ATF4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description activating transcription factor 4|This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 468)
External Link http://www.ncbi.nlm.nih.gov/gene/468
Similar Terms
Downloads & Tools

Genes

80 interacting proteins for ATF4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APH1A APH1A gamma secretase subunit
APP amyloid beta (A4) precursor protein
ASB7 ankyrin repeat and SOCS box containing 7
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATF7 activating transcription factor 7
BATF basic leucine zipper transcription factor, ATF-like
BATF2 basic leucine zipper transcription factor, ATF-like 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCDC106 coiled-coil domain containing 106
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CKAP4 cytoskeleton-associated protein 4
CREB3 cAMP responsive element binding protein 3
CREB5 cAMP responsive element binding protein 5
CREBBP CREB binding protein
CREBZF CREB/ATF bZIP transcription factor
DAPK3 death-associated protein kinase 3
DDIT3 DNA-damage-inducible transcript 3
DISC1 disrupted in schizophrenia 1
E2F1 E2F transcription factor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EP300 E1A binding protein p300
FBXW11 F-box and WD repeat domain containing 11
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPS2 G protein pathway suppressor 2
GTF2A1L general transcription factor IIA, 1-like
GTF2B general transcription factor IIB
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HAUS7 HAUS augmin-like complex, subunit 7
HK3 hexokinase 3 (white cell)
HLF hepatic leukemia factor
HNF4A hepatocyte nuclear factor 4, alpha
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
LDOC1 leucine zipper, down-regulated in cancer 1
LMNB1 lamin B1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPZL2 myelin protein zero-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEK6 NIMA-related kinase 6
NFE2 nuclear factor, erythroid 2
NFE2L1 nuclear factor, erythroid 2-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
PTCD3 pentatricopeptide repeat domain 3
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REPS1 RALBP1 associated Eps domain containing 1
RPS6 ribosomal protein S6
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SNAP29 synaptosomal-associated protein, 29kDa
SRA1 steroid receptor RNA activator 1
SUMO2 small ubiquitin-like modifier 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBP TATA box binding protein
TGM2 transglutaminase 2
TREX2 three prime repair exonuclease 2
TRIB3 tribbles pseudokinase 3
TRIM24 tripartite motif containing 24
TTR transthyretin
UBC ubiquitin C
ZNF212 zinc finger protein 212
ZNF226 zinc finger protein 226