ATF6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description activating transcription factor 6|This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 22926)
External Link http://www.ncbi.nlm.nih.gov/gene/22926
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Genes

33 interacting proteins for ATF6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APP amyloid beta (A4) precursor protein
ATF6B activating transcription factor 6 beta
BPGM 2,3-bisphosphoglycerate mutase
CREB1 cAMP responsive element binding protein 1
CREB3L3 cAMP responsive element binding protein 3-like 3
CREBZF CREB/ATF bZIP transcription factor
CRTC2 CREB regulated transcription coactivator 2
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
FBXO6 F-box protein 6
GTF2I general transcription factor IIi
HNF4A hepatocyte nuclear factor 4, alpha
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAX MYC associated factor X
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFYA nuclear transcription factor Y, alpha
NFYC nuclear transcription factor Y, gamma
NNMT nicotinamide N-methyltransferase
SAR1A secretion associated, Ras related GTPase 1A
SREBF2 sterol regulatory element binding transcription factor 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SUMO2 small ubiquitin-like modifier 2
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
UBC ubiquitin C
WFS1 Wolfram syndrome 1 (wolframin)
XBP1 X-box binding protein 1
YY1 YY1 transcription factor