| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | activating transcription factor 6|This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 22926) |
| External Link | https://ncbi.nlm.nih.gov/gene/22926 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the ATF6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CSTA | cystatin A (stefin A) | 0.00908774 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00890974 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00762419 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00721577 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.0070174 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00668983 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.0063214 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00622995 |
| TARP | TCR gamma alternate reading frame protein | 0.00622147 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.00622061 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | 0.00618476 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00615283 |
| CST7 | cystatin F (leukocystatin) | 0.0061324 |
| ACP3 | acid phosphatase 3 | 0.00603731 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00600787 |
| PRF1 | perforin 1 (pore forming protein) | 0.00598221 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00589817 |
| HBD | hemoglobin, delta | 0.0057981 |
| ALAS2 | 5'-aminolevulinate synthase 2 | 0.00576131 |
| S100A8 | S100 calcium binding protein A8 | 0.00568195 |
| NKG7 | natural killer cell granule protein 7 | 0.00567136 |
| TSPAN13 | tetraspanin 13 | 0.00562887 |
| EREG | epiregulin | 0.00562349 |
| OLFM4 | olfactomedin 4 | 0.0056142 |
| XIC | X chromosome inactivation center | 0.00559083 |
| LCN2 | lipocalin 2 | 0.00556735 |
| AHSP | alpha hemoglobin stabilizing protein | 0.00551833 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00550662 |
| PRDX2 | peroxiredoxin 2 | 0.00550429 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00534687 |
| CD8A | CD8a molecule | 0.00533402 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.00520761 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | 0.00519795 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.00510712 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00509516 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 0.00504485 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.0050185 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00500843 |
| MAMLD1 | mastermind-like domain containing 1 | 0.00499581 |
| FABP7 | fatty acid binding protein 7, brain | 0.00493627 |
| TCL1A | T-cell leukemia/lymphoma 1A | 0.00493493 |
| AK4 | adenylate kinase 4 | 0.00489438 |
| ITK | IL2-inducible T-cell kinase | 0.00488382 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.00484976 |
| WT1 | Wilms tumor 1 | 0.00483942 |
| FOXG1 | forkhead box G1 | 0.00483714 |
| GNLY | granulysin | 0.00482356 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0047918 |
| VPREB3 | pre-B lymphocyte 3 | 0.00478031 |
| CCND2 | cyclin D2 | 0.00477897 |
| S100A9 | S100 calcium binding protein A9 | 0.00477183 |
| C7 | complement component 7 | 0.00477081 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.00476442 |
| KIAA0226L | KIAA0226-like | 0.00473525 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00472619 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00471498 |
| IL7R | interleukin 7 receptor | 0.00469799 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.00468856 |
| RPA2 | replication protein A2, 32kDa | 0.00468696 |
| PITX3 | paired-like homeodomain 3 | 0.00462755 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00461704 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.00459837 |
| CLC | Charcot-Leyden crystal galectin | 0.00457029 |
| CD19 | CD19 molecule | 0.00452073 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00446621 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00444778 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.00443151 |
| NTS | neurotensin | 0.0044112 |
| H1-0 | H1.0 linker histone | 0.00437492 |
| MT1G | metallothionein 1G | 0.0043426 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.00431423 |
| EPB42 | erythrocyte membrane protein band 4.2 | 0.00429392 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00425497 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00424997 |
| MMP9 | matrix metallopeptidase 9 | 0.00424829 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00420497 |
| GPR171 | G protein-coupled receptor 171 | 0.00419777 |
| SKP1 | S-phase kinase-associated protein 1 | 0.00418152 |
| DCK | deoxycytidine kinase | 0.00417377 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00416641 |
| RPL36 | ribosomal protein L36 | 0.00416574 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00414197 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00412865 |
| FGF13 | fibroblast growth factor 13 | 0.0041136 |
| S100A12 | S100 calcium binding protein A12 | 0.0041006 |
| MT2A | metallothionein 2A | 0.0040955 |
| CD72 | CD72 molecule | 0.00409242 |
| MT1H | metallothionein 1H | 0.00408723 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.00407751 |
| HIST3H2A | histone cluster 3, H2a | 0.00403161 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00402039 |
| GLOD4 | glyoxalase domain containing 4 | 0.00401802 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00397349 |
| PRAME | preferentially expressed antigen in melanoma | 0.00397244 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00397033 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00396369 |
| SLC44A4 | solute carrier family 44, member 4 | 0.00395988 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | 0.00394878 |
| PAX5 | paired box 5 | 0.00394106 |
| ELANE | elastase, neutrophil expressed | 0.00391579 |
| NPRL2 | nitrogen permease regulator-like 2 (S. cerevisiae) | 0.00391513 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00390608 |
| CD247 | CD247 molecule | 0.00390097 |
| EPHB2 | EPH receptor B2 | 0.00388778 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00388266 |
| BEX1 | brain expressed, X-linked 1 | 0.00386798 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.00385404 |
| DMTN | dematin actin binding protein | 0.00384747 |
| MT1F | metallothionein 1F | 0.00384358 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.00383869 |
| FBXO11 | F-box protein 11 | 0.00383129 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00382774 |
| RRM2 | ribonucleotide reductase M2 | 0.00382025 |
| MGAM | maltase-glucoamylase | 0.00381187 |
| GPR65 | G protein-coupled receptor 65 | 0.00380291 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00379608 |
| PRR15L | proline rich 15-like | 0.0037844 |
| CD9 | CD9 molecule | 0.00376518 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.00376444 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.00375651 |
| SMAGP | small cell adhesion glycoprotein | 0.00374669 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00374445 |
| CD27 | CD27 molecule | 0.0037419 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.0037372 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 0.00372713 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.00371871 |
| BPI | bactericidal/permeability-increasing protein | 0.00370591 |
| NLRP2 | NLR family, pyrin domain containing 2 | 0.00369372 |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.00369157 |
| REG1B | regenerating islet-derived 1 beta | 0.00368092 |
| GPR18 | G protein-coupled receptor 18 | 0.00367268 |
| REG1A | regenerating islet-derived 1 alpha | 0.00364465 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00363107 |
| IL2RB | interleukin 2 receptor, beta | 0.00358836 |
| XK | X-linked Kx blood group | 0.00357755 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.003577 |
| RAD54B | RAD54 homolog B (S. cerevisiae) | 0.00357688 |
| KRT13 | keratin 13, type I | 0.00357185 |
| MMP8 | matrix metallopeptidase 8 | 0.00356864 |
| CHEK1 | checkpoint kinase 1 | 0.00355897 |
| HMBS | hydroxymethylbilane synthase | 0.00354566 |
| SNX11 | sorting nexin 11 | 0.00354085 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.00353403 |
| LTA4H | leukotriene A4 hydrolase | 0.00352749 |
| LEFTY1 | left-right determination factor 1 | 0.00352684 |
| IL2RG | interleukin 2 receptor, gamma | 0.00352664 |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | 0.00352339 |
| MPO | myeloperoxidase | 0.00351475 |
| AHCY | adenosylhomocysteinase | 0.00351233 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | 0.00349477 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00347043 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.0034663 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.00345827 |
| STK26 | serine/threonine protein kinase 26 | 0.00345175 |
| HOXB13 | homeobox B13 | 0.00345125 |
| RPIA | ribose 5-phosphate isomerase A | 0.00344921 |
| NPTX2 | neuronal pentraxin II | 0.00344616 |
| DNTT | DNA nucleotidylexotransferase | 0.00344581 |
| RGS20 | regulator of G-protein signaling 20 | 0.00344242 |
| ODC1 | ornithine decarboxylase 1 | 0.00342444 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.00341689 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00341029 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 0.00340661 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | 0.00339697 |
| CCN3 | cellular communication network factor 3 | 0.00339243 |
| FCMR | Fc fragment of IgM receptor | 0.00338736 |
| PF4 | platelet factor 4 | 0.00337978 |
| BST1 | bone marrow stromal cell antigen 1 | 0.00337547 |
| FABP6 | fatty acid binding protein 6, ileal | 0.00337266 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | 0.00336899 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | 0.00336689 |
| TRIB2 | tribbles pseudokinase 2 | 0.00336012 |
| RGS13 | regulator of G-protein signaling 13 | 0.00335524 |
| FZD5 | frizzled class receptor 5 | 0.00334621 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 0.00334478 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.00333702 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.00333204 |
| PHB2 | prohibitin 2 | 0.00332587 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00332214 |
| SCEL | sciellin | 0.00332012 |
| DIAPH2 | diaphanous-related formin 2 | 0.00330823 |
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 0.00330561 |
| GLUD2 | glutamate dehydrogenase 2 | 0.00329955 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 0.00329545 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | 0.00328794 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.00327397 |
| ADD3 | adducin 3 (gamma) | 0.0032716 |
| CD2 | CD2 molecule | 0.00325409 |
| MSMB | microseminoprotein, beta- | 0.00325084 |
| MT1E | metallothionein 1E | 0.00325047 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.0032257 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 0.00321334 |
| GLRX5 | glutaredoxin 5 | 0.00321034 |
| ATP10B | ATPase, class V, type 10B | 0.00320963 |
| SATB2 | SATB homeobox 2 | 0.00319805 |
| CD22 | CD22 molecule | 0.00319722 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.00319577 |
| FAM162A | family with sequence similarity 162, member A | 0.00319046 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 0.00318738 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.00317931 |
| KIF5C | kinesin family member 5C | 0.00317205 |
| MAT2B | methionine adenosyltransferase II, beta | 0.00316802 |
| GSTZ1 | glutathione S-transferase zeta 1 | 0.00316474 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 0.00315569 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00315486 |
| TRAF4 | TNF receptor-associated factor 4 | 0.00315147 |
| RSL24D1 | ribosomal L24 domain containing 1 | 0.00315124 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00314897 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | 0.00314837 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00314454 |
| CCDC47 | coiled-coil domain containing 47 | 0.00313811 |
| ZFAND1 | zinc finger, AN1-type domain 1 | 0.00313407 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00313077 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.00311306 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00311135 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.00310182 |
| RPL36AL | ribosomal protein L36a-like | 0.00310117 |
| MME | membrane metallo-endopeptidase | 0.0031001 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.00309781 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.00309738 |
| GLO1 | glyoxalase I | 0.00309603 |
| NKX3-1 | NK3 homeobox 1 | 0.00309421 |
| OIP5 | Opa interacting protein 5 | 0.00309173 |
| BLVRB | biliverdin reductase B | 0.00308383 |
| KLRF1 | killer cell lectin-like receptor subfamily F, member 1 | 0.00308134 |
| CDK14 | cyclin-dependent kinase 14 | 0.00307074 |
| ARRB2 | arrestin, beta 2 | 0.00305889 |
| DSCC1 | DNA replication and sister chromatid cohesion 1 | 0.00305408 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00305016 |
| PKM | pyruvate kinase, muscle | 0.00304875 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00304807 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | 0.00304611 |
| AKR1A1 | aldo-keto reductase family 1, member A1 (aldehyde reductase) | 0.00304583 |
| S100P | S100 calcium binding protein P | 0.00304051 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | 0.00303648 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00303587 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 0.00303175 |
| ACE2 | angiotensin I converting enzyme 2 | 0.00302852 |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | 0.00302436 |
| ADD2 | adducin 2 (beta) | 0.00302168 |
| DEFA6 | defensin, alpha 6, Paneth cell-specific | 0.00301523 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.00301493 |
| IRF8 | interferon regulatory factor 8 | 0.00301426 |
| RPL14 | ribosomal protein L14 | 0.00301316 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00301273 |
| PCTP | phosphatidylcholine transfer protein | 0.00301255 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00301173 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.00301118 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 0.00300472 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00299795 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATF6 | activating transcription factor 6 | -0.0111791 |
| KRT7 | keratin 7, type II | -0.00924032 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00753552 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00706982 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00706563 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00683733 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00670853 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.00664486 |
| ACKR3 | atypical chemokine receptor 3 | -0.00655809 |
| REEP1 | receptor accessory protein 1 | -0.00649866 |
| PLXND1 | plexin D1 | -0.00639175 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00632608 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00631993 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.00630902 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.00630509 |
| SIK1 | salt-inducible kinase 1 | -0.00621201 |
| EFHD1 | EF-hand domain family, member D1 | -0.00619723 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00612541 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00601492 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00594031 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00586426 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00575703 |
| MFAP5 | microfibrillar associated protein 5 | -0.00574257 |
| AK1 | adenylate kinase 1 | -0.00573613 |
| RTN2 | reticulon 2 | -0.00571351 |
| ZIC1 | Zic family member 1 | -0.00570737 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00559942 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -0.0055764 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00549038 |
| RGS5 | regulator of G-protein signaling 5 | -0.00545584 |
| SYNM | synemin, intermediate filament protein | -0.00543166 |
| SH3BP4 | SH3-domain binding protein 4 | -0.00537514 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -0.00531282 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00525275 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00523951 |
| PEG10 | paternally expressed 10 | -0.00522738 |
| MGLL | monoglyceride lipase | -0.0052051 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00518992 |
| DAPK1 | death-associated protein kinase 1 | -0.00516651 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.00516347 |
| OPN3 | opsin 3 | -0.00515679 |
| MGP | matrix Gla protein | -0.00510506 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -0.00502999 |
| IER5 | immediate early response 5 | -0.00501507 |
| PLK2 | polo-like kinase 2 | -0.00498511 |
| PODXL | podocalyxin-like | -0.00495123 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00492051 |
| POGK | pogo transposable element with KRAB domain | -0.00487972 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00487133 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00485556 |
| RGS16 | regulator of G-protein signaling 16 | -0.00485261 |
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | -0.00483664 |
| PALMD | palmdelphin | -0.00483645 |
| PFDN2 | prefoldin subunit 2 | -0.00478144 |
| RGCC | regulator of cell cycle | -0.004766 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00475807 |
| EFNA1 | ephrin-A1 | -0.00472941 |
| EMP3 | epithelial membrane protein 3 | -0.00464114 |
| PLPP3 | phospholipid phosphatase 3 | -0.0046114 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00460695 |
| CCNA2 | cyclin A2 | -0.00453314 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00453006 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00452868 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.00451463 |
| RCAN2 | regulator of calcineurin 2 | -0.00445027 |
| DST | dystonin | -0.00443489 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00443345 |
| RUFY3 | RUN and FYVE domain containing 3 | -0.00440851 |
| CLU | clusterin | -0.00440823 |
| KRT17 | keratin 17, type I | -0.00438839 |
| LAMB1 | laminin, beta 1 | -0.00437406 |
| TP53BP2 | tumor protein p53 binding protein 2 | -0.00437287 |
| MAP7 | microtubule-associated protein 7 | -0.00436684 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00431382 |
| CEP350 | centrosomal protein 350kDa | -0.00430262 |
| FBLN2 | fibulin 2 | -0.00428509 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00428294 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00426832 |
| PROM1 | prominin 1 | -0.00425119 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | -0.00422189 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.00421978 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00421008 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00420404 |
| HEATR1 | HEAT repeat containing 1 | -0.0042038 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00419399 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00418655 |
| NNMT | nicotinamide N-methyltransferase | -0.00416842 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00416677 |
| PENK | proenkephalin | -0.00416395 |
| DIO2 | deiodinase, iodothyronine, type II | -0.00413198 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.00412777 |
| TAGLN2 | transgelin 2 | -0.00412494 |
| A2M | alpha-2-macroglobulin | -0.0041147 |
| MYOF | myoferlin | -0.00411118 |
| BRD2 | bromodomain containing 2 | -0.00407635 |
| PMP22 | peripheral myelin protein 22 | -0.00406283 |
| LMNA | lamin A/C | -0.00404514 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00404336 |
| PCDH17 | protocadherin 17 | -0.00404236 |
| RBPMS | RNA binding protein with multiple splicing | -0.00404054 |
| PTN | pleiotrophin | -0.00402069 |
| INSR | insulin receptor | -0.00400552 |
| THBS4 | thrombospondin 4 | -0.0039933 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.00398749 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.00397594 |
| VWF | von Willebrand factor | -0.00396283 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.00395419 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.00394483 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00393605 |
| CSRP1 | cysteine and glycine-rich protein 1 | -0.00393223 |
| PERP | PERP, TP53 apoptosis effector | -0.00390437 |
| TXLNA | taxilin alpha | -0.00389738 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00389385 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.00389074 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00388727 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00386462 |
| PLXNA2 | plexin A2 | -0.00384946 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00384834 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.00384713 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0038441 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00383794 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00383471 |
| SQSTM1 | sequestosome 1 | -0.0038313 |
| IL6R | interleukin 6 receptor | -0.00383019 |
| C9ORF3 | chromosome 9 open reading frame 3 | -0.00382638 |
| ESRRG | estrogen-related receptor gamma | -0.00382398 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -0.00382297 |
| PRRC2C | proline-rich coiled-coil 2C | -0.00381684 |
| CTSZ | cathepsin Z | -0.00378467 |
| RUFY2 | RUN and FYVE domain containing 2 | -0.00378193 |
| DUSP1 | dual specificity phosphatase 1 | -0.00375553 |
| FBN1 | fibrillin 1 | -0.00374363 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.00374282 |
| CAPN6 | calpain 6 | -0.00373863 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | -0.00372507 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00370626 |
| CERK | ceramide kinase | -0.00370387 |
| KIF14 | kinesin family member 14 | -0.00370201 |
| AMOTL2 | angiomotin like 2 | -0.00369482 |
| FILIP1L | filamin A interacting protein 1-like | -0.00368905 |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | -0.00367848 |
| MMP7 | matrix metallopeptidase 7 | -0.00365923 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0036586 |
| GSDME | gasdermin E | -0.00364878 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.00363743 |
| INHBB | inhibin, beta B | -0.0036279 |
| CEP170 | centrosomal protein 170kDa | -0.00362515 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.00361779 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | -0.00359826 |
| MEF2C | myocyte enhancer factor 2C | -0.00358969 |
| IRS1 | insulin receptor substrate 1 | -0.00358213 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00356341 |
| WASL | Wiskott-Aldrich syndrome-like | -0.00356055 |
| DCX | doublecortin | -0.00355432 |
| CD93 | CD93 molecule | -0.00355057 |
| IFRD1 | interferon-related developmental regulator 1 | -0.00354198 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.00353586 |
| ACOT9 | acyl-CoA thioesterase 9 | -0.00353447 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00353203 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00351398 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.00350247 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | -0.00348759 |
| ICAM2 | intercellular adhesion molecule 2 | -0.00347905 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.0034739 |
| FOLR1 | folate receptor 1 (adult) | -0.00347325 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00347264 |
| MITF | microphthalmia-associated transcription factor | -0.0034702 |
| SEPTIN2 | septin 2 | -0.0034667 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00346047 |
| CHKA | choline kinase alpha | -0.00344404 |
| STEAP3 | STEAP family member 3, metalloreductase | -0.00344007 |
| HIST1H2BK | histone cluster 1, H2bk | -0.00343937 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.00343768 |
| STK25 | serine/threonine kinase 25 | -0.00343715 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00343183 |
| JUNB | jun B proto-oncogene | -0.00342943 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00342708 |
| C1ORF56 | chromosome 1 open reading frame 56 | -0.00341651 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.00340933 |
| GAS6 | growth arrest-specific 6 | -0.00340462 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | -0.00339857 |
| SDC2 | syndecan 2 | -0.00339762 |
| NCOR2 | nuclear receptor corepressor 2 | -0.00339725 |
| FZD10 | frizzled class receptor 10 | -0.0033972 |
| PLXDC1 | plexin domain containing 1 | -0.00339344 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00338853 |
| C4BPB | complement component 4 binding protein, beta | -0.00338382 |
| MECOM | MDS1 and EVI1 complex locus | -0.00337879 |
| SDC1 | syndecan 1 | -0.00337725 |
| MXRA5 | matrix-remodelling associated 5 | -0.00337128 |
| OSR2 | odd-skipped related transciption factor 2 | -0.00337059 |
| AREG | amphiregulin | -0.00336575 |
| CFH | complement factor H | -0.00336417 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | -0.00335771 |
| KIF1A | kinesin family member 1A | -0.00335586 |
| SRGN | serglycin | -0.00335483 |
| TIMM17A | translocase of inner mitochondrial membrane 17 homolog A (yeast) | -0.00335024 |
| FAM50A | family with sequence similarity 50, member A | -0.00332979 |
| SDHAP1 | succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 | -0.00332965 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00332676 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.00331719 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.00331597 |
| TRIM8 | tripartite motif containing 8 | -0.00331493 |
| RRBP1 | ribosome binding protein 1 | -0.00331439 |
| TRIM16 | tripartite motif containing 16 | -0.00331201 |
| AHR | aryl hydrocarbon receptor | -0.0033061 |
| ITM2A | integral membrane protein 2A | -0.00330607 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.00330448 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00330287 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00330068 |
| MAP1B | microtubule-associated protein 1B | -0.00329141 |
| TAGLN | transgelin | -0.00329116 |
| CLGN | calmegin | -0.00328662 |
| BMP2 | bone morphogenetic protein 2 | -0.00328023 |
| NAV2 | neuron navigator 2 | -0.00327577 |
| NUTF2 | nuclear transport factor 2 | -0.0032689 |
| ANGPT1 | angiopoietin 1 | -0.00326357 |
| FRY | furry homolog (Drosophila) | -0.00326314 |
| EXT1 | exostosin glycosyltransferase 1 | -0.00323652 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.0032357 |
| MATN2 | matrilin 2 | -0.00323287 |
| SNX7 | sorting nexin 7 | -0.00323269 |
| RIN2 | Ras and Rab interactor 2 | -0.00323037 |
| RELN | reelin | -0.00323006 |
| PLCB4 | phospholipase C, beta 4 | -0.00322942 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | -0.00322704 |
| KRT14 | keratin 14, type I | -0.00321262 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00321155 |
| IPO9 | importin 9 | -0.00320936 |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit | -0.00320746 |
| DUSP10 | dual specificity phosphatase 10 | -0.00320522 |
| GRB7 | growth factor receptor-bound protein 7 | -0.00320305 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.00320065 |
| TXNRD1 | thioredoxin reductase 1 | -0.0031999 |
| TLR5 | toll-like receptor 5 | -0.00319749 |
| SLC25A44 | solute carrier family 25, member 44 | -0.00319564 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00318934 |
| SELE | selectin E | -0.0031882 |
| BTG2 | BTG family, member 2 | -0.00318685 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.00318427 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | -0.00318353 |
| DESI1 | desumoylating isopeptidase 1 | -0.00318264 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00317555 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.00317489 |
| STMN2 | stathmin 2 | -0.00317397 |
| ANGPT2 | angiopoietin 2 | -0.00316042 |
| CRY1 | cryptochrome circadian clock 1 | -0.00316023 |
| KMT5B | lysine methyltransferase 5B | -0.00315417 |
| CD14 | CD14 molecule | -0.0031527 |
| THBS1 | thrombospondin 1 | -0.00314933 |
