullin | -0.00526143 |
| FKBP9 | FK506 binding protein 9, 63 kDa | -0.00524935 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.00519912 |
| HLX | H2.0-like homeobox | -0.00517905 |
| NRN1 | neuritin 1 | -0.00517721 |
| INSR | insulin receptor | -0.00515866 |
| MXRA8 | matrix-remodelling associated 8 | -0.00515156 |
| RPS17 | ribosomal protein S17 | -0.00514388 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -0.0051331 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00511889 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | -0.00511341 |
| TP63 | tumor protein p63 | -0.0051085 |
| UNC13B | unc-13 homolog B (C. elegans) | -0.00510643 |
| XPOT | exportin, tRNA | -0.00510591 |
| COL5A2 | collagen, type V, alpha 2 | -0.00508863 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | -0.0050868 |
| LIMS2 | LIM and senescent cell antigen-like domains 2 | -0.00508585 |
| TNS3 | tensin 3 | -0.00507863 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00507316 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00506668 |
| JAG2 | jagged 2 | -0.00501189 |
| TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) | -0.00500188 |
| RCAN1 | regulator of calcineurin 1 | -0.00500021 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00499713 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00497348 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0049687 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.00495997 |
| TSPYL5 | TSPY-like 5 | -0.00495173 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00493292 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.0049321 |
| OLFM4 | olfactomedin 4 | -0.00492773 |
| VEGFA | vascular endothelial growth factor A | -0.0049245 |
| BPI | bactericidal/permeability-increasing protein | -0.00491891 |
| NCOR2 | nuclear receptor corepressor 2 | -0.00491224 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00490024 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | -0.00488864 |
| EDNRB | endothelin receptor type B | -0.00488605 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00485551 |
| CHGB | chromogranin B | -0.00485039 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.00482918 |
| C21ORF33 | chromosome 21 open reading frame 33 | -0.00482236 |
| ANGPTL2 | angiopoietin-like 2 | -0.00480864 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | -0.0048041 |
| GRAMD4 | GRAM domain containing 4 | -0.00478047 |
| REPIN1 | replication initiator 1 | -0.00475711 |
| FERMT2 | fermitin family member 2 | -0.00475593 |
| RGS5 | regulator of G-protein signaling 5 | -0.00472641 |
| COPZ2 | coatomer protein complex, subunit zeta 2 | -0.00472592 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00471828 |
| IDE | insulin-degrading enzyme | -0.00471802 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00471204 |
| PF4 | platelet factor 4 | -0.00470997 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00470737 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00470316 |
| SDC1 | syndecan 1 | -0.00469683 |
| MFAP3L | microfibrillar-associated protein 3-like | -0.00468888 |
| KLK12 | kallikrein-related peptidase 12 | -0.00468144 |
| BAG3 | BCL2-associated athanogene 3 | -0.00464489 |
| FUS | FUS RNA binding protein | -0.0046382 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.00463025 |
| AZU1 | azurocidin 1 | -0.00462793 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.0046265 |
| ACLY | ATP citrate lyase | -0.00462521 |
| TBX2 | T-box 2 | -0.00459868 |
| FADS1 | fatty acid desaturase 1 | -0.00459272 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | -0.00457752 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00457644 |
| BRD4 | bromodomain containing 4 | -0.00457375 |
| CBS | cystathionine-beta-synthase | -0.00456184 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -0.00455382 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00453417 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0045288 |
| JADE1 | jade family PHD finger 1 | -0.00452584 |
| KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 | -0.00451224 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00449936 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0044928 |
| MMP12 | matrix metallopeptidase 12 | -0.00448965 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.00448961 |
| HSPB7 | heat shock 27kDa protein family, member 7 (cardiovascular) | -0.00448666 |
| STK39 | serine threonine kinase 39 | -0.00448656 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00448365 |
| AOC3 | amine oxidase, copper containing 3 | -0.00448162 |
| SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | -0.00447063 |
| KAT6A | K(lysine) acetyltransferase 6A | -0.0044561 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00445199 |
| CD248 | CD248 molecule, endosialin | -0.00443049 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | -0.00442539 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00442289 |
| FBLN2 | fibulin 2 | -0.00441633 |
| GRB7 | growth factor receptor-bound protein 7 | -0.00441102 |
| RASA4 | RAS p21 protein activator 4 | -0.00440184 |
| SELP | selectin P (granule membrane protein 140kDa, antigen CD62) | -0.00439557 |
| CD93 | CD93 molecule | -0.00439369 |
| BEX1 | brain expressed, X-linked 1 | -0.0043809 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.00437591 |
| MALL | mal, T-cell differentiation protein-like | -0.0043634 |
| PLXND1 | plexin D1 | -0.0043554 |
| ATP5F1D | ATP synthase F1 subunit delta | -0.00434044 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00433905 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00432217 |
| LXN | latexin | -0.00431288 |
| ZW10 | zw10 kinetochore protein | -0.00431272 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00431023 |
| AP2A2 | adaptor-related protein complex 2, alpha 2 subunit | -0.0043057 |
| SLC38A10 | solute carrier family 38, member 10 | -0.00430556 |
| ATXN10 | ataxin 10 | -0.00428686 |
| CIT | citron rho-interacting serine/threonine kinase | -0.00427789 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.004272 |
| CTSG | cathepsin G | -0.00426797 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.00425708 |
| AMOTL2 | angiomotin like 2 | -0.00425558 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.00425248 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | -0.00424949 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | -0.00423923 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.00423511 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.0042308 |
| FSTL1 | follistatin-like 1 | -0.00422837 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.00422024 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00421876 |
| PLIN1 | perilipin 1 | -0.00421574 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0042063 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.00420167 |
| PRTN3 | proteinase 3 | -0.00419619 |
| GNAL | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | -0.00419371 |
| MME | membrane metallo-endopeptidase | -0.00418386 |
| MED13L | mediator complex subunit 13-like | -0.00417326 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.00416565 |
| GPM6B | glycoprotein M6B | -0.00416266 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.00415411 |
| COL8A2 | collagen, type VIII, alpha 2 | -0.0041497 |
| IRS2 | insulin receptor substrate 2 | -0.00414157 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.00413943 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | -0.0041305 |
| NFIB | nuclear factor I/B | -0.00412602 |
| THBS2 | thrombospondin 2 | -0.00410235 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.00409804 |
| STC1 | stanniocalcin 1 | -0.00409324 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0040783 |
| PHF10 | PHD finger protein 10 | -0.00407672 |
| ACKR3 | atypical chemokine receptor 3 | -0.00407332 |
| GSTP1 | glutathione S-transferase pi 1 | -0.00405752 |
| ACTB | actin, beta | -0.00404739 |
| SCNN1B | sodium channel, non voltage gated 1 beta subunit | -0.00403912 |
| YY1AP1 | YY1 associated protein 1 | -0.00403015 |
| ENAH | enabled homolog (Drosophila) | -0.00401923 |
| EHD2 | EH-domain containing 2 | -0.00401525 |
